Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 16 January 1998:
Vol. 279. no. 5349, pp. 389 - 393
DOI: 10.1126/science.279.5349.389
Prev | Table of Contents | Next

Reports

Genetic Restriction of AIDS Pathogenesis by an SDF-1 Chemokine Gene Variant

Cheryl Winkler, William Modi, Michael W. Smith, George W. Nelson, Xueyun Wu, Mary Carrington, Michael Dean, Tasaku Honjo, Kai Tashiro, D. Yabe, Susan Buchbinder, Eric Vittinghoff, James J. Goedert, Thomas R. O'Brien, Lisa P. Jacobson, Roger Detels, Sharyne Donfield, Anne Willoughby, Edward Gomperts, David Vlahov, John Phair, ALIVE Study, Hemophilia Growth and Development Study (HGDS), Multicenter AIDS Cohort Study (MACS), Multicenter Hemophilia Cohort Study (MHCS), San Francisco City Cohort (SFCC), Stephen J. O'Brien *

Stromal-derived factor (SDF-1) is the principal ligand for CXCR4, a coreceptor with CD4 for T lymphocyte cell line-tropic human immunodeficiency virus-type 1 (HIV-1). A common polymorphism, SDF1-3'A, was identified in an evolutionarily conserved segment of the 3' untranslated region of the SDF-1 structural gene transcript. In the homozygous state, SDF1-3'A/3'A delays the onset of acquired immunodeficiency syndrome (AIDS), according to a genetic association analysis of 2857 patients enrolled in five AIDS cohort studies. The recessive protective effect of SDF1-3'A was increasingly pronounced in individuals infected with HIV-1 for longer periods, was twice as strong as the dominant genetic restriction of AIDS conferred by CCR5 and CCR2 chemokine receptor variants in these populations, and was complementary with these mutations in delaying the onset of AIDS.

C. Winkler, W. Modi, M. W. Smith, G. W. Nelson, X. Wu, M. Carrington, Science Applications International Corporation (SAIC), National Cancer Institute, Frederick, MD 21702, USA.
M. Dean and S. J. O'Brien, Laboratory of Genomic Diversity, National Cancer Institute, Frederick, MD 21702, USA.
T. Honjo and D. Yabe, Department of Medical Chemistry, Kyoto University, Kyoto, Japan.
K. Tashiro, Center for Molecular Biology and Genetics, Kyoto University, Kyoto, Japan.
S. Buchbinder and E. Vittinghoff, AIDS Office, Department of Public Health, 25 Van Ness Avenue, Suite 500, San Francisco, CA 94102, USA.
J. J. Goedert and T. R. O'Brien, Viral Epidemiology Branch, National Cancer Institute, Executive Plaza North, 6130 Executive Boulevard, Bethesda, MD 20892, USA.
L. P. Jacobson, CAMACS, Department of Epidemiology, Johns Hopkins School of Hygiene and Public Health, Room E-7006, 615 North Wolfe Street, Baltimore, MD 21205, USA.
R. Detels, UCLA School of Public Health, Department of Epidemiology, Center for Health Sciences, Room 71-267, Box 951772, Los Angeles, CA 90095, USA.
S. Donfield, Rho Inc., 121 South Estes Drive, Suite 100, Chapel Hill, NC 27514, USA.
A. Willoughby, Center for Research for Mothers and Children, National Institute of Child Health and Human Development, Building 61E, Room 4B11H, Bethesda, MD 20892, USA.
E. Gomperts, Children's Hospital of Los Angeles, 4650 Sunset Boulevard, Los Angeles, CA 90027, USA.
D. Vlahov, Department of Epidemiology, Johns Hopkins School of Hygiene and Public Health, Room E-6008, 615 North Wolfe Street, Baltimore, MD 21205, USA.
J. Phair, Northwestern University Medical School, Comprehensive AIDS Center, 6980 North Lake Shore Drive, Suite 1106, Chicago, IL 60611, USA.
*   To whom correspondence should be addressed.

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Elevated Plasma Stromal Cell-derived Factor 1 Protein and its Gene Polymorphism in Patients With Pelvic Inflammatory Disease.
H.-T. Tsai, Y.-T. Tee, Y.-H. Hsieh, H.-L. Chiou, C.-W. Lin, H.-C. Tsai, P.-H. Wang, and S.-F. Yang (2009)
Reproductive Sciences 16, 610-617
   Abstract »    PDF »
Patterns of Diversity in HIV-Related Loci among Subspecies of Chimpanzee: Concordance at CCR5 and Differences at CXCR4 and CX3CR1.
T.S. MacFie, E. Nerrienet, N.G. de Groot, R.E. Bontrop, and N.I. Mundy (2009)
Mol. Biol. Evol. 26, 719-727
   Abstract »    Full Text »    PDF »
No Association between Common Chemokine and Chemokine Receptor Gene Variants and Prostate Cancer Risk.
