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Science 16 January 1998:
Vol. 279. no. 5349, pp. 399 - 403
DOI: 10.1126/science.279.5349.399
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Reports

Postsynaptic Membrane Fusion and Long-Term Potentiation

Pierre-Marie Lledo, * Xiangyang Zhang, Thomas C. Südhof, Robert C. Malenka, Roger A. Nicoll dagger

The possibility that membrane fusion events in the postsynaptic cell may be required for the change in synaptic strength resulting from long-term potentiation (LTP) was examined. Introducing substances into the postsynaptic cell that block membrane fusion at a number of different steps reduced LTP. Introducing SNAP, a protein that promotes membrane fusion, into cells enhanced synaptic transmission, and this enhancement was significantly less when generated in synapses that expressed LTP. Thus, postsynaptic fusion events, which could be involved either in retrograde signaling or in regulating postsynaptic receptor function or both, contribute to LTP.

P.-M. Lledo, Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94143, USA.
X. Zhang and T. C. Südhof, Department of Molecular Genetics and Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75235, USA.
R. C. Malenka, Departments of Psychiatry and Physiology, University of California, San Francisco, CA 94143, USA.
R. A. Nicoll, Departments of Cellular and Molecular Pharmacology and Physiology, University of California, San Francisco, CA 94143, USA.
*   Present address: CNRS, Institut A. Fessard, Avenue de la Terrasse, 91198 Gif-sur-Yvette Cedex, France.

dagger    To whom correspondence should be addressed. E-mail: nicoll{at}phy.ucsf.edu

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