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Science 12 December 1997:
Vol. 278. no. 5345, pp. 1963 - 1965
DOI: 10.1126/science.278.5345.1963
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Reports

NDR1, a Pathogen-Induced Component Required for Arabidopsis Disease Resistance

Karen S. Century, * Allan D. Shapiro, dagger Peter P. Repetti, Douglas Dahlbeck, Eric Holub, Brian J. Staskawicz ddagger

Plant disease resistance (R) genes confer an ability to resist infection by pathogens expressing specific corresponding avirulence genes. In Arabidopsis thaliana, resistance to both bacterial and fungal pathogens, mediated by several R gene products, requires the NDR1 gene. Positional cloning was used to isolate NDR1, which encodes a 660-base pair open reading frame. The predicted 219-amino acid sequence suggests that NDR1 may be associated with a membrane. NDR1 expression is induced in response to pathogen challenge and may function to integrate various pathogen recognition signals.

K. S. Century, A. D. Shapiro, P. P. Repetti, D. Dahlbeck, B. J. Staskawicz, Department of Plant and Microbial Biology, University of California, Berkeley, CA 94720-3102, USA.
E. Holub, Plant Pathology and Weed Science Department, Horticulture Research International-Wellesbourne, Warwickshire CV35 9EF, UK.
*   Present address: Biology Department, San Francisco State University, San Francisco, CA 94132, USA.

dagger    Present address: Department of Plant and Soil Sciences, University of Delaware, Newark, DE 19717, USA.

ddagger    To whom correspondence should be addressed. E-mail: stask{at}nature.berkeley.edu

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