Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 3 October 1997:
Vol. 278. no. 5335, pp. 138 - 141
DOI: 10.1126/science.278.5335.138
Prev | Table of Contents | Next

Reports

NF-AT Activation Induced by a CAML-Interacting Member of the Tumor Necrosis Factor Receptor Superfamily

Götz-Ulrich von Bülow, Richard J. Bram *

Activation of the nuclear factor of activated T cells transcription factor (NF-AT) is a key event underlying lymphocyte action. The CAML (calcium-modulator and cyclophilin ligand) protein is a coinducer of NF-AT activation when overexpressed in Jurkat T cells. A member of the tumor necrosis factor receptor superfamily was isolated by virtue of its affinity for CAML. Cross-linking of this lymphocyte-specific protein, designated TACI (transmembrane activator and CAML-interactor), on the surface of transfected Jurkat cells with TACI-specific antibodies led to activation of the transcription factors NF-AT, AP-1, and NFkappa B. TACI-induced activation of NF-AT was specifically blocked by a dominant-negative CAML mutant, thus implicating CAML as a signaling intermediate.

G.-U. von Bülow, Department of Experimental Oncology, St. Jude Children's Research Hospital, 332 North Lauderdale, Memphis, TN 38105, USA.
R. J. Bram, Departments of Experimental Oncology and Hematology/Oncology, St. Jude Children's Research Hospital, 332 North Lauderdale, and Department of Pediatrics, University of Tennessee, Memphis, TN 38105, USA.
*   To whom correspondence should be addressed. E-mail: richard.bram{at}stjude.org

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Effect of Calcium-Modulating Cyclophilin Ligand on Human Immunodeficiency Virus Type 1 Particle Release and Cell Surface Expression of Tetherin.
M. G. Bego, M. Dube, J. Mercier, and E. A. Cohen (2009)
J. Virol. 83, 13032-13036
   Abstract »    Full Text »    PDF »
The murine equivalent of the A181E TACI mutation associated with common variable immunodeficiency severely impairs B-cell function.
J. J. Lee, I. Rauter, L. Garibyan, E. Ozcan, T. Sannikova, S. R. Dillon, A. C. Cruz, R. M. Siegel, R. Bram, H. Jabara, et al. (2009)
Blood 114, 2254-2262
   Abstract »    Full Text »    PDF »
Functional implication of BAFF synthesis and release in gangliosides-stimulated microglia.
K. S. Kim, J.-Y. Park, I. Jou, and S. M. Park (2009)
J. Leukoc. Biol. 86, 349-359
   Abstract »    Full Text »    PDF »
CD4+CD25+ T-Cells Control Autoimmunity in the Absence of B-Cells.
E. Marino, J. Villanueva, S. Walters, D. Liuwantara, F. Mackay, and S. T. Grey (2009)
Diabetes 58, 1568-1577
   Abstract »    Full Text »    PDF »
A proliferation-inducing ligand mediates follicular lymphoma B-cell proliferation and cyclin D1 expression through phosphatidylinositol 3-kinase-regulated mammalian target of rapamycin activation.
M. Gupta, S. R. Dillon, S. C. Ziesmer, A. L. Feldman, T. E. Witzig, S. M. Ansell, J. R. Cerhan, and A. J. Novak (2009)
Blood 113, 5206-5216
   Abstract »    Full Text »    PDF »
Fc{gamma}RIIB signals inhibit BLyS signaling and BCR-mediated BLyS receptor up-regulation.
J. E. Crowley, J. E. Stadanlick, J. C. Cambier, and M. P. Cancro (2009)
Blood 113, 1464-1473
   Abstract »    Full Text »    PDF »
Increased CD4+Foxp3+ T Cells in BAFF-Transgenic Mice Suppress T Cell Effector Responses.
S. Walters, K. E. Webster, A. Sutherland, S. Gardam, J. Groom, D. Liuwantara, E. Marino, J. Thaxton, A. Weinberg, F. Mackay, et al. (2009)
J. Immunol. 182, 793-801
   Abstract »    Full Text »    PDF »
Aberrant expression of BAFF receptor, a member of the tumor necrosis factor receptor family, in malignant cells of nonhematopoietic origins.
T. Kohno, T. Daa, H. Otani, I. Shimokawa, S. Yokoyama, and T. Matsuyama (2008)
Genes Cells 13, 1061-1073
   Abstract »    Full Text »    PDF »
APRIL facilitates viral-induced erythroleukemia but is dispensable for T cell immunity and lymphomagenesis.
