Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 10 October 1997:
Vol. 278. no. 5336, pp. 290 - 294
DOI: 10.1126/science.278.5336.290
Prev | Table of Contents | Next

Reports

Angiogenic and HIV-Inhibitory Functions of KSHV-Encoded Chemokines

Chris Boshoff, * Yoshio Endo, Paul D. Collins, Yasuhiro Takeuchi, Jacqueline D. Reeves, Vicki L. Schweickart, Michael A. Siani, Takuma Sasaki, Timothy J. Williams, Patrick W. Gray, Patrick S. Moore, Yuan Chang, Robin A. Weiss

Unique among known human herpesviruses, Kaposi's sarcoma-associated herpesvirus (KSHV or HHV-8) encodes chemokine-like proteins (vMIP-I and vMIP-II). vMIP-II was shown to block infection of human immunodeficiency virus-type 1 (HIV-1) on a CD4-positive cell line expressing CCR3 and to a lesser extent on one expressing CCR5, whereas both vMIP-I and vMIP-II partially inhibited HIV infection of peripheral blood mononuclear cells. Like eotaxin, vMIP-II activated and chemoattracted human eosinophils by way of CCR3. vMIP-I and vMIP-II, but not cellular MIP-1alpha or RANTES, were highly angiogenic in the chorioallantoic assay, suggesting a possible pathogenic role in Kaposi's sarcoma.

C. Boshoff, Y. Takeuchi, J. D. Reeves, R. A. Weiss, Institute of Cancer Research, Chester Beatty Laboratories, London SW3 6JB, UK.
Y. Endo and T. Sasaki, Department of Experimental Therapeutics and Development Center for Molecular Target Drugs, Cancer Research Institute, Kanazawa University, Japan.
P. D. Collins and T. J. Williams, Department of Applied Pharmacology, Imperial College School of Medicine at National Heart and Lung Institute, London SW3 6LY, UK.
V. L. Schweickart and P. W. Gray, ICOS, 22021 20th Avenue Southeast, Bothell, WA 98021, USA.
M. A. Siani, Gryphon Sciences, San Francisco, CA 94080, USA.
P. S Moore and Y. Chang, Department of Pathology and Epidemiology, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA.
*   To whom correspondence should be addressed.

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Autocrine and Paracrine Promotion of Cell Survival and Virus Replication by Human Herpesvirus 8 Chemokines.
Y. B. Choi and J. Nicholas (2008)
J. Virol. 82, 6501-6513
   Abstract »    Full Text »    PDF »
Virion-Wide Protein Interactions of Kaposi's Sarcoma-Associated Herpesvirus.
R. Rozen, N. Sathish, Y. Li, and Y. Yuan (2008)
J. Virol. 82, 4742-4750
   Abstract »    Full Text »    PDF »
Stimulation of c-Myc Transcriptional Activity by vIRF-3 of Kaposi Sarcoma-associated Herpesvirus.
B. Lubyova, M. J. Kellum, J. A. Frisancho, and P. M. Pitha (2007)
J. Biol. Chem. 282, 31944-31953
   Abstract »    Full Text »    PDF »
Inhibition of HIV-1 infection by viral chemokine U83A via high-affinity CCR5 interactions that block human chemokine-induced leukocyte chemotaxis and receptor internalization.
J. Catusse, C. M. Parry, D. R. Dewin, and U. A. Gompels (2007)
Blood 109, 3633-3639
   Abstract »    Full Text »    PDF »
Kaposi's Sarcoma-Associated Herpesvirus Promotes Angiogenesis by Inducing Angiopoietin-2 Expression via AP-1 and Ets1.
F.-C. Ye, D. J. Blackbourn, M. Mengel, J.-P. Xie, L.-W. Qian, W. Greene, I-T. Yeh, D. Graham, and S.-J. Gao (2007)
J. Virol. 81, 3980-3991
   Abstract »    Full Text »    PDF »
Functional Characterization of Kaposi's Sarcoma-Associated Herpesvirus ORF45 by Bacterial Artificial Chromosome-Based Mutagenesis.
F. X. Zhu, X. Li, F. Zhou, S.-J. Gao, and Y. Yuan (2006)
J. Virol. 80, 12187-12196
   Abstract »    Full Text »    PDF »
Kaposi's sarcoma-associated herpesvirus immune modulation: an overview.