D. C. Petersen, G. Severi, H. N. Hoang, E. J.D. Padilla, M. C. Southey, D. R. English, J. L. Hopper, G. G. Giles, and V. M. Hayes (2008)
Cancer Epidemiol. Biomarkers Prev. 17, 3615-3617
   Abstract »    Full Text »    PDF »
Plasma Stromal Cell-Derived Factor-1: Host Derived Marker Predictive of Distant Metastasis in Breast Cancer.
S. Hassan, A. Baccarelli, O. Salvucci, and M. Basik (2008)
Clin. Cancer Res. 14, 446-454
   Abstract »    Full Text »    PDF »
CXCL12 G801A Polymorphism Is a Risk Factor for Sporadic Prostate Cancer Susceptibility.
H. Hirata, Y. Hinoda, N. Kikuno, K. Kawamoto, A. V. Dahiya, Y. Suehiro, Y. Tanaka, and R. Dahiya (2007)
Clin. Cancer Res. 13, 5056-5062
   Abstract »    Full Text »    PDF »
The Role of Immunity and Inflammation in the Progression of Atherosclerosis in Patients With HIV Infection.
B. Coll, S. Parra, C. Alonso-Villaverde, G. Aragones, M. Montero, J. Camps, J. Joven, and L. Masana (2007)
Stroke 38, 2477-2484
   Abstract »    Full Text »    PDF »
Genetic Susceptibility, HIV Infection, and the Kidney.
K. Kiryluk, J. Martino, and A. G. Gharavi (2007)
Clin. J. Am. Soc. Nephrol. 2, S25-S35
   Abstract »    Full Text »    PDF »
CXCL12 polymorphism and malignant cell dissemination/tissue infiltration in acute myeloid leukemia.
F. Dommange, G. Cartron, C. Espanel, N. Gallay, J. Domenech, L. Benboubker, M. Ohresser, P. Colombat, C. Binet, H. Watier, et al. (2006)
FASEB J 20, 1913-1915
   Abstract »    Full Text »    PDF »
Long-lasting CCR5 internalization by antibodies in a subset of long-term nonprogressors: a possible protective effect against disease progression.
C. Pastori, B. Weiser, C. Barassi, C. Uberti-Foppa, S. Ghezzi, R. Longhi, G. Calori, H. Burger, K. Kemal, G. Poli, et al. (2006)
Blood 107, 4825-4833
   Abstract »    Full Text »    PDF »
Association of stromal cell-derived factor 1 genotype with diabetic foot syndrome and macrovascular disease in patients with type 2 diabetes..
P. M. Humpert, M. J. Battista, A. Lammert, P. Reismann, Z. Djuric, G. Rudofsky Jr, M. Zorn, M. Morcos, H.-P. Hammes, P. P. Nawroth, et al. (2006)
Clin. Chem. 52, 1206-1208
   Full Text »    PDF »
CD8+ and CD20+ Lymphocytes Cooperate To Control Acute Simian Immunodeficiency Virus/Human Immunodeficiency Virus Chimeric Virus Infections in Rhesus Monkeys: Modulation by Major Histocompatibility Complex Genotype.
H. Mao, B. A. P. Lafont, T. Igarashi, Y. Nishimura, C. Brown, V. Hirsch, A. Buckler-White, R. Sadjadpour, and M. A. Martin (2005)
J. Virol. 79, 14887-14898
   Abstract »    Full Text »    PDF »
SDF1-3'A Gene Polymorphism Is Associated with Chronic Myeloproliferative Disease and Thrombotic Events.
G. Gerli, C. Vanelli, O. Turri, M. Erario, A. Gardellini, M. Pugliano, and M. L. Biondi (2005)
Clin. Chem. 51, 2411-2414
   Full Text »    PDF »
Use of a Combined Ex Vivo/In Vivo Population Approach for Screening of Human Genes Involved in the Human Immunodeficiency Virus Type 1 Life Cycle for Variants Influencing Disease Progression.
G. Bleiber, M. May, R. Martinez, P. Meylan, J. Ott, J. S. Beckmann, A. Telenti, and the Swiss HIV Cohort Study (2005)
J. Virol. 79, 12674-12680
   Abstract »    Full Text »    PDF »
Allele-specific transcript quantification detects haplotypic variation in the levels of the SDF-1 transcripts.
R. Kimura, T. Nishioka, A. Soemantri, and T. Ishida (2005)
Hum. Mol. Genet. 14, 1579-1585
   Abstract »    Full Text »    PDF »
Effectiveness of Highly Active Antiretroviral Therapy among Injection Drug Users with Late-Stage Human Immunodeficiency Virus Infection.
