Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 24 October 1997:
Vol. 278. no. 5338, pp. 672 - 675
DOI: 10.1126/science.278.5338.672
Prev | Table of Contents | Next

Reports

Requirement for CD44 in Activated T Cell Extravasation into an Inflammatory Site

Heather C. DeGrendele, Pila Estess, * Mark H. Siegelman

Leukocytes extravasate from the blood into inflammatory sites through complementary ligand interactions between leukocytes and endothelial cells. Activation of T cells increases their binding to hyaluronate (HA) and enables CD44-mediated primary adhesion (rolling). This rolling could be induced in vivo in murine Vbeta 8+ T cells in response to specific superantigen stimulation; it was initially found in lymph nodes, then in peripheral blood, and finally within the peritoneum, the original inflamed site. The migration of Vbeta 8+ cells into the peritoneal cavity was dependent on CD44 and HA, as shown by inhibition studies. Thus, CD44-HA interactions can target lymphocytes to specific extralymphoid effector sites.

Laboratory of Molecular Pathology, Department of Pathology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75235, USA.
*   To whom correspondence should be addressed. E-mail: estess.pila{at}pathology.swmed.edu

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Phosphoinositide-dependent kinase 1 controls migration and malignant transformation but not cell growth and proliferation in PTEN-null lymphocytes.
D. K. Finlay, L. V. Sinclair, C. Feijoo, C. M. Waugh, T. J. Hagenbeek, H. Spits, and D. A. Cantrell (2009)
J. Exp. Med. 206, 2441-2454
   Abstract »    Full Text »    PDF »
Endogenous galectins and the control of the host inflammatory response.
L. V Norling, M. Perretti, and D. Cooper (2009)
J. Endocrinol. 201, 169-184
   Abstract »    Full Text »    PDF »
A Mechanism of Sialylation Functionally Silences the Hyaluronan Receptor LYVE-1 in Lymphatic Endothelium.
T. D. Nightingale, M. E. F. Frayne, S. Clasper, S. Banerji, and D. G. Jackson (2009)
J. Biol. Chem. 284, 3935-3945
   Abstract »    Full Text »    PDF »
Core2 1-6-N-Glucosaminyltransferase-I Is Crucial for the Formation of Atherosclerotic Lesions in Apolipoprotein E-Deficient Mice.
H. Wang, R. Tang, W. Zhang, K. Amirikian, Z. Geng, J. Geng, R. P. Hebbel, L. Xia, J. D. Marth, M. Fukuda, et al. (2009)
Arterioscler Thromb Vasc Biol 29, 180-187
   Abstract »    Full Text »    PDF »
Transfer of Inter-{alpha}-inhibitor Heavy Chains to Hyaluronan by Surface-linked Hyaluronan-TSG-6 Complexes.
E. Colon, A. Shytuhina, M. K. Cowman, P. A. Band, K. W. Sanggaard, J. J. Enghild, and H.-G. Wisniewski (2009)
J. Biol. Chem. 284, 2320-2331
   Abstract »    Full Text »    PDF »
A high-mobility, low-cost phenotype defines human effector-memory CD8+ T cells.
G. Zenhaeusern, P. Gubser, P. Eisele, O. Gasser, A. Steinhuber, A. Trampuz, C. Handschin, A. D. Luster, and C. Hess (2009)
Blood 113, 95-99
   Abstract »    Full Text »    PDF »
CD44-specific antibody treatment and CD44 deficiency exert distinct effects on leukocyte recruitment in experimental arthritis.
G. Hutas, E. Bajnok, I. Gal, A. Finnegan, T. T. Glant, and K. Mikecz (2008)
Blood 112, 4999-5006
   Abstract »    Full Text »    PDF »
Hyaluronan Induces Cell Death in Activated T Cells through CD44.
B. Ruffell and P. Johnson (2008)
J. Immunol. 181, 7044-7054
   Abstract »    Full Text »    PDF »
Galectin-9 suppresses tumor metastasis by blocking adhesion to endothelium and extracellular matrices.
A. Nobumoto, K. Nagahara, S. Oomizu, S. Katoh, N. Nishi, K. Takeshita, T. Niki, A. Tominaga, A. Yamauchi, and M. Hirashima (2008)
Glycobiology 18, 735-744
   Abstract »    Full Text »    PDF »
Effects of donor T-cell trafficking and priming site on graft-versus-host disease induction by naive and memory phenotype CD4 T cells.