S. A. R. Rezaee, C. Cunningham, A. J. Davison, and D. J. Blackbourn (2006)
J. Gen. Virol. 87, 1781-1804
   Abstract »    Full Text »    PDF »
Activity of subcutaneous interleukin-12 in AIDS-related Kaposi sarcoma.
R. F. Little, J. M. Pluda, K. M. Wyvill, I. R. Rodriguez-Chavez, G. Tosato, A. T. Catanzaro, S. M. Steinberg, and R. Yarchoan (2006)
Blood 107, 4650-4657
   Abstract »    Full Text »    PDF »
Identification and Characterization of U83A Viral Chemokine, a Broad and Potent {beta}-Chemokine Agonist for Human CCRs with Unique Selectivity and Inhibition by Spliced Isoform.
D. R. Dewin, J. Catusse, and U. A. Gompels (2006)
J. Immunol. 176, 544-556
   Abstract »    Full Text »    PDF »
A rich chemokine environment strongly enhances leukocyte migration and activities.
S. Paoletti, V. Petkovic, S. Sebastiani, M. G. Danelon, M. Uguccioni, and B. O. Gerber (2005)
Blood 105, 3405-3412
   Abstract »    Full Text »    PDF »
Dissection of the Kaposi's Sarcoma-Associated Herpesvirus Gene Expression Program by Using the Viral DNA Replication Inhibitor Cidofovir.
M. Lu, J. Suen, C. Frias, R. Pfeiffer, M.-H. Tsai, E. Chuang, and S. L. Zeichner (2004)
J. Virol. 78, 13637-13652
   Abstract »    Full Text »    PDF »
Viral Macrophage-Inflammatory Protein-II: A Viral Chemokine That Differentially Affects Adaptive Mucosal Immunity Compared with Its Mammalian Counterparts.
U. P. Singh, S. Singh, P. Ravichandran, D. D. Taub, and J. W. Lillard Jr. (2004)
J. Immunol. 173, 5509-5516
   Abstract »    Full Text »    PDF »
Lytic Replication-Defective Kaposi's Sarcoma-Associated Herpesvirus: Potential Role in Infection and Malignant Transformation.
J.-H. Deng, Y.-J. Zhang, X.-P. Wang, and S.-J. Gao (2004)
J. Virol. 78, 11108-11120
   Abstract »    Full Text »    PDF »
I-TAC/CXCL11 is a natural antagonist for CCR5.
V. Petkovic, C. Moghini, S. Paoletti, M. Uguccioni, and B. Gerber (2004)
J. Leukoc. Biol. 76, 701-708
   Abstract »    Full Text »    PDF »
Inhibition of Infection and Replication of Human Herpesvirus 8 in Microvascular Endothelial Cells by Alpha Interferon and Phosphonoformic Acid.
L. T. Krug, V. P. Pozharskaya, Y. Yu, N. Inoue, and M. K. Offermann (2004)
J. Virol. 78, 8359-8371
   Abstract »    Full Text »    PDF »
RBP-J (CSL) Is Essential for Activation of the K14/vGPCR Promoter of Kaposi's Sarcoma-Associated Herpesvirus by the Lytic Switch Protein RTA.
Y. Liang and D. Ganem (2004)
J. Virol. 78, 6818-6826
   Abstract »    Full Text »    PDF »
Effective inhibition of Rta expression and lytic replication of Kaposi's sarcoma-associated herpesvirus by human RNase P.
J. Zhu, P. Trang, K. Kim, T. Zhou, H. Deng, and F. Liu (2004)
PNAS 101, 9073-9078
   Abstract »    Full Text »    PDF »
Eotaxin-3/CCL26 Is a Natural Antagonist for CC Chemokine Receptors 1 and 5: A HUMAN CHEMOKINE WITH A REGULATORY ROLE.
V. Petkovic, C. Moghini, S. Paoletti, M. Uguccioni, and B. Gerber (2004)
J. Biol. Chem. 279, 23357-23363
   Abstract »    Full Text »    PDF »
KSHV induces heme oxygenase: another trick by a wily virus.
R. Yarchoan (2004)
Blood 103, 3252-3253
   Full Text »    PDF »
Epstein-Barr Virus Nuclear Antigen Leader Protein Induces Expression of Thymus- and Activation-Regulated Chemokine in B Cells.
