Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 28 November 1997:
Vol. 278. no. 5343, pp. 1626 - 1629
DOI: 10.1126/science.278.5343.1626
Prev | Table of Contents | Next

Reports

CD1d-Restricted and TCR-Mediated Activation of Valpha14 NKT Cells by Glycosylceramides

Tetsu Kawano, Junqing Cui, Yasuhiko Koezuka, Isao Toura, Yoshikatsu Kaneko, Kazuhiro Motoki, Hitomi Ueno, Ryusuke Nakagawa, Hiroshi Sato, Eisuke Kondo, Haruhiko Koseki, Masaru Taniguchi *

Natural killer T (NKT) lymphocytes express an invariant T cell antigen receptor (TCR) encoded by the Valpha 14 and Jalpha 281 gene segments. A glycosylceramide-containing alpha -anomeric sugar with a longer fatty acyl chain (C26) and sphingosine base (C18) was identified as a ligand for this TCR. Glycosylceramide-mediated proliferative responses of Valpha 14 NKT cells were abrogated by treatment with chloroquine-concanamycin A or by monoclonal antibodies against CD1d/Vbeta 8, CD40/CD40L, or B7/CTLA-4/CD28, but not by interference with the function of a transporter-associated protein. Thus, this lymphocyte shares distinct recognition systems with either T or NK cells.

T. Kawano, J. Cui, I. Toura, Y. Kaneko, H. Sato, E. Kondo, H. Koseki, M. Taniguchi, CREST (Core Research for Evolutional Science and Technology) Project, Japan Science and Technology Corporation (JST), and Division of Molecular Immunology, Center for Biomedical Science, School of Medicine, Chiba University, 1-8-1 Inohana, Chuo, Chiba 260, Japan.
Y. Koezuka, K. Motoki, H. Ueno, R. Nakagawa, Pharmaceutical Research Laboratory, Kirin Brewery, 3 Miyahara, Takasaki, Gunma 370-12, Japan.
*   To whom correspondence should be addressed. E-mail: taniguti{at}med.m.chiba-u.ac.jp

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Cytokine-Dependent Modification of IL-12p70 and IL-23 Balance in Dendritic Cells by Ligand Activation of V{alpha}24 Invariant NKT Cells.
Y. Uemura, T.-Y. Liu, Y. Narita, M. Suzuki, R. Nakatsuka, T. Araki, M. Matsumoto, L. K. Iwai, N. Hirosawa, Y. Matsuoka, et al. (2009)
J. Immunol. 183, 201-208
   Abstract »    Full Text »    PDF »
Adoptive immunotherapy mediated by ex vivo expanded natural killer T cells against CD1d-expressing lymphoid neoplasms.
D. Bagnara, A. Ibatici, M. Corselli, N. Sessarego, C. Tenca, A. De Santanna, A. Mazzarello, A. Daga, R. Corvo, G. De Rossi, et al. (2009)
Haematologica 94, 967-974
   Abstract »    Full Text »    PDF »
Cutting Edge: B and T Lymphocyte Attenuator Signaling on NKT Cells Inhibits Cytokine Release and Tissue Injury in Early Immune Responses.
M. L. Miller, Y. Sun, and Y.-X. Fu (2009)
J. Immunol. 183, 32-36
   Abstract »    Full Text »    PDF »
Invariant NKT cells inhibit development of the Th17 lineage.
L. T. Mars, L. Araujo, P. Kerschen, S. Diem, E. Bourgeois, L. P. Van, N. Carrie, M. Dy, R. S. Liblau, and A. Herbelin (2009)
PNAS 106, 6238-6243
   Abstract »    Full Text »    PDF »
Combined NKT cell activation and influenza virus vaccination boosts memory CTL generation and protective immunity.
C. Guillonneau, J. D. Mintern, F.-X. Hubert, A. C. Hurt, G. S. Besra, S. Porcelli, I. G. Barr, P. C. Doherty, D. I. Godfrey, and S. J. Turner (2009)
PNAS 106, 3330-3335
   Abstract »    Full Text »    PDF »
Failure of {alpha}-Galactosylceramide to Prevent Diabetes in Virus-inducible Models of Type 1 Diabetes in the Rat.
P. CHOPRA, P. DIIORIO, S. C. PINO, S. B. WILSON, N. E. PHILLIPS, J. P. MORDES, A. A. ROSSINI, D. L. GREINER, L. D. SHULTZ, and R. BORTELL (2009)
In Vivo 23, 195-201
   Abstract »    Full Text »    PDF »
PD-1/PD-L Blockade Prevents Anergy Induction and Enhances the Anti-Tumor Activities of Glycolipid-Activated Invariant NKT Cells.
