Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 3 October 1997:
Vol. 278. no. 5335, pp. 66 - 70
DOI: 10.1126/science.278.5335.66

Articles

A Range of Research-Based Pharmacotherapies for Addiction

Charles P. O'Brien

Modern approaches to the treatment of addiction have been influenced by several important factors. These include advances in our understanding of the nature of addiction based on longitudinal studies, and progress in elucidating the biological underpinnings of addictive behavior. In addition, changes in the system for delivery of services have begun to shape the way that addiction is treated.

The author is at the University of Pennsylvania VA Medical Center, 3900 Chestnut Street, Philadelphia, PA 19104-6178, USA. E-mail: obrien{at}research.trc.upenn.edu

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Ginsenoside Rg1 restores the impairment of learning induced by chronic morphine administration in rats.
D. Qi, Y. Zhu, L. Wen, Q. Liu, and H. Qiao (2009)
J Psychopharmacol 23, 74-83
   Abstract »    PDF »
Development and initial validation of a caffeine craving questionnaire.
O. West and G. Roderique-Davies (2008)
J Psychopharmacol 22, 80-91
   Abstract »    PDF »
The Genetics of Addictions: Uncovering the Genes.
D. Goldman, G. Oroszi, and F. Ducci (2006)
Focus 4, 401
   Abstract »    Full Text »    PDF »
Role for hypocretin in mediating stress-induced reinstatement of cocaine-seeking behavior.
B. Boutrel, P. J. Kenny, S. E. Specio, R. Martin-Fardon, A. Markou, G. F. Koob, and L. de Lecea (2005)
PNAS 102, 19168-19173
   Abstract »    Full Text »    PDF »
Cocaine Self-Administration Selectively Decreases Noradrenergic Regulation of Metabotropic Glutamate Receptor-Mediated Inhibition in Dopamine Neurons.
C. A. Paladini, J. M. Mitchell, J. T. Williams, and G. P. Mark (2004)
J. Neurosci. 24, 5209-5215
   Abstract »    Full Text »    PDF »
A Single Infusion of Brain-Derived Neurotrophic Factor into the Ventral Tegmental Area Induces Long-Lasting Potentiation of Cocaine Seeking after Withdrawal.
L. Lu, J. Dempsey, S. Y. Liu, J. M. Bossert, and Y. Shaham (2004)
J. Neurosci. 24, 1604-1611
   Abstract »    Full Text »    PDF »
Bridging the Gap: A Hybrid Model to Link Efficacy and Effectiveness Research in Substance Abuse Treatment.
K. M. Carroll and B. J. Rounsaville (2003)
Psychiatr Serv 54, 333-339
   Abstract »    Full Text »    PDF »
Time-Dependent Increases in Brain-Derived Neurotrophic Factor Protein Levels within the Mesolimbic Dopamine System after Withdrawal from Cocaine: Implications for Incubation of Cocaine Craving.
J. W. Grimm, L. Lu, T. Hayashi, B. T. Hope, T.-P. Su, and Y. Shaham (2003)
J. Neurosci. 23, 742-747
   Abstract »    Full Text »    PDF »
Dopamine Release in the Dorsal Striatum during Cocaine-Seeking Behavior under the Control of a Drug-Associated Cue.
R. Ito, J. W. Dalley, T. W. Robbins, and B. J. Everitt (2002)
J. Neurosci. 22, 6247-6253
   Abstract »    Full Text »    PDF »
Neurobiology of Relapse to Heroin and Cocaine Seeking: A Review.
U. Shalev, J. W. Grimm, and Y. Shaham (2002)
Pharmacol. Rev. 54, 1-42
   Abstract »    Full Text »    PDF »
Hippocampal Long-Term Potentiation Is Reduced by Chronic Opiate Treatment and Can Be Restored by Re-Exposure to Opiates.
L. Pu, G.-B. Bao, N.-J. Xu, L. Ma, and G. Pei (2002)
J. Neurosci. 22, 1914-1921
   Abstract »    Full Text »    PDF »
Long-lasting increase in voluntary ethanol consumption and transcriptional regulation in the rat brain after intermittent exposure to alcohol.
R. RIMONDINI, C. ARLINDE, W. SOMMER, and M. HEILIG (2002)
FASEB J 16, 27-35
   Abstract »    Full Text »    PDF »
A 28-Year-Old Man Addicted to Cocaine.
S. E. Hyman (2001)
JAMA 286, 2586-2594
   Full Text »    PDF »
Targeting Behavioral Therapies to Enhance Naltrexone Treatment of Opioid Dependence: Efficacy of Contingency Management and Significant Other Involvement.
K. M. Carroll, S. A. Ball, C. Nich, P. G. O'Connor, D. A. Eagan, T. L. Frankforter, E. G. Triffleman, J. Shi, and B. J. Rounsaville (2001)
Arch Gen Psychiatry 58, 755-761
   Abstract »    Full Text »    PDF »
Full Parity: Steps Toward Treatment Equity For Mental And Addictive Disorders.
K. D. Hennessy and H. H. Goldman (2001)
Health Aff. 20, 58-67
   Abstract »    Full Text »    PDF »
Cocaine Reward and Dopamine Receptors: Love at First Site.
G. F. Koob (1999)
Arch Gen Psychiatry 56, 1107-1108
   Full Text »    PDF »
Science-Based Views of Drug Addiction and Its Treatment.
A. I. Leshner (1999)
JAMA 282, 1314-1316
   Full Text »    PDF »
Reinforcing Effects of Psychostimulants in Humans Are Associated with Increases in Brain Dopamine and Occupancy of D2 Receptors.
N. D. Volkow, G.-J. Wang, J. S. Fowler, J. Logan, S. J. Gatley, C. Wong, R. Hitzemann, and N. R. Pappas (1999)
J. Pharmacol. Exp. Ther. 291, 409-415
   Abstract »    Full Text »
Opioids, Reward and Addiction: An Encounter of Biology, Psychology, and Medicine.
J. M. van Ree, M. A. F. M. Gerrits, and L. J. M. J. Vanderschuren (1999)
Pharmacol. Rev. 51, 341-396
   Abstract »    Full Text »    PDF »
Management of Adults Recovering From Alcohol or Other Drug Problems: Relapse Prevention in Primary Care.
P. D. Friedmann, R. Saitz, and J. H. Samet (1998)
JAMA 279, 1227-1231
   Abstract »    Full Text »    PDF »



To Advertise     Find Products


Science. ISSN 0036-8075 (print), 1095-9203 (online)