G. Hardenberg, L. Fernandez, J. Hendriks, K. Chebli, C. Jacquet, M. Sitbon, M. Hahne, and J. P. Medema (2008)
J. Leukoc. Biol. 84, 380-388
   Abstract »    Full Text »    PDF »
Global T Cell Dysregulation in Non-Autoimmune-Prone Mice Promotes Rapid Development of BAFF-Independent, Systemic Lupus Erythematosus-Like Autoimmunity.
W. Stohl, N. Jacob, W. J. Quinn III, M. P. Cancro, H. Gao, C. Putterman, X. Gao, L. Pricop, and M. N. Koss (2008)
J. Immunol. 181, 833-841
   Abstract »    Full Text »    PDF »
In vivo identification of novel STAT5 target genes.
B. Basham, M. Sathe, J. Grein, T. McClanahan, A. D'Andrea, E. Lees, and A. Rascle (2008)
Nucleic Acids Res. 36, 3802-3818
   Abstract »    Full Text »    PDF »
B Lymphocyte Stimulator Regulates Adaptive Immune Responses by Directly Promoting Dendritic Cell Maturation.
S. K. Chang, S. A. Mihalcik, and D. F. Jelinek (2008)
J. Immunol. 180, 7394-7403
   Abstract »    Full Text »    PDF »
Pharmacokinetics and Biological Activity of Atacicept in Patients With Rheumatoid Arthritis.
I. Nestorov, A. Munafo, O. Papasouliotis, and J. Visich (2008)
J. Clin. Pharmacol. 48, 406-417
   Abstract »    Full Text »    PDF »
BAFF enhances chemotaxis of primary human B cells: a particular synergy between BAFF and CXCL13 on memory B cells.
G. Badr, G. Borhis, E. A. Lefevre, N. Chaoul, F. Deshayes, V. Dessirier, G. Lapree, A. Tsapis, and Y. Richard (2008)
Blood 111, 2744-2754
   Abstract »    Full Text »    PDF »
In Vitro and In Vivo Activation Induces BAFF and APRIL Expression in B Cells.
V. T. Chu, P. Enghard, G. Riemekasten, and C. Berek (2007)
J. Immunol. 179, 5947-5957
   Abstract »    Full Text »    PDF »
Identification of a Novel Immunosubversion Mechanism Mediated by a Virologue of the B-Lymphocyte Receptor TACI.
J. R. Grant, A. R. Moise, and W. A. Jefferies (2007)
Clin. Vaccine Immunol. 14, 907-917
   Abstract »    Full Text »    PDF »
Divergent Effects of BAFF on Human Memory B Cell Differentiation into Ig-Secreting Cells.
J. R. Darce, B. K. Arendt, S. K. Chang, and D. F. Jelinek (2007)
J. Immunol. 178, 5612-5622
   Abstract »    Full Text »    PDF »
Role of APRIL (TNFSF13) polymorphisms in the susceptibility to systemic lupus erythematosus in Japanese.
A. Kawasaki, N. Tsuchiya, J. Ohashi, Y. Murakami, T. Fukazawa, M. Kusaoi, S. Morimoto, K. Matsuta, H. Hashimoto, Y. Takasaki, et al. (2007)
Rheumatology 46, 776-782
   Abstract »    Full Text »    PDF »
TACI regulates IgA production by APRIL in collaboration with HSPG.
D. Sakurai, H. Hase, Y. Kanno, H. Kojima, K. Okumura, and T. Kobata (2007)
Blood 109, 2961-2967
   Abstract »    Full Text »    PDF »
The growth factor fusion construct containing B-lymphocyte stimulator (BLyS) and the toxin rGel induces apoptosis specifically in BAFF-R-positive CLL cells.
R. Nimmanapalli, M.-A. Lyu, M. Du, M. J. Keating, M. G. Rosenblum, and V. Gandhi (2007)
Blood 109, 2557-2564
   Abstract »    Full Text »    PDF »
The rGel/BLyS fusion toxin specifically targets malignant B cells expressing the BLyS receptors BAFF-R, TACI, and BCMA.
M.-A. Lyu, L. H. Cheung, W. N. Hittelman, J. W. Marks, R. C.T. Aguiar, and M. G. Rosenblum (2007)
Mol. Cancer Ther. 6, 460-470
   Abstract »    Full Text »    PDF »
Hodgkin lymphoma cells express TACI and BCMA receptors and generate survival and proliferation signals in response to BAFF and APRIL.
