Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 1 August 1997:
Vol. 277. no. 5326, pp. 693 - 696
DOI: 10.1126/science.277.5326.693
Prev | Table of Contents | Next

Reports

A Cytoplasmic Inhibitor of the JNK Signal Transduction Pathway

Martin Dickens, Jeffrey S. Rogers, Julie Cavanagh, Art Raitano, Zhengui Xia, Jocelyn R. Halpern, Michael E. Greenberg, Charles L. Sawyers, Roger J. Davis *

The c-Jun amino-terminal kinase (JNK) is a member of the stress-activated group of mitogen-activated protein (MAP) kinases that are implicated in the control of cell growth. A murine cytoplasmic protein that binds specifically to JNK [the JNK interacting protein-1 (JIP-1)] was characterized and cloned. JIP-1 caused cytoplasmic retention of JNK and inhibition of JNK-regulated gene expression. In addition, JIP-1 suppressed the effects of the JNK signaling pathway on cellular proliferation, including transformation by the Bcr-Abl oncogene. This analysis identifies JIP-1 as a specific inhibitor of the JNK signal transduction pathway and establishes protein targeting as a mechanism that regulates signaling by stress-activated MAP kinases.

M. Dickens, J. S. Rogers, J. Cavanagh, R. J. Davis, Howard Hughes Medical Institute and Program in Molecular Medicine, Department of Biochemistry and Molecular Biology, University of Massachusetts Medical School, 373 Plantation Street, Worcester, MA 01605, USA.
A. Raitano, J. R. Halpern, C. L. Sawyers, Department of Medicine, University of California School of Medicine, Los Angeles, CA 90095, USA.
Z. Xia and M. E. Greenberg, Division of Neuroscience, Department of Neurology, Children's Hospital, and Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.
*   To whom correspondence should be addressed.

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Identification of a Novel Amino Acid Response Pathway Triggering ATF2 Phosphorylation in Mammals.
C. Chaveroux, C. Jousse, Y. Cherasse, A.-C. Maurin, L. Parry, V. Carraro, B. Derijard, A. Bruhat, and P. Fafournoux (2009)
Mol. Cell. Biol. 29, 6515-6526
   Abstract »    Full Text »    PDF »
A Major Effect of Simulated Microgravity on Several Stages of Preimplantation Mouse Development is Lethality Associated With Elevated Phosphorylated SAPK/JNK.
Y. Wang, Y. Xie, D. Wygle, H. H. Shen, E. E. Puscheck, and D. A. Rappolee (2009)
Reproductive Sciences 16, 947-959
   Abstract »    PDF »
Signal Transduction Cross Talk Mediated by Jun N-Terminal Kinase-Interacting Protein and Insulin Receptor Substrate Scaffold Protein Complexes.
C. L. Standen, N. J. Kennedy, R. A. Flavell, and R. J. Davis (2009)
Mol. Cell. Biol. 29, 4831-4840
   Abstract »    Full Text »    PDF »
MAPK signaling pathways in the regulation of hematopoiesis.
C. R. Geest and P. J. Coffer (2009)
J. Leukoc. Biol. 86, 237-250
   Abstract »    Full Text »    PDF »
Phosphorylated Tau Interacts with c-Jun N-terminal Kinase-interacting Protein 1 (JIP1) in Alzheimer Disease.
L. M. Ittner, Y. D. Ke, and J. Gotz (2009)
J. Biol. Chem. 284, 20909-20916
   Abstract »    Full Text »    PDF »
Expression of JNK-interacting Protein JIP-1 and Insulin-like Growth Factor II in Wilms Tumour Cell Lines and Primary Wilms Tumours.
W. ENGSTROM and M. GRANERUS (2009)
Anticancer Res 29, 2467-2472
   Abstract »    Full Text »    PDF »
Soluble Epoxide Inhibition Is Protective Against Cerebral Ischemia via Vascular and Neural Protection.
A. N. Simpkins, R. D. Rudic, D. A. Schreihofer, S. Roy, M. Manhiani, H.-J. Tsai, B. D. Hammock, and J. D. Imig (2009)
Am. J. Pathol. 174, 2086-2095
   Abstract »    Full Text »    PDF »
Regulation of leukemic cell differentiation and retinoid-induced gene expression by statins.
A. Sassano, M. Lo Iacono, G. Antico, A. Jordan, S. Uddin, R. A. Calogero, and L. C. Platanias (2009)
Mol. Cancer Ther. 8, 615-625
   Abstract »    Full Text »    PDF »
Growth Factor Signals in Neural Cells: COHERENT PATTERNS OF INTERACTION CONTROL MULTIPLE LEVELS OF MOLECULAR AND PHENOTYPIC RESPONSES.
