Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.
Click Me!

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 14 November 1997:
Vol. 278. no. 5341, pp. 1288 - 1291
DOI: 10.1126/science.278.5341.1288
Prev | Table of Contents | Next

Reports

Regulation of Distinct Stages of Skeletal Muscle Differentiation by Mitogen-Activated Protein Kinases

Anton M. Bennett, Nicholas K. Tonks *

The signal transduction pathway or pathways linking extracellular signals to myogenesis are poorly defined. Upon mitogen withdrawal from C2C12 myoblasts, the mitogen-activated protein kinase (MAPK) p42Erk2 is inactivated concomitant with up-regulation of muscle-specific genes. Overexpression of MAPK phosphatase-1 (MKP-1) inhibited p42Erk2 activity and was sufficient to relieve the inhibitory effects of mitogens on muscle-specific gene expression. Later during myogenesis, endogenous expression of MKP-1 decreased. MKP-1 overexpression during differentiation prevented myotube formation despite appropriate expression of myosin heavy chain. This indicates that muscle-specific gene expression is necessary but not sufficient to commit differentiated myocytes to myotubes and suggests a function for the MAPKs during the early and late stages of skeletal muscle differentiation.

Cold Spring Harbor Laboratory, Demerec Building, 1 Bungtown Road, Post Office Box 100, Cold Spring Harbor, NY 11724, USA.
*   To whom correspondence should be addressed. E-mail: tonks{at}cshl.org

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
The chemokine SDF1 controls multiple steps of myogenesis through atypical PKC{zeta}.
V. Odemis, K. Boosmann, M. T. Dieterlen, and J. Engele (2007)
J. Cell Sci. 120, 4050-4059
   Abstract »    Full Text »    PDF »
JAK1 STAT1 STAT3, a key pathway promoting proliferation and preventing premature differentiation of myoblasts.
L. Sun, K. Ma, H. Wang, F. Xiao, Y. Gao, W. Zhang, K. Wang, X. Gao, N. Ip, and Z. Wu (2007)
J. Cell Biol. 179, 129-138
   Abstract »    Full Text »    PDF »
ROCK2 and Its Alternatively Spliced Isoform ROCK2m Positively Control the Maturation of the Myogenic Program.
M. Pelosi, F. Marampon, B. M. Zani, S. Prudente, E. Perlas, V. Caputo, L. Cianetti, V. Berno, S. Narumiya, S. W. Kang, et al. (2007)
Mol. Cell. Biol. 27, 6163-6176
   Abstract »    Full Text »    PDF »
RAGE Expression in Rhabdomyosarcoma Cells Results in Myogenic Differentiation and Reduced Proliferation, Migration, Invasiveness, and Tumor Growth.
F. Riuzzi, G. Sorci, and R. Donato (2007)
Am. J. Pathol. 171, 947-961
   Abstract »    Full Text »    PDF »
DA-Raf1, a competent intrinsic dominant-negative antagonist of the Ras-ERK pathway, is required for myogenic differentiation.
T. Yokoyama, K. Takano, A. Yoshida, F. Katada, P. Sun, T. Takenawa, T. Andoh, and T. Endo (2007)
J. Cell Biol. 177, 781-793
   Abstract »    Full Text »    PDF »
Extracellular signal-regulated kinase pathway is differentially involved in beta-agonist-induced hypertrophy in slow and fast muscles.
H. Shi, C. Zeng, A. Ricome, K. M. Hannon, A. L. Grant, and D. E. Gerrard (2007)
Am J Physiol Cell Physiol 292, C1681-C1689
   Abstract »    Full Text »    PDF »
TNF-{alpha} regulates myogenesis and muscle regeneration by activating p38 MAPK.
S.-E. Chen, B. Jin, and Y.-P. Li (2007)
Am J Physiol Cell Physiol 292, C1660-C1671
   Abstract »    Full Text »    PDF »
Conditional Activation of MET in Differentiated Skeletal Muscle Induces Atrophy.
T. Crepaldi, F. Bersani, C. Scuoppo, P. Accornero, C. Prunotto, R. Taulli, P. E. Forni, C. Leo, R. Chiarle, J. Griffiths, et al. (2007)
J. Biol. Chem. 282, 6812-6822
   Abstract »    Full Text »    PDF »
Quantitative Transcriptional Control of ErbB Receptor Signaling Undergoes Graded to Biphasic Response for Cell Differentiation.
