Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 26 September 1997:
Vol. 277. no. 5334, pp. 2002 - 2004
DOI: 10.1126/science.277.5334.2002
Prev | Table of Contents | Next

Reports

Requirement for Macrophage Elastase for Cigarette Smoke-Induced Emphysema in Mice

R. Dean Hautamaki, Dale K. Kobayashi, Robert M. Senior, Steven D. Shapiro *

To determine which proteinases are responsible for the lung destruction characteristic of pulmonary emphysema, macrophage elastase-deficient (MME-/-) mice were subjected to cigarette smoke. In contrast to wild-type mice, MME-/- mice did not have increased numbers of macrophages in their lungs and did not develop emphysema in response to long-term exposure to cigarette smoke. Smoke-exposed MME-/- mice that received monthly intratracheal instillations of monocyte chemoattractant protein-1 showed accumulation of alveolar macrophages but did not develop air space enlargement. Thus, macrophage elastase is probably sufficient for the development of emphysema that results from chronic inhalation of cigarette smoke.

Departments of Internal Medicine, and Cell Biology and Physiology, Washington University School of Medicine at Barnes-Jewish Hospital, St. Louis, MO 63110, USA.
*   To whom correspondence should be addressed. E-mail: sshapiro{at}imgate.wustl.edu

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Pneumocystis murina Infection and Cigarette Smoke Exposure Interact To Cause Increased Organism Burden, Development of Airspace Enlargement, and Pulmonary Inflammation in Mice.
P. J. Christensen, A. M. Preston, T. Ling, M. Du, W. B. Fields, J. L. Curtis, and J. M. Beck (2008)
Infect. Immun. 76, 3481-3490
   Abstract »    Full Text »    PDF »
Disruption of p21 Attenuates Lung Inflammation Induced by Cigarette Smoke, LPS, and fMLP in Mice.
H. Yao, S.-R. Yang, I. Edirisinghe, S. Rajendrasozhan, S. Caito, D. Adenuga, M. A. O'Reilly, and I. Rahman (2008)
Am. J. Respir. Cell Mol. Biol. 39, 7-18
   Abstract »    Full Text »    PDF »
Cigarette Smoke Triggers Code Red: p21CIP1/WAF1/SDI1 Switches on Danger Responses in the Lung.
R. M. Tuder, J. H. Yun, and B. B. Graham (2008)
Am. J. Respir. Cell Mol. Biol. 39, 1-6
   Abstract »    Full Text »    PDF »
Metalloelastase in lungs and alveolar macrophages is modulated by extracellular substance P in mice.
J. Xu, F. Xu, and E. Barrett (2008)
Am J Physiol Lung Cell Mol Physiol 295, L162-L170
   Abstract »    Full Text »    PDF »
Multifaceted mechanisms in COPD: inflammation, immunity, and tissue repair and destruction.
K. F. Chung and I. M. Adcock (2008)
Eur. Respir. J. 31, 1334-1356
   Abstract »    Full Text »    PDF »
Alveolar macrophage activation and an emphysema-like phenotype in adiponectin-deficient mice.
R. Summer, F. F. Little, N. Ouchi, Y. Takemura, T. Aprahamian, D. Dwyer, K. Fitzsimmons, B. Suki, H. Parameswaran, A. Fine, et al. (2008)
Am J Physiol Lung Cell Mol Physiol 294, L1035-L1042
   Abstract »    Full Text »    PDF »
MMP-12 induces IL-8/CXCL8 secretion through EGFR and ERK1/2 activation in epithelial cells.
C. L. Quement, I. Guenon, J.-Y. Gillon, V. Lagente, and E. Boichot (2008)
Am J Physiol Lung Cell Mol Physiol 294, L1076-L1084
   Abstract »    Full Text »    PDF »
Transgenic expression of matrix metalloproteinase-9 causes adult-onset emphysema in mice associated with the loss of alveolar elastin.
R. Foronjy, T. Nkyimbeng, A. Wallace, J. Thankachen, Y. Okada, V. Lemaitre, and J. D'Armiento (2008)
Am J Physiol Lung Cell Mol Physiol 294, L1149-L1157
   Abstract »    Full Text »    PDF »
Cigarette Smoke Exposure Impairs Dendritic Cell Maturation and T Cell Proliferation in Thoracic Lymph Nodes of Mice.
