Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 29 August 1997:
Vol. 277. no. 5330, pp. 1310 - 1313
DOI: 10.1126/science.277.5330.1310
Prev | Table of Contents | Next

Reports

Induced alpha  Helix in the VP16 Activation Domain upon Binding to a Human TAF

Motonari Uesugi, Origène Nyanguile, Hua Lu, Arnold J. Levine, Gregory L. Verdine *

Activation domains are functional modules that enable sequence-specific DNA binding proteins to stimulate transcription. The structural basis for the function of activation domains is poorly understood. A combination of nuclear magnetic resonance (NMR) and biochemical experiments revealed that the minimal acidic activation domain of the herpes simplex virus VP16 protein undergoes an induced transition from random coil to alpha  helix upon binding to its target protein, hTAFII31 (a human TFIID TATA box-binding protein-associated factor). Identification of the two hydrophobic residues that make nonpolar contacts suggests a general recognition motif of acidic activation domains for hTAFII31.

M. Uesugi, O. Nyanguile, G. L. Verdine, Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA.
H. Lu and A. J. Levine, Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA.
*   To whom correspondence should be addressed.

Volume 277, Number 5330, Issue of 29 August 1997, pp. 1310-1313
©1997 by The American Association for the Advancement of Science.

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Interaction between the Transactivation Domain of p53 and PC4 Exemplifies Acidic Activation Domains as Single-stranded DNA Mimics.
S. Rajagopalan, A. Andreeva, D. P. Teufel, S. M. Freund, and A. R. Fersht (2009)
J. Biol. Chem. 284, 21728-21737
   Abstract »    Full Text »    PDF »
Analysis of the Varicella-Zoster Virus IE62 N-Terminal Acidic Transactivating Domain and Its Interaction with the Human Mediator Complex.
S. Yamamoto, A. Eletsky, T. Szyperski, J. Hay, and W. T. Ruyechan (2009)
J. Virol. 83, 6300-6305
   Abstract »    Full Text »    PDF »
The Interaction between an Acidic Transcriptional Activator and Its Inhibitor: THE MOLECULAR BASIS OF Gal4p RECOGNITION BY Gal80p.
J. B. Thoden, L. A. Ryan, R. J. Reece, and H. M. Holden (2008)
J. Biol. Chem. 283, 30266-30272
   Abstract »    Full Text »    PDF »
Functional Silencing of TATA-binding Protein (TBP) by a Covalent Linkage of the N-terminal Domain of TBP-associated Factor 1.
T. K. Mal, S. Takahata, S. Ki, L. Zheng, T. Kokubo, and M. Ikura (2007)
J. Biol. Chem. 282, 22228-22238
   Abstract »    Full Text »    PDF »
Walleye Dermal Sarcoma Virus Retroviral Cyclin Directly Contacts TAF9.
J. Rovnak and S. L. Quackenbush (2006)
J. Virol. 80, 12041-12048
   Abstract »    Full Text »    PDF »
Transcriptional regulation by Modulo integrates meiosis and spermatid differentiation in male germ line.
L. M. Mikhaylova, A. M. Boutanaev, and D. I. Nurminsky (2006)
PNAS 103, 11975-11980
   Abstract »    Full Text »    PDF »
Downstream signaling mechanism of the C-terminal activation domain of transcriptional coactivator CoCoA..
J. H. Kim, C. K. Yang, and M. R. Stallcup (2006)
Nucleic Acids Res. 34, 2736-2750
   Abstract »    Full Text »    PDF »
Mechanism of Transcription Factor Recruitment by Acidic Activators.
M. E. Ferreira, S. Hermann, P. Prochasson, J. L. Workman, K. D. Berndt, and A. P. H. Wright (2005)
J. Biol. Chem. 280, 21779-21784
   Abstract »    Full Text »    PDF »
Common Effects of Acidic Activators on Large-Scale Chromatin Structure and Transcription.
A. E. Carpenter, S. Memedula, M. J. Plutz, and A. S. Belmont (2005)
Mol. Cell. Biol. 25, 958-968
   Abstract »    Full Text »    PDF »
Constitutive and Interleukin-1-inducible Phosphorylation of p65 NF-{kappa}B at Serine 536 Is Mediated by Multiple Protein Kinases Including I{kappa}B Kinase (IKK)-{alpha}, IKK{beta}, IKK{epsilon}, TRAF Family Member-associated (TANK)-binding Kinase 1 (TBK1), and an Unknown Kinase and Couples p65 to TATA-binding Protein-associated Factor II31-mediated Interleukin-8 Transcription.