A. Chiu, W. Xu, B. He, S. R. Dillon, J. A. Gross, E. Sievers, X. Qiao, P. Santini, E. Hyjek, J.-w. Lee, et al. (2007)
Blood 109, 729-739
   Abstract »    Full Text »    PDF »
BAFF and APRIL support chronic lymphocytic leukemia B-cell survival through activation of the canonical NF-{kappa}B pathway.
T. Endo, M. Nishio, T. Enzler, H. B. Cottam, T. Fukuda, D. F. James, M. Karin, and T. J. Kipps (2007)
Blood 109, 703-710
   Abstract »    Full Text »    PDF »
A role for BLyS in the activation of innate immune cells.
S. K. Chang, B. K. Arendt, J. R. Darce, X. Wu, and D. F. Jelinek (2006)
Blood 108, 2687-2694
   Abstract »    Full Text »    PDF »
Paucity of Clinical Disease despite Serological Autoimmunity and Kidney Pathology in Lupus-Prone New Zealand Mixed 2328 Mice Deficient in BAFF.
C. O. Jacob, L. Pricop, C. Putterman, M. N. Koss, Y. Liu, M. Kollaros, S. A. Bixler, C. M. Ambrose, M. L. Scott, and W. Stohl (2006)
J. Immunol. 177, 2671-2680
   Abstract »    Full Text »    PDF »
APRIL and BAFF Promote Increased Viability of Replicating Human B2 Cells via Mechanism Involving Cyclooxygenase 2..
P. K. A. Mongini, J. K. Inman, H. Han, R. J. Fattah, S. B. Abramson, and M. Attur (2006)
J. Immunol. 176, 6736-6751
   Abstract »    Full Text »    PDF »
Selective activation of TACI by syndecan-2.
D. Bischof, S. F. Elsawa, G. Mantchev, J. Yoon, G. E. Michels, A. Nilson, S. L. Sutor, J. L. Platt, S. M. Ansell, G. von Bulow, et al. (2006)
Blood 107, 3235-3242
   Abstract »    Full Text »    PDF »
B-lymphocyte stimulator (BLyS) stimulates immunoglobulin production and malignant B-cell growth in Waldenstrom macroglobulinemia.
S. F. Elsawa, A. J. Novak, D. M. Grote, S. C. Ziesmer, T. E. Witzig, R. A. Kyle, S. R. Dillon, B. Harder, J. A. Gross, and S. M. Ansell (2006)
Blood 107, 2882-2888
   Abstract »    Full Text »    PDF »
Elevated blood pressure and cardiac hypertrophy after ablation of the gly96/IEX-1 gene.
S. L. Sommer, T. J. Berndt, E. Frank, J. B. Patel, M. M. Redfield, X. Dong, M. D. Griffin, J. P. Grande, J. M. A. van Deursen, G. C. Sieck, et al. (2006)
J Appl Physiol 100, 707-716
   Abstract »    Full Text »    PDF »
TACI-BLyS signaling via B-cell-dendritic cell cooperation is required for naive CD8+ T-cell priming in vivo.
Y. Diaz-de-Durana, G. T. Mantchev, R. J. Bram, and A. Franco (2006)
Blood 107, 594-601
   Abstract »    Full Text »    PDF »
A Role for B Cell-Activating Factor of the TNF Family in Chemically Induced Autoimmunity.
Y. Zheng, S. Gallucci, J. P. Gaughan, J. A. Gross, and M. Monestier (2005)
J. Immunol. 175, 6163-6168
   Abstract »    Full Text »    PDF »
Identification of Calcium-modulating Cyclophilin Ligand (CAML) as Transducer of Angiotensin II-mediated Nuclear Factor of Activated T Cells (NFAT) Activation.
S. Guo, M. Lopez-Ilasaca, and V. J. Dzau (2005)
J. Biol. Chem. 280, 12536-12541
   Abstract »    Full Text »    PDF »
Structures of APRIL-Receptor Complexes: LIKE BCMA, TACI EMPLOYS ONLY A SINGLE CYSTEINE-RICH DOMAIN FOR HIGH AFFINITY LIGAND BINDING.