M. Kanamori, S. Watanabe, R. Honma, M. Kuroda, S. Imai, K. Takada, N. Yamamoto, Y. Nishiyama, and Y. Kawaguchi (2004)
J. Virol. 78, 3984-3993
   Abstract »    Full Text »    PDF »
CCL16 activates an angiogenic program in vascular endothelial cells.
M. Strasly, G. Doronzo, P. Capello, D. Valdembri, M. Arese, S. Mitola, P. Moore, G. Alessandri, M. Giovarelli, and F. Bussolino (2004)
Blood 103, 40-49
   Abstract »    Full Text »    PDF »
Chromatin Remodeling of the Kaposi's Sarcoma-Associated Herpesvirus ORF50 Promoter Correlates with Reactivation from Latency.
F. Lu, J. Zhou, A. Wiedmer, K. Madden, Y. Yuan, and P. M. Lieberman (2003)
J. Virol. 77, 11425-11435
   Abstract »    Full Text »    PDF »
Lytic but not latent infection by Kaposi's sarcoma-associated herpesvirus requires host CSL protein, the mediator of Notch signaling.
Y. Liang and D. Ganem (2003)
PNAS 100, 8490-8495
   Abstract »    Full Text »    PDF »
The Virus-Encoded Chemokine vMIP-II Inhibits Virus-Induced Tc1-Driven Inflammation.
M. Lindow, A. Nansen, C. Bartholdy, A. Stryhn, N. J. V. Hansen, T. P. Boesen, T. N. C. Wells, T. W. Schwartz, and A. R. Thomsen (2003)
J. Virol. 77, 7393-7400
   Abstract »    Full Text »    PDF »
Molecular Genetics of Kaposi's Sarcoma-Associated Herpesvirus (Human Herpesvirus 8) Epidemiology and Pathogenesis.
L. A. Dourmishev, A. L. Dourmishev, D. Palmeri, R. A. Schwartz, and D. M. Lukac (2003)
Microbiol. Mol. Biol. Rev. 67, 175-212
   Abstract »    Full Text »    PDF »
Sustained Inhibition of Corneal Neovascularization by Genetic Ablation of CCR5.
B. K. Ambati, A. Anand, A. M. Joussen, W. A. Kuziel, A. P. Adamis, and J. Ambati (2003)
Invest. Ophthalmol. Vis. Sci. 44, 590-593
   Abstract »    Full Text »    PDF »
Kaposi's Sarcoma-Associated Herpesvirus Mitochondrial K7 Protein Targets a Cellular Calcium-Modulating Cyclophilin Ligand To Modulate Intracellular Calcium Concentration and Inhibit Apoptosis.
P. Feng, J. Park, B.-S. Lee, S.-H. Lee, R. J. Bram, and J. U. Jung (2002)
J. Virol. 76, 11491-11504
   Abstract »    Full Text »    PDF »
A case-control study of HIV-1-related dementia and co-infection with HHV-8.
S. Polk, A. Munoz, N. C. Sacktor, F. J. Jenkins, B. Cohen, E. N. Miller, and L. P. Jacobson (2002)
Neurology 59, 950-953
   Abstract »    Full Text »    PDF »
The lytic switch protein of KSHV activates gene expression via functional interaction with RBP-Jkappa (CSL), the target of the Notch signaling pathway.
Y. Liang, J. Chang, S. J. Lynch, D. M. Lukac, and D. Ganem (2002)
Genes & Dev. 16, 1977-1989
   Abstract »    Full Text »    PDF »
Kaposi's Sarcoma-Associated Herpesvirus-Induced Upregulation of the c-kit Proto-Oncogene, as Identified by Gene Expression Profiling, Is Essential for the Transformation of Endothelial Cells.
A. V. Moses, M. A. Jarvis, C. Raggo, Y. C. Bell, R. Ruhl, B. G. M. Luukkonen, D. J. Griffith, C. L. Wait, B. J. Druker, M. C. Heinrich, et al. (2002)
J. Virol. 76, 8383-8399
   Abstract »    Full Text »    PDF »
Exploring the Stereochemistry of CXCR4-Peptide Recognition and Inhibiting HIV-1 Entry with D-Peptides Derived from Chemokines.