B. Martin, R. Brenneman, E. Golden, T. Walent, K. G. Becker, V. V. Prabhu, W. Wood III, B. Ladenheim, J.-L. Cadet, and S. Maudsley (2009)
J. Biol. Chem. 284, 2493-2511
   Abstract »    Full Text »    PDF »
Regulation of Amyloid {beta}-Protein Precursor by Phosphorylation and Protein Interactions.
T. Suzuki and T. Nakaya (2008)
J. Biol. Chem. 283, 29633-29637
   Abstract »    Full Text »    PDF »
Identification of a new JNK inhibitor targeting the JNK-JIP interaction site.
J. L. Stebbins, S. K. De, T. Machleidt, B. Becattini, J. Vazquez, C. Kuntzen, L.-H. Chen, J. F. Cellitti, M. Riel-Mehan, A. Emdadi, et al. (2008)
PNAS 105, 16809-16813
   Abstract »    Full Text »    PDF »
c-Jun NH2-Terminal Kinase 1 Is a Critical Regulator for the Development of Gastric Cancer in Mice.
W. Shibata, S. Maeda, Y. Hikiba, A. Yanai, K. Sakamoto, H. Nakagawa, K. Ogura, M. Karin, and M. Omata (2008)
Cancer Res. 68, 5031-5039
   Abstract »    Full Text »    PDF »
RACK1 and CIS Mediate the Degradation of BimEL in Cancer Cells.
W. Zhang, G. Z. Cheng, J. Gong, U. Hermanto, C. S. Zong, J. Chan, J. Q. Cheng, and L.-H. Wang (2008)
J. Biol. Chem. 283, 16416-16426
   Abstract »    Full Text »    PDF »
Exendin-4 Protects {beta}-Cells From Interleukin-1{beta}-Induced Apoptosis by Interfering With the c-Jun NH2-Terminal Kinase Pathway.
M. Ferdaoussi, S. Abdelli, J.-Y. Yang, M. Cornu, G. Niederhauser, D. Favre, C. Widmann, R. Regazzi, B. Thorens, G. Waeber, et al. (2008)
Diabetes 57, 1205-1215
   Abstract »    Full Text »    PDF »
Endophilin I Expression Is Increased in the Brains of Alzheimer Disease Patients.
Y. Ren, H. W. Xu, F. Davey, M. Taylor, J. Aiton, P. Coote, F. Fang, J. Yao, D. Chen, J. X. Chen, et al. (2008)
J. Biol. Chem. 283, 5685-5691
   Abstract »    Full Text »    PDF »
3', 5'-Cyclic Adenosine 5'-Monophosphate Response Element-Dependent Transcriptional Regulation of the Secretogranin II Gene Promoter Depends on Gonadotropin-Releasing Hormone-Induced Mitogen-Activated Protein Kinase Activation and the Transactivator Activating Transcription Factor 3.
J. Xie and M. S. Roberson (2008)
Endocrinology 149, 783-792
   Abstract »    Full Text »    PDF »
Requirement of JIP scaffold proteins for NMDA-mediated signal transduction.
N. J. Kennedy, G. Martin, A. G. Ehrhardt, J. Cavanagh-Kyros, C.-Y. Kuan, P. Rakic, R. A. Flavell, S. N. Treistman, and R. J. Davis (2007)
Genes & Dev. 21, 2336-2346
   Abstract »    Full Text »    PDF »
Guggulsterone-Induced Apoptosis in Human Prostate Cancer Cells Is Caused by Reactive Oxygen Intermediate Dependent Activation of c-Jun NH2-Terminal Kinase.
S. V. Singh, S. Choi, Y. Zeng, E.-R. Hahm, and D. Xiao (2007)
Cancer Res. 67, 7439-7449
   Abstract »    Full Text »    PDF »
T-Lymphokine-Activated Killer Cell-Originated Protein Kinase Functions as a Positive Regulator of c-Jun-NH2-Kinase 1 Signaling and H-Ras-Induced Cell Transformation.
S.-M. Oh, F. Zhu, Y.-Y. Cho, K. W. Lee, B. S. Kang, H.-G. Kim, T. Zykova, A. M. Bode, and Z. Dong (2007)
Cancer Res. 67, 5186-5194
   Abstract »    Full Text »    PDF »
Src Family Kinases Directly Regulate JIP1 Module Dynamics and Activation.
