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Science 3 October 1997:
Vol. 278. no. 5335, pp. 117 - 120
DOI: 10.1126/science.278.5335.117
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Reports

Immunotherapy of Tumors with Autologous Tumor-Derived Heat Shock Protein Preparations

Yasuaki Tamura, * Ping Peng, * Kang Liu, Maria Daou, Pramod K. Srivastava dagger

Immunotherapy of mice with preexisting cancers with heat shock protein preparations derived from autologous cancer resulted in retarded progression of the primary cancer, a reduced metastatic load, and prolongation of life-span. Treatment with heat shock protein preparations derived from cancers other than the autologous cancer did not provide significant protection. Spontaneous cancers (lung cancer and melanoma), chemically induced cancers (fibrosarcoma and colon carcinoma), and an ultraviolet radiation-induced spindle cell carcinoma were tested, and the results support the efficacy of autologous cancer-derived heat shock protein-peptide complexes in immunotherapy of cancers without the need to identify specific tumor antigenic epitopes.

Center for Immunotherapy of Cancer and Infectious Diseases, MC1601, University of Connecticut School of Medicine, Farmington, CT 06030, USA.
*   These authors contributed equally to this work.

dagger    To whom correspondence should be addressed.

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W.-F. Cheng, C.-F. Hung, C.-Y. Chai, K.-F. Hsu, L. He, C. M. Rice, M. Ling, and T.-C. Wu (2001)
J. Immunol. 166, 6218-6226
   Abstract »    Full Text »    PDF »
Human Heat Shock Protein 70 Peptide Complexes Specifically Activate Antimelanoma T Cells.
C. Castelli, A.-M. T. Ciupitu, F. Rini, L. Rivoltini, A. Mazzocchi, R. Kiessling, and G. Parmiani (2001)
Cancer Res. 61, 222-227
   Abstract »    Full Text »
Characterization of Heat Shock Protein 110 and Glucose-Regulated Protein 170 as Cancer Vaccines and the Effect of Fever-Range Hyperthermia on Vaccine Activity.
X.-Y. Wang, L. Kazim, E. A. Repasky, and J. R. Subjeck (2001)
J. Immunol. 166, 490-497
   Abstract »    Full Text »    PDF »
Cutting Edge: Heat Shock Protein gp96 Induces Maturation and Migration of CD11c+ Cells In Vivo.
R. J. Binder, K. M. Anderson, S. Basu, and P. K. Srivastava (2000)
J. Immunol. 165, 6029-6035
   Abstract »    Full Text »    PDF »
Role of the Heat Shock Response and Molecular Chaperones in Oncogenesis and Cell Death.
C. Jolly and R. I. Morimoto (2000)
J Natl Cancer Inst 92, 1564-1572
   Abstract »    Full Text »    PDF »
Tumor Prevention and Antitumor Immunity with Heat Shock Protein 70 Induced by 15-Deoxy-{{Delta}}12,14-prostaglandin J2 in Transgenic Adenocarcinoma of Mouse Prostate Cells.
D. K. Vanaja, M. E. Grossmann, E. Celis, and C. Y. F. Young (2000)
Cancer Res. 60, 4714-4718
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Saturation, Competition, and Specificity in Interaction of Heat Shock Proteins (hsp) gp96, hsp90, and hsp70 with CD11b+ Cells.
R. J. Binder, M. L. Harris, A. Menoret, and P. K. Srivastava (2000)
J. Immunol. 165, 2582-2587
   Abstract »    Full Text »    PDF »
One-Step Single-Chain Fv Recombinant Antibody-based Purification of gp96 for Vaccine Development.
D. Arnold-Schild, C. Kleist, M. Welschof, G. Opelz, H.-G. Rammensee, H. Schild, and P. Terness (2000)
Cancer Res. 60, 4175-4178
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Cationic Lipid:Bacterial DNA Complexes Elicit Adaptive Cellular Immunity in Murine Intraperitoneal Tumor Models.
M. Lanuti, S. Rudginsky, S. D. Force, E. S. Lambright, W. M. Siders, M. Y. Chang, K. M. Amin, L. R. Kaiser, R. K. Scheule, and S. M. Albelda (2000)
Cancer Res. 60, 2955-2963
   Abstract »    Full Text »    PDF »
Reduced amount of the glucose-regulated protein GRP94 in skeletal myoblasts results in loss of fusion competence.