N. Zhou, Z. Luo, J. Luo, X. Fan, M. Cayabyab, M. Hiraoka, D. Liu, X. Han, J. Pesavento, C.-Z. Dong, et al. (2002)
J. Biol. Chem. 277, 17476-17485
   Abstract »    Full Text »    PDF »
Enhanced Atherogenesis Is Not an Obligatory Response to Systemic Herpesvirus Infection in the ApoE-Deficient Mouse: Comparison of Murine {gamma}-Herpesvirus-68 and Herpes Simplex Virus-1.
D. G. Alber, P. Vallance, and K. L. Powell (2002)
Arterioscler Thromb Vasc Biol 22, 793-798
   Abstract »    Full Text »    PDF »
Human Herpesvirus 8 (HHV-8)-Encoded Cytokines Induce Expression of and Autocrine Signaling by Vascular Endothelial Growth Factor (VEGF) in HHV-8-Infected Primary-Effusion Lymphoma Cell Lines and Mediate VEGF-Independent Antiapoptotic Effects.
C. Liu, Y. Okruzhnov, H. Li, and J. Nicholas (2001)
J. Virol. 75, 10933-10940
   Abstract »    Full Text »    PDF »
Structural and Functional Characterization of Human CXCR4 as a Chemokine Receptor and HIV-1 Co-receptor by Mutagenesis and Molecular Modeling Studies.
N. Zhou, Z. Luo, J. Luo, D. Liu, J. W. Hall, R. J. Pomerantz, and Z. Huang (2001)
J. Biol. Chem. 276, 42826-42833
   Abstract »    Full Text »    PDF »
Murine Cytomegalovirus CC Chemokine Homolog MCK-2 (m131-129) Is a Determinant of Dissemination That Increases Inflammation at Initial Sites of Infection.
N. Saederup, S. A. Aguirre, T. E. Sparer, D. M. Bouley, and E. S. Mocarski (2001)
J. Virol. 75, 9966-9976
   Abstract »    Full Text »    PDF »
Fractalkine: A Novel Angiogenic Chemokine in Rheumatoid Arthritis.
M. V. Volin, J. M. Woods, M. A. Amin, M. A. Connors, L. A. Harlow, and A. E. Koch (2001)
Am. J. Pathol. 159, 1521-1530
   Abstract »    Full Text »
Activation of NF-{kappa}B by the Human Herpesvirus 8 Chemokine Receptor ORF74: Evidence for a Paracrine Model of Kaposi's Sarcoma Pathogenesis.
S. Pati, M. Cavrois, H.-G. Guo, J. S. Foulke Jr., J. Kim, R. A. Feldman, and M. Reitz (2001)
J. Virol. 75, 8660-8673
   Abstract »    Full Text »    PDF »
MC148 encoded by human molluscum contagiosum poxvirus is an antagonist for human but not murine CCR8.
H. R. Luttichau, J. Gerstoft, and T. W. Schwartz (2001)
J. Leukoc. Biol. 70, 277-282
   Abstract »    Full Text »    PDF »
Eotaxin (CCL11) Induces In Vivo Angiogenic Responses by Human CCR3+ Endothelial Cells.
R. Salcedo, H. A. Young, M. L. Ponce, J. M. Ward, H. K. Kleinman, W. J. Murphy, and J. J. Oppenheim (2001)
J. Immunol. 166, 7571-7578
   Abstract »    Full Text »    PDF »
Transcription Program of Human Herpesvirus 8 (Kaposi's Sarcoma-Associated Herpesvirus).
M. Paulose-Murphy, N.-K. Ha, C. Xiang, Y. Chen, L. Gillim, R. Yarchoan, P. Meltzer, M. Bittner, J. Trent, and S. Zeichner (2001)
J. Virol. 75, 4843-4853
   Abstract »    Full Text »
Hypoxia induces lytic replication of Kaposi sarcoma-associated herpesvirus.
D. A. Davis, A. S. Rinderknecht, J. P. Zoeteweij, Y. Aoki, E. L. Read-Connole, G. Tosato, A. Blauvelt, and R. Yarchoan (2001)
Blood 97, 3244-3250
   Abstract »    Full Text »    PDF »
Kaposi's Sarcoma-Associated Herpesvirus K-bZIP Protein Is Phosphorylated by Cyclin-Dependent Kinases.
A. G. Polson, L. Huang, D. M. Lukac, J. D. Blethrow, D. O. Morgan, A. L. Burlingame, and D. Ganem (2001)
J. Virol. 75, 3175-3184
   Abstract »    Full Text »
Spontaneous Activation of the Lytic Cycle in Cells Infected with a Recombinant Kaposi's Sarcoma-Associated Virus.