B. E. Anderson, P. A. Taylor, J. M. McNiff, D. Jain, A. J. Demetris, A. Panoskaltsis-Mortari, A. Ager, B. R. Blazar, W. D. Shlomchik, and M. J. Shlomchik (2008)
Blood 111, 5242-5251
   Abstract »    Full Text »    PDF »
Interaction of CD44 and hyaluronan is the dominant mechanism for neutrophil sequestration in inflamed liver sinusoids.
B. McDonald, E. F. McAvoy, F. Lam, V. Gill, C. de la Motte, R. C. Savani, and P. Kubes (2008)
J. Exp. Med. 205, 915-927
   Abstract »    Full Text »    PDF »
Prevention of acute graft-versus-host disease by blocking T-cell entry to secondary lymphoid organs.
A. Beilhack, S. Schulz, J. Baker, G. F. Beilhack, R. Nishimura, E. M. Baker, G. Landan, E. I. Herman, E. C. Butcher, C. H. Contag, et al. (2008)
Blood 111, 2919-2928
   Abstract »    Full Text »    PDF »
CD44 Is Critically Involved in Infarct Healing by Regulating the Inflammatory and Fibrotic Response.
P. Huebener, T. Abou-Khamis, P. Zymek, M. Bujak, X. Ying, K. Chatila, S. Haudek, G. Thakker, and N. G. Frangogiannis (2008)
J. Immunol. 180, 2625-2633
   Abstract »    Full Text »    PDF »
Hyaluronan Synthesis Is Required for IL-2-Mediated T Cell Proliferation.
C. L. Mahaffey and M. E. Mummert (2007)
J. Immunol. 179, 8191-8199
   Abstract »    Full Text »    PDF »
Anti-CD44-mediated blockade of leukocyte migration in skin-associated immune diseases.
M. Zoller, P. Gupta, R. Marhaba, M. Vitacolonna, and P. Freyschmidt-Paul (2007)
J. Leukoc. Biol. 82, 57-71
   Abstract »    Full Text »    PDF »
Galectin-9 Inhibits CD44-Hyaluronan Interaction and Suppresses a Murine Model of Allergic Asthma.
S. Katoh, N. Ishii, A. Nobumoto, K. Takeshita, S.-Y. Dai, R. Shinonaga, T. Niki, N. Nishi, A. Tominaga, A. Yamauchi, et al. (2007)
Am. J. Respir. Crit. Care Med. 176, 27-35
   Abstract »    Full Text »    PDF »
Recognition of Hyaluronan Released in Sterile Injury Involves a Unique Receptor Complex Dependent on Toll-like Receptor 4, CD44, and MD-2.
K. R. Taylor, K. Yamasaki, K. A. Radek, A. D. Nardo, H. Goodarzi, D. Golenbock, B. Beutler, and R. L. Gallo (2007)
J. Biol. Chem. 282, 18265-18275
   Abstract »    Full Text »    PDF »
CD44 Is a Negative Regulator of Acute Pulmonary Inflammation and Lipopolysaccharide-TLR Signaling in Mouse Macrophages.
J. Liang, D. Jiang, J. Griffith, S. Yu, J. Fan, X. Zhao, R. Bucala, and P. W. Noble (2007)
J. Immunol. 178, 2469-2475
   Abstract »    Full Text »    PDF »
A recombinant non-pathogenic Leishmania vaccine expressing human immunodeficiency virus 1 (HIV-1) Gag elicits cell-mediated immunity in mice and decreases HIV-1 replication in human tonsillar tissue following exposure to HIV-1 infection.
M. Breton, C. Zhao, M. Ouellette, M. J. Tremblay, and B. Papadopoulou (2007)
J. Gen. Virol. 88, 217-225
   Abstract »    Full Text »    PDF »
Mechanistic insights into targeting T cell membrane proteinase to promote islet {beta}-cell rejuvenation in type 1 diabetes.