C. S. Robbins, F. Franco, M. Mouded, M. Cernadas, and S. D. Shapiro (2008)
J. Immunol. 180, 6623-6628
   Abstract »    Full Text »    PDF »
Pathogenesis of Emphysema: From the Bench to the Bedside.
A. Sharafkhaneh, N. A. Hanania, and V. Kim (2008)
Proceedings of the ATS 5, 475-477
   Abstract »    Full Text »    PDF »
Thioredoxin-1 Ameliorates Cigarette Smoke-Induced Lung Inflammation and Emphysema in Mice.
A. Sato, Y. Hoshino, T. Hara, S. Muro, H. Nakamura, M. Mishima, and J. Yodoi (2008)
J. Pharmacol. Exp. Ther. 325, 380-388
   Abstract »    Full Text »    PDF »
A Novel Proteolytic Cascade Generates an Extracellular Matrix-Derived Chemoattractant in Chronic Neutrophilic Inflammation.
A. Gaggar, P. L. Jackson, B. D. Noerager, P. J. O'Reilly, D. B. McQuaid, S. M. Rowe, J. P. Clancy, and J. E. Blalock (2008)
J. Immunol. 180, 5662-5669
   Abstract »    Full Text »    PDF »
Development of Chronic Bronchitis and Emphysema in {beta}-Epithelial Na+ Channel-Overexpressing Mice.
M. A. Mall, J. R. Harkema, J. B. Trojanek, D. Treis, A. Livraghi, S. Schubert, Z. Zhou, S. M. Kreda, S. L. Tilley, E. J. Hudson, et al. (2008)
Am. J. Respir. Crit. Care Med. 177, 730-742
   Abstract »    Full Text »    PDF »
Mechanisms of cigarette smoke-induced COPD: insights from animal models.
A. Churg, M. Cosio, and J. L. Wright (2008)
Am J Physiol Lung Cell Mol Physiol 294, L612-L631
   Abstract »    Full Text »    PDF »
Early changes of lung function and structure in an elastase model of emphysema--a hyperpolarized 3He MRI study.
K. Emami, R. V. Cadman, J. M. Woodburn, M. C. Fischer, S. J. Kadlecek, J. Zhu, S. Pickup, R. A. Guyer, M. Law, V. Vahdat, et al. (2008)
J Appl Physiol 104, 773-786
   Abstract »    Full Text »    PDF »
p38{alpha}-Selective Mitogen-Activated Protein Kinase Inhibitor SD-282 Reduces Inflammation in a Subchronic Model of Tobacco Smoke-Induced Airway Inflammation.
S. Medicherla, M. F. Fitzgerald, D. Spicer, P. Woodman, J. Y. Ma, A. M. Kapoun, S. Chakravarty, S. Dugar, A. A. Protter, and L. S. Higgins (2008)
J. Pharmacol. Exp. Ther. 324, 921-929
   Abstract »    Full Text »    PDF »
Cigarette Smoke Exposure Attenuates Cytokine Production by Mouse Alveolar Macrophages.
G. J. Gaschler, C. C. J. Zavitz, C. M. T. Bauer, M. Skrtic, M. Lindahl, C. S. Robbins, B. Chen, and M. R. Stampfli (2008)
Am. J. Respir. Cell Mol. Biol. 38, 218-226
   Abstract »    Full Text »    PDF »
Phosphodiesterase 4 inhibitor GPD-1116 markedly attenuates the development of cigarette smoke-induced emphysema in senescence-accelerated mice P1 strain.
H. Mori, T. Nose, K. Ishitani, S. Kasagi, S. Souma, T. Akiyoshi, Y. Kodama, T. Mori, M. Kondo, S. Sasaki, et al. (2008)
Am J Physiol Lung Cell Mol Physiol 294, L196-L204
   Abstract »    Full Text »    PDF »
Arterial Stiffness Is Independently Associated with Emphysema Severity in Patients with Chronic Obstructive Pulmonary Disease.
D. A. McAllister, J. D. Maclay, N. L. Mills, G. Mair, J. Miller, D. Anderson, D. E. Newby, J. T. Murchison, and W. MacNee (2007)
Am. J. Respir. Crit. Care Med. 176, 1208-1214
   Abstract »    Full Text »    PDF »
The Interaction of Host and Pathogen Factors in Chronic Obstructive Pulmonary Disease Exacerbations and Their Role in Tissue Damage.