S. G. Hymowitz, D. R. Patel, H. J. A. Wallweber, S. Runyon, M. Yan, J. Yin, S. K. Shriver, N. C. Gordon, B. Pan, N. J. Skelton, et al. (2005)
J. Biol. Chem. 280, 7218-7227
   Abstract »    Full Text »    PDF »
Homeostatic cell-cycle control by BLyS: Induction of cell-cycle entry but not G1/S transition in opposition to p18INK4c and p27Kip1.
X. Huang, M. Di Liberto, A. F. Cunningham, L. Kang, S. Cheng, S. Ely, H.-c. Liou, I. C. M. MacLennan, and S. Chen-Kiang (2004)
PNAS 101, 17789-17794
   Abstract »    Full Text »    PDF »
Expression of BLyS and its receptors in B-cell non-Hodgkin lymphoma: correlation with disease activity and patient outcome.
A. J. Novak, D. M. Grote, M. Stenson, S. C. Ziesmer, T. E. Witzig, T. M. Habermann, B. Harder, K. M. Ristow, R. J. Bram, D. F. Jelinek, et al. (2004)
Blood 104, 2247-2253
   Abstract »    Full Text »    PDF »
B Cell-Activating Factor Belonging to the TNF Family Acts through Separate Receptors to Support B Cell Survival and T Cell-Independent Antibody Formation.
S. Shulga-Morskaya, M. Dobles, M. E. Walsh, L. G. Ng, F. MacKay, S. P. Rao, S. L. Kalled, and M. L. Scott (2004)
J. Immunol. 173, 2331-2341
   Abstract »    Full Text »    PDF »
B Cell-Activating Factor Belonging to the TNF Family (BAFF)-R Is the Principal BAFF Receptor Facilitating BAFF Costimulation of Circulating T and B Cells.
L. G. Ng, A. P. R. Sutherland, R. Newton, F. Qian, T. G. Cachero, M. L. Scott, J. S. Thompson, J. Wheway, T. Chtanova, J. Groom, et al. (2004)
J. Immunol. 173, 807-817
   Abstract »    Full Text »    PDF »
A therapeutic role for BLyS antagonists.
W Stohl (2004)
Lupus 13, 317-322
   Abstract »    PDF »
BAFF and APRIL protect myeloma cells from apoptosis induced by interleukin 6 deprivation and dexamethasone.
J. Moreaux, E. Legouffe, E. Jourdan, P. Quittet, T. Reme, C. Lugagne, P. Moine, J.-F. Rossi, B. Klein, and K. Tarte (2004)
Blood 103, 3148-3157
   Abstract »    Full Text »    PDF »
The Calcineurin/Nuclear Factor of Activated T Cells Signaling Pathway Regulates Osteoclastogenesis in RAW264.7 Cells.
H. Hirotani, N. A. Tuohy, J.-T. Woo, P. H. Stern, and N. A. Clipstone (2004)
J. Biol. Chem. 279, 13984-13992
   Abstract »    Full Text »    PDF »
Impaired IgA class switching in APRIL-deficient mice.
E. Castigli, S. Scott, F. Dedeoglu, P. Bryce, H. Jabara, A. K. Bhan, E. Mizoguchi, and R. S. Geha (2004)
PNAS 101, 3903-3908
   Abstract »    Full Text »    PDF »
BAFF production by antigen-presenting cells provides T cell co-stimulation.
B. Huard, L. Arlettaz, C. Ambrose, V. Kindler, D. Mauri, E. Roosnek, J. Tschopp, P. Schneider, and L. E. French (2004)
Int. Immunol. 16, 467-475
   Abstract »    Full Text »    PDF »
APRIL-Deficient Mice Have Normal Immune System Development.
E. Varfolomeev, F. Kischkel, F. Martin, D. Seshasayee, H. Wang, D. Lawrence, C. Olsson, L. Tom, S. Erickson, D. French, et al. (2004)
Mol. Cell. Biol. 24, 997-1006
   Abstract »    Full Text »    PDF »
Involvement of BAFF and APRIL in the resistance to apoptosis of B-CLL through an autocrine pathway.
C. Kern, J.-F. Cornuel, C. Billard, R. Tang, D. Rouillard, V. Stenou, T. Defrance, F. Ajchenbaum-Cymbalista, P.-Y. Simonin, S. Feldblum, et al. (2004)
Blood 103, 679-688
   Abstract »    Full Text »    PDF »
Chicken BAFF--a highly conserved cytokine that mediates B cell survival.