T. Nagashima, H. Shimodaira, K. Ide, T. Nakakuki, Y. Tani, K. Takahashi, N. Yumoto, and M. Hatakeyama (2007)
J. Biol. Chem. 282, 4045-4056
   Abstract »    Full Text »    PDF »
Notch Signaling Suppresses p38 MAPK Activity via Induction of MKP-1 in Myogenesis.
K. Kondoh, K. Sunadome, and E. Nishida (2007)
J. Biol. Chem. 282, 3058-3065
   Abstract »    Full Text »    PDF »
{micro}- and {kappa}-Opioids Induce the Differentiation of Embryonic Stem Cells to Neural Progenitors.
E. Kim, A. L. Clark, A. Kiss, J. W. Hahn, R. Wesselschmidt, C. J. Coscia, and M. M. Belcheva (2006)
J. Biol. Chem. 281, 33749-33760
   Abstract »    Full Text »    PDF »
Macrophage-Colony-Stimulating Factor-Induced Proliferation and Lipopolysaccharide-Dependent Activation of Macrophages Requires Raf-1 Phosphorylation to Induce Mitogen Kinase Phosphatase-1 Expression..
E. Sanchez-Tillo, M. Comalada, C. Farrera, A. F. Valledor, J. Lloberas, and A. Celada (2006)
J. Immunol. 176, 6594-6602
   Abstract »    Full Text »    PDF »
The Amphoterin (HMGB1)/Receptor for Advanced Glycation End Products (RAGE) Pair Modulates Myoblast Proliferation, Apoptosis, Adhesiveness, Migration, and Invasiveness: FUNCTIONAL INACTIVATION OF RAGE IN L6 MYOBLASTS RESULTS IN TUMOR FORMATION IN VIVO.
F. Riuzzi, G. Sorci, and R. Donato (2006)
J. Biol. Chem. 281, 8242-8253
   Abstract »    Full Text »    PDF »
Induction of DMBT1 expression by reduced ERK activity during a gastric mucosa differentiation-like process and its association with human gastric cancer.
W. Kang, O. Nielsen, C. Fenger, G. Leslie, U. Holmskov, and K. B.M. Reid (2005)
Carcinogenesis 26, 1129-1137
   Abstract »    Full Text »    PDF »
Essential Role for Mitogen-activated Protein (MAP) Kinase Phosphatase-1 in Stress-responsive MAP Kinase and Cell Survival Signaling.
J. J. Wu and A. M. Bennett (2005)
J. Biol. Chem. 280, 16461-16466
   Abstract »    Full Text »    PDF »
The p38{alpha}/{beta} MAPK functions as a molecular switch to activate the quiescent satellite cell.
N. C. Jones, K. J. Tyner, L. Nibarger, H. M. Stanley, D. D.W. Cornelison, Y. V. Fedorov, and B. B. Olwin (2005)
J. Cell Biol. 169, 105-116
   Abstract »    Full Text »    PDF »
Akt Phosphorylation Is Not Sufficient for Insulin-Like Growth Factor-Stimulated Myogenin Expression but Must Be Accompanied by Down-Regulation of Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase Phosphorylation.
N. Tiffin, S. Adi, D. Stokoe, N.-Y. Wu, and S. M. Rosenthal (2004)
Endocrinology 145, 4991-4996
   Abstract »    Full Text »    PDF »
Role of the p66Shc Isoform in Insulin-like Growth Factor I Receptor Signaling through MEK/Erk and Regulation of Actin Cytoskeleton in Rat Myoblasts.
A. Natalicchio, L. Laviola, C. De Tullio, L. A. Renna, C. Montrone, S. Perrini, G. Valenti, G. Procino, M. Svelto, and F. Giorgino (2004)
J. Biol. Chem. 279, 43900-43909
   Abstract »    Full Text »    PDF »
Smooth muscle archvillin: a novel regulator of signaling and contractility in vascular smooth muscle.