D. Vlahov, N. Galai, M. Safaeian, S. Galea, G. D. Kirk, G. M. Lucas, and T. R. Sterling (2005)
Am. J. Epidemiol. 161, 999-1012
   Abstract »    Full Text »    PDF »
Multiple Products Derived from Two CCL4 Loci: High Incidence of a New Polymorphism in HIV+ Patients.
R. Colobran, P. Adreani, Y. Ashhab, A. Llano, J. A. Este, O. Dominguez, R. Pujol-Borrell, and M. Juan (2005)
J. Immunol. 174, 5655-5664
   Abstract »    Full Text »    PDF »
SDF-1 Genotype Influences Insulin-Dependent Mobilization of Adult Progenitor Cells in Type 2 Diabetes.
P. M. Humpert, R. Neuwirth, M. J. Battista, O. Voronko, M. von Eynatten, I. Konrade, G. Rudofsky Jr, T. Wendt, A. Hamann, M. Morcos, et al. (2005)
Diabetes Care 28, 934-936
   Full Text »    PDF »
Breast Cancer Progression and Host Polymorphisms in the Chemokine System: Role of the Macrophage Chemoattractant Protein-1 (MCP-1) -2518 G Allele.
G. Ghilardi, M. L. Biondi, A. La Torre, L. Battaglioli, and R. Scorza (2005)
Clin. Chem. 51, 452-455
   Full Text »    PDF »
Genetics of infectious diseases.
A. J. Frodsham and A. V.S. Hill (2004)
Hum. Mol. Genet. 13, R187-R194
   Abstract »    Full Text »    PDF »
Association of RANTES G-403A gene polymorphism with increased risk of coronary arteriosclerosis.
E. Simeoni, B. R. Winkelmann, M. M. Hoffmann, S. Fleury, J. Ruiz, L. Kappenberger, W. Marz, and G. Vassalli (2004)
Eur. Heart J. 25, 1438-1446
   Abstract »    Full Text »    PDF »
Significant involvement of CCR2-64I and CXCL12-3a in the development of sporadic breast cancer.
A Zafiropoulos, N Crikas, A M Passam, and D A Spandidos (2004)
J. Med. Genet. 41, e59
   Full Text »    PDF »
Induction of Autoantibodies to CCR5 in Macaques and Subsequent Effects upon Challenge with an R5-Tropic Simian/Human Immunodeficiency Virus.
B. Chackerian, L. Briglio, P. S. Albert, D. R. Lowy, and J. T. Schiller (2004)
J. Virol. 78, 4037-4047
   Abstract »    Full Text »    PDF »
Patterns of ethnic diversity among the genes that influence AIDS.
C. Winkler, P. An, and S. J. O'Brien (2004)
Hum. Mol. Genet. 13, R9-19
   Abstract »    Full Text »    PDF »
Fraction of Cases of Acquired Immunodeficiency Syndrome Prevented by the Interactions of Identified Restriction Gene Variants.
M. J. Silverberg, M. W. Smith, J. S. Chmiel, R. Detels, J. B. Margolick, C. R. Rinaldo, S. J. O'Brien, and A. Munoz (2004)
Am. J. Epidemiol. 159, 232-241
   Abstract »    Full Text »    PDF »
HIV-1 fitness and macrophages.
M. M. Goodenow, S. L. Rose, D. L. Tuttle, and J. W. Sleasman (2003)
J. Leukoc. Biol. 74, 657-666
   Abstract »    Full Text »    PDF »
Serum inactivation contributes to the failure of stromal-derived factor-1 to block HIV-I infection in vivo.
S. Villalba, O. Salvucci, Y. Aoki, M. D. L. L. Sierra, G. Gupta, D. Davis, K. Wyvill, R. Little, R. Yarchoan, and G. Tosato (2003)
J. Leukoc. Biol. 74, 880-888
   Abstract »    Full Text »    PDF »
Importance of B-Cell Responses for Immunological Control of Variant Strains of Simian Immunodeficiency Virus.
W. E. Johnson, J. D. Lifson, S. M. Lang, R. P. Johnson, and R. C. Desrosiers (2002)
J. Virol. 77, 375-381
   Abstract »    Full Text »    PDF »
Tyrosine-sulfated Peptides Functionally Reconstitute a CCR5 Variant Lacking a Critical Amino-terminal Region.
M. Farzan, S. Chung, W. Li, N. Vasilieva, P. L. Wright, C. E. Schnitzler, R. J. Marchione, C. Gerard, N. P. Gerard, J. Sodroski, et al. (2002)
J. Biol. Chem. 277, 40397-40402
   Abstract »    Full Text »    PDF »
Inhibition of Human Immunodeficiency Virus Type 1 (HIV-1) Replication by a Two-Amino-Acid Insertion in HIV-1 Vif from a Nonprogressing Mother and Child.