L. GORZA and M. VITADELLO (2000)
FASEB J 14, 461-475
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Fusogenic Membrane Glycoproteins As a Novel Class of Genes for the Local and Immune-mediated Control of Tumor Growth.
A. Bateman, F. Bullough, S. Murphy, L. Emiliusen, D. Lavillette, F.-L. Cosset, R. Cattaneo, S. J. Russell, and R. G. Vile (2000)
Cancer Res. 60, 1492-1497
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Immunoprotective Activities of Multiple Chaperone Proteins Isolated from Murine B-Cell Leukemia/Lymphoma.
M. Graner, A. Raymond, D. Romney, L. He, L. Whitesell, and E. Katsanis (2000)
Clin. Cancer Res. 6, 909-915
   Abstract »    Full Text »
Identification of the Peptide-binding Site in the Heat Shock Chaperone/Tumor Rejection Antigen gp96 (Grp94).
N. A. Linderoth, A. Popowicz, and S. Sastry (2000)
J. Biol. Chem. 275, 5472-5477
   Abstract »    Full Text »    PDF »
Induction of Tumor Immunity and Cytotoxic T Lymphocyte Responses Using Dendritic Cells Transfected with Messenger RNA Amplified from Tumor Cells.
D. Boczkowski, S. K. Nair, J.-H. Nam, H. K. Lyerly, and E. Gilboa (2000)
Cancer Res. 60, 1028-1034
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Enhancement of DNA Vaccine Potency by Linkage of Antigen Gene to an HSP70 Gene.
C.-H. Chen, T.-L. Wang, C.-F. Hung, Y. Yang, R. A. Young, D. M. Pardoll, and T-C. Wu (2000)
Cancer Res. 60, 1035-1042
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Induction of CTL Responses by Simultaneous Administration of Liposomal Peptide Vaccine with Anti-CD40 and Anti-CTLA-4 mAb.
D. Ito, K. Ogasawara, K. Iwabuchi, Y. Inuyama, and K. Onoe (2000)
J. Immunol. 164, 1230-1235
   Abstract »    Full Text »    PDF »
In Vivo Cytotoxic T Lymphocyte Elicitation by Mycobacterial Heat Shock Protein 70 Fusion Proteins Maps to a Discrete Domain and Is Cd4+ T Cell Independent.
Q. Huang, J. F.L. Richmond, K. Suzue, H. N. Eisen, and R. A. Young (2000)
J. Exp. Med. 191, 403-408
   Abstract »    Full Text »    PDF »
Flt3-Ligand Administration after Radiation Therapy Prolongs Survival in a Murine Model of Metastatic Lung Cancer.
P. K. Chakravarty, A. Alfieri, E. K. Thomas, V. Beri, K. E. Tanaka, B. Vikram, and C. Guha (1999)
Cancer Res. 59, 6028-6032
   Abstract »    Full Text »    PDF »
Cutting Edge: Tumor Secreted Heat Shock-Fusion Protein Elicits CD8 Cells for Rejection.
K. Yamazaki, T. Nguyen, and E. R. Podack (1999)
J. Immunol. 163, 5178-5182
   Abstract »    Full Text »    PDF »
Hyperthermia enhances cytomegalovirus regulation of HIV-1 and TNF-alpha gene expression.
G. K. Iwamoto, A. M. Ainsworth, and P. L. Moseley (1999)
Am J Physiol Lung Cell Mol Physiol 277, L1051-L1056
   Abstract »    Full Text »    PDF »
Cell Surface Expression of the Endoplasmic Reticular Heat Shock Protein gp96 Is Phylogenetically Conserved.
J. Robert, A. Menoret, and N. Cohen (1999)
J. Immunol. 163, 4133-4139
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Heat Shock Protein 70 Induced During Tumor Cell Killing Induces Th1 Cytokines and Targets Immature Dendritic Cell Precursors to Enhance Antigen Uptake.
S. Todryk, A. A. Melcher, N. Hardwick, E. Linardakis, A. Bateman, M. P. Colombo, A. Stoppacciaro, and R. G. Vile (1999)
J. Immunol. 163, 1398-1408
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Calreticulin Displays In Vivo Peptide-Binding Activity and Can Elicit CTL Responses Against Bound Peptides.
S. Nair, P. A. Wearsch, D. A. Mitchell, J. J. Wassenberg, E. Gilboa, and C. V. Nicchitta (1999)
J. Immunol. 162, 6426-6432
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The Dual Nature of Specific Immunological Activity of Tumor-derived gp96 Preparations.
R. Y. Chandawarkar, M. S. Wagh, and P. K. Srivastava (1999)
J. Exp. Med. 189, 1437-1442
   Abstract »    Full Text »    PDF »


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