D. Nihalani, H. Wong, R. Verma, and L. B. Holzman (2007)
Mol. Cell. Biol. 27, 2431-2441
   Abstract »    Full Text »    PDF »
Helix-Loop-Helix Protein p8, a Transcriptional Regulator Required for Cardiomyocyte Hypertrophy and Cardiac Fibroblast Matrix Metalloprotease Induction.
S. Goruppi, R. D. Patten, T. Force, and J. M. Kyriakis (2007)
Mol. Cell. Biol. 27, 993-1006
   Abstract »    Full Text »    PDF »
Peptides Targeting Protein Kinases: Strategies and Implications..
O. Kaidanovich-Beilin and H. Eldar-Finkelman (2006)
Physiology 21, 411-418
   Abstract »    Full Text »    PDF »
Uses for JNK: the Many and Varied Substrates of the c-Jun N-Terminal Kinases.
M. A. Bogoyevitch and B. Kobe (2006)
Microbiol. Mol. Biol. Rev. 70, 1061-1095
   Abstract »    Full Text »    PDF »
Activated c-Jun N-Terminal Kinase Is Required for Axon Formation..
A. A. Oliva Jr, C. M. Atkins, L. Copenagle, and G. A. Banker (2006)
J. Neurosci. 26, 9462-9470
   Abstract »    Full Text »    PDF »
c-Jun N-terminal kinase-dependent mechanisms in respiratory disease..
B. L. Bennett (2006)
Eur. Respir. J. 28, 651-661
   Abstract »    Full Text »    PDF »
Growth suppression of human mast cells expressing constitutively active c-kit receptors by JNK inhibitor SP600125..
B. Wang, J. Tsukada, T. Higashi, T. Mizobe, A. Matsuura, F. Mouri, N. Sawamukai, C. Ra, and Y. Tanaka (2006)
Genes Cells 11, 983-992
   Abstract »    Full Text »    PDF »
Direct Interaction of the Molecular Scaffolds POSH and JIP Is Required for Apoptotic Activation of JNKs.
N. V. Kukekov, Z. Xu, and L. A. Greene (2006)
J. Biol. Chem. 281, 15517-15524
   Abstract »    Full Text »    PDF »
Insulin Vesicle Release: Walk, Kiss, Pause ... Then Run.
G. A. Rutter and E. V. Hill (2006)
Physiology 21, 189-196
   Abstract »    Full Text »    PDF »
JNK1 phosphorylation of SCG10 determines microtubule dynamics and axodendritic length.
T. Tararuk, N. Ostman, W. Li, B. Bjorkblom, A. Padzik, J. Zdrojewska, V. Hongisto, T. Herdegen, W. Konopka, M. J. Courtney, et al. (2006)
J. Cell Biol. 173, 265-277
   Abstract »    Full Text »    PDF »
Activation of the E3 ubiquitin ligase Itch through a phosphorylation-induced conformational change.
E. Gallagher, M. Gao, Y.-C. Liu, and M. Karin (2006)
PNAS 103, 1717-1722
   Abstract »    Full Text »    PDF »
A role for Ets1, synergizing with AP-1 and GATA-3 in the regulation of IL-5 transcription in mouse Th2 lymphocytes.
J. Wang, M. F. Shannon, and I. G. Young (2006)
Int. Immunol. 18, 313-323
   Abstract »    Full Text »    PDF »
Hyperphosphorylation of JNK-interacting Protein 1, a Protein Associated with Alzheimer Disease.
C. D'Ambrosio, S. Arena, G. Fulcoli, M. H. Scheinfeld, D. Zhou, L. D'Adamio, and A. Scaloni (2006)
Mol. Cell. Proteomics 5, 97-113
   Abstract »    Full Text »    PDF »
Notch interferes with the scaffold function of JNK-interacting protein 1 to inhibit the JNK signaling pathway.
J. W. Kim, M. J. Kim, K. J. Kim, H. J. Yun, J. S. Chae, S. G. Hwang, T.-S. Chang, H.-S. Park, K.-W. Lee, P.-L. Han, et al. (2005)
PNAS 102, 14308-14313
   Abstract »    Full Text »    PDF »
Increased JNK Phosphorylation and Oxidative Stress in Response to Increased Glucose Flux through Increased GLUT1 Expression in Rat Retinal Endothelial Cells.
J. Zhou, B. K. Deo, K. Hosoya, T. Terasaki, I. G. Obrosova, F. C. Brosius III, and A. K. Kumagai (2005)
Invest. Ophthalmol. Vis. Sci. 46, 3403-3410
   Abstract »    Full Text »    PDF »
Puckered, a Drosophila MAPK phosphatase, ensures cell viability by antagonizing JNK-induced apoptosis.