A. Y. Savinov, D. V. Rozanov, and A. Y. Strongin (2006)
FASEB J 20, 1793-1801
   Abstract »    Full Text »    PDF »
Expression of CD44 and L-Selectin in the Innate Immune System Is Required for Severe Joint Inflammation in the Proteoglycan-Induced Murine Model of Rheumatoid Arthritis.
B. Sarraj, K. Ludanyi, T. T. Glant, A. Finnegan, and K. Mikecz (2006)
J. Immunol. 177, 1932-1940
   Abstract »    Full Text »    PDF »
SHAP Potentiates the CD44-mediated Leukocyte Adhesion to the Hyaluronan Substratum.
L. Zhuo, A. Kanamori, R. Kannagi, N. Itano, J. Wu, M. Hamaguchi, N. Ishiguro, and K. Kimata (2006)
J. Biol. Chem. 281, 20303-20314
   Abstract »    Full Text »    PDF »
Use of CD44 by CD4+ Th1 and Th2 lymphocytes to roll and adhere.
C. S. Bonder, S. R. Clark, M. U. Norman, P. Johnson, and P. Kubes (2006)
Blood 107, 4798-4806
   Abstract »    Full Text »    PDF »
Emerging roles for ectodomain shedding in the regulation of inflammatory responses.
K. J. Garton, P. J. Gough, and E. W. Raines (2006)
J. Leukoc. Biol. 79, 1105-1116
   Abstract »    Full Text »    PDF »
CD44 Disruption Prevents Degeneration of the Capillary Network in Obstructive Nephropathy via Reduction of TGF-beta1-Induced Apoptosis.
K. M.A. Rouschop, N. Claessen, S. T. Pals, J. J. Weening, and S. Florquin (2006)
J. Am. Soc. Nephrol. 17, 746-753
   Abstract »    Full Text »    PDF »
Molecular mechanisms of cell recruitment to inflammatory sites: general and tissue-specific pathways.
T. Garrood, L. Lee, and C. Pitzalis (2006)
Rheumatology 45, 250-260
   Full Text »    PDF »
Suppressor activity and potency among regulatory T cells is discriminated by functionally active CD44.
M. Firan, S. Dhillon, P. Estess, and M. H. Siegelman (2006)
Blood 107, 619-627
   Abstract »    Full Text »    PDF »
Pre-transplant plasma and cellular levels of CD44 correlate with acute renal allograft rejection.
K. M. A. Rouschop, J. J. T. H. Roelofs, A. T. Rowshani, J. C. Leemans, T. van der Poll, I. J. M. ten Berge, J. J. Weening, and S. Florquin (2005)
Nephrol. Dial. Transplant. 20, 2248-2254
   Abstract »    Full Text »    PDF »
Regulation of hyaluronan synthase-2 expression in human intestinal mesenchymal cells: mechanisms of interleukin-1{beta}-mediated induction.
A. E. Ducale, S. I. Ward, T. Dechert, and D. R. Yager (2005)
Am J Physiol Gastrointest Liver Physiol 289, G462-G470
   Abstract »    Full Text »    PDF »
Stress as an endogenous adjuvant: augmentation of the immunization phase of cell-mediated immunity.
K. Viswanathan, C. Daugherty, and F. S. Dhabhar (2005)
Int. Immunol. 17, 1059-1069
   Abstract »    Full Text »    PDF »
Inhibition of Membrane Type-1 Matrix Metalloproteinase by Cancer Drugs Interferes with the Homing of Diabetogenic T Cells into the Pancreas.
A. Y. Savinov, D. V. Rozanov, V. S. Golubkov, F. S. Wong, and A. Y. Strongin (2005)
J. Biol. Chem. 280, 27755-27758
   Abstract »    Full Text »    PDF »
Expression of N-acetylglucosamine 6-O-sulfotransferases (GlcNAc6STs)-1 and -4 in human monocytes: GlcNAc6ST-1 is implicated in the generation of the 6-sulfo N-acetyllactosamine/Lewis x epitope on CD44 and is induced by TNF-{alpha}.
S. L. Tjew, K. L. Brown, R. Kannagi, and P. Johnson (2005)
Glycobiology 15, 7C-13C
   Abstract »    Full Text »    PDF »
Protection against Renal Ischemia Reperfusion Injury by CD44 Disruption.