L. Alexander, M. J. Aquino-DeJesus, M. Chan, and W. A. Andiman (2002)
J. Virol. 76, 10533-10539
   Abstract »    Full Text »    PDF »
Cell surface receptors, virus entry and tropism of primate lentiviruses.
P. R. Clapham and A. McKnight (2002)
J. Gen. Virol. 83, 1809-1829
   Abstract »    Full Text »    PDF »
Modulating influence on HIV/AIDS by interacting RANTES gene variants.
P. An, G. W. Nelson, L. Wang, S. Donfield, J. J. Goedert, J. Phair, D. Vlahov, S. Buchbinder, W. L. Farrar, W. Modi, et al. (2002)
PNAS 99, 10002-10007
   Abstract »    Full Text »    PDF »
Rhesus Macaque Resistance to Mucosal Simian Immunodeficiency Virus Infection Is Associated with a Postentry Block in Viral Replication.
B. Peng, R. Voltan, L. Lim, Y. Edghill-Smith, S. Phogat, D. S. Dimitrov, K. Arora, M. Leno, S. Than, R. Woodward, et al. (2002)
J. Virol. 76, 6016-6026
   Abstract »    Full Text »    PDF »
Distribution of Chemokine Receptor CCR2 and CCR5 Genotypes and Their Relative Contribution to Human Immunodeficiency Virus Type 1 (HIV-1) Seroconversion, Early HIV-1 RNA Concentration in Plasma, and Later Disease Progression.
J. Tang, B. Shelton, N. J. Makhatadze, Y. Zhang, M. Schaen, L. G. Louie, J. J. Goedert, E. C. Seaberg, J. B. Margolick, J. Mellors, et al. (2002)
J. Virol. 76, 662-672
   Abstract »    Full Text »    PDF »
Effects of CCR5-{Delta} 32, CCR2-64I, and SDF-1 3'A Alleles on HIV-1 Disease Progression: An International Meta-Analysis of Individual-Patient Data.
J. P.A. Ioannidis, P. S. Rosenberg, J. J. Goedert, L. J. Ashton, T. L. Benfield, S. P. Buchbinder, R. A. Coutinho, J. Eugen-Olsen, T. Gallart, T. L. Katzenstein, et al. (2001)
Ann Intern Med 135, 782-795
   Abstract »    Full Text »    PDF »
Frequent Substitution Polymorphisms in African Green Monkey CCR5 Cluster at Critical Sites for Infections by Simian Immunodeficiency Virus SIVagm, Implying Ancient Virus-Host Coevolution.
S. E. Kuhmann, N. Madani, O. M. Diop, E. J. Platt, J. Morvan, M. C. Muller-Trutwin, F. Barre-Sinoussi, and D. Kabat (2001)
J. Virol. 75, 8449-8460
   Abstract »    Full Text »    PDF »
Increased Level of Stromal Cell-Derived Factor-1 mRNA in Peripheral Blood Mononuclear Cells from Children with AIDS-related Lymphoma.
S. Sei, D. P. O'Neill, S. K. Stewart, Q.-e. Yang, M. Kumagai, A. M. Boler, M. A. Adde, S. L. Zwerski, L. V. Wood, D. J. Venzon, et al. (2001)
Cancer Res. 61, 5028-5037
   Abstract »    Full Text »    PDF »
Host Determinants in HIV Infection and Disease: Part 2: Genetic Factors and Implications for Antiretroviral Therapeutics.
C. M. Hogan and S. M. Hammer (2001)
Ann Intern Med 134, 978-996
   Abstract »    Full Text »    PDF »
A Common Stromal Cell-Derived Factor-1 Chemokine Gene Variant is Associated With the Early Onset of Type 1 Diabetes.
D. Dubois-Laforgue, H. Hendel, S. Caillat-Zucman, J.-F. Zagury, C. Winkler, C. Boitard, and J. Timsit (2001)
Diabetes 50, 1211-1213
   Abstract »    Full Text »
Expression of Stromal-Derived Factor-1 Is Decreased by IL-1 and TNF and in Dermal Wound Healing.
E. R. Fedyk, D. Jones, H. O. D. Critchley, R. P. Phipps, T. M. Blieden, and T. A. Springer (2001)
J. Immunol. 166, 5749-5754
   Abstract »    Full Text »    PDF »
Control of HIV-1 viremia and protection from AIDS are associated with HLA-Bw4 homozygosity.
P. O. Flores-Villanueva, E. J. Yunis, J. C. Delgado, E. Vittinghoff, S. Buchbinder, J. Y. Leung, A. M. Uglialoro, O. P. Clavijo, E. S. Rosenberg, S. A. Kalams, et al. (2001)
PNAS
   Abstract »    Full Text »
From the Cover: Retroviral RNA identified in the cerebrospinal fluids and brains of individuals with schizophrenia.
