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Science 26 September 1997:
Vol. 277. no. 5334, pp. 1986 - 1990
DOI: 10.1126/science.277.5334.1986
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Reports

LKLF: A Transcriptional Regulator of Single-Positive T Cell Quiescence and Survival

Chay T. Kuo, Margaret L. Veselits, Jeffrey M. Leiden *

Mature single-positive (SP) T lymphocytes enter a "resting" state in which they are proliferatively quiescent and relatively resistant to apoptosis. The molecular mechanisms regulating this quiescent phenotype were unknown. Here it was found that the expression of a Kruppel-like zinc finger transcription factor, lung Kruppel-like factor (LKLF), is developmentally induced during the maturation of SP quiescent T cells and rapidly extinguished after SP T cell activation. LKLF-deficient T cells produced by gene targeting had a spontaneously activated phenotype and died in the spleen and lymph nodes from Fas ligand-induced apoptosis. Thus, LKLF is required to program the quiescent state of SP T cells and to maintain their viability in the peripheral lymphoid organs and blood.

Departments of Medicine and Pathology and The Committee on Genetics, University of Chicago, Chicago, IL 60637, USA.
*   To whom correspondence should be addressed. E-mail: jleiden{at}medicine.bsd.uchicago.edu

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X. Chen, D. C. Johns, D. E. Geiman, E. Marban, D. T. Dang, G. Hamlin, R. Sun, and V. W. Yang (2001)
J. Biol. Chem. 276, 30423-30428
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Lung Kruppel-like Factor Contains an Autoinhibitory Domain That Regulates Its Transcriptional Activation by Binding WWP1, an E3 Ubiquitin Ligase.
M. D. Conkright, M. A. Wani, and J. B Lingrel (2001)
J. Biol. Chem. 276, 29299-29306
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The Sp1-like Protein BTEB3 Inhibits Transcription via the Basic Transcription Element Box by Interacting with mSin3A and HDAC-1 Co-repressors and Competing with Sp1.
J. Kaczynski, J.-S. Zhang, V. Ellenrieder, A. Conley, T. Duenes, H. Kester, B. van der Burg, and R. Urrutia (2001)
J. Biol. Chem. 276, 36749-36756
   Abstract »    Full Text »    PDF »
Kruppel-like Factors: Three Fingers in Many Pies.
J. J. Bieker (2001)
J. Biol. Chem. 276, 34355-34358
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IL-15 mimics T cell receptor crosslinking in the induction of cellular proliferation, gene expression, and cytotoxicity in CD8+ memory T cells.
K. Liu, M. Catalfamo, Y. Li, P. A. Henkart, and N.-p. Weng (2002)
PNAS 99, 6192-6197
   Abstract »    Full Text »    PDF »


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