H. Abusriwil and R. A. Stockley (2007)
Proceedings of the ATS 4, 611-617
   Abstract »    Full Text »    PDF »
Chemokine and cytokine processing by matrix metalloproteinases and its effect on leukocyte migration and inflammation.
P. Van Lint and C. Libert (2007)
J. Leukoc. Biol. 82, 1375-1381
   Abstract »    Full Text »    PDF »
Matrix Metalloproteinase-2 Protein in Lung Periphery Is Related to COPD Progression.
S. Baraldo, E. Bazzan, M. E. Zanin, G. Turato, S. Garbisa, P. Maestrelli, A. Papi, M. Miniati, L. M. Fabbri, R. Zuin, et al. (2007)
Chest 132, 1733-1740
   Abstract »    Full Text »    PDF »
Secretory Leucocyte Protease Inhibitor Inhibits Interferon-{gamma}-induced Cathepsin S Expression.
P. Geraghty, C. M. Greene, M. O'Mahony, S. J. O'Neill, C. C. Taggart, and N. G. McElvaney (2007)
J. Biol. Chem. 282, 33389-33395
   Abstract »    Full Text »    PDF »
Comprehensive gene expression profiling of rat lung reveals distinct acute and chronic responses to cigarette smoke inhalation.
C. S. Stevenson, C. Docx, R. Webster, C. Battram, D. Hynx, J. Giddings, P. R. Cooper, P. Chakravarty, I. Rahman, J. A. Marwick, et al. (2007)
Am J Physiol Lung Cell Mol Physiol 293, L1183-L1193
   Abstract »    Full Text »    PDF »
The Immunopathogenesis of Chronic Obstructive Pulmonary Disease: Insights from Recent Research.
J. L. Curtis, C. M. Freeman, and J. C. Hogg (2007)
Proceedings of the ATS 4, 512-521
   Abstract »    Full Text »    PDF »
Contribution of alveolar macrophages to the response of the TIMP-3 null lung during a septic insult.
E. L. Martin, T. A. Sheikh, K. J. Leco, J. F. Lewis, and R. A. W. Veldhuizen (2007)
Am J Physiol Lung Cell Mol Physiol 293, L779-L789
   Abstract »    Full Text »    PDF »
{alpha}1-Antitrypsin Suppresses TNF-{alpha} and MMP-12 Production by Cigarette Smoke-Stimulated Macrophages.
A. Churg, X. Wang, R. D. Wang, S. C. Meixner, E. L. G. Pryzdial, and J. L. Wright (2007)
Am. J. Respir. Cell Mol. Biol. 37, 144-151
   Abstract »    Full Text »    PDF »
Essential Role of MMP-12 in Fas-Induced Lung Fibrosis.
G. Matute-Bello, M. M. Wurfel, J. S. Lee, D. R. Park, C. W. Frevert, D. K. Madtes, S. D. Shapiro, and T. R. Martin (2007)
Am. J. Respir. Cell Mol. Biol. 37, 210-221
   Abstract »    Full Text »    PDF »
Molecular Multitasking in the Airspace: {alpha}1-Antitrypsin Takes on Thrombin and Plasmin.
R. M. Tuder and I. Petrache (2007)
Am. J. Respir. Cell Mol. Biol. 37, 130-134
   Full Text »    PDF »
Effect of an MMP-9/MMP-12 inhibitor on smoke-induced emphysema and airway remodelling in guinea pigs.
A. Churg, R. Wang, X. Wang, P.-O. Onnervik, K. Thim, and J. L Wright (2007)
Thorax 62, 706-713
   Abstract »    Full Text »    PDF »
A Young Patient With a Minimal Smoking History Presents With Bullous Emphysema and Recurrent Pneumothorax.
E. Mireles-Cabodevila, H. Sahi, C. Farver, T.-L. Mohammed, and D. A. Culver (2007)
Chest 132, 338-343
   Full Text »    PDF »
Pathobiology of Cigarette Smoke-Induced Chronic Obstructive Pulmonary Disease.
T. Yoshida and R. M. Tuder (2007)
Physiol Rev 87, 1047-1082
   Abstract »    Full Text »    PDF »
Pulmonary Inflammation and Emphysema: Role of the Cytokines IL-18 and IL-13.
