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Science 24 October 1997:
Vol. 278. no. 5338, pp. 675 - 680
DOI: 10.1126/science.278.5338.675
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Reports

Functional Coherence of the Human Y Chromosome

Bruce T. Lahn, David C. Page

A systematic search of the nonrecombining region of the human Y chromosome (NRY) identified 12 novel genes or families, 10 with full-length complementary DNA sequences. All 12 genes, and six of eight NRY genes or families previously isolated by less systematic means, fell into two classes. Genes in the first group were expressed in many organs; these housekeeping genes have X homologs that escape X inactivation. The second group, consisting of Y-chromosomal gene families expressed specifically in testes, may account for infertility among men with Y deletions. The coherence of the NRY's gene content contrasts with the apparently haphazard content of most eukaryotic chromosomes.

Howard Hughes Medical Institute, Whitehead Institute, and Department of Biology, Massachusetts Institute of Technology, 9 Cambridge Center, Cambridge, MA 02142, USA.

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   Abstract »    Full Text »
Y-Chromosome Transfer Induces Changes in Blood Pressure and Blood Lipids in SHR.
V. Kren, N. Qi, D. Krenova, V. Zidek, M. Sladka, M. Jachymova, B. Mikova, K. Horky, A. Bonne, H. A. Van Lith, et al. (2001)
Hypertension 37, 1147-1152
   Abstract »    Full Text »    PDF »
The prognostic role of the extent of Y microdeletion on spermatogenesis and maturity of Sertoli cells.
S.E. Kleiman, B.B.-S. Maymon, L. Yogev, G. Paz, and H. Yavetz (2001)
Hum. Reprod. 16, 399-402
   Abstract »    Full Text »    PDF »
Molecular diagnosis of Y chromosome microdeletions in Europe: state-of-the-art and quality control.
M. Simoni (2001)
Hum. Reprod. 16, 402-409
   Abstract »    Full Text »    PDF »
Decreased fertilization rate and embryo quality after ICSI in oligozoospermic men with microdeletions in the azoospermia factor c region of the Y chromosome.
R. J.T. van Golde, A. M.M. Wetzels, R. de Graaf, J. H.A.M. Tuerlings, D. D.M. Braat, and J. A.M. Kremer (2001)
Hum. Reprod. 16, 289-292
   Abstract »    Full Text »    PDF »
A Novel Chromatin Protein, Distantly Related to Histone H2A, Is Largely Excluded from the Inactive X Chromosome.
B. P. Chadwick and H. F. Willard (2001)
J. Cell Biol. 152, 375-384
   Abstract »    Full Text »    PDF »
X chromosome-specific cDNA arrays: identification of genes that escape from X-inactivation and other applications.
R. Sudbrak, G. Wieczorek, U. A. Nuber, W. Mann, R. Kirchner, F. Erdogan, C. J. Brown, D. Wohrle, P. Sterk, V. M. Kalscheuer, et al. (2001)
Hum. Mol. Genet. 10, 77-83
   Abstract »    Full Text »    PDF »
Prognostic value of Y deletion analysis: How reliable is the outcome of Y deletion analysis in providing a sound prognosis?.
S. L. Liow, E. L. Yong, and S. C. Ng (2001)
Hum. Reprod. 16, 9-12
   Abstract »    Full Text »    PDF »
Non-Myeloablative Transplants for Malignant Disease.
R. F. Storb, R. Champlin, S. R. Riddell, M. Murata, S. Bryant, and E. H. Warren (2001)
Hematology 2001, 375-391
   Abstract »    Full Text »    PDF »
Real-time PCR using molecular beacons for accurate detection of the Y chromosome in single human blastomeres.
K. E. Pierce, J. E. Rice, J.A. Sanchez, C. Brenner, and L. J. Wangh (2000)
Mol. Hum. Reprod. 6, 1155-1164
   Abstract »    Full Text »    PDF »
The human sex-reversing ATRX gene has a homologue on the marsupial Y chromosome, ATRY: Implications for the evolution of mammalian sex determination.
A. Pask, M. B. Renfree, and J. A. Marshall Graves (2000)
PNAS
   Abstract »    Full Text »
Y chromosomal fertility factors kl-2 and kl-3 of Drosophila melanogaster encode dynein heavy chain polypeptides.
A. B. Carvalho, B. P. Lazzaro, and A. G. Clark (2000)
PNAS
   Abstract »    Full Text »
Male Infertility Caused by a de Novo Partial Deletion of the DAZ Cluster on the Y Chromosome.
E. Moro, A. Ferlin, P. H. Yen, P. G. Franchi, G. Palka, and C. Foresta (2000)
J. Clin. Endocrinol. Metab. 85, 4069-4073
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UTY gene codes for an HLA-B60-restricted human male-specific minor histocompatibility antigen involved in stem cell graft rejection: characterization of the critical polymorphic amino acid residues for T-cell recognition.
M. H. J. Vogt, E. Goulmy, F. M. Kloosterboer, E. Blokland, R. A. de Paus, R. Willemze, and J. H. F. Falkenburg (2000)
Blood 96, 3126-3132
   Abstract »    Full Text »    PDF »


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