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Science 9 January 1998:
Vol. 279. no. 5348, pp. 227 - 230
DOI: 10.1126/science.279.5348.227
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Reports

Sensitivity of CaM Kinase II to the Frequency of Ca2+ Oscillations

Paul De Koninck, Howard Schulman *

The transduction of many cellular stimuli results in oscillations in the intracellular concentration of calcium ions (Ca2+). Although information is thought to be encoded in the frequency of such oscillations, no frequency decoder has been identified. Rapid superfusion of immobilized Ca2+- and calmodulin-dependent protein kinase II (CaM kinase II) in vitro showed that the enzyme can decode the frequency of Ca2+ spikes into distinct amounts of kinase activity. The frequency response of CaM kinase II was modulated by several factors, including the amplitude and duration of individual spikes as well as the subunit composition and previous state of activation of the kinase. These features should provide specificity in the activation of this multifunctional enzyme by distinct cellular stimuli and may underlie its pivotal role in activity-dependent forms of synaptic plasticity.

Department of Neurobiology, Stanford University School of Medicine, Stanford, CA 94305-5401, USA.
*   To whom correspondence should be addressed. E-mail: schulman{at}cmgm.stanford.edu

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Ca2+-Calmodulin-dependent Protein Kinase II Potentiates Store-operated Ca2+ Current.
K. Machaca (2003)
J. Biol. Chem. 278, 33730-33737
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An ultrasensitive Ca2+/calmodulin-dependent protein kinase II-protein phosphatase 1 switch facilitates specificity in postsynaptic calcium signaling.
J. M. Bradshaw, Y. Kubota, T. Meyer, and H. Schulman (2003)
PNAS 100, 10512-10517
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ICSI-generated mouse zygotes exhibit altered calcium oscillations, inositol 1,4,5-trisphosphate receptor-1 down-regulation, and embryo development.
M. Kurokawa and R. A. Fissore (2003)
Mol. Hum. Reprod. 9, 523-533
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Calmodulin kinase modulates Ca2+ release in mouse skeletal muscle.
P. Tavi, D. G Allen, P. Niemela, O. Vuolteenaho, M. Weckstrom, and H. Westerblad (2003)
J. Physiol. 551, 5-12
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Identification of Store-independent and Store-operated Ca2+ Conductances in Caenorhabditis elegans Intestinal Epithelial Cells.
A. Y. Estevez, R. K. Roberts, and K. Strange (2003)
J. Gen. Physiol. 122, 207-223
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Gonadotropin-Releasing Hormone Stimulation of Gonadotropin Subunit Transcription: Evidence for the Involvement of Calcium/Calmodulin-Dependent Kinase II (Ca/CAMK II) Activation in Rat Pituitaries.
D. J. Haisenleder, L. L. Burger, K. W. Aylor, A. C. Dalkin, and J. C. Marshall (2003)
Endocrinology 144, 2768-2774
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Self-Organizing Neural Integrator Predicts Interval Times through Climbing Activity.
D. Durstewitz (2003)
J. Neurosci. 23, 5342-5353
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A genetically encoded fluorescent reporter reveals oscillatory phosphorylation by protein kinase C.
J. D. Violin, J. Zhang, R. Y. Tsien, and A. C. Newton (2003)
J. Cell Biol. 161, 899-909
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Role of Ca2+ Feedback on Single Cell Inositol 1,4,5-Trisphosphate Oscillations Mediated by G-protein-coupled Receptors.
K. W. Young, M. S. Nash, R. A. J. Challiss, and S. R. Nahorski (2003)
J. Biol. Chem. 278, 20753-20760
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