K. M. A. Rouschop, J. J.T.H. Roelofs, N. Claessen, P. d. C. Martins, J.-J. Zwaginga, S. T. Pals, J. J. Weening, and S. Florquin (2005)
J. Am. Soc. Nephrol. 16, 2034-2043
   Abstract »    Full Text »    PDF »
CD44 is a physiological E-selectin ligand on neutrophils.
Y. Katayama, A. Hidalgo, J. Chang, A. Peired, and P. S. Frenette (2005)
J. Exp. Med. 201, 1183-1189
   Abstract »    Full Text »    PDF »
TSG-6 Protein Binding to Glycosaminoglycans: FORMATION OF STABLE COMPLEXES WITH HYALURONAN AND BINDING TO CHONDROITIN SULFATES.
H.-G. Wisniewski, E. S. Snitkin, C. Mindrescu, M. H. Sweet, and J. Vilcek (2005)
J. Biol. Chem. 280, 14476-14484
   Abstract »    Full Text »    PDF »
CD44 cross-linking induces protein kinase C-regulated migration of human T lymphocytes.
A. Fanning, Y. Volkov, M. Freeley, D. Kelleher, and A. Long (2005)
Int. Immunol. 17, 449-458
   Abstract »    Full Text »    PDF »
PD-1 blockade inhibits hematogenous spread of poorly immunogenic tumor cells by enhanced recruitment of effector T cells.
Y. Iwai, S. Terawaki, and T. Honjo (2005)
Int. Immunol. 17, 133-144
   Abstract »    Full Text »    PDF »
Role of CD44 and Its v7 Isoform in Staphylococcal Enterotoxin B-Induced Toxic Shock: CD44 Deficiency on Hepatic Mononuclear Cells Leads to Reduced Activation-Induced Apoptosis That Results in Increased Liver Damage.
R. J. McKallip, M. Fisher, U. Gunthert, A. K. Szakal, P. S. Nagarkatti, and M. Nagarkatti (2005)
Infect. Immun. 73, 50-61
   Abstract »    Full Text »    PDF »
Role of CD44 and Hyaluronan in Neutrophil Recruitment.
A. I. Khan, S. M. Kerfoot, B. Heit, L. Liu, G. Andonegui, B. Ruffell, P. Johnson, and P. Kubes (2004)
J. Immunol. 173, 7594-7601
   Abstract »    Full Text »    PDF »
Leflunomide inhibits transendothelial migration of peripheral blood mononuclear cells.
J Grisar, M Aringer, M D Koller, G H Stummvoll, D Eselbock, B Zwolfer, C W Steiner, B Zierhut, L Wagner, P Pietschmann, et al. (2004)
Ann Rheum Dis 63, 1632-1637
   Abstract »    Full Text »    PDF »
Intrapleural Staphylococcal Superantigen Induces Resolution of Malignant Pleural Effusions and a Survival Benefit in Non-Small Cell Lung Cancer.
S. Ren, D. S. Terman, G. Bohach, A. Silvers, C. Hansen, H. Colt, and S. A. Sahn (2004)
Chest 126, 1529-1539
   Abstract »    Full Text »    PDF »
Functional T cells in primary immune response to histoplasmosis.
J.-S. Lin and B. A. Wu-Hsieh (2004)
Int. Immunol. 16, 1663-1673
   Abstract »    Full Text »    PDF »
Anti-Idiotype x Anti-CD44 Bispecific Antibodies Inhibit Invasion of Lymphoid Organs by B Cell Lymphoma.
E. Avin, J. Haimovich, and N. Hollander (2004)
J. Immunol. 173, 4736-4743
   Abstract »    Full Text »    PDF »
Dendritic Cells Strongly Boost the Antitumor Activity of Adoptively Transferred T Cells In vivo.
Y. Lou, G. Wang, G. Lizee, G. J. Kim, S. E. Finkelstein, C. Feng, N. P. Restifo, and P. Hwu (2004)
Cancer Res. 64, 6783-6790
   Abstract »    Full Text »    PDF »
Characterization of Nonpathogenic, Live, Viral Vaccine Vectors Inducing Potent Cellular Immune Responses.
J. Publicover, E. Ramsburg, and J. K. Rose (2004)
J. Virol. 78, 9317-9324
   Abstract »    Full Text »    PDF »
Renal Proximal Tubular Epithelial Cell Transforming Growth Factor-{beta}1 Generation and Monocyte Binding.
