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Science 7 November 1997:
Vol. 278. no. 5340, pp. 1050 - 1054
DOI: 10.1126/science.278.5340.1050
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Articles

Genetic Testing for Cancer Risk

Bruce Ponder

Genetic testing for cancer susceptibility is already part of the clinical management of families with some of the well-defined (but uncommon) inherited cancer syndromes. In cases where the risks associated with a predisposing mutation are less certain, or where there is no clearly effective intervention to offer those with a positive result, its use is more controversial. Careful evaluation of costs and benefits, and of the efficacy of interventions in those found to be at risk, is essential and is only just beginning. An immediate challenge is to ensure that both health professionals and the public understand clearly the issues involved.

The author is at the Cancer Research Campaign (CRC) Human Cancer Genetics Group and Department of Oncology, University of Cambridge, Addenbrooke's Hospital, Box 238, Level 3 Lab Block, Hills Road, Cambridge CB2 2QQ, UK. E-mail: bajp{at}mole.bio.cam.ac.uk

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Science. ISSN 0036-8075 (print), 1095-9203 (online)