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Science 12 December 1997:
Vol. 278. no. 5345, pp. 1947 - 1950
DOI: 10.1126/science.278.5345.1947
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Reports

Mediation of Sonic Hedgehog-Induced Expression of COUP-TFII by a Protein Phosphatase

Venkatesh Krishnan, Fred A. Pereira, Yuhong Qiu, Chien-Huan Chen, Philip A. Beachy, Sophia Y. Tsai, * Ming-Jer Tsai *dagger

A Sonic hedgehog (Shh) response element was identified in the chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII) promoter that binds to a factor distinct from Gli, a gene known to mediate Shh signaling. Although this binding activity is specifically stimulated by Shh-N (amino-terminal signaling domain), it can also be unmasked with protein phosphatase treatment in the mouse cell line P19, and induction by Shh-N can be blocked by phosphatase inhibitors. Thus, Shh-N signaling may result in dephosphorylation of a target factor that is required for activation of COUP-TFII-, Islet1-, and Gli response element-dependent gene expression. This finding identifies another step in the Shh-N signaling pathway.

V. Krishnan, F. A. Pereira, Y. Qiu, S. Y. Tsai, M.-J. Tsai, Department of Cell Biology, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030 USA.
C.-H. Chen and P. A. Beachy, Department of Molecular Biology and Genetics, Howard Hughes Medical Institute, Johns Hopkins University, School of Medicine, Baltimore, MD 21205 USA.
*   These authors contributed equally to this report.

dagger    To whom correspondence should be addressed. E-mail: mtsai{at}bcm.tmc.edu

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