X. L. Zhang, W. Selbi, C. de la Motte, V. Hascall, and A. Phillips (2004)
Am. J. Pathol. 165, 763-773
   Abstract »    Full Text »    PDF »
Intratumoral NAMI-A Treatment Triggers Metastasis Reduction, Which Correlates to CD44 Regulation and Tumor Infiltrating Lymphocyte Recruitment.
S. Pacor, S. Zorzet, M. Cocchietto, M. Bacac, M. Vadori, C. Turrin, B. Gava, A. Castellarin, and G. Sava (2004)
J. Pharmacol. Exp. Ther. 310, 737-744
   Abstract »    Full Text »    PDF »
TSG-6 Modulates the Interaction between Hyaluronan and Cell Surface CD44.
J. Lesley, I. Gal, D. J. Mahoney, M. R. Cordell, M. S. Rugg, R. Hyman, A. J. Day, and K. Mikecz (2004)
J. Biol. Chem. 279, 25745-25754
   Abstract »    Full Text »    PDF »
Biochemical and Functional Analysis of Smallpox Growth Factor (SPGF) and Anti-SPGF Monoclonal Antibodies.
M. Kim, H. Yang, S.-K. Kim, P. A. Reche, R. S. Tirabassi, R. E. Hussey, Y. Chishti, J. G. Rheinwald, T. J. Morehead, T. Zech, et al. (2004)
J. Biol. Chem. 279, 25838-25848
   Abstract »    Full Text »    PDF »
Expression of L-Selectin, but Not CD44, Is Required for Early Neutrophil Extravasation in Antigen-Induced Arthritis.
S. Szanto, I. Gal, A. Gonda, T. T. Glant, and K. Mikecz (2004)
J. Immunol. 172, 6723-6734
   Abstract »    Full Text »    PDF »
CD44 and hyaluronic acid cooperate with SDF-1 in the trafficking of human CD34+ stem/progenitor cells to bone marrow.
A. Avigdor, P. Goichberg, S. Shivtiel, A. Dar, A. Peled, S. Samira, O. Kollet, R. Hershkoviz, R. Alon, I. Hardan, et al. (2004)
Blood 103, 2981-2989
   Abstract »    Full Text »    PDF »
CD44 Regulates Arteriogenesis in Mice and Is Differentially Expressed in Patients With Poor and Good Collateralization.
N. van Royen, M. Voskuil, I. Hoefer, M. Jost, S. de Graaf, F. Hedwig, J.-P. Andert, T.A.M. Wormhoudt, J. Hua, S. Hartmann, et al. (2004)
Circulation 109, 1647-1652
   Abstract »    Full Text »    PDF »
CD44 Deficiency Increases Tubular Damage But Reduces Renal Fibrosis in Obstructive Nephropathy.
K. M.A. Rouschop, M. E. Sewnath, N. Claessen, J. J.T.H. Roelofs, I. Hoedemaeker, R. van der Neut, J. Aten, S. T. Pals, J. J. Weening, and S. Florquin (2004)
J. Am. Soc. Nephrol. 15, 674-686
   Abstract »    Full Text »    PDF »
Recruitment of IFN-{gamma}-Producing (Th1-Like) Cells into the Inflamed Retina In Vivo Is Preferentially Regulated by P-Selectin Glycoprotein Ligand 1:P/E-Selectin Interactions.
H. Xu, A. Manivannan, H.-R. Jiang, J. Liversidge, P. F. Sharp, J. V. Forrester, and I. J. Crane (2004)
J. Immunol. 172, 3215-3224
   Abstract »    Full Text »    PDF »
Glucocorticoids inhibit induced and non-induced mRNA accumulation of genes encoding hyaluronan synthases (HAS): hydrocortisone inhibits HAS1 activation by blocking the p38 mitogen-activated protein kinase signalling pathway.
K. M. Stuhlmeier and C. Pollaschek (2004)
Rheumatology 43, 164-169
   Abstract »    Full Text »    PDF »
CD44-hyaluronic acid interactions mediate shear-resistant binding of lymphocytes to dermal endothelium in acute cutaneous GVHD.
