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Science 12 December 1997:
Vol. 278. no. 5345, pp. 1940 - 1943
DOI: 10.1126/science.278.5345.1940
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Reports

Role of Inositol 1,4,5-Trisphosphate Receptor in Ventral Signaling in Xenopus Embryos

Shoen Kume, *dagger Akira Muto, Takafumi Inoue, Kei Suga, Hideyuki Okano, Katsuhiko Mikoshiba

The inositol 1,4,5-trisphosphate (IP3) receptor is a calcium ion channel involved in the release of free Ca2+ from intracellular stores. For analysis of the role of IP3-induced Ca2+ release (IICR) on patterning of the embryonic body, monoclonal antibodies that inhibit IICR were produced. Injection of these blocking antibodies into the ventral part of early Xenopus embryos induced modest dorsal differentiation. A close correlation between IICR blocking potencies and ectopic dorsal axis induction frequency suggests that an active IP3-Ca2+ signal may participate in the modulation of ventral differentiation.

S. Kume, Mikoshiba Calciosignal Net Project, Exploratory Research for Advanced Technology (ERATO), Japan Science and Technology Corporation (JST), 2-9-3 Shimo-Meguro, Meguro-ku, Tokyo 153, Japan, and Department of Molecular Neurobiology, Institute of Medical Science, University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108, Japan.
A. Muto, Mikoshiba Calciosignal Net Project, ERATO, JST, 2-9-3 Shimo-Meguro, Meguro-ku, Tokyo 153, Japan.
T. Inoue and K. Suga, Department of Molecular Neurobiology, Institute of Medical Science, University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108, Japan.
H. Okano, Department of Neuroanatomy, Biomedical Research Center, Osaka University Medical School, Suita, Osaka 565, Japan, and Core Research for Evolutional Science and Technology (CREST), JST, Suita, Osaka 565, Japan.
K. Mikoshiba, Mikoshiba Calciosignal Net Project, ERATO, JST, 2-9-3 Shimo-Meguro, Meguro-ku, Tokyo 153, Japan; Department of Molecular Neurobiology, Institute of Medical Science, University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108, Japan; and RIKEN Brain Science Institute, 2-1 Hirosawa, Wako, Saitama 351-01, Japan.
*   To whom correspondence should be addressed. E-mail: skume{at}ims.u-tokyo.ac.jp

dagger    Present address: Mikoshiba Calciosignal Net Project, ERATO, JST, 2-9-3 Shimo-Meguro, Meguro-ku, Tokyo 153, Japan.

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