V. V. Parekh, S. Lalani, S. Kim, R. Halder, M. Azuma, H. Yagita, V. Kumar, L. Wu, and L. Van Kaer (2009)
J. Immunol. 182, 2816-2826
   Abstract »    Full Text »    PDF »
Reciprocal Interactions Between Human Mesenchymal Stem Cells and {gamma}{delta} T Cells Or Invariant Natural Killer T Cells.
I. Prigione, F. Benvenuto, P. Bocca, L. Battistini, A. Uccelli, and V. Pistoia (2009)
Stem Cells 27, 693-702
   Abstract »    Full Text »    PDF »
Role of Invariant NK T Lymphocytes in Immune Responses to CpG Oligodeoxynucleotides.
C. Paget, E. Bialecki, J. Fontaine, C. Vendeville, T. Mallevaey, C. Faveeuw, and F. Trottein (2009)
J. Immunol. 182, 1846-1853
   Abstract »    Full Text »    PDF »
The Role of Hepatic Invariant NKT Cells in Systemic/Local Inflammation and Mortality during Polymicrobial Septic Shock.
C. K. Hu, F. Venet, D. S. Heffernan, Y. L. Wang, B. Horner, X. Huang, C.-S. Chung, S. H. Gregory, and A. Ayala (2009)
J. Immunol. 182, 2467-2475
   Abstract »    Full Text »    PDF »
A Phase I-II Study of {alpha}-Galactosylceramide-Pulsed IL-2/GM-CSF-Cultured Peripheral Blood Mononuclear Cells in Patients with Advanced and Recurrent Non-Small Cell Lung Cancer.
S. Motohashi, K. Nagato, N. Kunii, H. Yamamoto, K. Yamasaki, K. Okita, H. Hanaoka, N. Shimizu, M. Suzuki, I. Yoshino, et al. (2009)
J. Immunol. 182, 2492-2501
   Abstract »    Full Text »    PDF »
NKT-cell help to B lymphocytes can occur independently of cognate interaction.
E. Tonti, G. Galli, C. Malzone, S. Abrignani, G. Casorati, and P. Dellabona (2009)
Blood 113, 370-376
   Abstract »    Full Text »    PDF »
{beta}-Glycosphingolipids improve glucose intolerance and hepatic steatosis of the Cohen diabetic rat.
E. Zigmond, S. W. Zangen, O. Pappo, M. Sklair-Levy, G. Lalazar, L. Zolotaryova, I. Raz, and Y. Ilan (2009)
Am J Physiol Endocrinol Metab 296, E72-E78
   Abstract »    Full Text »    PDF »
Critical role of ROR-{gamma}t in a new thymic pathway leading to IL-17-producing invariant NKT cell differentiation.
M.-L. Michel, D. Mendes-da-Cruz, A. C. Keller, M. Lochner, E. Schneider, M. Dy, G. Eberl, and M. C. Leite-de-Moraes (2008)
PNAS 105, 19845-19850
   Abstract »    Full Text »    PDF »
CD5-low expression lymphocytes in canine peripheral blood show characteristics of natural killer cells.
Y.-C. Huang, S.-W. Hung, T.-R. Jan, K.-W. Liao, C.-H. Cheng, Y.-S. Wang, and R.-M. Chu (2008)
J. Leukoc. Biol. 84, 1501-1510
   Abstract »    Full Text »    PDF »
Importance of NKT Cells in Resistance to Herpes Simplex Virus, Fate of Virus-Infected Neurons, and Level of Latency in Mice.
B. Grubor-Bauk, J. L. Arthur, and G. Mayrhofer (2008)
J. Virol. 82, 11073-11083
   Abstract »    Full Text »    PDF »
Regulatory Roles for NKT Cell Ligands in Environmentally Induced Autoimmunity.
J. Vas, J. Mattner, S. Richardson, R. Ndonye, J. P. Gaughan, A. Howell, and M. Monestier (2008)
J. Immunol. 181, 6779-6788
   Abstract »    Full Text »    PDF »
Natural killer T-cell autoreactivity leads to a specialized activation state.