M. Milinkovic, J. H. Antin, C. A. Hergrueter, C. B. Underhill, and R. Sackstein (2004)
Blood 103, 740-742
   Abstract »    Full Text »    PDF »
Endoplasmic Reticulum Stress Induces Hyaluronan Deposition and Leukocyte Adhesion.
A. K. Majors, R. C. Austin, C. A. de la Motte, R. E. Pyeritz, V. C. Hascall, S. P. Kessler, G. Sen, and S. A. Strong (2003)
J. Biol. Chem. 278, 47223-47231
   Abstract »    Full Text »    PDF »
Involvement of Serum Response Factor Isoforms in Myofibroblast Differentiation During Bleomycin-Induced Lung Injury.
Y. Yang, X. Zhe, S. H. Phan, M. Ullenbruch, and L. Schuger (2003)
Am. J. Respir. Cell Mol. Biol. 29, 583-590
   Abstract »    Full Text »
Membrane lymphotoxin is required for resistance to Theiler's virus infection.
X. Lin, X. Ma, M. Rodriguez, X. Feng, L. Zoecklein, Y.-X. Fu, and R. P. Roos (2003)
Int. Immunol. 15, 955-962
   Abstract »    Full Text »    PDF »
CD44v7 interferes with activation-induced cell death by up-regulation of anti-apoptotic gene expression.
R. Marhaba, M. Bourouba, and M. Zoller (2003)
J. Leukoc. Biol. 74, 135-148
   Abstract »    Full Text »    PDF »
Mononuclear Leukocytes Bind to Specific Hyaluronan Structures on Colon Mucosal Smooth Muscle Cells Treated with Polyinosinic Acid:Polycytidylic Acid: Inter-{alpha}-Trypsin Inhibitor Is Crucial to Structure and Function.
C. A. de la Motte, V. C. Hascall, J. Drazba, S. K. Bandyopadhyay, and S. A. Strong (2003)
Am. J. Pathol. 163, 121-133
   Abstract »    Full Text »    PDF »
The liberation of CD44.
J. Cichy and E. Pure (2003)
J. Cell Biol. 161, 839-843
   Abstract »    Full Text »    PDF »
Role of the Extracellular and Cytoplasmic Domains of CD44 in the Rolling Interaction of Lymphoid Cells with Hyaluronan under Physiologic Flow.
I. Gal, J. Lesley, W. Ko, A. Gonda, R. Stoop, R. Hyman, and K. Mikecz (2003)
J. Biol. Chem. 278, 11150-11158
   Abstract »    Full Text »    PDF »
Chemokine-independent Preference for T-helper-1 Cells in Transendothelial Migration.
T. Katakai, T. Hara, M. Sugai, H. Gonda, Y. Nambu, E. Matsuda, Y. Agata, and A. Shimizu (2002)
J. Biol. Chem. 277, 50948-50958
   Abstract »    Full Text »    PDF »
Involvement of CD44 in leukocyte trafficking at the blood-retinal barrier.
H. Xu, A. Manivannan, J. Liversidge, P. F. Sharp, J. V. Forrester, and I. J. Crane (2002)
J. Leukoc. Biol. 72, 1133-1141
   Abstract »    Full Text »    PDF »
CD44 Deficiency Leads to Enhanced Neutrophil Migration and Lung Injury in Escherichia coli Pneumonia in Mice.
Q. Wang, P. Teder, N. P. Judd, P. W. Noble, and C. M. Doerschuk (2002)
Am. J. Pathol. 161, 2219-2228
   Abstract »    Full Text »    PDF »
CD4 Effector T Cell Subsets in the Response to Influenza: Heterogeneity, Migration, and Function.
E. Roman, E. Miller, A. Harmsen, J. Wiley, U. H. von Andrian, G. Huston, and S. L. Swain (2002)
J. Exp. Med. 196, 957-968
   Abstract »    Full Text »    PDF »
TNF-{alpha} increases the carbohydrate sulfation of CD44: induction of 6-sulfo N-acetyl lactosamine on N- and O-linked glycans.
M. Delcommenne, R. Kannagi, and P. Johnson (2002)
Glycobiology 12, 613-622
   Abstract »    Full Text »    PDF »
Elevated levels of circulating CD44 in patients with systemic sclerosis: association with a milder subset.