H. Karlsson, S. Bachmann, J. Schroder, J. McArthur, E. F. Torrey, and R. H. Yolken (2001)
PNAS 98, 4634-4639
   Abstract »    Full Text »    PDF »
Naturally Occurring Deletional Mutation in the C-Terminal Cytoplasmic Tail of CCR5 Affects Surface Trafficking of CCR5.
T. Shioda, E. E. Nakayama, Y. Tanaka, X. Xin, H. Liu, A. Kawana-Tachikawa, A. Kato, Y. Sakai, Y. Nagai, and A. Iwamoto (2001)
J. Virol. 75, 3462-3468
   Abstract »    Full Text »
Human Immunodeficiency Virus-Related Mortality in Infants and Children: Data From the Pediatric Pulmonary and Cardiovascular Complications of Vertically Transmitted HIV (P2C2) Study.
C. Langston, E. R. Cooper, J. Goldfarb, K. A. Easley, S. Husak, S. Sunkle, T. J. Starc, A. A. Colin, and for the P2C2 HIV Study Group (2001)
Pediatrics 107, 328-338
   Abstract »    Full Text »
Genetic restriction of HIV-1 pathogenesis to AIDS by promoter alleles of IL10.
H. D. Shin, C. Winkler, J. C. Stephens, J. Bream, H. Young, J. J. Goedert, T. R. O'Brien, D. Vlahov, S. Buchbinder, J. Giorgi, et al. (2000)
PNAS 97, 14467-14472
   Abstract »    Full Text »    PDF »
An IL6 promoter polymorphism is associated with a lifetime risk of development of Kaposi sarcoma in men infected with human immunodeficiency virus.
C. B. Foster, T. Lehrnbecher, S. Samuels, S. Stein, F. Mol, J. A. Metcalf, K. Wyvill, S. M. Steinberg, J. Kovacs, A. Blauvelt, et al. (2000)
Blood 96, 2562-2567
   Abstract »    Full Text »    PDF »
Current Evidence and Future Directions for Targeting HIV Entry: Therapeutic and Prophylactic Strategies.
M. P. D'Souza, J. S. Cairns, and S. F. Plaeger (2000)
JAMA 284, 215-222
   Abstract »    Full Text »    PDF »
Polymorphism in the Interleukin-4 Promoter Affects Acquisition of Human Immunodeficiency Virus Type 1 Syncytium-Inducing Phenotype.
E. E. Nakayama, Y. Hoshino, X. Xin, H. Liu, M. Goto, N. Watanabe, H. Taguchi, A. Hitani, A. Kawana-Tachikawa, M. Fukushima, et al. (2000)
J. Virol. 74, 5452-5459
   Abstract »    Full Text »
Maternal SDF1 3'A Polymorphism Is Associated with Increased Perinatal Human Immunodeficiency Virus Type 1 Transmission.
G. C. John, C. Rousseau, T. Dong, S. Rowland-Jones, R. Nduati, D. Mbori-Ngacha, T. Rostron, J. K. Kreiss, B. A. Richardson, and J. Overbaugh (2000)
J. Virol. 74, 5736-5739
   Abstract »    Full Text »
Unusual Polymorphisms in Human Immunodeficiency Virus Type 1 Associated with Nonprogressive Infection.
L. Alexander, E. Weiskopf, T. C. Greenough, N. C. Gaddis, M. R. Auerbach, M. H. Malim, S. J. O'Brien, B. D. Walker, J. L. Sullivan, and R. C. Desrosiers (2000)
J. Virol. 74, 4361-4376
   Abstract »    Full Text »
Chemokine Receptor CCR5 and CXCR4 Expression in HIV-Associated Kidney Disease.
F. EITNER, Y. CUI, K. L. HUDKINS, M. B. STOKES, S. SEGERER, M. MACK, P. L. LEWIS, A. A. ABRAHAM, D. SCHLÖNDORFF, G. GALLO, et al. (2000)
J. Am. Soc. Nephrol. 11, 856-867
   Abstract »    Full Text »
Variant genotypes of Fcgamma RIIIA influence the development of Kaposi's sarcoma in HIV-infected men.
T. L. nbecher, C. B. Foster, S. Zhu, D. Venzon, S. M. Steinberg, K. Wyvill, J. A. Metcalf, S. S. Cohen, J. Kovacs, R. Yarchoan, et al. (2000)
Blood 95, 2386-2390
   Abstract »    Full Text »    PDF »
International Union of Pharmacology. XXII. Nomenclature for Chemokine Receptors.