T. Hoshino, S. Kato, N. Oka, H. Imaoka, T. Kinoshita, S. Takei, Y. Kitasato, T. Kawayama, T. Imaizumi, K. Yamada, et al. (2007)
Am. J. Respir. Crit. Care Med. 176, 49-62
   Abstract »    Full Text »    PDF »
Matrix metalloprotease-9 dysregulation in lower airway secretions of cystic fibrosis patients.
A. Gaggar, Y. Li, N. Weathington, M. Winkler, M. Kong, P. Jackson, J. E. Blalock, and J. P. Clancy (2007)
Am J Physiol Lung Cell Mol Physiol 293, L96-L104
   Abstract »    Full Text »    PDF »
CD8+ T Cells Are Required for Inflammation and Destruction in Cigarette Smoke-Induced Emphysema in Mice.
T. Maeno, A. M. Houghton, P. A. Quintero, S. Grumelli, C. A. Owen, and S. D. Shapiro (2007)
J. Immunol. 178, 8090-8096
   Abstract »    Full Text »    PDF »
Mainstream Tobacco Smoke Causes Paternal Germ-Line DNA Mutation.
C. L. Yauk, M. L. Berndt, A. Williams, A. Rowan-Carroll, G. R. Douglas, and M. R. Stampfli (2007)
Cancer Res. 67, 5103-5106
   Abstract »    Full Text »    PDF »
Accumulation of Dendritic Cells and Increased CCL20 Levels in the Airways of Patients with Chronic Obstructive Pulmonary Disease.
I. K. Demedts, K. R. Bracke, G. Van Pottelberge, D. Testelmans, G. M. Verleden, F. E. Vermassen, G. F. Joos, and G. G. Brusselle (2007)
Am. J. Respir. Crit. Care Med. 175, 998-1005
   Abstract »    Full Text »    PDF »
Neutrophil Elastase Up-Regulates Cathepsin B and Matrix Metalloprotease-2 Expression.
P. Geraghty, M. P. Rogan, C. M. Greene, R. M. M. Boxio, T. Poiriert, M. O'Mahony, A. Belaaouaj, S. J. O'Neill, C. C. Taggart, and N. G. McElvaney (2007)
J. Immunol. 178, 5871-5878
   Abstract »    Full Text »    PDF »
Enhanced Expression of MafB Inhibits Macrophage Apoptosis Induced by Cigarette Smoke Exposure.
J.-i. Machiya, Y. Shibata, K. Yamauchi, N. Hirama, T. Wada, S. Inoue, S. Abe, N. Takabatake, M. Sata, and I. Kubota (2007)
Am. J. Respir. Cell Mol. Biol. 36, 418-426
   Abstract »    Full Text »    PDF »
Fibulin-5/DANCE has an elastogenic organizer activity that is abrogated by proteolytic cleavage in vivo.
M. Hirai, T. Ohbayashi, M. Horiguchi, K. Okawa, A. Hagiwara, K. R. Chien, T. Kita, and T. Nakamura (2007)
J. Cell Biol. 176, 1061-1071
   Abstract »    Full Text »    PDF »
Transforming Growth Factor (TGF)-beta1 Stimulates Pulmonary Fibrosis and Inflammation via a Bax-dependent, Bid-activated Pathway That Involves Matrix Metalloproteinase-12.
H.-R. Kang, S. J. Cho, C. G. Lee, R. J. Homer, and J. A. Elias (2007)
J. Biol. Chem. 282, 7723-7732
   Abstract »    Full Text »    PDF »
Plasma matrix metalloproteinase-9 and left ventricular remodelling after acute myocardial infarction in man: a prospective cohort study.
D. Kelly, G. Cockerill, L. L. Ng, M. Thompson, S. Khan, N. J. Samani, and I. B. Squire (2007)
Eur. Heart J.
   Abstract »    Full Text »    PDF »
IL-18 Is Induced and IL-18 Receptor {alpha} Plays a Critical Role in the Pathogenesis of Cigarette Smoke-Induced Pulmonary Emphysema and Inflammation.
M.-J. Kang, R. J. Homer, A. Gallo, C. G. Lee, K. A. Crothers, S. J. Cho, C. Rochester, H. Cain, G. Chupp, H. J. Yoon, et al. (2007)
J. Immunol. 178, 1948-1959
   Abstract »    Full Text »    PDF »
Cigarette Smoke Impairs NK Cell-Dependent Tumor Immune Surveillance.