K. Komura, S. Sato, M. Fujimoto, M. Hasegawa, and K. Takehara (2002)
Rheumatology 41, 1149-1154
   Abstract »    Full Text »    PDF »
Role of CD44 in activation-induced cell death: CD44-deficient mice exhibit enhanced T cell response to conventional and superantigens.
R. J. McKallip, Y. Do, M. T. Fisher, J. L. Robertson, P. S. Nagarkatti, and M. Nagarkatti (2002)
Int. Immunol. 14, 1015-1026
   Abstract »    Full Text »    PDF »
Robust Recall and Long-Term Memory T-Cell Responses Induced by Prime-Boost Regimens with Heterologous Live Viral Vectors Expressing Human Immunodeficiency Virus Type 1 Gag and Env Proteins.
K. Haglund, I. Leiner, K. Kerksiek, L. Buonocore, E. Pamer, and J. K. Rose (2002)
J. Virol. 76, 7506-7517
   Abstract »    Full Text »    PDF »
IgG plasma cells display a unique spectrum of leukocyte adhesion and homing molecules.
G. H. Underhill, H. A. Minges-Wols, J. L. Fornek, P. L. Witte, and G. S. Kansas (2002)
Blood 99, 2905-2912
   Abstract »    Full Text »    PDF »
Resolution of Lung Inflammation by CD44.
P. Teder, R. W. Vandivier, D. Jiang, J. Liang, L. Cohn, E. Pure, P. M. Henson, and P. W. Noble (2002)
Science 296, 155-158
   Abstract »    Full Text »    PDF »
Role of Sulfation in CD44-Mediated Hyaluronan Binding Induced by Inflammatory Mediators in Human CD14+ Peripheral Blood Monocytes.
K. L. Brown, A. Maiti, and P. Johnson (2001)
J. Immunol. 167, 5367-5374
   Abstract »    Full Text »    PDF »
Migratory Properties of Naive, Effector, and Memory Cd8+ T Cells.
W. Weninger, M. A. Crowley, N. Manjunath, and U. H. von Andrian (2001)
J. Exp. Med. 194, 953-966
   Abstract »    Full Text »    PDF »
Expression of Interleukin-15 in Mouse and Human Atherosclerotic Lesions.
D. M. Wuttge, P. Eriksson, A. Sirsjo, G. K. Hansson, and S. Stemme (2001)
Am. J. Pathol. 159, 417-423
   Abstract »    Full Text »
Plaque T-Cell Activity : Not So Specific?.
S. Stemme (2001)
Arterioscler Thromb Vasc Biol 21, 1099-1101
   Full Text »    PDF »
A Role for CD44 in the Production of IFN-{{gamma}} and Immunopathology During Infection with Toxoplasma gondii.
S. L. Blass, E. Pure, and C. A. Hunter (2001)
J. Immunol. 166, 5726-5732
   Abstract »    Full Text »    PDF »
A Unique Pathway in the Homing of Murine Multiple Myeloma Cells: CD44v10 Mediates Binding to Bone Marrow Endothelium.
K. Asosingh, U. Günthert, H. De Raeve, I. Van Riet, B. Van Camp, and K. Vanderkerken (2001)
Cancer Res. 61, 2862-2865
   Abstract »    Full Text »
Layilin, a Novel Integral Membrane Protein, Is a Hyaluronan Receptor.
P. Bono, K. Rubin, J. M. G. Higgins, and R. O. Hynes (2001)
Mol. Biol. Cell 12, 891-900
   Abstract »    Full Text »
Inflammation and Clearance of Chlamydia trachomatis in Enteric and Nonenteric Mucosae.
J. U. Igietseme, J. L. Portis, and L. L. Perry (2001)
Infect. Immun. 69, 1832-1840
   Abstract »    Full Text »    PDF »
CD44 binds a chondroitin sulfate proteoglycan, aggrecan.
T. Fujimoto, H. Kawashima, T. Tanaka, M. Hirose, N. Toyama-Sorimachi, Y. Matsuzawa, and M. Miyasaka (2001)
Int. Immunol. 13, 359-366
   Abstract »    Full Text »    PDF »
Negative regulation of epithelium-neutrophil interactions via activation of CD44.