X. Wang, X. Chen, L. Rodenkirch, W. Simonson, S. Wernimont, R. M. Ndonye, N. Veerapen, D. Gibson, A. R. Howell, G. S. Besra, et al. (2008)
Blood 112, 4128-4138
   Abstract »    Full Text »    PDF »
Osteopontin regulates development and function of invariant natural killer T cells.
H. Diao, K. Iwabuchi, L. Li, K. Onoe, L. Van Kaer, S. Kon, Y. Saito, J. Morimoto, D. T. Denhardt, S. Rittling, et al. (2008)
PNAS 105, 15884-15889
   Abstract »    Full Text »    PDF »
Interferon regulatory factor 4 differentially regulates the production of Th2 cytokines in naive vs. effector/memory CD4+ T cells.
K. Honma, D. Kimura, N. Tominaga, M. Miyakoda, T. Matsuyama, and K. Yui (2008)
PNAS 105, 15890-15895
   Abstract »    Full Text »    PDF »
Human Invariant NKT Cells Display Alloreactivity Instructed by Invariant TCR-CD1d Interaction and Killer Ig Receptors.
S. Patterson, A. Chaidos, D. C. A. Neville, A. Poggi, T. D. Butters, I. A. G. Roberts, and A. Karadimitris (2008)
J. Immunol. 181, 3268-3276
   Abstract »    Full Text »    PDF »
Regulation of Thymic NKT Cell Development by the B7-CD28 Costimulatory Pathway.
J. A. Williams, J. M. Lumsden, X. Yu, L. Feigenbaum, J. Zhang, S. M. Steinberg, and R. J. Hodes (2008)
J. Immunol. 181, 907-917
   Abstract »    Full Text »    PDF »
IL-2 triggers specific signaling pathways in human NKT cells leading to the production of pro- and anti-inflammatory cytokines.
S. Bessoles, F. Fouret, S. Dudal, G. S. Besra, F. Sanchez, and V. Lafont (2008)
J. Leukoc. Biol. 84, 224-233
   Abstract »    Full Text »    PDF »
Structural characterization of glycosylinositolphospholipids with a blood group type B sugar unit from the edible mushroom, Hypsizygus marmoreus.
S. Itonori, S. Yamawaki, K. Aoki, K. Yamamoto, N. Hada, T. Takeda, J. T. Dulaney, and M. Sugita (2008)
Glycobiology 18, 540-548
   Abstract »    Full Text »    PDF »
B cell receptor-mediated uptake of CD1d-restricted antigen augments antibody responses by recruiting invariant NKT cell help in vivo.
P. Barral, J. Eckl-Dorna, N. E. Harwood, C. De Santo, M. Salio, P. Illarionov, G. S. Besra, V. Cerundolo, and F. D. Batista (2008)
PNAS 105, 8345-8350
   Abstract »    Full Text »    PDF »
MR1 uses an endocytic pathway to activate mucosal-associated invariant T cells.
S. Huang, S. Gilfillan, S. Kim, B. Thompson, X. Wang, A. J. Sant, D. H. Fremont, O. Lantz, and T. H. Hansen (2008)
J. Exp. Med. 205, 1201-1211
   Abstract »    Full Text »    PDF »
Aberrant Genetic Control of Invariant TCR-Bearing NKT Cell Function in New Zealand Mouse Strains: Possible Involvement in Systemic Lupus Erythematosus Pathogenesis.
K. Tsukamoto, M. Ohtsuji, W. Shiroiwa, Q. Lin, K. Nakamura, H. Tsurui, Y. Jiang, K. Sudo, H. Nishimura, T. Shirai, et al. (2008)
J. Immunol. 180, 4530-4539
   Abstract »    Full Text »    PDF »
The vitamin D receptor is required for iNKT cell development.
S. Yu and M. T. Cantorna (2008)
PNAS 105, 5207-5212
   Abstract »    Full Text »    PDF »
Deficiency of invariant V{alpha}14 natural killer T cells decreases atherosclerosis in LDL receptor null mice.
L. Rogers, S. Burchat, J. Gage, M. Hasu, M. Thabet, L. Wilcox, T. A. Ramsamy, and S. C. Whitman (2008)
Cardiovasc Res 78, 167-174
   Abstract »    Full Text »    PDF »
NKT Cells in Tumor Immunity: Opposing Subsets Define a New Immunoregulatory Axis.
J. A. Berzofsky and M. Terabe (2008)
J. Immunol. 180, 3627-3635
   Abstract »    Full Text »    PDF »
Distinct regulatory functions of SLP-76 and MIST in NK cell cytotoxicity and IFN-{gamma} production.