P. M. Murphy, M. Baggiolini, I. F. Charo, C. A. Hebert, R. Horuk, K. Matsushima, L. H. Miller, J. J. Oppenheim, and C. A. Power (2000)
Pharmacol. Rev. 52, 145-176
   Abstract »    Full Text »    PDF »
5' Nuclease Assays for the Loci CCR5-+/{Delta}32, CCR2-V64I, and SDF1-G801A Related to Pathogenesis of AIDS.
C.-C. Yuan, R. J. Peterson, C.-D. Wang, F. Goodsaid, and D. J. Waters (2000)
Clin. Chem. 46, 24-30
   Abstract »    Full Text »    PDF »
Specific passage of simian immunodeficiency virus fromend-stage disease results in accelerated progression to AIDS in rhesus macaques.
L. Holterman, H. Niphuis, P. J. F. ten Haaft, J. Goudsmit, G. Baskin, and J. L. Heeney (1999)
J. Gen. Virol. 80, 3089-3097
   Abstract »    Full Text »
Consistent Viral Evolutionary Changes Associated with the Progression of Human Immunodeficiency Virus Type 1 Infection.
R. Shankarappa, J. B. Margolick, S. J. Gange, A. G. Rodrigo, D. Upchurch, H. Farzadegan, P. Gupta, C. R. Rinaldo, G. H. Learn, X. He, et al. (1999)
J. Virol. 73, 10489-10502
   Abstract »    Full Text »
Stromal-Cell Derived Factor Is Expressed by Dendritic Cells and Endothelium in Human Skin.
J. L. Pablos, A. Amara, A. Bouloc, B. Santiago, A. Caruz, M. Galindo, T. Delaunay, J. L. Virelizier, and F. Arenzana-Seisdedos (1999)
Am. J. Pathol. 155, 1577-1586
   Abstract »    Full Text »    PDF »
Resistance against Syncytium-Inducing Human Immunodeficiency Virus Type 1 (HIV-1) in Selected CD4+ T Cells from an HIV-1-Infected Nonprogressor: Evidence of a Novel Pathway of Resistance Mediated by a Soluble Factor(s) That Acts after Virus Entry.
K. Saha, D. J. Volsky, and E. Matczak (1999)
J. Virol. 73, 7891-7898
   Abstract »    Full Text »
Characterization of V3 Sequence Heterogeneity in Subtype C Human Immunodeficiency Virus Type 1 Isolates from Malawi: Underrepresentation of X4 Variants.
L.-H. Ping, J. A. E. Nelson, I. F. Hoffman, J. Schock, S. L. Lamers, M. Goodman, P. Vernazza, P. Kazembe, M. Maida, D. Zimba, et al. (1999)
J. Virol. 73, 6271-6281
   Abstract »    Full Text »
Human CD34+ Cells Express CXCR4 and Its Ligand Stromal Cell-Derived Factor-1. Implications for Infection by T-Cell Tropic Human Immunodeficiency Virus.
A. Aiuti, L. Turchetto, M. Cota, A. Cipponi, A. Brambilla, C. Arcelloni, R. Paroni, E. Vicenzi, C. Bordignon, and G. Poli (1999)
Blood 94, 62-73
   Abstract »    Full Text »    PDF »
Immunologic and Virologic Status after 14 to 18 Years of Infection with an Attenuated Strain of HIV-1 -- A Report from the Sydney Blood Bank Cohort.
J. C. Learmont, A. F. Geczy, J. Mills, L. J. Ashton, C. H. Raynes-Greenow, R. J. Garsia, W. B. Dyer, L. McIntyre, R. B. Oelrichs, D. I. Rhodes, et al. (1999)
N. Engl. J. Med. 340, 1715-1722
   Abstract »    Full Text »    PDF »
Enhanced Inhibition of Human Immunodeficiency Virus Type 1 by Met-Stromal-Derived Factor 1beta Correlates with Down-Modulation of CXCR4.
O. O. Yang, S. L. Swanberg, Z. Lu, M. Dziejman, J. McCoy, A. D. Luster, B. D. Walker, and S. H. Herrmann (1999)
J. Virol. 73, 4582-4589
   Abstract »    Full Text »
Simian Immunodeficiency Virus Disease Course Is Predicted by the Extent of Virus Replication during Primary Infection.
S. I. Staprans, P. J. Dailey, A. Rosenthal, C. Horton, R. M. Grant, N. Lerche, and M. B. Feinberg (1999)
J. Virol. 73, 4829-4839
   Abstract »    Full Text »
Definition of the Stage of Host Cell Genetic Restriction of Replication of Human Immunodeficiency Virus Type 1 in Monocytes and Monocyte-Derived Macrophages by Using Twins.
H. M. Naif, S. Li, M. Alali, J. Chang, C. Mayne, J. Sullivan, and A. L. Cunningham (1999)
J. Virol. 73, 4866-4881
   Abstract »    Full Text »
New Class I and II HLA Alleles Strongly Associated with Opposite Patterns of Progression to AIDS.