S. S. Gangopadhyay, N. Takizawa, C. Gallant, A. L. Barber, H.-D. Je, T. C. Smith, E. J. Luna, and K. G. Morgan (2004)
J. Cell Sci. 117, 5043-5057
   Abstract »    Full Text »    PDF »
Glutathione Depletion Impairs Myogenic Differentiation of Murine Skeletal Muscle C2C12 Cells through Sustained NF-{kappa}B Activation.
E. Ardite, J. A. Barbera, J. Roca, and J. C. Fernandez-Checa (2004)
Am. J. Pathol. 165, 719-728
   Abstract »    Full Text »    PDF »
SHP-2 Positively Regulates Myogenesis by Coupling to the Rho GTPase Signaling Pathway.
M. I. Kontaridis, S. Eminaga, M. Fornaro, C. I. Zito, R. Sordella, J. Settleman, and A. M. Bennett (2004)
Mol. Cell. Biol. 24, 5340-5352
   Abstract »    Full Text »    PDF »
Amphoterin Stimulates Myogenesis and Counteracts the Antimyogenic Factors Basic Fibroblast Growth Factor and S100B via RAGE Binding.
G. Sorci, F. Riuzzi, C. Arcuri, I. Giambanco, and R. Donato (2004)
Mol. Cell. Biol. 24, 4880-4894
   Abstract »    Full Text »    PDF »
Extracellular Signal-Regulated Kinase Induces the Megakaryocyte GPIIb/CD41 Gene through MafB/Kreisler.
J. R. Sevinsky, A. M. Whalen, and N. G. Ahn (2004)
Mol. Cell. Biol. 24, 4534-4545
   Abstract »    Full Text »    PDF »
Permissive Roles of Phosphatidyl Inositol 3-Kinase and Akt in Skeletal Myocyte Maturation.
E. M. Wilson, J. Tureckova, and P. Rotwein (2004)
Mol. Biol. Cell 15, 497-505
   Abstract »    Full Text »    PDF »
Reciprocal Inhibition between MyoD and STAT3 in the Regulation of Growth and Differentiation of Myoblasts.
Y. Kataoka, I. Matsumura, S. Ezoe, S. Nakata, E. Takigawa, Y. Sato, A. Kawasaki, T. Yokota, K. Nakajima, A. Felsani, et al. (2003)
J. Biol. Chem. 278, 44178-44187
   Abstract »    Full Text »    PDF »
Inhibition of the Stem Cell Factor-Induced Migration of Mast Cells by Dexamethasone.
H.-J. Jeong, H.-J. Na, S.-H. Hong, and H.-M. Kim (2003)
Endocrinology 144, 4080-4086
   Abstract »    Full Text »    PDF »
MAP kinase phosphatase-1 is induced in abnormal fibers in inclusion body myositis.
S. Nakano, A. Shinde, H. Ito, H. Ito, and H. Kusaka (2003)
Neurology 61, 322-326
   Abstract »    Full Text »    PDF »
Regulation of keratinocyte shape, migration and wound epithelialization by IGF-1- and EGF-dependent signalling pathways.
I. Haase, R. Evans, R. Pofahl, and F. M. Watt (2003)
J. Cell Sci. 116, 3227-3238
   Abstract »    Full Text »    PDF »
Interleukin-1{beta} and Tumor Necrosis Factor-{alpha} Induce MUC5AC Overexpression through a Mechanism Involving ERK/p38 Mitogen-activated Protein Kinases-MSK1-CREB Activation in Human Airway Epithelial Cells.
K. S. Song, W.-J. Lee, K. C. Chung, J. S. Koo, E. J. Yang, J. Y. Choi, and J.-H. Yoon (2003)
J. Biol. Chem. 278, 23243-23250
   Abstract »    Full Text »    PDF »
ERK1/2 Achieves Sustained Activation by Stimulating MAPK Phosphatase-1 Degradation via the Ubiquitin-Proteasome Pathway.
Y.-W. Lin, S.-M. Chuang, and J.-L. Yang (2003)
J. Biol. Chem. 278, 21534-21541
   Abstract »    Full Text »    PDF »
Glial Cell-induced Endothelial Morphogenesis Is Inhibited by Interfering with Extracellular Signal-regulated Kinase Signaling.
N. Chandrasekar, S. Mohanam, S. S. Lakka, D. H. Dinh, W. C. Olivero, M. Gujrati, and Jasti. S. Rao (2003)
Clin. Cancer Res. 9, 2342-2349
   Abstract »    Full Text »    PDF »
Phosphorylation Motifs Regulating the Stability and Function of Myocyte Enhancer Factor 2A.