K. Schneider, S. Kothlow, P. Schneider, A. Tardivel, T. Gobel, B. Kaspers, and P. Staeheli (2004)
Int. Immunol. 16, 139-148
   Abstract »    Full Text »    PDF »
{Delta}BAFF, an Alternate Splice Isoform That Regulates Receptor Binding and Biopresentation of the B Cell Survival Cytokine, BAFF.
A. L Gavin, D. Ait-Azzouzene, C. F. Ware, and D. Nemazee (2003)
J. Biol. Chem. 278, 38220-38228
   Abstract »    Full Text »    PDF »
Comparison of Soluble Decoy IgG Fusion Proteins of BAFF-R and BCMA as Antagonists for BAFF.
M. Pelletier, J. S. Thompson, F. Qian, S. A. Bixler, D. Gong, T. Cachero, K. Gilbride, E. Day, M. Zafari, C. Benjamin, et al. (2003)
J. Biol. Chem. 278, 33127-33133
   Abstract »    Full Text »    PDF »
Cell-specific expression of B lymphocyte (APRIL, BLyS)- and Th2 (CD30L/CD153)-promoting tumor necrosis factor superfamily ligands in human placentas.
T. A. Phillips, J. Ni, and J. S. Hunt (2003)
J. Leukoc. Biol. 74, 81-87
   Abstract »    Full Text »    PDF »
Macrophage- and dendritic cell--dependent regulation of human B-cell proliferation requires the TNF family ligand BAFF.
A. Craxton, D. Magaletti, E. J. Ryan, and E. A. Clark (2003)
Blood 101, 4464-4471
   Abstract »    Full Text »    PDF »
A Conserved Calcineurin-binding Motif in Human T Lymphotropic Virus Type 1 p12I Functions to Modulate Nuclear Factor of Activated T Cell Activation.
S.-j. Kim, W. Ding, B. Albrecht, P. L. Green, and M. D. Lairmore (2003)
J. Biol. Chem. 278, 15550-15557
   Abstract »    Full Text »    PDF »
TNFR-Associated Factor-3 Is Associated With BAFF-R and Negatively Regulates BAFF-R-Mediated NF-{kappa}B Activation and IL-10 Production.
L.-G. Xu and H.-B. Shu (2002)
J. Immunol. 169, 6883-6889
   Abstract »    Full Text »    PDF »
Kaposi's Sarcoma-Associated Herpesvirus Mitochondrial K7 Protein Targets a Cellular Calcium-Modulating Cyclophilin Ligand To Modulate Intracellular Calcium Concentration and Inhibit Apoptosis.
P. Feng, J. Park, B.-S. Lee, S.-H. Lee, R. J. Bram, and J. U. Jung (2002)
J. Virol. 76, 11491-11504
   Abstract »    Full Text »    PDF »
Aberrant expression of B-lymphocyte stimulator by B chronic lymphocytic leukemia cells: a mechanism for survival.
A. J. Novak, R. J. Bram, N. E. Kay, and D. F. Jelinek (2002)
Blood 100, 2973-2979
   Abstract »    Full Text »    PDF »
Identification of downstream genes up-regulated by the tumor necrosis factor family member TALL-1.
L.-G. Xu, M. Wu, J. Hu, Z. Zhai, and H.-B. Shu (2002)
J. Leukoc. Biol. 72, 410-416
   Abstract »    Full Text »    PDF »
T Cell Costimulation by the TNF Ligand BAFF.
B. Huard, P. Schneider, D. Mauri, J. Tschopp, and L. E. French (2001)
J. Immunol. 167, 6225-6231
   Abstract »    Full Text »    PDF »
Negative Regulation of the NFAT1 Factor by CD45: Implication in HIV-1 Long Terminal Repeat Activation.
B. Barbeau, G. A. Robichaud, J.-F. Fortin, and M. J. Tremblay (2001)
J. Immunol. 167, 2700-2713
   Abstract »    Full Text »    PDF »
B-Cell Maturation Protein, Which Binds the Tumor Necrosis Factor Family Members BAFF and APRIL, Is Dispensable for Humoral Immune Responses.
S. Xu and K.-P. Lam (2001)
Mol. Cell. Biol. 21, 4067-4074
   Abstract »    Full Text »    PDF »
RELT, a new member of the tumor necrosis factor receptor superfamily, is selectively expressed in hematopoietic tissues and activates transcription factor NF-{kappa}B.