H. Buss, A. Dorrie, M. L. Schmitz, E. Hoffmann, K. Resch, and M. Kracht (2004)
J. Biol. Chem. 279, 55633-55643
   Abstract »    Full Text »    PDF »
VP16-Dependent Association of Chromatin-Modifying Coactivators and Underrepresentation of Histones at Immediate-Early Gene Promoters during Herpes Simplex Virus Infection.
F. J. Herrera and S. J. Triezenberg (2004)
J. Virol. 78, 9689-9696
   Abstract »    Full Text »    PDF »
An Androgen Receptor NH2-terminal Conserved Motif Interacts with the COOH Terminus of the Hsp70-interacting Protein (CHIP).
B. He, S. Bai, A. T. Hnat, R. I. Kalman, J. T. Minges, C. Patterson, and E. M. Wilson (2004)
J. Biol. Chem. 279, 30643-30653
   Abstract »    Full Text »    PDF »
Transcriptional Coactivator PC4 Stimulates Promoter Escape and Facilitates Transcriptional Synergy by GAL4-VP16.
A. Fukuda, T. Nakadai, M. Shimada, T. Tsukui, M. Matsumoto, Y. Nogi, M. Meisterernst, and K. Hisatake (2004)
Mol. Cell. Biol. 24, 6525-6535
   Abstract »    Full Text »    PDF »
Identification of a Novel TATA Element-binding Protein Binding Region at the N Terminus of the Saccharomyces cerevisiae TAF1 Protein.
S. Takahata, H. Ryu, K. Ohtsuki, K. Kasahara, M. Kawaichi, and T. Kokubo (2003)
J. Biol. Chem. 278, 45888-45902
   Abstract »    Full Text »    PDF »
Activation domain-mediator interactions promote transcription preinitiation complex assembly on promoter DNA.
G. T. Cantin, J. L. Stevens, and A. J. Berk (2003)
PNAS 100, 12003-12008
   Abstract »    Full Text »    PDF »
Activation Functions 1 and 2 of Nuclear Receptors: Molecular Strategies for Transcriptional Activation.
A. Warnmark, E. Treuter, A. P. H. Wright, and J.-A. Gustafsson (2003)
Mol. Endocrinol. 17, 1901-1909
   Abstract »    Full Text »    PDF »
Functional Analysis of RF2a, a Rice Transcription Factor.
S. Dai, S. Petruccelli, M. I. Ordiz, Z. Zhang, S. Chen, and R. N. Beachy (2003)
J. Biol. Chem. 278, 36396-36402
   Abstract »    Full Text »    PDF »
NMR structure of a complex containing the TFIIF subunit RAP74 and the RNA polymerase II carboxyl-terminal domain phosphatase FCP1.
B. D. Nguyen, K. L. Abbott, K. Potempa, M. S. Kobor, J. Archambault, J. Greenblatt, P. Legault, and J. G. Omichinski (2003)
PNAS 100, 5688-5693
   Abstract »    Full Text »    PDF »
Electrostatic Modulation in Steroid Receptor Recruitment of LXXLL and FXXLF Motifs.
B. He and E. M. Wilson (2003)
Mol. Cell. Biol. 23, 2135-2150
   Abstract »    Full Text »    PDF »
Dynamic Chromatin Alterations Triggered by Natural and Synthetic Activation Domains.
A. M. Erkine and D. S. Gross (2003)
J. Biol. Chem. 278, 7755-7764
   Abstract »    Full Text »    PDF »
Use of a Genetically Introduced Cross-linker to Identify Interaction Sites of Acidic Activators within Native Transcription Factor IID and SAGA.
J. Klein, M. Nolden, S. L. Sanders, J. Kirchner, P. A. Weil, and K. Melcher (2003)
J. Biol. Chem. 278, 6779-6786
   Abstract »    Full Text »    PDF »
Transcriptional Activities of the Zinc Finger Protein Zac Are Differentially Controlled by DNA Binding.