S. Hidano, H. Sasanuma, K. Ohshima, K.-i. Seino, L. Kumar, K. Hayashi, M. Hikida, T. Kurosaki, M. Taniguchi, R. S. Geha, et al. (2008)
Int. Immunol. 20, 345-352
   Abstract »    Full Text »    PDF »
Role of human non-invariant NKT lymphocytes in the maintenance of type 2 T helper environment during pregnancy.
Y. Uemura, M. Suzuki, T.-Y. Liu, Y. Narita, S. Hirata, H. Ohyama, O. Ishihara, and S. Matsushita (2008)
Int. Immunol. 20, 405-412
   Abstract »    Full Text »    PDF »
Cutting Edge: Activation by Innate Cytokines or Microbial Antigens Can Cause Arrest of Natural Killer T Cell Patrolling of Liver Sinusoids.
P. Velazquez, T. O. Cameron, Y. Kinjo, N. Nagarajan, M. Kronenberg, and M. L. Dustin (2008)
J. Immunol. 180, 2024-2028
   Abstract »    Full Text »    PDF »
A Critical Role of Costimulation during Intrathymic Development of Invariant NK T Cells.
Y. Chung, R. Nurieva, E. Esashi, Y.-H. Wang, D. Zhou, L. Gapin, and C. Dong (2008)
J. Immunol. 180, 2276-2283
   Abstract »    Full Text »    PDF »
S1P1 receptor expression regulates emergence of NKT cells in peripheral tissues.
M. L. Allende, D. Zhou, D. N. Kalkofen, S. Benhamed, G. Tuymetova, C. Borowski, A. Bendelac, and R. L. Proia (2008)
FASEB J 22, 307-315
   Abstract »    Full Text »    PDF »
Lack of iNKT cells in patients with combined immune deficiency due to hypomorphic RAG mutations.
P. Matangkasombut, M. Pichavant, D. E. Saez, S. Giliani, E. Mazzolari, A. Finocchi, A. Villa, C. Sobacchi, P. Cortes, D. T. Umetsu, et al. (2008)
Blood 111, 271-274
   Abstract »    Full Text »    PDF »
Modulation of human natural killer T cell ligands on TLR-mediated antigen-presenting cell activation.
M. Salio, A. O. Speak, D. Shepherd, P. Polzella, P. A. Illarionov, N. Veerapen, G. S. Besra, F. M. Platt, and V. Cerundolo (2007)
PNAS 104, 20490-20495
   Abstract »    Full Text »    PDF »
Critical Role for CXC Chemokine Ligand 16 (SR-PSOX) in Th1 Response Mediated by NKT Cells.
T. Shimaoka, K.-i. Seino, N. Kume, M. Minami, C. Nishime, M. Suematsu, T. Kita, M. Taniguchi, K. Matsushima, and S. Yonehara (2007)
J. Immunol. 179, 8172-8179
   Abstract »    Full Text »    PDF »
Donor Bone Marrow Type II (Non-V{alpha}14J{alpha}18 CD1d-Restricted) NKT Cells Suppress Graft-Versus-Host Disease by Producing IFN-{gamma} and IL-4.
J. H. Kim, E. Y. Choi, and D. H. Chung (2007)
J. Immunol. 179, 6579-6587
   Abstract »    Full Text »    PDF »
Cross-Regulation between Type I and Type II NKT Cells in Regulating Tumor Immunity: A New Immunoregulatory Axis.
E. Ambrosino, M. Terabe, R. C. Halder, J. Peng, S. Takaku, S. Miyake, T. Yamamura, V. Kumar, and J. A. Berzofsky (2007)
J. Immunol. 179, 5126-5136
   Abstract »    Full Text »    PDF »
Role of NKT Cells in the Digestive System. I. Invariant NKT cells and liver diseases: is there strength in numbers?.
M. N. Ajuebor (2007)
Am J Physiol Gastrointest Liver Physiol 293, G651-G656
   Abstract »    Full Text »    PDF »
Invariant NKT Cells Biased for IL-5 Production Act as Crucial Regulators of Inflammation.
K. Sakuishi, S. Oki, M. Araki, S. A. Porcelli, S. Miyake, and T. Yamamura (2007)
J. Immunol. 179, 3452-3462
   Abstract »    Full Text »    PDF »
B Subunit of Shiga Toxin-Based Vaccines Synergize with {alpha}-Galactosylceramide to Break Tolerance against Self Antigen and Elicit Antiviral Immunity.