H. Hendel, S. Caillat-Zucman, H. Lebuanec, M. Carrington, S. O'Brien, J.-M. Andrieu, F. Schachter, D. Zagury, J. Rappaport, C. Winkler, et al. (1999)
J. Immunol. 162, 6942-6946
   Abstract »    Full Text »    PDF »
USF/c-Myc Enhances, While Yin-Yang 1 Suppresses, the Promoter Activity of CXCR4, a Coreceptor for HIV-1 Entry.
M. Moriuchi, H. Moriuchi, D. M. Margolis, and A. S. Fauci (1999)
J. Immunol. 162, 5986-5992
   Abstract »    Full Text »    PDF »
Current Concepts in Human Immunodeficiency Virus Infection and AIDS.
S. A. Schwartz and M. P. N. Nair (1999)
Clin. Vaccine Immunol. 6, 295-305
   Full Text »    PDF »
Quantification of CD4, CCR5, and CXCR4 levels on lymphocyte subsets, dendritic cells, and differentially conditioned monocyte-derived macrophages.
B. Lee, M. Sharron, L. J. Montaner, D. Weissman, and R. W. Doms (1999)
PNAS 96, 5215-5220
   Abstract »    Full Text »    PDF »
Polymorphism in chemokine promoter affects HIV-1 disease progression.
H. Liu, D. Chao, E. E. Nakayama, H. Taguchi, M. Goto, X. Xin, J.-k. Takamatsu, H. Saito, Y. Ishikawa, T. Akaza, et al. (1999)
PNAS 96, 4581-4585
   Abstract »    Full Text »    PDF »
Identification of CXCR4 Domains That Support Coreceptor and Chemokine Receptor Functions.
B. J. Doranz, M. J. Orsini, J. D. Turner, T. L. Hoffman, J. F. Berson, J. A. Hoxie, S. C. Peiper, L. F. Brass, and R. W. Doms (1999)
J. Virol. 73, 2752-2761
   Abstract »    Full Text »
Chemokine and Chemokine Receptor Gene Variants and Risk of Non-Hodgkin's Lymphoma in Human Immunodeficiency Virus-1-Infected Individuals.
C. S. Rabkin, Q.-e. Yang, J. J. Goedert, G. Nguyen, H. Mitsuya, and S. Sei (1999)
Blood 93, 1838-1842
   Abstract »    Full Text »    PDF »
Induction of autoantibodies to mouse CCR5 with recombinant papillomavirus particles.
B. Chackerian, D. R. Lowy, and J. T. Schiller (1999)
PNAS 96, 2373-2378
   Abstract »    Full Text »    PDF »
CCR2-64I Polymorphism Is Not Associated with Altered CCR5 Expression or Coreceptor Function.
R. Mariani, S. Wong, L. C. F. Mulder, D. A. Wilkinson, A. L. Reinhart, G. LaRosa, R. Nibbs, T. R. O'Brien, N. L. Michael, R. I. Connor, et al. (1999)
J. Virol. 73, 2450-2459
   Abstract »    Full Text »
cAMP Up-Regulates Cell Surface Expression of Lymphocyte CXCR4: Implications for Chemotaxis and HIV-1 Infection.
S. W. Cole, B. D. Jamieson, and J. A. Zack (1999)
J. Immunol. 162, 1392-1400
   Abstract »    Full Text »    PDF »
Combined Genotypes of CCR5, CCR2, SDF1, and HLA Genes Can Predict the Long-Term Nonprogressor Status in Human Immunodeficiency Virus-1-Infected Individuals.
M. Magierowska, I. Theodorou, P. Debre, F. Sanson, B. Autran, Y. Riviere, D. Charron, F. ALT, I. S. Groups, and D. Costagliola (1999)
Blood 93, 936-941
   Abstract »    Full Text »    PDF »
Activity of Different Bicyclam Derivatives against Human Immunodeficiency Virus Depends on Their Interaction with the CXCR4 Chemokine Receptor.
J. A. Esté, C. Cabrera, E. De Clercq, S. Struyf, J. Van Damme, G. Bridger, R. T. Skerlj, M. J. Abrams, G. Henson, A. Gutierrez, et al. (1999)
Mol. Pharmacol. 55, 67-73
   Abstract »    Full Text »
An HIV-Resistant Allele Is Exceptionally Frequent in New Guinean Highlanders.
B. Su, R. Chakraborty, L. Jin, J. Xiao, and D. Lu (1998)
JAMA 280, 1830
   Full Text »    PDF »
Potential Contributions of Viral Envelope and Host Genetic Factors in a Human Immunodeficiency Virus Type 1-Infected Long-Term Survivor.
