Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 7 November 1997:
Vol. 278. no. 5340, pp. 1050 - 1054
DOI: 10.1126/science.278.5340.1050
Prev | Table of Contents | Next

Articles

Genetic Testing for Cancer Risk

Bruce Ponder

Genetic testing for cancer susceptibility is already part of the clinical management of families with some of the well-defined (but uncommon) inherited cancer syndromes. In cases where the risks associated with a predisposing mutation are less certain, or where there is no clearly effective intervention to offer those with a positive result, its use is more controversial. Careful evaluation of costs and benefits, and of the efficacy of interventions in those found to be at risk, is essential and is only just beginning. An immediate challenge is to ensure that both health professionals and the public understand clearly the issues involved.

The author is at the Cancer Research Campaign (CRC) Human Cancer Genetics Group and Department of Oncology, University of Cambridge, Addenbrooke's Hospital, Box 238, Level 3 Lab Block, Hills Road, Cambridge CB2 2QQ, UK. E-mail: bajp{at}mole.bio.cam.ac.uk

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Utilizing the Molecular Gateway: The Path to Personalized Cancer Management.
J. B. Overdevest, D. Theodorescu, and J. K. Lee (2009)
Clin. Chem. 55, 684-697
   Abstract »    Full Text »    PDF »
Genetic Testing for Hereditary Breast and Ovarian Cancer: Responsibility and Choice.
L. d'Agincourt-Canning (2006)
Qual Health Res 16, 97-118
   Abstract »    PDF »
The Genetics of Colorectal Cancer.
P. M. Calvert and H. Frucht (2002)
Ann Intern Med 137, 603-612
   Abstract »    Full Text »    PDF »
BRCAPRO Validation, Sensitivity of Genetic Testing of BRCA1/BRCA2, and Prevalence of Other Breast Cancer Susceptibility Genes.
D. A. Berry, E. S. Iversen Jr, D. F. Gudbjartsson, E. H. Hiller, J. E. Garber, B. N. Peshkin, C. Lerman, P. Watson, H. T. Lynch, S. G. Hilsenbeck, et al. (2002)
J. Clin. Oncol. 20, 2701-2712
   Abstract »    Full Text »    PDF »
Cancer Patients Who Experienced Diagnostic Genetic Testing for Cancer Susceptibility: Reactions and Behavior after the Disclosure of a Positive Test Result.
V. Bonadona, P. Saltel, F. Desseigne, H. Mignotte, J.-C. Saurin, Q. Wang, O. Sinilnikova, S. Giraud, G. Freyer, H. Plauchu, et al. (2002)
Cancer Epidemiol. Biomarkers Prev. 11, 97-104
   Abstract »    Full Text »
Comprehension of cancer risk one and 12 months after predictive genetic testing for hereditary non-polyposis colorectal cancer.
K. Aktan-Collan, A. Haukkala, J.-P. Mecklin, A. Uutela, and H. Kaariainen (2001)
J. Med. Genet. 38, 787-792
   Full Text »    PDF »
Diagnostic Strategy for Analytical Scanning of BRCA1 Gene by Fluorescence-assisted Mismatch Analysis Using Large, Bifluorescently Labeled Amplicons.
E. Ricevuto, H. Sobol, D. Stoppa-Lyonnet, A. Gulino, P. Marchetti, C. Ficorella, S. Martinotti, T. Meo, and M. Tosi (2001)
Clin. Cancer Res. 7, 1638-1646
   Abstract »    Full Text »    PDF »
The Human Genome: An Introduction.
J. Aerssens, M. Armstrong, R. Gilissen, and N. Cohen (2001)
Oncologist 6, 100-109
   Full Text »
Cancer Risk and Low-Penetrance Susceptibility Genes in Gene-Environment Interactions.
P. G. Shields and C. C. Harris (2000)
J. Clin. Oncol. 18, 2309-2315
   Abstract »    Full Text »    PDF »
Breast MR Imaging Screening in 192 Women Proved or Suspected to Be Carriers of a Breast Cancer Susceptibility Gene: Preliminary Results.
C. K. Kuhl, R. K. Schmutzler, C. C. Leutner, A. Kempe, E. Wardelmann, A. Hocke, M. Maringa, U. Pfeifer, D. Krebs, and H. H. Schild (2000)
Radiology 215, 267-279
   Abstract »    Full Text »
Evaluation of a counselling protocol for predictive genetic testing for hereditary non-polyposis colorectal cancer.
K. Aktan-Collan, J.-P. Mecklin, A. de la Chapelle, P. Peltomäki, A. Uutela, and H. Kääriäinen (2000)
J. Med. Genet. 37, 108-113
   Abstract »    Full Text »
Induced Micronucleus Frequencies in Peripheral Lymphocytes as a Screening Test for Carriers of a BRCA1 Mutation in Breast Cancer Families.
A. Rothfuss, P. Schütz, S. Bochum, T. Volm, E. Eberhardt, R. Kreienberg, W. Vogel, and G. Speit (2000)
Cancer Res. 60, 390-394
   Abstract »    Full Text »
Testing for Hereditary Cancer Risk: Pandora or Prometheus?.
T. S. Frank and M. H. Skolnick (1999)
J. Clin. Endocrinol. Metab. 84, 1882-1885
   Full Text »
Professional and public attitudes towards unsolicited medical intervention.
M. Zwitter, T. Nilstun, L. E Knudsen, B. Zakotnik, J. Klocker, S. Bremberg, G. Frentz, U. Klocker-Kaiser, and J. Pedersen (1999)
BMJ 318, 251-253
   Full Text »
Hereditary Risk of Breast and Ovarian Carcinoma: The Role of the Oncologist.
T. S. Frank (1998)
Oncologist 3, 403-412
   Abstract »    Full Text »
Detection of Early Prostate Cancer: Serendipitous or Systematic?.
K. A. Iczkowski, D. G. Bostwick, W. J. Catalona, D. S. Smith, E. Foucar, W. R. Pitts, Jr, M. McNaughton Collins, M. J. Barry, and D. F. Ransohoff (1998)
JAMA 279, 1439-1441
   Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)