G. L. Sica, G. Zhu, K. Tamada, D. Liu, J. Ni, and L. Chen (2001)
Blood 97, 2702-2707
   Abstract »    Full Text »    PDF »
April and Baff Connect Autoimmunity and Cancer.
C. F. Ware (2000)
J. Exp. Med. 192, F35-F38
   Full Text »    PDF »
A Soluble Form of B Cell Maturation Antigen, a Receptor for the Tumor Necrosis Factor Family Member April, Inhibits Tumor Cell Growth.
P. Rennert, P. Schneider, T. G. Cachero, J. Thompson, L. Trabach, S. Hertig, N. Holler, F. Qian, C. Mullen, K. Strauch, et al. (2000)
J. Exp. Med. 192, 1677-1684
   Abstract »    Full Text »    PDF »
Baff Mediates Survival of Peripheral Immature B Lymphocytes.
M. Batten, J. Groom, T. G. Cachero, F. Qian, P. Schneider, J. Tschopp, J. L. Browning, and F. Mackay (2000)
J. Exp. Med. 192, 1453-1466
   Abstract »    Full Text »    PDF »
Attenuation of Apoptosis Underlies B Lymphocyte Stimulator Enhancement of Humoral Immune Response.
R. K.G. Do, E. Hatada, H. Lee, M. R. Tourigny, D. Hilbert, and S. Chen-Kiang (2000)
J. Exp. Med. 192, 953-964
   Abstract »    Full Text »    PDF »
Taci Is a Traf-Interacting Receptor for Tall-1, a Tumor Necrosis Factor Family Member Involved in B Cell Regulation.
X.-Z. Xia, J. Treanor, G. Senaldi, S. D. Khare, T. Boone, M. Kelley, L. E. Theill, A. Colombero, I. Solovyev, F. Lee, et al. (2000)
J. Exp. Med. 192, 137-144
   Abstract »    Full Text »    PDF »
A Monoclonal Antibody Reactive with a 40-kDa Molecule on Fetal Thymocytes and Tumor Cells Blocks Proliferation and Stimulates Aggregation and Apoptosis.
D. M. Fernandes, A. M. Baird, L. J. Berg, and K. L. Rock (1999)
J. Immunol. 163, 1306-1314
   Abstract »    Full Text »    PDF »
Herpesvirus Entry Mediator Ligand (HVEM-L), a Novel Ligand for HVEM/TR2, Stimulates Proliferation of T Cells and Inhibits HT29 Cell Growth.
J. A. Harrop, P. C. McDonnell, M. Brigham-Burke, S. D. Lyn, J. Minton, K. B. Tan, K. Dede, J. Spampanato, C. Silverman, P. Hensley, et al. (1998)
J. Biol. Chem. 273, 27548-27556
   Abstract »    Full Text »    PDF »
Co-localization of Calcium-modulating Cyclophilin Ligand with Intracellular Calcium Pools.
M. P. Holloway and R. J. Bram (1998)
J. Biol. Chem. 273, 16346-16350
   Abstract »    Full Text »    PDF »
The Tpl-2 protooncoprotein activates the nuclear factor of activated T cells and induces interleukin 2 expression in T cell lines.
C. Tsatsanis, C. Patriotis, S. E. Bear, and P. N. Tsichlis (1998)
PNAS 95, 3827-3832
   Abstract »    Full Text »    PDF »
An Essential Role for BAFF in the Normal Development of B Cells Through a BCMA-Independent Pathway.
B. Schiemann, J. L. Gommerman, K. Vora, T. G. Cachero, S. Shulga-Morskaya, M. Dobles, E. Frew, and M. L. Scott (2001)
Science 293, 2111-2114
   Abstract »    Full Text »    PDF »
BAFF-R, a Newly Identified TNF Receptor That Specifically Interacts with BAFF.
J. S. Thompson, S. A. Bixler, F. Qian, K. Vora, M. L. Scott, T. G. Cachero, C. Hession, P. Schneider, I. D. Sizing, C. Mullen, et al. (2001)
Science 293, 2108-2111
   Abstract »    Full Text »    PDF »
Tumor Necrosis Factor (TNF) Receptor Superfamily Member TACI Is a High Affinity Receptor for TNF Family Members APRIL and BLyS.
Y. Wu, D. Bressette, J. A. Carrell, T. Kaufman, P. Feng, K. Taylor, Y. Gan, Y. H. Cho, A. D. Garcia, E. Gollatz, et al. (2000)
J. Biol. Chem. 275, 35478-35485
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)