D. M. Cox, M. Du, M. Marback, E. C. C. Yang, J. Chan, K. W. M. Siu, and J. C. McDermott (2003)
J. Biol. Chem. 278, 15297-15303
   Abstract »    Full Text »    PDF »
Alteration of Mesodermal Cell Differentiation by EWS/FLI-1, the Oncogene Implicated in Ewing's Sarcoma.
S. Eliazer, J. Spencer, D. Ye, E. Olson, and R. L. Ilaria Jr. (2003)
Mol. Cell. Biol. 23, 482-492
   Abstract »    Full Text »    PDF »
Cell Condition-dependent Regulation of ERK5 by cAMP.
G. W. Pearson and M. H. Cobb (2002)
J. Biol. Chem. 277, 48094-48098
   Abstract »    Full Text »    PDF »
Transcriptional Induction of Mitogen-activated Protein Kinase Phosphatase 1 by Retinoids. SELECTIVE ROLES OF NUCLEAR RECEPTORS AND CONTRIBUTION TO THE ANTIAPOPTOTIC EFFECT.
Q. Xu, T. Konta, A. Furusu, K. Nakayama, J. Lucio-Cazana, L. G. Fine, and M. Kitamura (2002)
J. Biol. Chem. 277, 41693-41700
   Abstract »    Full Text »    PDF »
PKC{alpha}-mediated ERK, JNK and p38 activation regulates the myogenic program in human rhabdomyosarcoma cells.
A. Mauro, C. Ciccarelli, P. De Cesaris, A. Scoglio, M. Bouche, M. Molinaro, A. Aquino, and B. M. Zani (2002)
J. Cell Sci. 115, 3587-3599
   Abstract »    Full Text »    PDF »
Tumor necrosis factor-alpha inhibits myogenesis through redox-dependent and -independent pathways.
R. C. J. Langen, A. M. W. J. Schols, M. C. J. M. Kelders, J. L. J. van der Velden, E. F. M. Wouters, and Y. M. W. Janssen-Heininger (2002)
Am J Physiol Cell Physiol 283, C714-C721
   Abstract »    Full Text »    PDF »
Inhibition of myogenin Expression by Activated Raf Is Not Responsible for the Block to Avian Myogenesis.
S. E. Johnson, C. M. Dorman, and S. A. Bolanowski (2002)
J. Biol. Chem. 277, 28742-28748
   Abstract »    Full Text »    PDF »
ATP regulates the differentiation of mammalian skeletal muscle by activation of a P2X5 receptor on satellite cells.
M. Ryten, P. M. Dunn, J. T. Neary, and G. Burnstock (2002)
J. Cell Biol. 158, 345-355
   Abstract »    Full Text »    PDF »
The roles of ERK1/2 and p38 MAP kinases in the preventive mechanisms of mushroom Phellinus linteus against the inhibition of gap junctional intercellular communication by hydrogen peroxide.
J.-H. Cho, S.-D. Cho, H. Hu, S.-H. Kim, S. K. Lee, Y.-S. Lee, and K.-S. Kang (2002)
Carcinogenesis 23, 1163-1169
   Abstract »    Full Text »    PDF »
Role of SHP-2 in Fibroblast Growth Factor Receptor-Mediated Suppression of Myogenesis in C2C12 Myoblasts.
M. I. Kontaridis, X. Liu, L. Zhang, and A. M. Bennett (2002)
Mol. Cell. Biol. 22, 3875-3891
   Abstract »    Full Text »    PDF »
p38 Mitogen-activated Protein Kinase-, Calcium-Calmodulin-dependent Protein Kinase-, and Calcineurin-mediated Signaling Pathways Transcriptionally Regulate Myogenin Expression.
Q. Xu, L. Yu, L. Liu, C. F. Cheung, X. Li, S.-P. Yee, X.-J. Yang, and Z. Wu (2002)
Mol. Biol. Cell 13, 1940-1952
   Abstract »    Full Text »    PDF »
Mitogen-activated Protein Kinases and Activator Protein 1 Are Required for Proliferation and Cardiomyocyte Differentiation of P19 Embryonal Carcinoma Cells.