D. G. McEwen and M. Peifer (2005)
Development 132, 3935-3946
   Abstract »    Full Text »    PDF »
Calcium-activated RAF/MEK/ERK Signaling Pathway Mediates p53-dependent Apoptosis and Is Abrogated by {alpha}B-Crystallin through Inhibition of RAS Activation.
D. W.-C. Li, J.-P. Liu, Y.-W. Mao, H. Xiang, J. Wang, W.-Y. Ma, Z. Dong, H. M. Pike, R. E. Brown, and J. C. Reed (2005)
Mol. Biol. Cell 16, 4437-4453
   Abstract »    Full Text »    PDF »
Cross-talk between JIP3 and JIP1 during Glucose Deprivation: SEK1-JNK2 AND Akt1 ACT AS MEDIATORS.
J. J. Song and Y. J. Lee (2005)
J. Biol. Chem. 280, 26845-26855
   Abstract »    Full Text »    PDF »
JNK antagonizes Akt-mediated survival signals by phosphorylating 14-3-3.
J. Sunayama, F. Tsuruta, N. Masuyama, and Y. Gotoh (2005)
J. Cell Biol. 170, 295-304
   Abstract »    Full Text »    PDF »
Constitutively Active Cytoplasmic c-Jun N-Terminal Kinase 1 Is a Dominant Regulator of Dendritic Architecture: Role of Microtubule-Associated Protein 2 as an Effector.
B. Bjorkblom, N. Ostman, V. Hongisto, V. Komarovski, J.-J. Filen, T. A. Nyman, T. Kallunki, M. J. Courtney, and E. T. Coffey (2005)
J. Neurosci. 25, 6350-6361
   Abstract »    Full Text »    PDF »
Dissociation of Akt1 from its negative regulator JIP1 is mediated through the ASK1-MEK-JNK signal transduction pathway during metabolic oxidative stress: a negative feedback loop.
J. J. Song and Y. J. Lee (2005)
J. Cell Biol. 170, 61-72
   Abstract »    Full Text »    PDF »
Prolactin and Estrogen Enhance the Activity of Activating Protein 1 in Breast Cancer Cells: Role of Extracellularly Regulated Kinase 1/2-Mediated Signals to c-fos.
J. H. Gutzman, S. E. Nikolai, D. E. Rugowski, J. J. Watters, and L. A. Schuler (2005)
Mol. Endocrinol. 19, 1765-1778
   Abstract »    Full Text »    PDF »
Ubiquitin Chains in the Ladder of MAPK Signaling.
A. Laine and Z. Ronai (2005)
Sci. STKE 2005, re5
   Abstract »    Full Text »    PDF »
Role of the JIP4 Scaffold Protein in the Regulation of Mitogen-Activated Protein Kinase Signaling Pathways.
N. Kelkar, C. L. Standen, and R. J. Davis (2005)
Mol. Cell. Biol. 25, 2733-2743
   Abstract »    Full Text »    PDF »
Antitumorigenic Effect of Proteasome Inhibitors on Insulinoma Cells.
J. Storling, N. Allaman-Pillet, A. E. Karlsen, N. Billestrup, C. Bonny, and T. Mandrup-Poulsen (2005)
Endocrinology 146, 1718-1726
   Abstract »    Full Text »    PDF »
Identification of a Specific Domain Responsible for JNK2{alpha}2 Autophosphorylation.
J. Cui, M. Holgado-Madruga, W. Su, H. Tsuiki, P. Wedegaertner, and A. J. Wong (2005)
J. Biol. Chem. 280, 9913-9920
   Abstract »    Full Text »    PDF »
The Function of Mitogen-activated Protein Kinase Phosphatase-1 in Peptidoglycan-stimulated Macrophages.
E. G. Shepherd, Q. Zhao, S. E. Welty, T. N. Hansen, C. V. Smith, and Y. Liu (2004)
J. Biol. Chem. 279, 54023-54031
   Abstract »    Full Text »    PDF »
Sustained Activation of p38 Mitogen-Activated Protein Kinase and c-Jun N-Terminal Kinase Pathways by Hepatitis B Virus X Protein Mediates Apoptosis via Induction of Fas/FasL and Tumor Necrosis Factor (TNF) Receptor 1/TNF-{alpha} Expression.