K. Grovit-Ferbas, J. Ferbas, V. Gudeman, S. Sadeghi, M. B. Goetz, J. V. Giorgi, I. S. Y. Chen, and W. A. O'Brien (1998)
J. Virol. 72, 8650-8658
   Abstract »    Full Text »    PDF »
Forecasting Methods for HIV/AIDS and Aging.
K. G. Manton and E. Stallard (1998)
Research on Aging 20, 846-864
   Abstract »
Cutting Edge: Cytokines Regulate Expression and Function of the HIV Coreceptor CXCR4 on Human Mature Dendritic Cells.
J. P. Zoeteweij, H. Golding, H. Mostowski, and A. Blauvelt (1998)
J. Immunol. 161, 3219-3223
   Abstract »    Full Text »    PDF »
Influence of the CCR2-V64I Polymorphism on Human Immunodeficiency Virus Type 1 Coreceptor Activity and on Chemokine Receptor Function of CCR2b, CCR3, CCR5, and CXCR4.
B. Lee, B. J. Doranz, S. Rana, Y. Yi, M. Mellado, J. M. R. Frade, C. Martinez-A., S. J. O'Brien, M. Dean, R. G. Collman, et al. (1998)
J. Virol. 72, 7450-7458
   Abstract »    Full Text »    PDF »
HIV/AIDS in 1998--Gaining the Upper Hand?.
O. J. Cohen and A. S. Fauci (1998)
JAMA 280, 87-88
   Full Text »    PDF »
CXCR4 and CCR5 Genetic Polymorphisms in Long-Term Nonprogressive Human Immunodeficiency Virus Infection: Lack of Association with Mutations other than CCR5-Delta 32.
O. J. Cohen, S. Paolucci, S. M. Bende, M. Daucher, H. Moriuchi, M. Moriuchi, C. Cicala, R. T. Davey Jr., B. Baird, and A. S. Fauci (1998)
J. Virol. 72, 6215-6217
   Abstract »    Full Text »    PDF »
Anti-HIV-1 and chemotactic activities of human stromal cell-derived factor 1alpha (SDF-1alpha ) and SDF-1beta are abolished by CD26/dipeptidyl peptidase IV-mediated cleavage.
T. Shioda, H. Kato, Y. Ohnishi, K. Tashiro, M. Ikegawa, E. E. Nakayama, H. Hu, A. Kato, Y. Sakai, H. Liu, et al. (1998)
PNAS 95, 6331-6336
   Abstract »    Full Text »    PDF »
Protective Effect of an SDF-1 Variant in HIV Disease: Abstract and Commentary.
N. L. Michael (1998)
JAMA 279, 1140
   Full Text »    PDF »
Chemokine Receptors and Genetic Variability: Another Leap in HIV Research.
T. R. O'Brien and J. J. Goedert (1998)
JAMA 279, 317-318
   Full Text »    PDF »
Aminooxypentane Addition to the Chemokine Macrophage Inflammatory Protein-1alpha P Increases Receptor Affinities and HIV Inhibition.
J. R. Townson, G. J. Graham, N. R. Landau, B. Rasala, and R. J. B. Nibbs (2000)
J. Biol. Chem. 275, 39254-39261
   Abstract »    Full Text »    PDF »
A Tyrosine-sulfated Peptide Based on the N Terminus of CCR5 Interacts with a CD4-enhanced Epitope of the HIV-1 gp120 Envelope Glycoprotein and Inhibits HIV-1 Entry.
M. Farzan, N. Vasilieva, C. E. Schnitzler, S. Chung, J. Robinson, N. P. Gerard, C. Gerard, H. Choe, and J. Sodroski (2000)
J. Biol. Chem. 275, 33516-33521
   Abstract »    Full Text »    PDF »
N-Linked Glycosylation of the HIV Type-1 gp120 Envelope Glycoprotein as a Major Determinant of CCR5 and CXCR4 Coreceptor Utilization.
G. Pollakis, S. Kang, A. Kliphuis, M. I. M. Chalaby, J. Goudsmit, and W. A. Paxton (2001)
J. Biol. Chem. 276, 13433-13441
   Abstract »    Full Text »    PDF »
Control of HIV-1 viremia and protection from AIDS are associated with HLA-Bw4 homozygosity.
P. O. Flores-Villanueva, E. J. Yunis, J. C. Delgado, E. Vittinghoff, S. Buchbinder, J. Y. Leung, A. M. Uglialoro, O. P. Clavijo, E. S. Rosenberg, S. A. Kalams, et al. (2001)
PNAS 98, 5140-5145
   Abstract »    Full Text »    PDF »
The coreceptor mutation CCR5Delta 32 influences the dynamics of HIV epidemics and is selected for by HIV.
A. D. Sullivan, J. Wigginton, and D. Kirschner (2001)
PNAS 98, 10214-10219
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)