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Science 19 December 1997:
Vol. 278. no. 5346, pp. 2126 - 2130
DOI: 10.1126/science.278.5346.2126
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Reports

Abscisic Acid Signaling Through Cyclic ADP-Ribose in Plants

Yan Wu, Jennifer Kuzma, Eric Maréchal, * Richard Graeff, Hon Cheung Lee, Randy Foster, Nam-Hai Chua dagger

Abscisic acid (ABA) is the primary hormone that mediates plant responses to stresses such as cold, drought, and salinity. Single-cell microinjection experiments in tomato were used to identify possible intermediates involved in ABA signal transduction. Cyclic ADP-ribose (cADPR) was identified as a signaling molecule in the ABA response and was shown to exert its effects by way of calcium. Bioassay experiments showed that the amounts of cADPR in Arabidopsis thaliana plants increased in response to ABA treatment and before ABA-induced gene expression.

Y. Wu, J. Kuzma, E. Maréchal, R. Foster, N.-H. Chua, Laboratory of Plant Molecular Biology, Rockefeller University, 1230 York Avenue, New York, NY 10021-6399, USA.
R. Graeff and H. C. Lee, Department of Physiology, University of Minnesota, Minneapolis, MN 55455, USA.
*   Present address: Laboratoire de Physiologie Cellulaire Végétale, Departement de Biologie Moleculaire et Cellulaire, Universite Joseph Fourier et CEA-Grenoble, 17 rue des Martyrs, F-38054 Grenoble Cedex 9, France.

dagger    To whom correspondence should be addressed. E-mail: chua{at}rockvax.rockefeller.edu

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J. Biol. Chem. 277, 1689-1694
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Calcium release from the endoplasmic reticulum of higher plants elicited by the NADP metabolite nicotinic acid adenine dinucleotide phosphate.
L. Navazio, M. A. Bewell, A. Siddiqua, G. D. Dickinson, A. Galione, and D. Sanders (2000)
PNAS 97, 8693-8698
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Inaugural Article: ABA activates multiple Ca2+ fluxes in stomatal guard cells, triggering vacuolar K+(Rb+) release.
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