O. Adotevi, B. Vingert, L. Freyburger, P. Shrikant, Y.-C. Lone, F. Quintin-Colonna, N. Haicheur, M. Amessou, A. Herbelin, P. Langlade-Demoyen, et al. (2007)
J. Immunol. 179, 3371-3379
   Abstract »    Full Text »    PDF »
A Pegylated Derivative of {alpha}-Galactosylceramide Exhibits Improved Biological Properties.
T. Ebensen, C. Link, P. Riese, K. Schulze, M. Morr, and C. A. Guzman (2007)
J. Immunol. 179, 2065-2073
   Abstract »    Full Text »    PDF »
Multiple Constraints at the Level of TCR{alpha} Rearrangement Impact V{alpha}14i NKT Cell Development.
E. Hager, A. Hawwari, J. L. Matsuda, M. S. Krangel, and L. Gapin (2007)
J. Immunol. 179, 2228-2234
   Abstract »    Full Text »    PDF »
A Single Early Activation of Invariant NK T Cells Confers Long-Term Protection against Collagen-Induced Arthritis in a Ligand-Specific Manner.
K. Coppieters, K. Van Beneden, P. Jacques, P. Dewint, A. Vervloet, B. Vander Cruyssen, S. Van Calenbergh, G. Chen, R. W. Franck, G. Verbruggen, et al. (2007)
J. Immunol. 179, 2300-2309
   Abstract »    Full Text »    PDF »
CD4 engagement by CD1d potentiates activation of CD4+ invariant NKT cells.
A. Thedrez, C. de Lalla, S. Allain, L. Zaccagnino, S. Sidobre, C. Garavaglia, G. Borsellino, P. Dellabona, M. Bonneville, E. Scotet, et al. (2007)
Blood 110, 251-258
   Abstract »    Full Text »    PDF »
Potent immune-modulating and anticancer effects of NKT cell stimulatory glycolipids.
Y.-J. Chang, J.-R. Huang, Y.-C. Tsai, J.-T. Hung, D. Wu, M. Fujio, C.-H. Wong, and A. L. Yu (2007)
PNAS 104, 10299-10304
   Abstract »    Full Text »    PDF »
Identification of an IL-17-producing NK1.1neg iNKT cell population involved in airway neutrophilia.
M.-L. Michel, A. C. Keller, C. Paget, M. Fujio, F. Trottein, P. B. Savage, C.-H. Wong, E. Schneider, M. Dy, and M. C. Leite-de-Moraes (2007)
J. Exp. Med. 204, 995-1001
   Abstract »    Full Text »    PDF »
Primary Infection of C57BL/6 Mice with Plasmodium yoelii Induces a Heterogeneous Response of NKT Cells.
V. Soulard, J. Roland, C. Sellier, A. C. Gruner, M. Leite-de-Moraes, J.-F. Franetich, L. Renia, P.-A. Cazenave, and S. Pied (2007)
Infect. Immun. 75, 2511-2522
   Abstract »    Full Text »    PDF »
Invariant and Noninvariant Natural Killer T Cells Exert Opposite Regulatory Functions on the Immune Response during Murine Schistosomiasis.
T. Mallevaey, J. Fontaine, L. Breuilh, C. Paget, A. Castro-Keller, C. Vendeville, M. Capron, M. Leite-de-Moraes, F. Trottein, and C. Faveeuw (2007)
Infect. Immun. 75, 2171-2180
   Abstract »    Full Text »    PDF »
The Pro-Th1 Cytokine IL-12 Enhances IL-4 Production by Invariant NKT Cells: Relevance for T Cell-Mediated Hepatitis.
R. Zhu, S. Diem, L. M. Araujo, A. Aumeunier, J. Denizeau, E. Philadelphe, D. Damotte, M. Samson, P. Gourdy, M. Dy, et al. (2007)
J. Immunol. 178, 5435-5442
   Abstract »    Full Text »    PDF »
The Niemann-Pick type C2 protein loads isoglobotrihexosylceramide onto CD1d molecules and contributes to the thymic selection of NKT cells.
N. Schrantz, Y. Sagiv, Y. Liu, P. B. Savage, A. Bendelac, and L. Teyton (2007)
J. Exp. Med. 204, 841-852
   Abstract »    Full Text »    PDF »
Interdependency of MHC Class II/Self-Peptide and CD1d/Self-Glycolipid Presentation by TNF-Matured Dendritic Cells for Protection from Autoimmunity.