W.-H. Wang, G. Gregori, R. L. Hullinger, and O. M. Andrisani (2004)
Mol. Cell. Biol. 24, 10352-10365
   Abstract »    Full Text »    PDF »
Multiple Kinase Cascades Mediate Prolactin Signals to Activating Protein-1 in Breast Cancer Cells.
J. H. Gutzman, D. E. Rugowski, M. D. Schroeder, J. J. Watters, and L. A. Schuler (2004)
Mol. Endocrinol. 18, 3064-3075
   Abstract »    Full Text »    PDF »
Thyrotropin-Releasing Hormone-Stimulated Thyrotropin Expression Involves Islet-Brain-1/c-Jun N-Terminal Kinase Interacting Protein-1.
H. Abe, K. Murao, H. Imachi, W. M. Cao, X. Yu, K. Yoshida, N. C. W. Wong, M. A. Shupnik, J.-A. Haefliger, G. Waeber, et al. (2004)
Endocrinology 145, 5623-5628
   Abstract »    Full Text »    PDF »
Reverse Two-hybrid Screening Identifies Residues of JNK Required for Interaction with the Kinase Interaction Motif of JNK-interacting Protein-1.
R. K. Barr, R. M. Hopkins, P. M. Watt, and M. A. Bogoyevitch (2004)
J. Biol. Chem. 279, 43178-43189
   Abstract »    Full Text »    PDF »
The ALX Src Homology 2 Domain Is Both Necessary and Sufficient to Inhibit T Cell receptor/CD28-mediated Up-regulation of RE/AP.
M. J. Shapiro, P. Powell, A. Ndubuizu, C. Nzerem, and V. S. Shapiro (2004)
J. Biol. Chem. 279, 40647-40652
   Abstract »    Full Text »    PDF »
The Critical Features and the Mechanism of Inhibition of a Kinase Interaction Motif-based Peptide Inhibitor of JNK.
R. K. Barr, I. Boehm, P. V. Attwood, P. M. Watt, and M. A. Bogoyevitch (2004)
J. Biol. Chem. 279, 36327-36338
   Abstract »    Full Text »    PDF »
An essential role of the JIP1 scaffold protein for JNK activation in adipose tissue.
A. Jaeschke, M. P. Czech, and R. J. Davis (2004)
Genes & Dev. 18, 1976-1980
   Abstract »    Full Text »    PDF »
Kinase Suppressor of Ras Couples Ras to the ERK Cascade during T Cell Development.
M. N. Laurent, D. M. Ramirez, and J. Alberola-Ila (2004)
J. Immunol. 173, 986-992
   Abstract »    Full Text »    PDF »
Epstein-Barr Virus Latent Membrane Protein 1 Induces Synthesis of Hypoxia-Inducible Factor 1{alpha}.
N. Wakisaka, S. Kondo, T. Yoshizaki, S. Murono, M. Furukawa, and J. S. Pagano (2004)
Mol. Cell. Biol. 24, 5223-5234
   Abstract »    Full Text »    PDF »
Reversible Regulation of the Transformed Phenotype of Ornithine Decarboxylase- and Ras-Overexpressing Cells by Dominant-Negative Mutants of c-Jun.
M. Kielosto, P. Nummela, R. Katainen, V. Leaner, M. J. Birrer, and E. Holtta (2004)
Cancer Res. 64, 3772-3779
   Abstract »    Full Text »    PDF »
Scaffold Proteins in Mammalian MAP Kinase Cascades.
K. Yoshioka (2004)
J. Biochem. 135, 657-661
   Abstract »    Full Text »    PDF »
The Molecular Scaffold KSR1 Regulates the Proliferative and Oncogenic Potential of Cells.
R. L. Kortum and R. E. Lewis (2004)
Mol. Cell. Biol. 24, 4407-4416
   Abstract »    Full Text »    PDF »
Modular construction of a signaling scaffold: MORG1 interacts with components of the ERK cascade and links ERK signaling to specific agonists.
T. Vomastek, H.-J. Schaeffer, A. Tarcsafalvi, M. E. Smolkin, E. A. Bissonette, and M. J. Weber (2004)
PNAS 101, 6981-6986
   Abstract »    Full Text »    PDF »
p38 MAPK-induced Nuclear Factor-{kappa}B Activity Is Required for Skeletal Muscle Differentiation: Role of Interleukin-6.
B. Baeza-Raja and P. Munoz-Canoves (2004)
Mol. Biol. Cell 15, 2013-2026
   Abstract »    Full Text »    PDF »
Docking Interactions in the c-Jun N-terminal Kinase Pathway.