H.-J. Delecluse, M. Kost, R. Feederle, L. Wilson, and W. Hammerschmidt (2001)
J. Virol. 75, 2921-2928
   Abstract »    Full Text »
Latently Expressed Human Herpesvirus 8-Encoded Interferon Regulatory Factor 2 Inhibits Double-Stranded RNA-Activated Protein Kinase.
P. M. Pitha (2001)
J. Virol. 75, 2345-2352
   Abstract »    Full Text »
Kaposi's Sarcoma-Associated Herpesvirus Latent and Lytic Gene Expression as Revealed by DNA Arrays.
R. G. Jenner, M. M. Albà, C. Boshoff, and P. Kellam (2001)
J. Virol. 75, 891-902
   Abstract »    Full Text »
Induction of Host Gene Expression following Infection of Chicken Embryo Fibroblasts with Oncogenic Marek's Disease Virus.
R. W. Morgan, L. Sofer, A. S. Anderson, E. L. Bernberg, J. Cui, and J. Burnside (2001)
J. Virol. 75, 533-539
   Abstract »    Full Text »
The chemokine receptor CCR8 mediates human endothelial cell chemotaxis induced by I-309 and Kaposi sarcoma herpesvirus-encoded vMIP-I and by lipoprotein(a)-stimulated endothelial cell conditioned medium.
N. S. Haque, J. T. Fallon, M. B. Taubman, and P. C. Harpel (2001)
Blood 97, 39-45
   Abstract »    Full Text »    PDF »
I-309 binds to and activates endothelial cell functions and acts as an angiogenic molecule in vivo.
G. Bernardini, G. Spinetti, D. Ribatti, G. Camarda, L. Morbidelli, M. Ziche, A. Santoni, M. C. Capogrossi, and M. Napolitano (2000)
Blood 96, 4039-4045
   Abstract »    Full Text »    PDF »
T-Cell Function and Migration -- Two Sides of the Same Coin.
U. H. von Andrian and C. R. Mackay (2000)
N. Engl. J. Med. 343, 1020-1034
   Full Text »    PDF »
Evolutionary aspects of oncogenic herpesviruses.
J Nicholas (2000)
Mol. Pathol. 53, 222-237
   Abstract »    Full Text »
Transcriptional Regulation of the Kaposi's Sarcoma-Associated Herpesvirus Viral Interferon Regulatory Factor Gene.
J. Chen, K. Ueda, S. Sakakibara, T. Okuno, and K. Yamanishi (2000)
J. Virol. 74, 8623-8634
   Abstract »    Full Text »
Identification of a Gammaherpesvirus Selective Chemokine Binding Protein That Inhibits Chemokine Action.
V. van Berkel, J. Barrett, H. L. Tiffany, D. H. Fremont, P. M. Murphy, G. McFadden, S. H. Speck, and H. W. Virgin IV (2000)
J. Virol. 74, 6741-6747
   Abstract »    Full Text »
Activity of Thalidomide in AIDS-Related Kaposi's Sarcoma.
R. F. Little, K. M. Wyvill, J. M. Pluda, L. Welles, V. Marshall, W. D. Figg, F. M. Newcomb, G. Tosato, E. Feigal, S. M. Steinberg, et al. (2000)
J. Clin. Oncol. 18, 2593-2602
   Abstract »    Full Text »    PDF »
Antiapoptotic Herpesvirus Bcl-2 Homologs Escape Caspase-Mediated Conversion to Proapoptotic Proteins.
D. S. Bellows, B. N. Chau, P. Lee, Y. Lazebnik, W. H. Burns, and J. M. Hardwick (2000)
J. Virol. 74, 5024-5031
   Abstract »    Full Text »
Kaposi's Sarcoma-Associated Herpesvirus Open Reading Frame 57 Encodes a Posttranscriptional Regulator with Multiple Distinct Activities.
J. R. Kirshner, D. M. Lukac, J. Chang, and D. Ganem (2000)
J. Virol. 74, 3586-3597
   Abstract »    Full Text »
Identification and Analysis of the K5 Gene of Kaposi's Sarcoma-Associated Herpesvirus.