C. Wiethe, M. Schiemann, D. Busch, L. Haeberle, M. Kopf, G. Schuler, and M. B. Lutz (2007)
J. Immunol. 178, 4908-4916
   Abstract »    Full Text »    PDF »
The Pten/PI3K pathway governs the homeostasis of V{alpha}14iNKT cells.
H. Kishimoto, T. Ohteki, N. Yajima, K. Kawahara, M. Natsui, S. Kawarasaki, K. Hamada, Y. Horie, Y. Kubo, S. Arase, et al. (2007)
Blood 109, 3316-3324
   Abstract »    Full Text »    PDF »
From the Cover: Normal development and function of invariant natural killer T cells in mice with isoglobotrihexosylceramide (iGb3) deficiency.
S. Porubsky, A. O. Speak, B. Luckow, V. Cerundolo, F. M. Platt, and H.-J. Grone (2007)
PNAS 104, 5977-5982
   Abstract »    Full Text »    PDF »
NKT cells: manipulable managers of joint inflammation.
K. Coppieters, P. Dewint, K. Van Beneden, P. Jacques, S. Seeuws, G. Verbruggen, D. Deforce, and D. Elewaut (2007)
Rheumatology 46, 565-571
   Abstract »    Full Text »    PDF »
Saposin B is the dominant saposin that facilitates lipid binding to human CD1d molecules.
W. Yuan, X. Qi, P. Tsang, S.-J. Kang, P. A. Illarionov, G. S. Besra, J. Gumperz, and P. Cresswell (2007)
PNAS 104, 5551-5556
   Abstract »    Full Text »    PDF »
Invariant NKT cells sustain specific B cell responses and memory.
G. Galli, P. Pittoni, E. Tonti, C. Malzone, Y. Uematsu, M. Tortoli, D. Maione, G. Volpini, O. Finco, S. Nuti, et al. (2007)
PNAS 104, 3984-3989
   Abstract »    Full Text »    PDF »
IL-21 Is Produced by NKT Cells and Modulates NKT Cell Activation and Cytokine Production.
J. M. Coquet, K. Kyparissoudis, D. G. Pellicci, G. Besra, S. P. Berzins, M. J. Smyth, and D. I. Godfrey (2007)
J. Immunol. 178, 2827-2834
   Abstract »    Full Text »    PDF »
Tumor Cells Loaded with {alpha}-Galactosylceramide Induce Innate NKT and NK Cell-Dependent Resistance to Tumor Implantation in Mice.
K. Shimizu, A. Goto, M. Fukui, M. Taniguchi, and S.-i. Fujii (2007)
J. Immunol. 178, 2853-2861
   Abstract »    Full Text »    PDF »
Type I IFN-Producing CD4 V{alpha}14i NKT Cells Facilitate Priming of IL-10-Producing CD8 T Cells by Hepatocytes.
C. Wahl, P. Bochtler, R. Schirmbeck, and J. Reimann (2007)
J. Immunol. 178, 2083-2093
   Abstract »    Full Text »    PDF »
An N-Linked Glycan Modulates the Interaction between the CD1d Heavy Chain and beta2-Microglobulin.
C. Paduraru, L. Spiridon, W. Yuan, G. Bricard, X. Valencia, S. A. Porcelli, P. A. Illarionov, G. S. Besra, S. M. Petrescu, A.-J. Petrescu, et al. (2006)
J. Biol. Chem. 281, 40369-40378
   Abstract »    Full Text »    PDF »
Regulatory Roles of NKT Cells in the Induction and Maintenance of Cyclophosphamide-Induced Tolerance.
T. Iwai, Y. Tomita, S. Okano, I. Shimizu, Y. Yasunami, T. Kajiwara, Y. Yoshikai, M. Taniguchi, K. Nomoto, and H. Yasui (2006)
J. Immunol. 177, 8400-8409
   Abstract »    Full Text »    PDF »
Hyporesponsiveness to Natural Killer T-Cell Ligand {alpha}-Galactosylceramide in Cancer-Bearing State Mediated by CD11b+ Gr-1+ Cells Producing Nitric Oxide.
K. Yanagisawa, M. A. Exley, X. Jiang, N. Ohkochi, M. Taniguchi, and K.-i. Seino (2006)
Cancer Res. 66, 11441-11446
   Abstract »    Full Text »    PDF »
IFN-beta-Mediated Up-Regulation of CD1d in Bacteria-Infected APCs.