L. M. Mooney and A. J. Whitmarsh (2004)
J. Biol. Chem. 279, 11843-11852
   Abstract »    Full Text »    PDF »
A phosphorylated, carboxy-terminal fragment of {beta}-amyloid precursor protein localizes to the splicing factor compartment.
Z. Muresan and V. Muresan (2004)
Hum. Mol. Genet. 13, 475-488
   Abstract »    Full Text »    PDF »
Inhibition of c-Jun NH2-Terminal Kinase Activity Improves Ischemia/Reperfusion Injury in Rat Lungs.
M. Ishii, Y. Suzuki, K. Takeshita, N. Miyao, H. Kudo, R. Hiraoka, K. Nishio, N. Sato, K. Naoki, T. Aoki, et al. (2004)
J. Immunol. 172, 2569-2577
   Abstract »    Full Text »    PDF »
Krox-20 inhibits Jun-NH2-terminal kinase/c-Jun to control Schwann cell proliferation and death.
D. B. Parkinson, A. Bhaskaran, A. Droggiti, S. Dickinson, M. D'Antonio, R. Mirsky, and K. R. Jessen (2004)
J. Cell Biol. 164, 385-394
   Abstract »    Full Text »    PDF »
Gene Profiling of Frizzled-1 and Frizzled-2 Signaling: Expression of G-Protein-Coupled Receptor Chimeras in Mouse F9 Teratocarcinoma Embryonal Cells.
H. Li, C. C. Malbon, and H.-Y. Wang (2004)
Mol. Pharmacol. 65, 45-55
   Abstract »    Full Text »    PDF »
The c-Jun N-terminal Kinase 1 Activity Is Differentially Regulated by Specific Mechanisms during Apoptosis.
Y.-M. Ham, J.-S. Choi, K.-H. Chun, S.-H. Joo, and S.-K. Lee (2003)
J. Biol. Chem. 278, 50330-50337
   Abstract »    Full Text »    PDF »
Calcium- and Proteasome-dependent Degradation of the JNK Scaffold Protein Islet-brain 1.
N. Allaman-Pillet, J. Storling, A. Oberson, R. Roduit, S. Negri, C. Sauser, P. Nicod, J. S. Beckmann, D. F. Schorderet, T. Mandrup-Poulsen, et al. (2003)
J. Biol. Chem. 278, 48720-48726
   Abstract »    Full Text »    PDF »
Oxidative Stress Induces Nucleo-Cytoplasmic Translocation of Pancreatic Transcription Factor PDX-1 Through Activation of c-Jun NH2-terminal Kinase.
D. Kawamori, Y. Kajimoto, H. Kaneto, Y. Umayahara, Y. Fujitani, T. Miyatsuka, H. Watada, I. B. Leibiger, Y. Yamasaki, and M. Hori (2003)
Diabetes 52, 2896-2904
   Abstract »    Full Text »    PDF »
Thrombin Protease-activated Receptor-1 Signals through Gq- and G13-initiated MAPK Cascades Regulating c-Jun Expression to Induce Cell Transformation.
M. J. Marinissen, J.-M. Servitja, S. Offermanns, M. I. Simon, and J. S. Gutkind (2003)
J. Biol. Chem. 278, 46814-46825
   Abstract »    Full Text »    PDF »
Human homologue of Drosophila CNK interacts with Ras effector proteins Raf and Rlf.
T. M. LANIGAN, A. LIU, Y. Z. HUANG, L. MEI, B. MARGOLIS, and K.-L. GUAN (2003)
FASEB J 17, 2048-2060
   Abstract »    Full Text »    PDF »
Amyloid {beta} Protein Precursor Is Phosphorylated by JNK-1 Independent of, yet Facilitated by, JNK-Interacting Protein (JIP)-1.
M. H. Scheinfeld, E. Ghersi, P. Davies, and L. D'Adamio (2003)
J. Biol. Chem. 278, 42058-42063
   Abstract »    Full Text »    PDF »
Alleviating the Suppression of Glycogen Synthase Kinase-3{beta} by Akt Leads to the Phosphorylation of cAMP-response Element-binding Protein and Its Transactivation in Intact Cell Nuclei.
T. R. Salas, S. A. Reddy, J. L. Clifford, R. J. Davis, A. Kikuchi, S. M. Lippman, and D. G. Menter (2003)
J. Biol. Chem. 278, 41338-41346
   Abstract »    Full Text »    PDF »
Variations in IB1/JIP1 Expression Regulate Susceptibility of {beta}-Cells to Cytokine-Induced Apoptosis Irrespective of C-Jun NH2-Terminal Kinase Signaling.