M. Si-Tahar, S. Sitaraman, T. Shibahara, and J. L. Madara (2001)
Am J Physiol Cell Physiol 280, C423-C432
   Abstract »    Full Text »    PDF »
Cell Surface-Expressed Moesin-Like Receptor Regulates T Cell Interactions with Tissue Components and Binds an Adhesion-Modulating IL-2 Peptide Generated by Elastase.
A. Ariel, R. Hershkoviz, I. Altbaum-Weiss, S. Ganor, and O. Lider (2001)
J. Immunol. 166, 3052-3060
   Abstract »    Full Text »    PDF »
Lymphotoxin {{alpha}}-/- Mice Develop Functionally Impaired CD8+ T Cell Responses and Fail to Contain Virus Infection of the Central Nervous System.
U. Kumaraguru, I. A. Davis, S. Deshpande, S. S. Tevethia, and B. T. Rouse (2001)
J. Immunol. 166, 1066-1074
   Abstract »    Full Text »    PDF »
CD44-dependent lymphoma cell dissemination: a cell surface CD44 variant, rather than standard CD44, supports in vitro lymphoma cell rolling on hyaluronic acid substrate and its in vivo accumulation in the peripheral lymph nodes.
S. B. Wallach-Dayan, V. Grabovsky, J. Moll, J. Sleeman, P. Herrlich, R. Alon, and D. Naor (2001)
J. Cell Sci. 114, 3463-3477
   Abstract »    Full Text »    PDF »
Involvement of CD44 in cytoskeleton rearrangement and raft reorganization in T cells.
N Foger, R Marhaba, and M Zoller (2001)
J. Cell Sci. 114, 1169-1178
   Abstract »    PDF »
Activated T Lymphocytes Regulate Hyaluronan Binding to Monocyte CD44 Via Production of IL-2 and IFN-{{gamma}}.
M. C. Levesque and B. F. Haynes (2001)
J. Immunol. 166, 188-196
   Abstract »    Full Text »    PDF »
Expression of c-Met and Heparan-Sulfate Proteoglycan Forms of CD44 in Colorectal Cancer.
V. J. M. Wielenga, R. van der Voort, T. E. I. Taher, L. Smit, E. A. Beuling, C. van Krimpen, M. Spaargaren, and S. T. Pals (2000)
Am. J. Pathol. 157, 1563-1573
   Abstract »    Full Text »    PDF »
Expression of Mucosal Homing Receptor alpha 4beta 7 Is Associated with Enhanced Migration to the Chlamydia-Infected Murine Genital Mucosa In Vivo.
R. A. Hawkins, R. G. Rank, and K. A. Kelly (2000)
Infect. Immun. 68, 5587-5594
   Abstract »    Full Text »    PDF »
Adenoids provide a microenvironment for the generation of CD4+, CD45RO+, L-selectin-, CXCR4+, CCR5+ T lymphocytes, a lymphocyte phenotype found in the middle ear effusion.
P. S. Mattila, A. Nykanen, M. Eloranta, and J. Tarkkanen (2000)
Int. Immunol. 12, 1235-1243
   Abstract »    Full Text »    PDF »
Murine Model of Interstitial Cytomegalovirus Pneumonia in Syngeneic Bone Marrow Transplantation: Persistence of Protective Pulmonary CD8-T-Cell Infiltrates after Clearance of Acute Infection.
J. Podlech, R. Holtappels, M.-F. Pahl-Seibert, H.-P. Steffens, and M. J. Reddehase (2000)
J. Virol. 74, 7496-7507
   Abstract »    Full Text »
Abrogation of Experimental Colitis Correlates with Increased Apoptosis in Mice Deficient for Cd44 Variant Exon 7 (Cd44v7).
B. M. Wittig, B. Johansson, M. Zoller, C. Schwarzler, and U. Gunthert (2000)
J. Exp. Med. 191, 2053-2064
   Abstract »    Full Text »    PDF »
Lymphocyte Migration Through Monolayers of Endothelial Cell Lines Involves VCAM-1 Signaling Via Endothelial Cell NADPH Oxidase.
H. E. Matheny, T. L. Deem, and J. M. Cook-Mills (2000)
J. Immunol. 164, 6550-6559
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)