A. Hoffmann, E. Ciani, J. Boeckardt, F. Holsboer, L. Journot, and D. Spengler (2003)
Mol. Cell. Biol. 23, 988-1003
   Abstract »    Full Text »    PDF »
Structural basis for the recognition of the E2F transactivation domain by the retinoblastoma tumor suppressor.
C. Lee, J. H. Chang, H. S. Lee, and Y. Cho (2002)
Genes & Dev. 16, 3199-3212
   Abstract »    Full Text »    PDF »
The vertebrate protein CTCF functions as an insulator in Saccharomyces cerevisiae.
P.-A. Defossez and E. Gilson (2002)
Nucleic Acids Res. 30, 5136-5141
   Abstract »    Full Text »    PDF »
The VP16 Activation Domain Interacts with Multiple Transcriptional Components as Determined by Protein-Protein Cross-linking in Vivo.
D. B. Hall and K. Struhl (2002)
J. Biol. Chem. 277, 46043-46050
   Abstract »    Full Text »    PDF »
Translational fusions with the engrailed repressor domain efficiently convert plant transcription factors into dominant-negative functions.
H. Markel, J. Chandler, and W. Werr (2002)
Nucleic Acids Res. 30, 4709-4719
   Abstract »    Full Text »    PDF »
Cooperative Activation of Human Papillomavirus Type 8 Gene Expression by the E2 Protein and the Cellular Coactivator p300.
A. Muller, A. Ritzkowsky, and G. Steger (2002)
J. Virol. 76, 11042-11053
   Abstract »    Full Text »    PDF »
Structural characterization of the PIT-1/ETS-1 interaction: PIT-1 phosphorylation regulates PIT-1/ETS-1 binding.
K. D. Augustijn, D. L. Duval, R. Wechselberger, R. Kaptein, A. Gutierrez-Hartmann, and P. C. van der Vliet (2002)
PNAS 99, 12657-12662
   Abstract »    Full Text »    PDF »
Conformational Analysis of the Androgen Receptor Amino-terminal Domain Involved in Transactivation. INFLUENCE OF STRUCTURE-STABILIZING SOLUTES AND PROTEIN-PROTEIN INTERACTIONS.
J. Reid, S. M. Kelly, K. Watt, N. C. Price, and I. J. McEwan (2002)
J. Biol. Chem. 277, 20079-20086
   Abstract »    Full Text »    PDF »
Chromatin-Dependent Cooperativity between Constitutive and Inducible Activation Domains in CREB.
H. Asahara, B. Santoso, E. Guzman, K. Du, P. A. Cole, I. Davidson, and M. Montminy (2001)
Mol. Cell. Biol. 21, 7892-7900
   Abstract »    Full Text »    PDF »
The N-terminal Regions of Estrogen Receptor alpha and beta Are Unstructured in Vitro and Show Different TBP Binding Properties.
A. Warnmark, A. Wikstrom, A. P. H. Wright, J.-A. Gustafsson, and T. Hard (2001)
J. Biol. Chem. 276, 45939-45944
   Abstract »    Full Text »    PDF »
Mapping the Sequences That Mediate Interaction of the Equine Herpesvirus 1 Immediate-Early Protein and Human TFIIB.
H. K. Jang, R. A. Albrecht, K. A. Buczynski, S. K. Kim, W. A. Derbigny, and D. J. O'Callaghan (2001)
J. Virol. 75, 10219-10230
   Abstract »    Full Text »    PDF »
Identification of Acidic and Aromatic Residues in the Zta Activation Domain Essential for Epstein-Barr Virus Reactivation.
Z. Deng, C.-J. Chen, D. Zerby, H.-J. Delecluse, and P. M. Lieberman (2001)
J. Virol. 75, 10334-10347
   Abstract »    Full Text »    PDF »
How Transcriptional Activators Bind Target Proteins.
S. Hermann, K. D. Berndt, and A. P. Wright (2001)
J. Biol. Chem. 276, 40127-40132
   Abstract »    Full Text »    PDF »
Ligand-Dependent Degradation of Retinoid X Receptors Does Not Require Transcriptional Activity or Coactivator Interactions.
D. L. Osburn, G. Shao, H. M. Seidel, and I. G. Schulman (2001)
Mol. Cell. Biol. 21, 4909-4918
   Abstract »    Full Text »    PDF »
Dual Roles of RNA Helicase A in CREB-Dependent Transcription.
