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Science 5 December 1997:
Vol. 278. no. 5344, pp. 1809 - 1812
DOI: 10.1126/science.278.5344.1809
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Reports

Multistep Control of Pituitary Organogenesis

Hui Z. Sheng, Kenji Moriyama, Tsuyoshi Yamashita, Hung Li, S. Steven Potter, Kathleen A. Mahon, Heiner Westphal *

Lhx3 and Lhx4 (Gsh4), two closely related LIM homeobox genes, determine formation of the pituitary gland in mice. Rathke's pouch is formed in two steps--first as a rudiment and later as a definitive pouch. Lhx3 and Lhx4 have redundant control over formation of the definitive pouch. Lhx3 controls a subsequent step of pituitary fate commitment. Thereafter, Lhx3 and Lhx4 together regulate proliferation and differentiation of pituitary-specific cell lineages. Thus, Lhx3 and Lhx4 dictate pituitary organ identity by controlling developmental decisions at multiple stages of organogenesis.

H. Z. Sheng, T. Yamashita, H. Westphal, Laboratory of Mammalian Genes and Development, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.
K. Moriyama, Department of Anatomy, Shimane Medical University, 89-1 Enya Izumo 693, Japan.
H. Li, Institute of Molecular Biology, Academia Sinica, Taipei 11529, Taiwan.
S. S. Potter, Division of Developmental Biology, Children's Hospital Research Foundation and Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA.
K. A. Mahon, Department of Cell Biology, Baylor College of Medicine, Houston, TX 77030, USA.
*   To whom correspondence should be addressed. E-mail: hw{at}helix.nih.gov

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   Abstract »    Full Text »    PDF »
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M. Treier, A. S. Gleiberman, S. M. O'Connell, D. P. Szeto, J. A. McMahon, A. P. McMahon, and M. G. Rosenfeld (1998)
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   Abstract »    Full Text »
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M. L. Brinkmeier, D. F. Gordon, J. M. Dowding, T. L. Saunders, S. K. Kendall, V. D. Sarapura, W. M. Wood, E. C. Ridgway, and S. A. Camper (1998)
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   Abstract »    Full Text »
Formation of Rathke's pouch requires dual induction from the diencephalon.
N Takuma, H. Sheng, Y Furuta, J. Ward, K Sharma, B. Hogan, S. Pfaff, H Westphal, S Kimura, and K. Mahon (1998)
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   Abstract »    PDF »
Function and specificity of LIM domains in Drosophila nervous system and wing development.
D. O'Keefe, S Thor, and J. Thomas (1998)
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   Abstract »    PDF »
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M Grigoriou, A. Tucker, P. Sharpe, and V Pachnis (1998)
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   Abstract »    PDF »
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G. E. Parker, R. M. Sandoval, H. A. Feister, J. P. Bidwell, and S. J. Rhodes (2000)
J. Biol. Chem. 275, 23891-23898
   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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J. Liu, C. Lin, A. Gleiberman, K. A. Ohgi, T. Herman, H.-P. Huang, M.-J. Tsai, and M. G. Rosenfeld (2001)
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   Abstract »    Full Text »    PDF »


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