L.-M. Lu, C. C. J. Zavitz, B. Chen, S. Kianpour, Y. Wan, and M. R. Stampfli (2007)
J. Immunol. 178, 936-943
   Abstract »    Full Text »    PDF »
Current Concepts in Mechanisms of Emphysema.
J. L. Wright and A. Churg (2007)
Toxicol Pathol 35, 111-115
   Abstract »    Full Text »    PDF »
Matrix Metalloproteinases in Lung: Multiple, Multifarious, and Multifaceted.
K. J. Greenlee, Z. Werb, and F. Kheradmand (2007)
Physiol Rev 87, 69-98
   Abstract »    Full Text »    PDF »
Cigarette smoke upregulates pulmonary vascular matrix metalloproteinases via TNF-{alpha} signaling.
J. L. Wright, H. Tai, R. Wang, X. Wang, and A. Churg (2007)
Am J Physiol Lung Cell Mol Physiol 292, L125-L133
   Abstract »    Full Text »    PDF »
Cigarette Smoke Impacts Immune Inflammatory Responses to Influenza in Mice.
C. S. Robbins, C. M. T. Bauer, N. Vujicic, G. J. Gaschler, B. D. Lichty, E. G. Brown, and M. R. Stampfli (2006)
Am. J. Respir. Crit. Care Med. 174, 1342-1351
   Abstract »    Full Text »    PDF »
Pulmonary Emphysema: When More is Less..
D. G. Morris and D. Sheppard (2006)
Physiology 21, 396-403
   Abstract »    Full Text »    PDF »
Animal Models of Asthma: Pro: Allergic Avoidance of Animal (Model[s]) Is Not an Option.
S. D. Shapiro (2006)
Am. J. Respir. Crit. Care Med. 174, 1171-1173
   Full Text »    PDF »
Haplotypes in Matrix Metalloproteinase Gene Cluster on Chromosome 11q22 Contribute to the Risk of Lung Cancer Development and Progression.
T. Sun, Y. Gao, W. Tan, S. Ma, X. Zhang, Y. Wang, Q. Zhang, Y. Guo, D. Zhao, C. Zeng, et al. (2006)
Clin. Cancer Res. 12, 7009-7017
   Abstract »    Full Text »    PDF »
Cigarette Smoke-Induced Pulmonary Inflammation and Emphysema Are Attenuated in CCR6-Deficient Mice.
K. R. Bracke, A. I. D'hulst, T. Maes, K. B. Moerloose, I. K. Demedts, S. Lebecque, G. F. Joos, and G. G. Brusselle (2006)
J. Immunol. 177, 4350-4359
   Abstract »    Full Text »    PDF »
Impact of the Loss of Hoxa5 Function on Lung Alveogenesis.
I. Mandeville, J. Aubin, M. LeBlanc, M. Lalancette-Hebert, M.-F. Janelle, G. M. Tremblay, and L. Jeannotte (2006)
Am. J. Pathol. 169, 1312-1327
   Abstract »    Full Text »    PDF »
Cigarette Smoke-Induced Egr-1 Upregulates Proinflammatory Cytokines in Pulmonary Epithelial Cells.
P. R. Reynolds, M. G. Cosio, and J. R. Hoidal (2006)
Am. J. Respir. Cell Mol. Biol. 35, 314-319
   Abstract »    Full Text »    PDF »
Role of Matrix Metalloproteinases in the Inflammatory Response in Human Airway Cell-Based Assays and in Rodent Models of Airway Disease.
M. A. Birrell, S. Wong, A. Dekkak, J. De Alba, S. Haj-Yahia, and M. G. Belvisi (2006)
J. Pharmacol. Exp. Ther. 318, 741-750
   Abstract »    Full Text »    PDF »
Interaction of HIV Tat and matrix metalloproteinase in HIV neuropathogenesis: a new host defense mechanism.
J. Rumbaugh, J. Turchan-Cholewo, D. Galey, C. St. Hillaire, C. Anderson, K. Conant, and A. Nath (2006)
FASEB J 20, 1736-1738
   Abstract »    Full Text »    PDF »
Extracellular matrix in lung disease. Proceedings of the Twenty-First Transatlantic Airway Conference..
S. D. Shapiro (2006)
Proceedings of the ATS 3, 397-455
   Full Text »    PDF »
Progress in chronic obstructive pulmonary disease genetics..
E. K. Silverman (2006)
Proceedings of the ATS 3, 405-408
   Abstract »    Full Text »    PDF »
Role of tumour necrosis factor-{alpha} receptor p75 in cigarette smoke-induced pulmonary inflammation and emphysema.