M. Eriksson and S. Leppa (2002)
J. Biol. Chem. 277, 15992-16001
   Abstract »    Full Text »    PDF »
Early Stimulation and Late Inhibition of Extracellular Signal-Regulated Kinase 1/2 Phosphorylation by IGF-I: A Potential Mechanism Mediating the Switch in IGF-I Action on Skeletal Muscle Cell Differentiation.
S. Adi, B. Bin-Abbas, N.-Y. Wu, and S. M. Rosenthal (2002)
Endocrinology 143, 511-516
   Abstract »    Full Text »    PDF »
Differential MAP kinase activation and Na+/H+ exchanger phosphorylation by H2O2 in rat cardiac myocytes.
S. Wei, E. C. Rothstein, L. Fliegel, L. J. Dell'Italia, and P. A. Lucchesi (2001)
Am J Physiol Cell Physiol 281, C1542-C1550
   Abstract »    Full Text »    PDF »
Insulin-like Growth Factor-mediated Muscle Differentiation. COLLABORATION BETWEEN PHOSPHATIDYLINOSITOL 3-KINASE-Akt-SIGNALING PATHWAYS AND MYOGENIN.
J. Tureckova, E. M. Wilson, J. L. Cappalonga, and P. Rotwein (2001)
J. Biol. Chem. 276, 39264-39270
   Abstract »    Full Text »    PDF »
Mitogen-Activated Protein (MAP) Kinase Pathways: Regulation and Physiological Functions.
G. Pearson, F. Robinson, T. Beers Gibson, B.-e Xu, M. Karandikar, K. Berman, and M. H. Cobb (2001)
Endocr. Rev. 22, 153-183
   Abstract »    Full Text »
SHP-2 complex formation with the SHP-2 substrate-1 during C2C12 myogenesis.
M. I. Kontaridis, X. Liu, L. Zhang, and A. M. Bennett (2001)
J. Cell Sci. 114, 2187-2198
   Abstract »    Full Text »    PDF »
Coordinate Control of Muscle Cell Survival by Distinct Insulin-like Growth Factor Activated Signaling Pathways.
M. A. Lawlor and P. Rotwein (2000)
J. Cell Biol. 151, 1131-1140
   Abstract »    Full Text »    PDF »
Gene Expression of Receptors for IL-6, LIF, and CNTF in Regenerating Skeletal Muscles.
K. Kami, Y. Morikawa, M. Sekimoto, and E. Senba (2000)
J. Histochem. Cytochem. 48, 1203-1214
   Abstract »    Full Text »
The Roles of Integrin-linked Kinase in the Regulation of Myogenic Differentiation.
Y. Huang, J. Li, Y. Zhang, and C. Wu (2000)
J. Cell Biol. 150, 861-872
   Abstract »    Full Text »    PDF »
Activation of JNK, p38 and ERK mitogen-activated protein kinases by chromium(VI) is mediated through oxidative stress but does not affect cytotoxicity.
S.-M. Chuang, G.-Y. Liou, and J.-L. Yang (2000)
Carcinogenesis 21, 1491-1500
   Abstract »    Full Text »    PDF »
Roles of JNK, p38 and ERK mitogen-activated protein kinases in the growth inhibition and apoptosis induced by cadmium.
S.-M. Chuang, I-C. Wang, and J.-L. Yang (2000)
Carcinogenesis 21, 1423-1432
   Abstract »    Full Text »    PDF »
Differential Role of beta 1C and beta 1A Integrin Cytoplasmic Variants in Modulating Focal Adhesion Kinase, Protein Kinase B/AKT, and Ras/Mitogen-activated Protein Kinase Pathways.
M. Fornaro, C. A. Steger, A. M. Bennett, J. J. Wu, and L. R. Languino (2000)
Mol. Biol. Cell 11, 2235-2249
   Abstract »    Full Text »
p38 and Extracellular Signal-Regulated Kinases Regulate the Myogenic Program at Multiple Steps.
Z. Wu, P. J. Woodring, K. S. Bhakta, K. Tamura, F. Wen, J. R. Feramisco, M. Karin, J. Y. J. Wang, and P. L. Puri (2000)
Mol. Cell. Biol. 20, 3951-3964
   Abstract »    Full Text »
Dual Control of Muscle Cell Survival by Distinct Growth Factor-Regulated Signaling Pathways.