S. Aratani, R. Fujii, T. Oishi, H. Fujita, T. Amano, T. Ohshima, M. Hagiwara, A. Fukamizu, and T. Nakajima (2001)
Mol. Cell. Biol. 21, 4460-4469
   Abstract »    Full Text »    PDF »
Recruitment of HAT Complexes by Direct Activator Interactions with the ATM-Related Tra1 Subunit.
C. E. Brown, L. Howe, K. Sousa, S. C. Alley, M. J. Carrozza, S. Tan, and J. L. Workman (2001)
Science 292, 2333-2337
   Abstract »    Full Text »    PDF »
Recruitment of the transcriptional machinery through GAL11P: structure and interactions of the GAL4 dimerization domain.
P. Hidalgo, A. Z. Ansari, P. Schmidt, B. Hare, N. Simkovich, S. Farrell, E. J. Shin, M. Ptashne, and G. Wagner (2001)
Genes & Dev. 15, 1007-1020
   Abstract »    Full Text »
Function of N-Terminal Transactivation Domain of the Estrogen Receptor Requires a Potential {alpha}-Helical Structure and Is Negatively Regulated by the A Domain.
R. Métivier, F. G. Petit, Y. Valotaire, and F. Pakdel (2000)
Mol. Endocrinol. 14, 1849-1871
   Abstract »    Full Text »
REPRESSION OF SHOOT GROWTH, a bZIP Transcriptional Activator, Regulates Cell Elongation by Controlling the Level of Gibberellins.
J. Fukazawa, T. Sakai, S. Ishida, I. Yamaguchi, Y. Kamiya, and Y. Takahashi (2000)
PLANT CELL 12, 901-915
   Abstract »    Full Text »
Divergent hTAFII31-binding Motifs Hidden in Activation Domains.
Y. Choi, S. Asada, and M. Uesugi (2000)
J. Biol. Chem. 275, 15912-15916
   Abstract »    Full Text »    PDF »
Stimulus-specific Interaction between Activator-Coactivator Cognates Revealed with a Novel Complex-specific Antiserum.
B. L. Wagner, A. Bauer, G. Schutz, and M. Montminy (2000)
J. Biol. Chem. 275, 8263-8266
   Abstract »    Full Text »    PDF »
The MSG1 Non-DNA-binding Transactivator Binds to the p300/CBP Coactivators, Enhancing Their Functional Link to the Smad Transcription Factors.
T. Yahata, M. P. de Caestecker, R. J. Lechleider, S. Andriole, A. B. Roberts, K. J. Isselbacher, and T. Shioda (2000)
J. Biol. Chem. 275, 8825-8834
   Abstract »    Full Text »    PDF »
The N-terminal Region of the Human Progesterone A-receptor. STRUCTURAL ANALYSIS AND THE INFLUENCE OF THE DNA BINDING DOMAIN.
D. L. Bain, M. A. Franden, J. L. McManaman, G. S. Takimoto, and K. B. Horwitz (2000)
J. Biol. Chem. 275, 7313-7320
   Abstract »    Full Text »    PDF »
The Role of AHA Motifs in the Activator Function of Tomato Heat Stress Transcription Factors HsfA1 and HsfA2.
P. Döring, E. Treuter, C. Kistner, R. Lyck, A. Chen, and L. Nover (2000)
PLANT CELL 12, 265-278
   Abstract »    Full Text »
The alpha -helical FXXPhi Phi motif in p53: TAF interaction and discrimination by MDM2.
M. Uesugi and G. L. Verdine (1999)
PNAS 96, 14801-14806
   Abstract »    Full Text »    PDF »
Further Biochemical and Kinetic Characterization of Human Eukaryotic Initiation Factor 4H.
N. J. Richter, G. W. Rogers Jr., J. O. Hensold, and W. C. Merrick (1999)
J. Biol. Chem. 274, 35415-35424
   Abstract »    Full Text »    PDF »
Characterization of the Amino-terminal Activation Domain of Peroxisome Proliferator-activated Receptor alpha . IMPORTANCE OF alpha -HELICAL STRUCTURE IN THE TRANSACTIVATING FUNCTION.
R. Hi, S. Osada, N. Yumoto, and T. Osumi (1999)
J. Biol. Chem. 274, 35152-35158
   Abstract »    Full Text »    PDF »
A general strategy to enhance the potency of chimeric transcriptional activators.
