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Science 23 January 1998:
Vol. 279. no. 5350, pp. 509 - 514
DOI: 10.1126/science.279.5350.509
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Articles

Rho GTPases and the Actin Cytoskeleton

Alan Hall

The actin cytoskeleton mediates a variety of essential biological functions in all eukaryotic cells. In addition to providing a structural framework around which cell shape and polarity are defined, its dynamic properties provide the driving force for cells to move and to divide. Understanding the biochemical mechanisms that control the organization of actin is thus a major goal of contemporary cell biology, with implications for health and disease. Members of the Rho family of small guanosine triphosphatases have emerged as key regulators of the actin cytoskeleton, and furthermore, through their interaction with multiple target proteins, they ensure coordinated control of other cellular activities such as gene transcription and adhesion.

The author is at the Medical Research Council Laboratory for Molecular Cell Biology, Cancer Research Campaign Oncogene and Signal Transduction Group, University College London, Gower Street, London WC1E 6BT, UK. E-mail: alan.hall{at}ucl.ac.uk

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Role of Small GTPase Rho in Regulating Corneal Epithelial Wound Healing.
J. Yin, J. Lu, and F.-S. X. Yu (2008)
Invest. Ophthalmol. Vis. Sci. 49, 900-909
   Abstract »    Full Text »    PDF »
Blocking LINGO-1 Function Promotes Retinal Ganglion Cell Survival Following Ocular Hypertension and Optic Nerve Transection.
Q.-L. Fu, B. Hu, W. Wu, R. B. Pepinsky, S. Mi, and K.-F. So (2008)
Invest. Ophthalmol. Vis. Sci. 49, 975-985
   Abstract »    Full Text »    PDF »
Proteomics Analysis of Host Cells Infected with Infectious Bursal Disease Virus.
X. Zheng, L. Hong, L. Shi, J. Guo, Z. Sun, and J. Zhou (2008)
Mol. Cell. Proteomics 7, 612-625
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Interaction and localization of Necl-5 and PDGF receptor beta at the leading edges of moving NIH3T3 cells: Implications for directional cell movement..
H. Amano, W. Ikeda, S. Kawano, M. Kajita, Y. Tamaru, N. Inoue, Y. Minami, A. Yamada, and Y. Takai (2008)
Genes Cells 13, 269-284
   Abstract »    Full Text »    PDF »
Bradykinin modulates focal adhesions and induces stress fiber remodeling in renal papillary collecting duct cells.
M. G. Marquez, M. del Carmen Fernandez-Tome, N. O. Favale, L. G. Pescio, and N. B. Sterin-Speziale (2008)
Am J Physiol Renal Physiol 294, F603-F613
   Abstract »    Full Text »    PDF »
Amelioration of Crescentic Glomerulonephritis by RhoA Kinase Inhibitor, Fasudil, through Podocyte Protection and Prevention of Leukocyte Migration.
T. Hidaka, Y. Suzuki, M. Yamashita, T. Shibata, Y. Tanaka, S. Horikoshi, and Y. Tomino (2008)
Am. J. Pathol. 172, 603-614
   Abstract »    Full Text »    PDF »
Heterotrimeric G Protein {gamma} Subunits Stimulate FLJ00018, a Guanine Nucleotide Exchange Factor for Rac1 and Cdc42.
H. Ueda, R. Nagae, M. Kozawa, R. Morishita, S. Kimura, T. Nagase, O. Ohara, S. Yoshida, and T. Asano (2008)
J. Biol. Chem. 283, 1946-1953
   Abstract »    Full Text »    PDF »
The IQGAP1-Rac1 and IQGAP1-Cdc42 Interactions: INTERFACES DIFFER BETWEEN THE COMPLEXES.
D. Owen, L. J. Campbell, K. Littlefield, K. A. Evetts, Z. Li, D. B. Sacks, P. N. Lowe, and H. R. Mott (2008)
J. Biol. Chem. 283, 1692-1704
   Abstract »    Full Text »    PDF »
Embryological Origin of Airway Smooth Muscle.
K. R. Badri, Y. Zhou, and L. Schuger (2008)
Proceedings of the ATS 5, 4-10
   Abstract »    Full Text »    PDF »
Histone Deacetylase 6 Regulates Growth Factor-Induced Actin Remodeling and Endocytosis.
Y.-s. Gao, C. C. Hubbert, J. Lu, Y.-S. Lee, J.-Y. Lee, and T.-P. Yao (2007)
Mol. Cell. Biol. 27, 8637-8647
   Abstract »    Full Text »    PDF »
Potential Role of Rho-Associated Protein Kinase Inhibitor Y-27632 in Glaucoma Filtration Surgery.
M. Honjo, H. Tanihara, T. Kameda, T. Kawaji, N. Yoshimura, and M. Araie (2007)
Invest. Ophthalmol. Vis. Sci. 48, 5549-5557
   Abstract »    Full Text »    PDF »


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