M. A. Lawlor, X. Feng, D. R. Everding, K. Sieger, C. E. H. Stewart, and P. Rotwein (2000)
Mol. Cell. Biol. 20, 3256-3265
   Abstract »    Full Text »
Ras/MEK/ERK Up-regulation of the Fibroblast KCa Channel FIK Is a Common Mechanism for Basic Fibroblast Growth Factor and Transforming Growth Factor-beta Suppression of Myogenesis.
T. L. Pena, S. H. Chen, S. F. Konieczny, and S. G. Rane (2000)
J. Biol. Chem. 275, 13677-13682
   Abstract »    Full Text »    PDF »
The muscle mitogen-activated protein kinase is altered in sporadic inclusion body myositis.
M. Li and M. C. Dalakas (2000)
Neurology 54, 1665-1670
   Abstract »    Full Text »    PDF »
Opposing Role of Mitogen-activated Protein Kinase Subtypes, Erk-1/2 and p38, in the Regulation of Chondrogenesis of Mesenchymes.
C.-D. Oh, S.-H. Chang, Y.-M. Yoon, S.-J. Lee, Y.-S. Lee, S.-S. Kang, and J.-S. Chun (2000)
J. Biol. Chem. 275, 5613-5619
   Abstract »    Full Text »    PDF »
Activated raf kinase inhibits muscle cell differentiation through a MEF2-dependent mechanism.
B Winter and H. Arnold (2000)
J. Cell Sci. 113, 4211-4220
   Abstract »    PDF »
Differentiation Stage-Specific Inhibition of the Raf-MEK-ERK Pathway by Akt.
C. Rommel, B. A. Clarke, S. Zimmermann, L. Nuñez, R. Rossman, K. Reid, K. Moelling, G. D. Yancopoulos, and D. J. Glass (1999)
Science 286, 1738-1741
   Abstract »    Full Text »
A Role for p38MAPK/HSP27 Pathway in Smooth Muscle Cell Migration.
J. C. Hedges, M. A. Dechert, I. A. Yamboliev, J. L. Martin, E. Hickey, L. A. Weber, and W. T. Gerthoffer (1999)
J. Biol. Chem. 274, 24211-24219
   Abstract »    Full Text »    PDF »
Cell Cycle Withdrawal Promotes Myogenic Induction of Akt, a Positive Modulator of Myocyte Survival.
Y. Fujio, K. Guo, T. Mano, Y. Mitsuuchi, J. R. Testa, and K. Walsh (1999)
Mol. Cell. Biol. 19, 5073-5082
   Abstract »    Full Text »    PDF »
Distinct Steps in Yeast Spore Morphogenesis Require Distinct SMK1 MAP Kinase Thresholds.
M. Wagner, P. Briza, M. Pierce, and E. Winter (1999)
Genetics 151, 1327-1340
   Abstract »    Full Text »
Quantitative Changes in Integrin and Focal Adhesion Signaling Regulate Myoblast Cell Cycle Withdrawal.
S. K. Sastry, M. Lakonishok, S. Wu, T. Q. Truong, A. Huttenlocher, C. E. Turner, and A. F. Horwitz (1999)
J. Cell Biol. 144, 1295-1309
   Abstract »    Full Text »    PDF »
Stress-activated Protein Kinase-2/p38 and a Rapamycin-sensitive Pathway Are Required for C2C12 Myogenesis.
A. Cuenda and P. Cohen (1999)
J. Biol. Chem. 274, 4341-4346
   Abstract »    Full Text »    PDF »
Polyomavirus Large T Antigen Induces Alterations in Cytoplasmic Signalling Pathways Involving Shc Activation.
V. Gottifredi, G. Pelicci, E. Munarriz, R. Maione, P. G. Pelicci, and P. Amati (1999)
J. Virol. 73, 1427-1437
   Abstract »    Full Text »
Insulin Receptor Substrate-1 and Phosphatidylinositol 3-Kinase Regulate Extracellular Signal-Regulated Kinase-Dependent and -Independent Signaling Pathways during Myogenic Differentiation.