G. Raghuraman, Y. Geng, and C.-R. Wang (2006)
J. Immunol. 177, 7841-7848
   Abstract »    Full Text »    PDF »
GATA-3 Regulates the Development and Function of Invariant NKT Cells.
P. J. Kim, S.-Y. Pai, M. Brigl, G. S. Besra, J. Gumperz, and I-C. Ho (2006)
J. Immunol. 177, 6650-6659
   Abstract »    Full Text »    PDF »
CD4+ T Cells in the Absence of the CD8+ Cytotoxic T Cells Are Critical and Sufficient for NKT Cell-Dependent Tumor Rejection.
C. Hong, H. Lee, M. Oh, C.-Y. Kang, S. Hong, and S.-H. Park (2006)
J. Immunol. 177, 6747-6757
   Abstract »    Full Text »    PDF »
CD1 Antigen Presentation by Human Dendritic Cells as a Target for Herpes Simplex Virus Immune Evasion.
M. J. Raftery, F. Winau, S. H. E. Kaufmann, U. E. Schaible, and G. Schonrich (2006)
J. Immunol. 177, 6207-6214
   Abstract »    Full Text »    PDF »
PPAR{gamma} controls CD1d expression by turning on retinoic acid synthesis in developing human dendritic cells.
I. Szatmari, A. Pap, R. Ruhl, J.-X. Ma, P. A. Illarionov, G. S. Besra, E. Rajnavolgyi, B. Dezso, and L. Nagy (2006)
J. Exp. Med. 203, 2351-2362
   Abstract »    Full Text »    PDF »
Chewing the fat on natural killer T cell development.
D. I. Godfrey, M. J. McConville, and D. G. Pellicci (2006)
J. Exp. Med. 203, 2229-2232
   Abstract »    Full Text »    PDF »
Rapid Development of a Gamma Interferon-Secreting Glycolipid/CD1d-Specific V{alpha}14+ NK1.1- T-Cell Subset after Bacterial Infection..
M. Emoto, I. Yoshizawa, Y. Emoto, M. Miamoto, R. Hurwitz, and S. H. E. Kaufmann (2006)
Infect. Immun. 74, 5903-5913
   Abstract »    Full Text »    PDF »
Glucocerebroside Ameliorates the Metabolic Syndrome in OB/OB Mice.
M. Margalit, Z. Shalev, O. Pappo, M. Sklair-Levy, R. Alper, M. Gomori, D. Engelhardt, E. Rabbani, and Y. Ilan (2006)
J. Pharmacol. Exp. Ther. 319, 105-110
   Abstract »    Full Text »    PDF »
Structural Characterization of Mycobacterial Phosphatidylinositol Mannoside Binding to Mouse CD1d.
D. M. Zajonc, G. D. Ainge, G. F. Painter, W. B. Severn, and I. A. Wilson (2006)
J. Immunol. 177, 4577-4583
   Abstract »    Full Text »    PDF »
Genome-Wide Expression Profiling Reveals EBV-Associated Inhibition of MHC Class I Expression in Nasopharyngeal Carcinoma.
S. Sengupta, J. A. den Boon, I-H. Chen, M. A. Newton, D. B. Dahl, M. Chen, Y.-J. Cheng, W. H. Westra, C.-J. Chen, A. Hildesheim, et al. (2006)
Cancer Res. 66, 7999-8006
   Abstract »    Full Text »    PDF »
Improving Antitumor Immune Responses by Circumventing Immunoregulatory Cells and Mechanisms..
G. Lizee, L. G. Radvanyi, W. W. Overwijk, and P. Hwu (2006)
Clin. Cancer Res. 12, 4794-4803
   Abstract »    Full Text »    PDF »
Dendritic cells pulsed with alpha-galactosylceramide induce anti-tumor immunity against pancreatic cancer in vivo.
S Nagaraj, C Ziske, J Strehl, D Messmer, T Sauerbruch, and I. Schmidt-Wolf (2006)
Int. Immunol. 18, 1279-1283
   Abstract »    Full Text »    PDF »
CD1d Ligands: The Good, the Bad, and the Ugly.
R. R. Brutkiewicz (2006)
J. Immunol. 177, 769-775
   Abstract »    Full Text »    PDF »
Activation of Plasmacytoid Dendritic Cells with TLR9 Agonists Initiates Invariant NKT Cell-Mediated Cross-Talk with Myeloid Dendritic Cells.