Z. Ling, M. Van de Casteele, J. Dong, H. Heimberg, J.-A. Haefliger, G. Waeber, F. Schuit, and D. Pipeleers (2003)
Diabetes 52, 2497-2502
   Abstract »    Full Text »    PDF »
Inflammatory Cytokine Expression Is Independent of the c-Jun N-Terminal Kinase/AP-1 Signaling Cascade in Human Neutrophils.
A. Cloutier, T. Ear, O. Borissevitch, P. Larivee, and P. P. McDonald (2003)
J. Immunol. 171, 3751-3761
   Abstract »    Full Text »    PDF »
A Peptide Inhibitor of c-Jun N-Terminal Kinase Protects against Both Aminoglycoside and Acoustic Trauma-Induced Auditory Hair Cell Death and Hearing Loss.
J. Wang, T. R. Van De Water, C. Bonny, F. de Ribaupierre, J. L. Puel, and A. Zine (2003)
J. Neurosci. 23, 8596-8607
   Abstract »    Full Text »    PDF »
The Cytoplasmic Domain of Alzheimer's Amyloid-{beta} Protein Precursor Causes Sustained Apoptosis Signal-Regulating Kinase 1/c-Jun NH2-Terminal Kinase-Mediated Neurotoxic Signal via Dimerization.
Y. Hashimoto, T. Niikura, T. Chiba, E. Tsukamoto, H. Kadowaki, H. Nishitoh, Y. Yamagishi, M. Ishizaka, M. Yamada, M. Nawa, et al. (2003)
J. Pharmacol. Exp. Ther. 306, 889-902
   Abstract »    Full Text »    PDF »
A Docking Site in MKK4 Mediates High Affinity Binding to JNK MAPKs and Competes with Similar Docking Sites in JNK Substrates.
D. T. Ho, A. J. Bardwell, M. Abdollahi, and L. Bardwell (2003)
J. Biol. Chem. 278, 32662-32672
   Abstract »    Full Text »    PDF »
Involvement of nitric oxide in farnesyltransferase inhibitor-mediated apoptosis in chronic myeloid leukemia cells.
C. Selleri, J. P. Maciejewski, N. Montuori, P. Ricci, V. Visconte, B. Serio, L. Luciano, and B. Rotoli (2003)
Blood 102, 1490-1498
   Abstract »    Full Text »    PDF »
JNK-interacting Protein 1 Promotes Akt1 Activation.
A. H. Kim, T. Sasaki, and M. V. Chao (2003)
J. Biol. Chem. 278, 29830-29836
   Abstract »    Full Text »    PDF »
Tyrosine phosphorylation of the CrkII adaptor protein modulates cell migration.
T. Takino, M. Tamura, H. Miyamori, M. Araki, K. Matsumoto, H. Sato, and K. M. Yamada (2003)
J. Cell Sci. 116, 3145-3155
   Abstract »    Full Text »    PDF »
Expression of the Activating Transcription Factor 3 Prevents c-Jun N-Terminal Kinase-Induced Neuronal Death by Promoting Heat Shock Protein 27 Expression and Akt Activation.
S. Nakagomi, Y. Suzuki, K. Namikawa, S. Kiryu-Seo, and H. Kiyama (2003)
J. Neurosci. 23, 5187-5196
   Abstract »    Full Text »    PDF »
Map kinase signaling pathways and hematologic malignancies.
L. C. Platanias (2003)
Blood 101, 4667-4679
   Abstract »    Full Text »    PDF »
A Scaffold Protein JIP-1b Enhances Amyloid Precursor Protein Phosphorylation by JNK and Its Association with Kinesin Light Chain 1.
H. Inomata, Y. Nakamura, A. Hayakawa, H. Takata, T. Suzuki, K. Miyazawa, and N. Kitamura (2003)
J. Biol. Chem. 278, 22946-22955
   Abstract »    Full Text »    PDF »
The scaffold protein IB1/JIP-1 is a critical mediator of cytokine-induced apoptosis in pancreatic {beta} cells.
J.-A. Haefliger, T. Tawadros, L. Meylan, S. L. Gurun, M.-E. Roehrich, D. Martin, B. Thorens, and G. Waeber (2003)
J. Cell Sci. 116, 1463-1469
   Abstract »    Full Text »    PDF »
Activation of Raf-1 Signaling by Protein Kinase C through a Mechanism Involving Raf Kinase Inhibitory Protein.
K. C. Corbit, N. Trakul, E. M. Eves, B. Diaz, M. Marshall, and M. R. Rosner (2003)
J. Biol. Chem. 278, 13061-13068
   Abstract »    Full Text »    PDF »
The JNK-interacting Protein-1 Scaffold Protein Targets MAPK Phosphatase-7 to Dephosphorylate JNK.