S. Natesan, E. Molinari, V. M. Rivera, R. J. Rickles, and M. Gilman (1999)
PNAS 96, 13898-13903
   Abstract »    Full Text »    PDF »
Genetic Dissection of hTAFII130 Defines a Hydrophobic Surface Required for Interaction with Glutamine-rich Activators.
E. Rojo-Niersbach, T. Furukawa, and N. Tanese (1999)
J. Biol. Chem. 274, 33778-33784
   Abstract »    Full Text »    PDF »
A 13-Amino Acid Amphipathic alpha -Helix Is Required for the Functional Interaction between the Transcriptional Repressor Mad1 and mSin3A.
A. L. Eilers, A. N. Billin, J. Liu, and D. E. Ayer (1999)
J. Biol. Chem. 274, 32750-32756
   Abstract »    Full Text »    PDF »
The C Terminus of AvrXa10 Can Be Replaced by the Transcriptional Activation Domain of VP16 from the Herpes Simplex Virus.
W. Zhu, B. Yang, N. Wills, L. B. Johnson, and F. F. White (1999)
PLANT CELL 11, 1665-1674
   Abstract »    Full Text »
Crystal structure of the conserved core of the herpes simplex virus transcriptional regulatory protein VP16.
Y. Liu, W. Gong, C. C. Huang, W. Herr, and X. Cheng (1999)
Genes & Dev. 13, 1692-1703
   Abstract »    Full Text »
Crystal Structure of the Human Papillomavirus Type 18 E2 Activation Domain.
S. F. Harris and M. R. Botchan (1999)
Science 284, 1673-1677
   Abstract »    Full Text »
Inhibition of hTAFII32-binding Implicated in the Transcriptional Repression by Central Regions of Mutant p53 Proteins.
S.-F. Tung, J.-Y. Chuang, C.-T. Lin, M.-Y. Lai, C.-W. Wu, and Y.-S. Lin (1999)
J. Biol. Chem. 274, 7748-7755
   Abstract »    Full Text »    PDF »
Mutation analysis of the Pip interaction domain reveals critical residues for protein-protein interactions.
M. A. Ortiz, J. Light, R. A. Maki, and N. Assa-Munt (1999)
PNAS 96, 2740-2745
   Abstract »    Full Text »    PDF »
Characterization of a p53-related Activation Domain in Adr1p That Is Sufficient for ADR1-dependent Gene Expression.
E. T. Young, J. Saario, N. Kacherovsky, A. Chao, J. S. Sloan, and K. M. Dombek (1998)
J. Biol. Chem. 273, 32080-32087
   Abstract »    Full Text »    PDF »
The orientation of the AP-1 heterodimer on DNA strongly affects transcriptional potency.
M. Chytil, B. R. Peterson, D. A. Erlanson, and G. L. Verdine (1998)
PNAS 95, 14076-14081
   Abstract »    Full Text »    PDF »
A transcriptional activating region with two contrasting modes of protein interaction.
A. Z. Ansari, R. J. Reece, and M. Ptashne (1998)
PNAS 95, 13543-13548
   Abstract »    Full Text »    PDF »
Critical Structural Elements and Multitarget Protein Interactions of the Transcriptional Activator AF-1 of Hepatocyte Nuclear Factor 4.
V. J. Green, E. Kokkotou, and J. A. A. Ladias (1998)
J. Biol. Chem. 273, 29950-29957
   Abstract »    Full Text »    PDF »
Structure and specificity of nuclear receptor-coactivator interactions.
B. D. Darimont, R. L. Wagner, J. W. Apriletti, M. R. Stallcup, P. J. Kushner, J. D. Baxter, R. J. Fletterick, and K. R. Yamamoto (1998)
Genes & Dev. 12, 3343-3356
   Abstract »    Full Text »
Requirements for Chromatin Modulation and Transcription Activation by the Pho4 Acidic Activation Domain.
P. C. McAndrew, J. Svaren, S. R. Martin, W. Horz, and C. R. Goding (1998)
Mol. Cell. Biol. 18, 5818-5827
   Abstract »    Full Text »    PDF »
DA-Complex Assembly Activity Required for VP16C Transcriptional Activation.
N. Kobayashi, P. J. Horn, S. M. Sullivan, S. J. Triezenberg, T. G. Boyer, and A. J. Berk (1998)
Mol. Cell. Biol. 18, 4023-4031
   Abstract »    Full Text »    PDF »
Two Distinct Domains in Staf To Selectively Activate Small Nuclear RNA-Type and mRNA Promoters.