M. Haque, J. Chen, K. Ueda, Y. Mori, K. Nakano, Y. Hirata, S. Kanamori, Y. Uchiyama, R. Inagi, T. Okuno, et al. (2000)
J. Virol. 74, 2867-2875
   Abstract »    Full Text »
International Union of Pharmacology. XXII. Nomenclature for Chemokine Receptors.
P. M. Murphy, M. Baggiolini, I. F. Charo, C. A. Hebert, R. Horuk, K. Matsushima, L. H. Miller, J. J. Oppenheim, and C. A. Power (2000)
Pharmacol. Rev. 52, 145-176
   Abstract »    Full Text »    PDF »
RANTES Binding and Down-Regulation by a Novel Human Herpesvirus-6 {beta} Chemokine Receptor.
R. S. B. Milne, C. Mattick, L. Nicholson, P. Devaraj, A. Alcami, and U. A. Gompels (2000)
J. Immunol. 164, 2396-2404
   Abstract »    Full Text »    PDF »
Signaling Activities of Gammaherpesvirus Membrane Proteins.
B. Damania, J.-K. Choi, and J. U. Jung (2000)
J. Virol. 74, 1593-1601
   Full Text »
KSHV-encoded CC chemokine vMIP-III is a CCR4 agonist, stimulates angiogenesis, and selectively chemoattracts TH2 cells.
J. T. Stine, C. Wood, M. Hill, A. Epp, C. J. Raport, V. L. Schweickart, Y. Endo, T. Sasaki, G. Simmons, C. Boshoff, et al. (2000)
Blood 95, 1151-1157
   Abstract »    Full Text »    PDF »
A Broad Spectrum Secreted Chemokine Binding Protein Encoded by a Herpesvirus.
C. M. Parry, J. P. Simas, V. P. Smith, C. A. Stewart, A. C. Minson, S. Efstathiou, and A. Alcami (2000)
J. Exp. Med. 191, 573-578
   Abstract »    Full Text »    PDF »
Viral G Protein-Coupled Receptor and Kaposi's Sarcoma: A Model of Paracrine Neoplasia?.
E. Cesarman, E. A. Mesri, and M. C. Gershengorn (2000)
J. Exp. Med. 191, 417-422
   Full Text »    PDF »
Viral Cytokines.
M. Dietz (2000)
Oncologist 5, 77-80
   Full Text »
A Highly Selective Cc Chemokine Receptor (Ccr)8 Antagonist Encoded by the Poxvirus Molluscum Contagiosum.
H. R. Luttichau, J. Stine, T. P. Boesen, A. H. Johnsen, D. Chantry, J. Gerstoft, and T. W. Schwartz (2000)
J. Exp. Med. 191, 171-180
   Abstract »    Full Text »    PDF »
Chemokines, Chemokine Receptors, and Renal Disease: From Basic ScienceTo Pathophysiologic and Therapeutic Studies.
S. SEGERER, P. J. NELSON, and D. SCHLÖNDORFF (2000)
J. Am. Soc. Nephrol. 11, 152-176
   Abstract »    Full Text »
Experimental Transmission of Kaposi's Sarcoma-Associated Herpesvirus (Kshv/Hhv-8) to Scid-Hu Thy/Liv Mice.
D. Dittmer, C. Stoddart, R. Renne, V. Linquist-Stepps, M.E. Moreno, C. Bare, J.M. McCune, and D. Ganem (1999)
J. Exp. Med. 190, 1857-1868
   Abstract »    Full Text »    PDF »
Role of Vascular Endothelial Growth Factor/Vascular Permeability Factor in the Pathogenesis of Kaposi's Sarcoma-Associated Herpesvirus-Infected Primary Effusion Lymphomas.
Y. Aoki and G. Tosato (1999)
Blood 94, 4247-4254
   Abstract »    Full Text »    PDF »
Does HHV-8 have a protective role on the development of HIV encephalopathy?.
G. Rezza, M. Dorrucci, M. Andreoni, C. Arpino, A. De Luca, P. Monini, E. Nicastri, M. B. Alliegro, P. Pezzotti, and B. Ensoli (1999)
Neurology 53, 2032
   Abstract »    Full Text »    PDF »
Transcriptional Activation by the Product of Open Reading Frame 50 of Kaposi's Sarcoma-Associated Herpesvirus Is Required for Lytic Viral Reactivation in B Cells.
