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Science 5 September 1997:
Vol. 277. no. 5331, pp. 1511 - 1515
DOI: 10.1126/science.277.5331.1511
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Reports

Binding of Neuroligins to PSD-95

M. Irie, Y. Hata, M. Takeuchi, K. Ichtchenko, A. Toyoda, K. Hirao, Y. Takai, T. W. Rosahl, T. C. Südhof *

PSD-95 is a component of postsynaptic densities in central synapses. It contains three PDZ domains that localize N-methyl-D-aspartate receptor subunit 2 (NMDA2 receptor) and K+ channels to synapses. In mouse forebrain, PSD-95 bound to the cytoplasmic COOH-termini of neuroligins, which are neuronal cell adhesion molecules that interact with beta -neurexins and form intercellular junctions. Neuroligins bind to the third PDZ domain of PSD-95, whereas NMDA2 receptors and K+ channels interact with the first and second PDZ domains. Thus different PDZ domains of PSD-95 are specialized for distinct functions. PSD-95 may recruit ion channels and neurotransmitter receptors to intercellular junctions formed between neurons by neuroligins and beta -neurexins.

M. Irie, M. Takeuchi, A. Toyoda, K. Hirao, Takai Biotimer Project, ERATO, Japan Science and Technology Corporation, 2-2-10, Murotani, Nishi-ku, Kobe, 651-22, Japan. Y. Hata, Howard Hughes Medical Institute and Department of Molecular Genetics, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75235-9050, USA, and Takai Biotimer Project, ERATO, Japan Science and Technology Corporation, 2-2-10, Murotani, Nishi-ku, Kobe 651-22, Japan.
K. Ichtchenko, T. W. Rosahl, T. C. Südhof, Howard Hughes Medical Institute and Department of Molecular Genetics, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75235-9050, USA.
Y. Takai, Takai Biotimer Project ERATO, Japan Science and Technology Corporation, 2-2-10, Murotani, Nishi-ku, Kobe 651-22, Japan, and Department of Molecular Biology and Biochemistry, Osaka University Medical School, Suita 565, Japan.
*   To whom correspondence should be addressed.

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   Abstract »    Full Text »    PDF »
A Novel Multiple PDZ Domain-containing Molecule Interacting with N-Methyl-D-aspartate Receptors and Neuronal Cell Adhesion Proteins.
K. Hirao, Y. Hata, N. Ide, M. Takeuchi, M. Irie, I. Yao, M. Deguchi, A. Toyoda, T. C. Sudhof, and Y. Takai (1998)
J. Biol. Chem. 273, 21105-21110
   Abstract »    Full Text »    PDF »
Coordination of an Array of Signaling Proteins through Homo- and Heteromeric Interactions Between PDZ Domains and Target Proteins.
X.-Z. S. Xu, A. Choudhury, X. Li, and C. Montell (1998)
J. Cell Biol. 142, 545-555
   Abstract »    Full Text »    PDF »
Direct Association of the Gap Junction Protein Connexin-43 with ZO-1 in Cardiac Myocytes.
T. Toyofuku, M. Yabuki, K. Otsu, T. Kuzuya, M. Hori, and M. Tada (1998)
J. Biol. Chem. 273, 12725-12731
   Abstract »    Full Text »    PDF »
Neurexophilins Form a Conserved Family of Neuropeptide-Like Glycoproteins.
M. Missler and T. C. Sudhof (1998)
J. Neurosci. 18, 3630-3638
   Abstract »    Full Text »    PDF »
Occludin-deficient Embryonic Stem Cells Can Differentiate into Polarized Epithelial Cells Bearing Tight Junctions.
M. Saitou, K. Fujimoto, Y. Doi, M. Itoh, T. Fujimoto, M. Furuse, H. Takano, T. Noda, and S. Tsukita (1998)
J. Cell Biol. 141, 397-408
   Abstract »    Full Text »    PDF »
Role of Actin in Anchoring Postsynaptic Receptors in Cultured Hippocampal Neurons: Differential Attachment of NMDA versus AMPA Receptors.
D. W. Allison, V. I. Gelfand, I. Spector, and A. M. Craig (1998)
J. Neurosci. 18, 2423-2436
   Abstract »    Full Text »    PDF »
Neurexin Ialpha Is a Major alpha -Latrotoxin Receptor That Cooperates in alpha -Latrotoxin Action.
M. Geppert, M. Khvotchev, V. Krasnoperov, Y. Goda, M. Missler, R. E. Hammer, K. Ichtchenko, A. G. Petrenko, and T. C. Sudhof (1998)
J. Biol. Chem. 273, 1705-1710
   Abstract »    Full Text »    PDF »
The formation of neuromuscular synapses.
S. J. Burden (1998)
Genes & Dev. 12, 133-148
   Full Text »
Signaling Through Scaffold, Anchoring, and Adaptor Proteins.
T. Pawson and J. D. Scott (1997)
Science 278, 2075-2080
   Abstract »    Full Text »
A stoichiometric complex of neurexins and dystroglycan in brain.
S. Sugita, F. Saito, J. Tang, J. Satz, K. Campbell, and T. C. Sudhof (2001)
J. Cell Biol. 154, 435-446
   Abstract »    Full Text »    PDF »
The Calcium-independent Receptor for alpha -Latrotoxin from Human and Rodent Brains Interacts with Members of the ProSAP/SSTRIP/Shank Family of Multidomain Proteins.
H.-J. Kreienkamp, H. Zitzer, E. D. Gundelfinger, D. Richter, and T. M. Bockers (2000)
J. Biol. Chem. 275, 32387-32390
   Abstract »    Full Text »    PDF »
Lano, a Novel LAP Protein Directly Connected to MAGUK Proteins in Epithelial Cells.
H. Saito, M.-J. Santoni, J.-P. Arsanto, F. Jaulin-Bastard, A. Le Bivic, S. Marchetto, S. Audebert, D. Isnardon, J. Adelaide, D. Birnbaum, et al. (2001)
J. Biol. Chem. 276, 32051-32055
   Abstract »    Full Text »    PDF »
beta 1-Adrenergic Receptor Association with PSD-95. INHIBITION OF RECEPTOR INTERNALIZATION AND FACILITATION OF beta 1-ADRENERGIC RECEPTOR INTERACTION WITH N-METHYL-D-ASPARTATE RECEPTORS.
L. A. Hu, Y. Tang, W. E. Miller, M. Cong, A. G. Lau, R. J. Lefkowitz, and R. A. Hall (2000)
J. Biol. Chem. 275, 38659-38666
   Abstract »    Full Text »    PDF »
The G Protein-coupled Receptor CL1 Interacts Directly with Proteins of the Shank Family.
S. Tobaben, T. C. Sudhof, and B. Stahl (2000)
J. Biol. Chem. 275, 36204-36210
   Abstract »    Full Text »    PDF »


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