C. Schuster, A. Krol, and P. Carbon (1998)
Mol. Cell. Biol. 18, 2650-2658
   Abstract »    Full Text »    PDF »
Activation of Chromosomal DNA Replication in Saccharomyces cerevisiae by Acidic Transcriptional Activation Domains.
R. Li, D. S. Yu, M. Tanaka, L. Zheng, S. L. Berger, and B. Stillman (1998)
Mol. Cell. Biol. 18, 1296-1302
   Abstract »    Full Text »    PDF »
GLI Activates Transcription through a Herpes Simplex Viral Protein 16-Like Activation Domain.
J. W. Yoon, C. Z. Liu, J. T. Yang, R. Swart, P. Iannaccone, and D. Walterhouse (1998)
J. Biol. Chem. 273, 3496-3501
   Abstract »    Full Text »    PDF »
Activation and Repression Mechanisms in Yeast.
K. STRUHL, D. KADOSH, M. KEAVENEY, L. KURAS, and Z. MOQTADERI (1998)
Cold Spring Harb Symp Quant Biol 63, 413-422
   Abstract »    PDF »
Building Transcriptional Regulatory Complexes: Signals and Surfaces.
K.R. YAMAMOTO, B.D. DARIMONT, R.L. WAGNER, and J.A. INIGUEZ-LLUHI (1998)
Cold Spring Harb Symp Quant Biol 63, 587-598
   Abstract »    PDF »
Autoinhibition as a Transcriptional Regulatory Mechanism.
B.J. GRAVES, D.O. COWLEY, T.L. GOETZ, J.M. PETERSEN, M.D. JONSEN, and M.E. GILLESPIE (1998)
Cold Spring Harb Symp Quant Biol 63, 621-630
   Abstract »    PDF »
Transcriptional activation: Is it rocket science?.
R. Pollock and M. Gilman (1997)
PNAS 94, 13388-13389
   Full Text »    PDF »
A nonnatural transcriptional coactivator.
O. Nyanguile, M. Uesugi, D. J. Austin, and G. L. Verdine (1997)
PNAS 94, 13402-13406
   Abstract »    Full Text »    PDF »
Insulin Responsiveness of the Glucagon Gene Conferred by Interactions between Proximal Promoter and More Distal Enhancer-like Elements Involving the Paired-domain Transcription Factor Pax6.
R. Grzeskowiak, J. Amin, E. Oetjen, and W. Knepel (2000)
J. Biol. Chem. 275, 30037-30045
   Abstract »    Full Text »    PDF »
Architectural Principles for the Structure and Function of the Glucocorticoid Receptor tau 1 Core Activation Domain.
A. Warnmark, J.-A. Gustafsson, and A. P. H. Wright (2000)
J. Biol. Chem. 275, 15014-15018
   Abstract »    Full Text »    PDF »
Local Structural Elements in the Mostly Unstructured Transcriptional Activation Domain of Human p53.
H. Lee, K. H. Mok, R. Muhandiram, K.-H. Park, J.-E. Suk, D.-H. Kim, J. Chang, Y. C. Sung, K. Y. Choi, and K.-H. Han (2000)
J. Biol. Chem. 275, 29426-29432
   Abstract »    Full Text »    PDF »
Autologous Biological Response Modification of the Gonadotropin Receptor.
S. D. Mahale, J. Cavanagh, A. Schmidt, R. MacColl, and J. A. Dias (2001)
J. Biol. Chem. 276, 12410-12419
   Abstract »    Full Text »    PDF »
The N-terminal Region of Human Progesterone B-receptors. BIOPHYSICAL AND BIOCHEMICAL COMPARISON TO A-RECEPTORS.
D. L. Bain, M. A. Franden, J. L. McManaman, G. S. Takimoto, and K. B. Horwitz (2001)
J. Biol. Chem. 276, 23825-23831
   Abstract »    Full Text »    PDF »
Dioxin-inducible Transactivation in a Chromosomal Setting. ANALYSIS OF THE ACIDIC DOMAIN OF THE Ah RECEPTOR.
L. C. Jones and J. P. Whitlock Jr. (2001)
J. Biol. Chem. 276, 25037-25042
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)