D. M. Lukac, J. R. Kirshner, and D. Ganem (1999)
J. Virol. 73, 9348-9361
   Abstract »    Full Text »    PDF »
Induction of B Cell Hyperplasia in Simian Immunodeficiency Virus-Infected Rhesus Macaques with the Simian Homologue of Kaposi's Sarcoma-Associated Herpesvirus.
S. W. Wong, E. P. Bergquam, R. M. Swanson, F. W. Lee, S. M. Shiigi, N. A. Avery, J. W. Fanton, and M. K. Axthelm (1999)
J. Exp. Med. 190, 827-840
   Abstract »    Full Text »    PDF »
Cytomegalovirus-encoded beta chemokine promotes monocyte-associated viremia in the host.
N. Saederup, Y. c. Lin, D. J. Dairaghi, T. J. Schall, and E. S. Mocarski (1999)
PNAS 96, 10881-10886
   Abstract »    Full Text »    PDF »
Cytomegalovirus encodes a potent alpha chemokine.
M. E. T. Penfold, D. J. Dairaghi, G. M. Duke, N. Saederup, E. S. Mocarski, G. W. Kemble, and T. J. Schall (1999)
PNAS 96, 9839-9844
   Abstract »    Full Text »    PDF »
The Murine Cytomegalovirus Chemokine Homolog, m131/129, Is a Determinant of Viral Pathogenicity.
P. Fleming, N. Davis-Poynter, M. Degli-Esposti, E. Densley, J. Papadimitriou, G. Shellam, and H. Farrell (1999)
J. Virol. 73, 6800-6809
   Abstract »    Full Text »
HHV8-encoded vMIP-I Selectively Engages Chemokine Receptor CCR8. AGONIST AND ANTAGONIST PROFILES OF VIRAL CHEMOKINES.
D. J. Dairaghi, R. A. Fan, B. E. McMaster, M. R. Hanley, and T. J. Schall (1999)
J. Biol. Chem. 274, 21569-21574
   Abstract »    Full Text »    PDF »
Identification of the Immediate-Early Transcripts of Kaposi's Sarcoma-Associated Herpesvirus.
F. X. Zhu, T. Cusano, and Y. Yuan (1999)
J. Virol. 73, 5556-5567
   Abstract »    Full Text »
Human Herpesvirus 6 Open Reading Frame U83 Encodes a Functional Chemokine.
P. Zou, Y. Isegawa, K. Nakano, M. Haque, Y. Horiguchi, and K. Yamanishi (1999)
J. Virol. 73, 5926-5933
   Abstract »    Full Text »
Expression of the Open Reading Frame 74 (G-Protein-Coupled Receptor) Gene of Kaposi's Sarcoma (KS)-Associated Herpesvirus: Implications for KS Pathogenesis.
J. R. Kirshner, K. Staskus, A. Haase, M. Lagunoff, and D. Ganem (1999)
J. Virol. 73, 6006-6014
   Abstract »    Full Text »
The Kaposi's Sarcoma-related Herpesvirus (KSHV)-encoded Chemokine vMIP-I is a Specific Agonist for the CC Chemokine Receptor (CCR)8.
M. J. Endres, C. G. Garlisi, H. Xiao, L. Shan, and J. A. Hedrick (1999)
J. Exp. Med. 189, 1993-1998
   Abstract »    Full Text »    PDF »
Angiogenesis and Hematopoiesis Induced by Kaposi's Sarcoma-Associated Herpesvirus-Encoded Interleukin-6.
Y. Aoki, E. S. Jaffe, Y. Chang, K. Jones, J. Teruya-Feldstein, P. S. Moore, and G. Tosato (1999)
Blood 93, 4034-4043
   Abstract »    Full Text »    PDF »
The Search for Unrecognized Pathogens.
D. A. Relman (1999)
Science 284, 1308-1310
   Abstract »    Full Text »
Spliced mRNA Encoding the Murine Cytomegalovirus Chemokine Homolog Predicts a beta  Chemokine of Novel Structure.
M. R. MacDonald, M. W. Burney, S. B. Resnick, and H. W. Virgin IV (1999)
J. Virol. 73, 3682-3691
   Abstract »    Full Text »
Alpha Interferon Inhibits Human Herpesvirus 8 (HHV-8) Reactivation in Primary Effusion Lymphoma Cells and Reduces HHV-8 Load in Cultured Peripheral Blood Mononuclear Cells.