C. J. Montoya, H.-B. Jie, L. Al-Harthi, C. Mulder, P. J. Patino, M. T. Rugeles, A. M. Krieg, A. L. Landay, and S. B. Wilson (2006)
J. Immunol. 177, 1028-1039
   Abstract »    Full Text »    PDF »
T-cell recognition of glycolipids presented by CD1 proteins.
D. C. Young and D. B. Moody (2006)
Glycobiology 16, 103R-112R
   Abstract »    Full Text »    PDF »
Dual function for the adaptor MIST in IFN-{gamma} production by NK and CD4+NKT cells regulated by the Src kinase Fgr.
H. Sasanuma, A. Tatsuno, S. Hidano, K. Ohshima, Y. Matsuzaki, K. Hayashi, C. A. Lowell, D. Kitamura, and R. Goitsuka (2006)
Blood 107, 3647-3655
   Abstract »    Full Text »    PDF »
DOCK2 Is Required in T Cell Precursors for Development of V{alpha}14 NK T Cells..
Y. Kunisaki, Y. Tanaka, T. Sanui, A. Inayoshi, M. Noda, T. Nakayama, M. Harada, M. Taniguchi, T. Sasazuki, and Y. Fukui (2006)
J. Immunol. 176, 4640-4645
   Abstract »    Full Text »    PDF »
The Bovine CD1 Family Contains Group 1 CD1 Proteins, but No Functional CD1d..
I. Van Rhijn, A. P. Koets, J. S. Im, D. Piebes, F. Reddington, G. S. Besra, S. A. Porcelli, W. van Eden, and V. P. M. G. Rutten (2006)
J. Immunol. 176, 4888-4893
   Abstract »    Full Text »    PDF »
Genetic and Functional Analysis of the Nkt1 Locus Using Congenic NOD Mice: Improved V{alpha}14-NKT Cell Performance but Failure to Protect Against Type 1 Diabetes..
A.-C. Rocha-Campos, R. Melki, R. Zhu, N. Deruytter, D. Damotte, M. Dy, A. Herbelin, and H.-J. Garchon (2006)
Diabetes 55, 1163-1170
   Abstract »    Full Text »    PDF »
Innovations and challenges in melanoma: summary statement from the first cambridge conference..
M. B. Atkins, D. E. Elder, R. Essner, K. T. Flaherty, T. F. Gajewski, F. G. Haluska, P. Hwu, U. Keilholz, J. M. Kirkwood, J. W. Mier, et al. (2006)
Clin. Cancer Res. 12, 2291s-2296s
   Abstract »    Full Text »    PDF »
Gestation stage-dependent mechanisms of invariant natural killer T cell-mediated pregnancy loss.
J. E. Boyson, N. Nagarkatti, L. Nizam, M. A. Exley, and J. L. Strominger (2006)
PNAS 103, 4580-4585
   Abstract »    Full Text »    PDF »
A structural basis for selection and cross-species reactivity of the semi-invariant NKT cell receptor in CD1d/glycolipid recognition.
L. Kjer-Nielsen, N. A. Borg, D. G. Pellicci, T. Beddoe, L. Kostenko, C. S. Clements, N. A. Williamson, M. J. Smyth, G. S. Besra, H. H. Reid, et al. (2006)
J. Exp. Med. 203, 661-673
   Abstract »    Full Text »    PDF »
Structure and binding kinetics of three different human CD1d-{alpha}-galactosylceramide-specific T cell receptors.
S. D. Gadola, M. Koch, J. Marles-Wright, N. M. Lissin, D. Shepherd, G. Matulis, K. Harlos, P. M. Villiger, D. I. Stuart, B. K. Jakobsen, et al. (2006)
J. Exp. Med. 203, 699-710
   Abstract »    Full Text »    PDF »
Engagement of Glucocorticoid-Induced TNF Receptor Costimulates NKT Cell Activation In Vitro and In Vivo.
H. J. Kim, H. Y. Kim, B. K. Kim, S. Kim, and D. H. Chung (2006)
J. Immunol. 176, 3507-3515
   Abstract »    Full Text »    PDF »
Conserved and Heterogeneous Lipid Antigen Specificities of CD1d-Restricted NKT Cell Receptors.
M. Brigl, P. van den Elzen, X. Chen, J. H. Meyers, D. Wu, C.-H. Wong, F. Reddington, P. A. Illarianov, G. S. Besra, M. B. Brenner, et al. (2006)
J. Immunol. 176, 3625-3634
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)