E. A. Willoughby, G. R. Perkins, M. K. Collins, and A. J. Whitmarsh (2003)
J. Biol. Chem. 278, 10731-10736
   Abstract »    Full Text »    PDF »
JNK phosphorylation of Bim-related members of the Bcl2 family induces Bax-dependent apoptosis.
K. Lei and R. J. Davis (2003)
PNAS 100, 2432-2437
   Abstract »    Full Text »    PDF »
JNK-interacting protein-1 promotes transcription of Abeta protein precursor but not Abeta precursor-like proteins, mechanistically different than Fe65.
M. H. Scheinfeld, S. Matsuda, and L. D'Adamio (2003)
PNAS 100, 1729-1734
   Abstract »    Full Text »    PDF »
Modulation of Cellular Signaling Pathways: Prospects for Targeted Therapy in Hematological Malignancies.
F. Ravandi, M. Talpaz, and Z. Estrov (2003)
Clin. Cancer Res. 9, 535-550
   Abstract »    Full Text »    PDF »
A Single c-Jun N-terminal Kinase Isoform (JNK3-p54) Is an Effector in Both Neuronal Differentiation and Cell Death.
V. Waetzig and T. Herdegen (2003)
J. Biol. Chem. 278, 567-572
   Abstract »    Full Text »    PDF »
Cutting Edge: Induced Expression of a RhoA-Specific Guanine Nucleotide Exchange Factor, p190RhoGEF, Following CD40 Stimulation and WEHI 231 B Cell Activation.
J. R. Lee, Y. J. Ha, and H. J. Kim (2003)
J. Immunol. 170, 19-23
   Abstract »    Full Text »    PDF »
C-Jun NH2-terminal Kinase Mediates Proliferation and Tumor Growth of Human Prostate Carcinoma.
Y.-M. Yang, F. Bost, W. Charbono, N. Dean, R. McKay, J. S. Rhim, C. Depatie, and D. Mercola (2003)
Clin. Cancer Res. 9, 391-401
   Abstract »    Full Text »    PDF »
ATF1 Phosphorylation by the ERK MAPK Pathway Is Required for Epidermal Growth Factor-induced c-jun Expression.
P. Gupta and R. Prywes (2002)
J. Biol. Chem. 277, 50550-50556
   Abstract »    Full Text »    PDF »
The p65/RelA Subunit of NF-{kappa}B Suppresses the Sustained, Antiapoptotic Activity of Jun Kinase Induced by Tumor Necrosis Factor.
J. Y. Reuther-Madrid, D. Kashatus, S. Chen, X. Li, J. Westwick, R. J. Davis, H. S. Earp, C.-Y. Wang, and A. S. Baldwin Jr. (2002)
Mol. Cell. Biol. 22, 8175-8183
   Abstract »    Full Text »    PDF »
Role of TRAF3 and -6 in the Activation of the NF-kappa B and JNK Pathways by X-linked Ectodermal Dysplasia Receptor.
S. K. Sinha, S. Zachariah, H. I. Quinones, M. Shindo, and P. M. Chaudhary (2002)
J. Biol. Chem. 277, 44953-44961
   Abstract »    Full Text »    PDF »
Evidence of Functional Modulation of the MEKK/JNK/cJun Signaling Cascade by the Low Density Lipoprotein Receptor-related Protein (LRP).
C. Lutz, J. Nimpf, M. Jenny, K. Boecklinger, C. Enzinger, G. Utermann, G. Baier-Bitterlich, and G. Baier (2002)
J. Biol. Chem. 277, 43143-43151
   Abstract »    Full Text »    PDF »
Phosphorylation-dependent Scaffolding Role of JSAP1/JIP3 in the ASK1-JNK Signaling Pathway. A NEW MODE OF REGULATION OF THE MAP KINASE CASCADE.
H. Matsuura, H. Nishitoh, K. Takeda, A. Matsuzawa, T. Amagasa, M. Ito, K. Yoshioka, and H. Ichijo (2002)
J. Biol. Chem. 277, 40703-40709
   Abstract »    Full Text »    PDF »
Multiple Mitogenic Pathways in Pancreatic Cancer Cells Are Blocked by a Truncated Epidermal Growth Factor Receptor.
K. Matsuda, T. Idezawa, X. J. You, N. H. Kothari, H. Fan, and M. Korc (2002)
Cancer Res. 62, 5611-5617
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)