P. Monini, F. Carlini, M. Stürzl, P. Rimessi, F. Superti, M. Franco, G. Melucci-Vigo, A. Cafaro, D. Goletti, C. Sgadari, et al. (1999)
J. Virol. 73, 4029-4041
   Abstract »    Full Text »
Kaposi's Sarcoma-Associated Herpesvirus Encodes a bZIP Protein with Homology to BZLF1 of Epstein-Barr Virus.
S.-F. Lin, D. R. Robinson, G. Miller, and H.-J. Kung (1999)
J. Virol. 73, 1909-1917
   Abstract »    Full Text »
Kinetics of Kaposi's Sarcoma-Associated Herpesvirus Gene Expression.
R. Sun, S.-F. Lin, K. Staskus, L. Gradoville, E. Grogan, A. Haase, and G. Miller (1999)
J. Virol. 73, 2232-2242
   Abstract »    Full Text »
The Viral Chemokine Macrophage Inflammatory Protein-II Is a Selective Th2 Chemoattractant.
S. Sozzani, W. Luini, G. Bianchi, P. Allavena, T.N.C. Wells, M. Napolitano, G. Bernardini, A. Vecchi, D. D'Ambrosio, D. Mazzeo, et al. (1998)
Blood 92, 4036-4039
   Abstract »    Full Text »    PDF »
beta -Chemokine MDC and HIV-1 Infection.
B. Lee, J. Rucker, R. W. Doms, M. Tsang, X. Hu, M. Dietz, R. Bailer, L. J. Montaner, C. Gerard, N. Sullivan, et al. (1998)
Science 281, 487a-487
   Full Text »
Human Interferon-{gamma}-inducible Protein 10 (IP-10) Inhibits Constitutive Signaling of Kaposi's Sarcoma-associated Herpesvirus G Protein-coupled Receptor.
E. Geras-Raaka, A. Varma, H. Ho, I. Clark-Lewis, and M. C. Gershengorn (1998)
J. Exp. Med. 188, 405-408
   Abstract »    Full Text »    PDF »
In Vivo Inhibition of CC and CX3C Chemokine-induced Leukocyte Infiltration and Attenuation of Glomerulonephritis in Wistar-Kyoto (WKY) Rats by vMIP-II.
S. Chen, K. B. Bacon, L. Li, G. E. Garcia, Y. Xia, D. Lo, D. A. Thompson, M. A. Siani, T. Yamamoto, J. K. Harrison, et al. (1998)
J. Exp. Med. 188, 193-198
   Abstract »    Full Text »    PDF »
Human Herpesvirus 8 as the Infectious Cause of Kaposi Sarcoma: Evidence and Involvement of Cofactors.
C. Lebbe (1998)
Arch Dermatol 134, 736-738
   Full Text »    PDF »
Broad spectrum chemokine antagonistic activity of a human poxvirus chemokine homolog.
I. Damon, P. M. Murphy, and B. Moss (1998)
PNAS 95, 6403-6407
   Abstract »    Full Text »    PDF »
Posttranslational Modifications Affect the Activity of the Human Monocyte Chemotactic Proteins MCP-1 and MCP-2: Identification of MCP-2(6-76) as a Natural Chemokine Inhibitor.
P. Proost, S. Struyf, M. Couvreur, J.-P. Lenaerts, R. Conings, P. Menten, P. Verhaert, A. Wuyts, and J. V. Damme (1998)
J. Immunol. 160, 4034-4041
   Abstract »    Full Text »    PDF »
Human Herpesvirus Type 8 and Kaposi's Sarcoma.
R. A. Weiss, D. Whitby, S. Talbot, P. Kellam, and C. Boshoff (1998)
J Natl Cancer Inst Monographs 1998, 51-54
   Abstract »    Full Text »
Kaposi's Sarcoma-Associated Herpesvirus-Encoded Oncogenes and Oncogenesis.
P. S. Moore and Y. Chang (1998)
J Natl Cancer Inst Monographs 1998, 65-71
   Abstract »    Full Text »
Comprehensive Mapping of Poxvirus vCCI Chemokine-binding Protein. EXPANDED RANGE OF LIGAND INTERACTIONS AND UNUSUAL DISSOCIATION KINETICS.
J. M. Burns, D. J. Dairaghi, M. Deitz, M. Tsang, and T. J. Schall (2002)
J. Biol. Chem. 277, 2785-2789
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)