A. I. D'hulst, K. R. Bracke, T. Maes, J. L. De Bleecker, R. A. Pauwels, G. F. Joos, and G. G. Brusselle (2006)
Eur. Respir. J. 28, 102-112
   Abstract »    Full Text »    PDF »
Macrophage elastase (matrix metalloproteinase-12) suppresses growth of lung metastases..
A. M. Houghton, J. L. Grisolano, M. L. Baumann, D. K. Kobayashi, R. D. Hautamaki, L. C. Nehring, L. A. Cornelius, and S. D. Shapiro (2006)
Cancer Res. 66, 6149-6155
   Abstract »    Full Text »    PDF »
Involvement of MMP-12 and phosphodiesterase type 4 in cigarette smoke-induced inflammation in mice.
O. Leclerc, V. Lagente, J-M. Planquois, C. Berthelier, M. Artola, T. Eichholtz, C. P. Bertrand, and F. Schmidlin (2006)
Eur. Respir. J. 27, 1102-1109
   Abstract »    Full Text »    PDF »
Oxidants and Signaling by Mitogen-Activated Protein Kinases in Lung Epithelium.
B. T. Mossman, K. M. Lounsbury, and S. P. Reddy (2006)
Am. J. Respir. Cell Mol. Biol. 34, 666-669
   Abstract »    Full Text »    PDF »
Expression of the Reverse Tetracycline-Transactivator Gene Causes Emphysema-Like Changes in Mice.
T. H. Sisson, J. M. Hansen, M. Shah, K. E. Hanson, M. Du, T. Ling, R. H. Simon, and P. J. Christensen (2006)
Am. J. Respir. Cell Mol. Biol. 34, 552-560
   Abstract »    Full Text »    PDF »
Differential protease, innate immunity, and NF-{kappa}B induction profiles during lung inflammation induced by subchronic cigarette smoke exposure in mice.
R. Vlahos, S. Bozinovski, J. E. Jones, J. Powell, J. Gras, A. Lilja, M. J. Hansen, R. C. Gualano, L. Irving, and G. P. Anderson (2006)
Am J Physiol Lung Cell Mol Physiol 290, L931-L945
   Abstract »    Full Text »    PDF »
Novel Transgenic Rabbit Model Sheds Light on the Puzzling Role of Matrix Metalloproteinase-12 in Atherosclerosis.
M. Tjwa, P. Carmeliet, and L. Moons (2006)
Circulation 113, 1929-1932
   Full Text »    PDF »
Macrophage Metalloelastase Accelerates the Progression of Atherosclerosis in Transgenic Rabbits.
J. Liang, E. Liu, Y. Yu, S. Kitajima, T. Koike, Y. Jin, M. Morimoto, K. Hatakeyama, Y. Asada, T. Watanabe, et al. (2006)
Circulation 113, 1993-2001
   Abstract »    Full Text »    PDF »
Development of Selective Inhibitors and Substrate of Matrix Metalloproteinase-12.
L. Devel, V. Rogakos, A. David, A. Makaritis, F. Beau, P. Cuniasse, A. Yiotakis, and V. Dive (2006)
J. Biol. Chem. 281, 11152-11160
   Abstract »    Full Text »    PDF »
Cigarette Smoke-induced Emphysema: A Role for the B Cell?.
B. W. A. van der Strate, D. S. Postma, C.-A. Brandsma, B. N. Melgert, M. A. Luinge, M. Geerlings, M. N. Hylkema, A. van den Berg, W. Timens, and H. A. M. Kerstjens (2006)
Am. J. Respir. Crit. Care Med. 173, 751-758
   Abstract »    Full Text »    PDF »
Superoxide Dismutase Expression Attenuates Cigarette Smoke- or Elastase-generated Emphysema in Mice.
R. F. Foronjy, O. Mirochnitchenko, O. Propokenko, V. Lemaitre, Y. Jia, M. Inouye, Y. Okada, and J. M. D'Armiento (2006)
Am. J. Respir. Crit. Care Med. 173, 623-631
   Abstract »    Full Text »    PDF »
Matrix metalloproteinases in destructive pulmonary pathology.
P T G Elkington and J S Friedland (2006)
Thorax 61, 259-266
   Abstract »    Full Text »    PDF »
Elevated MMP-12 protein levels in induced sputum from patients with COPD.
