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Science 23 January 1998:
Vol. 279. no. 5350, pp. 509 - 514
DOI: 10.1126/science.279.5350.509
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Articles

Rho GTPases and the Actin Cytoskeleton

Alan Hall

The actin cytoskeleton mediates a variety of essential biological functions in all eukaryotic cells. In addition to providing a structural framework around which cell shape and polarity are defined, its dynamic properties provide the driving force for cells to move and to divide. Understanding the biochemical mechanisms that control the organization of actin is thus a major goal of contemporary cell biology, with implications for health and disease. Members of the Rho family of small guanosine triphosphatases have emerged as key regulators of the actin cytoskeleton, and furthermore, through their interaction with multiple target proteins, they ensure coordinated control of other cellular activities such as gene transcription and adhesion.

The author is at the Medical Research Council Laboratory for Molecular Cell Biology, Cancer Research Campaign Oncogene and Signal Transduction Group, University College London, Gower Street, London WC1E 6BT, UK. E-mail: alan.hall{at}ucl.ac.uk

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Plasticity of Neuron-Glial Interactions Mediated by Astrocytic EphARs.
M. W. Nestor, L.-P. Mok, M. E. Tulapurkar, and S. M. Thompson (2007)
J. Neurosci. 27, 12817-12828
   Abstract »    Full Text »    PDF »
16-kDa Prolactin Inhibits Endothelial Cell Migration by Down-Regulating the Ras-Tiam1-Rac1-Pak1 Signaling Pathway.
S.-H. Lee, J. Kunz, S.-H. Lin, and L.-y. Yu-Lee (2007)
Cancer Res. 67, 11045-11053
   Abstract »    Full Text »    PDF »
SH4-domain-induced plasma membrane dynamization promotes bleb-associated cell motility.
S. Tournaviti, S. Hannemann, S. Terjung, T. M. Kitzing, C. Stegmayer, J. Ritzerfeld, P. Walther, R. Grosse, W. Nickel, and O. T. Fackler (2007)
J. Cell Sci. 120, 3820-3829
   Abstract »    Full Text »    PDF »
Fragile Histidine Triad Mediated Tumor Suppression of Lung Cancer by Targeting Multiple Components of the Ras/Rho GTPase Molecular Switch.
G. Jayachandran, J.-i. Sazaki, M. Nishizaki, K. Xu, L. Girard, J. D. Minna, J. A. Roth, and L. Ji (2007)
Cancer Res. 67, 10379-10388
   Abstract »    Full Text »    PDF »
Actin cytoskeleton dynamics linked to synovial fibroblast activation as a novel pathogenic principle in TNF-driven arthritis.
Y Vasilopoulos, V Gkretsi, M Armaka, V Aidinis, and G Kollias (2007)
Ann Rheum Dis 66, iii23-iii28
   Abstract »    Full Text »    PDF »
Arp2/3-independent assembly of actin by Vibrio type III effector VopL.
A. D. B. Liverman, H.-C. Cheng, J. E. Trosky, D. W. Leung, M. L. Yarbrough, D. L. Burdette, M. K. Rosen, and K. Orth (2007)
PNAS 104, 17117-17122
   Abstract »    Full Text »    PDF »
Stimulation of Actin Polymerization by Vacuoles via Cdc42p-dependent Signaling.
S. Isgandarova, L. Jones, D. Forsberg, A. Loncar, J. Dawson, K. Tedrick, and G. Eitzen (2007)
J. Biol. Chem. 282, 30466-30475
   Abstract »    Full Text »    PDF »
G{alpha}q Directly Activates p63RhoGEF and Trio via a Conserved Extension of the Dbl Homology-associated Pleckstrin Homology Domain.
R. J. Rojas, M. E. Yohe, S. Gershburg, T. Kawano, T. Kozasa, and J. Sondek (2007)
J. Biol. Chem. 282, 29201-29210
   Abstract »    Full Text »    PDF »
The PP2A-associated Protein {alpha}4 Plays a Critical Role in the Regulation of Cell Spreading and Migration.
M. Kong, T. V. Bui, D. Ditsworth, J. J. Gruber, D. Goncharov, V. P. Krymskaya, T. Lindsten, and C. B. Thompson (2007)
J. Biol. Chem. 282, 29712-29720
   Abstract »    Full Text »    PDF »
Cdc42 and Phosphoinositide 3-Kinase Drive Rac-Mediated Actin Polymerization Downstream of c-Met in Distinct and Common Pathways.
T. Bosse, J. Ehinger, A. Czuchra, S. Benesch, A. Steffen, X. Wu, K. Schloen, H. H. Niemann, G. Scita, T. E. B. Stradal, et al. (2007)
Mol. Cell. Biol. 27, 6615-6628
   Abstract »    Full Text »    PDF »
Cdc42 is required for EGF-stimulated protrusion and motility in MTLn3 carcinoma cells.
M. El-Sibai, P. Nalbant, H. Pang, R. J. Flinn, C. Sarmiento, F. Macaluso, M. Cammer, J. S. Condeelis, K. M. Hahn, and J. M. Backer (2007)
J. Cell Sci. 120, 3465-3474
   Abstract »    Full Text »    PDF »


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