D. D. Sarbassov and C. A. Peterson (1998)
Mol. Endocrinol. 12, 1870-1878
   Abstract »    Full Text »
Ras- and Raf-induced Down-modulation of Non-muscle Tropomyosin Are MEK-independent.
R. A. J. Janssen, K. G. Veenstra, P. Jonasch, E. Jonasch, and J. W. Mier (1998)
J. Biol. Chem. 273, 32182-32186
   Abstract »    Full Text »    PDF »
Integration of Growth Factor, Extracellular Matrix, and Retinoid Signals during Bronchial Epithelial Cell Differentiation.
N. Moghal and B. G. Neel (1998)
Mol. Cell. Biol. 18, 6666-6678
   Abstract »    Full Text »
Extracellular Signal-regulated Protein Kinase/Jun Kinase Cross-talk Underlies Vascular Endothelial Cell Growth Factor-induced Endothelial Cell Proliferation.
A. Pedram, M. Razandi, and E. R. Levin (1998)
J. Biol. Chem. 273, 26722-26728
   Abstract »    Full Text »    PDF »
Regulation of Myogenesis by Fibroblast Growth Factors Requires Beta-Gamma Subunits of Pertussis Toxin-Sensitive G Proteins.
Y. V. Fedorov, N. C. Jones, and B. B. Olwin (1998)
Mol. Cell. Biol. 18, 5780-5787
   Abstract »    Full Text »
Sorcin Associates with the Pore-forming Subunit of Voltage-dependent L-type Ca2+ Channels.
M. B. Meyers, T. S. Puri, A. J. Chien, T. Gao, P.-H. Hsu, M. M. Hosey, and G. I. Fishman (1998)
J. Biol. Chem. 273, 18930-18935
   Abstract »    Full Text »    PDF »
Protein Kinase C Regulates Chondrogenesis of Mesenchymes via Mitogen-activated Protein Kinase Signaling.
S.-H. Chang, C.-D. Oh, M.-S. Yang, S.-S. Kang, Y.-S. Lee, J.-K. Sonn, and J.-S. Chun (1998)
J. Biol. Chem. 273, 19213-19219
   Abstract »    Full Text »    PDF »
Mitogen-activated Protein Kinase Pathway Is Involved in the Differentiation of Muscle Cells.
E. Gredinger, A. N. Gerber, Y. Tamir, S. J. Tapscott, and E. Bengal (1998)
J. Biol. Chem. 273, 10436-10444
   Abstract »    Full Text »    PDF »
Negative Regulation of the Serine/Threonine Kinase B-Raf by Akt.
K.-L. Guan, C. Figueroa, T. R. Brtva, T. Zhu, J. Taylor, T. D. Barber, and A. B. Vojtek (2000)
J. Biol. Chem. 275, 27354-27359
   Abstract »    Full Text »    PDF »
Activated Raf Inhibits Myogenesis through a Mechanism Independent of Activator Protein 1-mediated Myoblast Transformation.
C. M. Dorman and S. E. Johnson (2000)
J. Biol. Chem. 275, 27481-27487
   Abstract »    Full Text »    PDF »
The Insulin-like Growth Factor-Phosphatidylinositol 3-Kinase-Akt Signaling Pathway Regulates Myogenin Expression in Normal Myogenic Cells but Not in Rhabdomyosarcoma-derived RD Cells.
Q. Xu and Z. Wu (2000)
J. Biol. Chem. 275, 36750-36757
   Abstract »    Full Text »    PDF »
Critical Proliferation-independent Window for Basic Fibroblast Growth Factor Repression of Myogenesis via the p42/p44 MAPK Signaling Pathway.
L. L. Tortorella, D. J. Milasincic, and P. F. Pilch (2001)
J. Biol. Chem. 276, 13709-13717
   Abstract »    Full Text »    PDF »
12-O-Tetradecanoylphorbol-13-acetate (TPA)-induced c-Jun N-terminal Kinase (JNK) Phosphatase Renders Immortalized or Transformed Epithelial Cells Refractory to TPA-inducible JNK Activity.
H. Zhou, A. Lin, Z. Gu, S. Chen, N.-H. Park, and R. Chiu (2000)
J. Biol. Chem. 275, 22868-22875
   Abstract »    Full Text »    PDF »


ADVERTISEMENT
Click Me!

ADVERTISEMENT
Click Me!

To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)