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Science 19 December 1997:
Vol. 278. no. 5346, pp. 2075 - 2080
DOI: 10.1126/science.278.5346.2075
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Articles

Signaling Through Scaffold, Anchoring, and Adaptor Proteins

Tony Pawson, John D. Scott

The process by which extracellular signals are relayed from the plasma membrane to specific intracellular sites is an essential facet of cellular regulation. Many signaling pathways do so by altering the phosphorylation state of tyrosine, serine, or threonine residues of target proteins. Recently, it has become apparent that regulatory mechanisms exist to influence where and when protein kinases and phosphatases are activated in the cell. The role of scaffold, anchoring, and adaptor proteins that contribute to the specificity of signal transduction events by recruiting active enzymes into signaling networks or by placing enzymes close to their substrates is discussed.

T. Pawson is at the Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada. J. D. Scott, Howard Hughes Medical Institute, Vollum Institute, Portland, OR 97201-3098, USA.

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A Protein Phosphatase 2c{alpha}-Ca2+ Channel Complex for Dephosphorylation of Neuronal Ca2+ Channels Phosphorylated by Protein Kinase C.
D. Li, F. Wang, M. Lai, Y. Chen, and J.-f. Zhang (2005)
J. Neurosci. 25, 1914-1923
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ACE gene titration in mice uncovers a new mechanism for ACE on the control of body weight.
A. S. Heimann, M. H. Favarato, F. C. Gozzo, V. Rioli, F. R. Carreno, M. N. Eberlin, E. S. Ferro, J. H. Krege, and J. E. Krieger (2005)
Physiol Genomics 20, 173-182
   Abstract »    Full Text »    PDF »
Stable Isotope Labeling with Amino Acids in Cell Culture (SILAC) for Studying Dynamics of Protein Abundance and Posttranslational Modifications.
R. Amanchy, D. E. Kalume, and A. Pandey (2005)
Sci. STKE 2005, pl2
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Molecular Diversity and Regulation of Renal Potassium Channels.
S. C. Hebert, G. Desir, G. Giebisch, and W. Wang (2005)
Physiol Rev 85, 319-371
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The 15-Amino Acid Motif of the C Terminus of the {beta}2-Adrenergic Receptor Is Sufficient to Confer Insulin-Stimulated Counterregulation to the {beta}1-Adrenergic Receptor.
S. Gavi, D. Yin, E. Shumay, H.-y. Wang, and C. C. Malbon (2005)
Endocrinology 146, 450-457
   Abstract »    Full Text »    PDF »
The Luteinizing Hormone-releasing Hormone Inhibits the Anti-apoptotic Activity of Insulin-like Growth Factor-1 in Pituitary {alpha}T3 Cells by Protein Kinase C{alpha}-mediated Negative Regulation of Akt.
A. Rose, P. Froment, V. Perrot, M. J. Quon, D. LeRoith, and J. Dupont (2004)
J. Biol. Chem. 279, 52500-52516
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Subcellular Distribution of Neurabin Immunolabeling in Primate Prefrontal Cortex: Comparison with Spinophilin.
E. C. Muly, P. Allen, M. Mazloom, Z. Aranbayeva, A. T. Greenfield, and P. Greengard (2004)
Cereb Cortex 14, 1398-1407
   Abstract »    Full Text »    PDF »
Localized Feedback Phosphorylation of Ste5p Scaffold by Associated MAPK Cascade.
A. Flotho, D. M. Simpson, M. Qi, and E. A. Elion (2004)
J. Biol. Chem. 279, 47391-47401
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Point mutations of 3BP2 identified in human-inherited disease cherubism result in the loss of function.
S. M. S. Miah, T. Hatani, X. Qu, H. Yamamura, and K. Sada (2004)
Genes Cells 9, 993-1004
   Abstract »    Full Text »    PDF »
A Gain of Function Mutation in the Activation Loop of Plateletderived Growth Factor {beta}-Receptor Deregulates Its Kinase Activity.
F. Chiara, M.-J. Goumans, H. Forsberg, A. Ahgren, A. Rasola, P. Aspenstrom, C. Wernstedt, C. Hellberg, C.-H. Heldin, and R. Heuchel (2004)
J. Biol. Chem. 279, 42516-42527
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The Pleckstrin Homology Domain of CK2 Interacting Protein-1 Is Required for Interactions and Recruitment of Protein Kinase CK2 to the Plasma Membrane.
M. E. K. Olsten, D. A. Canton, C. Zhang, P. A. Walton, and D. W. Litchfield (2004)
J. Biol. Chem. 279, 42114-42127
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Inhibition of angiogenesis by growth factor receptor bound protein 2-Src homology 2 domain bound antagonists.
J. V. Soriano, N. Liu, Y. Gao, Z.-J. Yao, T. Ishibashi, C. Underhill, T. R. Burke Jr., and D. P. Bottaro (2004)
Mol. Cancer Ther. 3, 1289-1299
   Abstract »    Full Text »    PDF »
Arabidopsis VARIEGATED 3 encodes a chloroplast-targeted, zinc-finger protein required for chloroplast and palisade cell development.
H. Naested, A. Holm, T. Jenkins, H. B. Nielsen, C. A. Harris, M. H. Beale, M. Andersen, A. Mant, H. Scheller, B. Camara, et al. (2004)
J. Cell Sci. 117, 4807-4818
   Abstract »    Full Text »    PDF »


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