I K Demedts, A Morel-Montero, S Lebecque, Y Pacheco, D Cataldo, G F Joos, R A Pauwels, and G G Brusselle (2006)
Thorax 61, 196-201
   Abstract »    Full Text »    PDF »
Failure of Elastic Fiber Homeostasis Leads to Pelvic Floor Disorders.
X. Liu, Y. Zhao, B. Pawlyk, M. Damaser, and T. Li (2006)
Am. J. Pathol. 168, 519-528
   Abstract »    Full Text »    PDF »
Smoking, Metalloproteinases, and Vascular Disease.
T. S. Perlstein and R. T. Lee (2006)
Arterioscler. Thromb. Vasc. Biol. 26, 250-256
   Abstract »    Full Text »    PDF »
Tomato juice prevents senescence-accelerated mouse P1 strain from developing emphysema induced by chronic exposure to tobacco smoke.
S. Kasagi, K. Seyama, H. Mori, S. Souma, T. Sato, T. Akiyoshi, H. Suganuma, and Y. Fukuchi (2006)
Am J Physiol Lung Cell Mol Physiol 290, L396-L404
   Abstract »    Full Text »    PDF »
Nrf2-deficient mice are highly susceptible to cigarette smoke-induced emphysema.
T. Iizuka, Y. Ishii, K. Itoh, T. Kiwamoto, T. Kimura, Y. Matsuno, Y. Morishima, A. E. Hegab, S. Homma, A. Nomura, et al. (2005)
Genes Cells 10, 1113-1125
   Abstract »    Full Text »    PDF »
A Distinctive Alveolar Macrophage Activation State Induced by Cigarette Smoking.
P. G. Woodruff, L. L. Koth, Y. H. Yang, M. W. Rodriguez, S. Favoreto, G. M. Dolganov, A. C. Paquet, and D. J. Erle (2005)
Am. J. Respir. Crit. Care Med. 172, 1383-1392
   Abstract »    Full Text »    PDF »
Proteinases and Oxidants as Targets in the Treatment of Chronic Obstructive Pulmonary Disease.
C. A. Owen (2005)
Proceedings of the ATS 2, 373-385
   Abstract »    Full Text »    PDF »
COPD: A Dust-Induced Disease?.
C. E. Girod and T. E. King Jr. (2005)
Chest 128, 3055-3064
   Abstract »    Full Text »    PDF »
Mainstream Cigarette Smoke Exposure Attenuates Airway Immune Inflammatory Responses to Surrogate and Common Environmental Allergens in Mice, Despite Evidence of Increased Systemic Sensitization.
C. S. Robbins, M. A. Pouladi, R. Fattouh, D. E. Dawe, N. Vujicic, C. D. Richards, M. Jordana, M. D. Inman, and M. R. Stampfli (2005)
J. Immunol. 175, 2834-2842
   Abstract »    Full Text »    PDF »
Pulmonary Dendritic Cells.
K. Vermaelen and R. Pauwels (2005)
Am. J. Respir. Crit. Care Med. 172, 530-551
   Abstract »    Full Text »    PDF »
NADPH Oxidase Restrains the Matrix Metalloproteinase Activity of Macrophages.
S. Y. Kassim, X. Fu, W. C. Liles, S. D. Shapiro, W. C. Parks, and J. W. Heinecke (2005)
J. Biol. Chem. 280, 30201-30205
   Abstract »    Full Text »    PDF »
Time course of cigarette smoke-induced pulmonary inflammation in mice.
A. I. D'hulst, K. Y. Vermaelen, G. G. Brusselle, G. F. Joos, and R. A. Pauwels (2005)
Eur. Respir. J. 26, 204-213
   Abstract »    Full Text »    PDF »
Short-Term Cigarette Smoke Exposure Enhances Allergic Airway Inflammation in Mice.
K. B. Moerloose, R. A. Pauwels, and G. F. Joos (2005)
Am. J. Respir. Crit. Care Med. 172, 168-172
   Abstract »    Full Text »    PDF »
Overexpression of Stat3C in Pulmonary Epithelium Protects against Hyperoxic Lung Injury.
X. Lian, Y. Qin, S. A. Hossain, L. Yang, A. White, H. Xu, J. M. Shipley, T. Li, R. M. Senior, H. Du, et al. (2005)
J. Immunol. 174, 7250-7256