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Science 27 June 1997:
Vol. 276. no. 5321, pp. 2057 - 2062
DOI: 10.1126/science.276.5321.2057
Prev | Table of Contents

Reports

Differential Requirements for Survival and Proliferation of CD8 Naïve or Memory T Cells

Corinne Tanchot, François A. Lemonnier, Beatrice Pérarnau, Antonio A. Freitas, Benedita Rocha *

The requisite molecular interactions for CD8 T cell memory were determined by comparison of monoclonal naïve and memory CD8+ T cells bearing the T cell receptor (TCR) for the HY antigen. Naïve T cells required only the right major histocompatibility complex (MHC) class I-restricting molecule to survive; to expand, they also needed antigen. In contrast, for survival, memory cells did not require the restricting MHC allele, but needed only a nonspecific class I; for expansion the correct class I, but not antigen, was required. Thus, maintenance of CD8 T cell memory still required TCR-MHC class I interactions, but memory T cells may have a lower functional activation threshold that facilitates secondary responses.

C. Tanchot and B. Rocha, INSERM U345, Institut Necker, 156 Rue Vaugirard, 75015 Paris, France.
F. A. Lemonnier and B. Pérarnau, Unité d'Immunité Cellulaire Antivirale, Institut Pasteur, Paris, France.
A. A. Freitas, Laboratoire des Dynamiques Lymphocytaires CNRS URA 1961, Institut Pasteur, 28 rue du Dr. Roux, 75015 Paris, France. E-mail: afreitas{at}pasteur.fr
*   To whom correspondence should be addressed.

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IL-15 availability conditions homeostasis of peripheral natural killer T cells.
T. Ranson, C. A. J. Vosshenrich, E. Corcuff, O. Richard, V. Laloux, A. Lehuen, and J. P. Di Santo (2003)
PNAS 100, 2663-2668
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Primary and Secondary Immunocompetence in Mixed Allogeneic Chimeras.
M. A. Williams, A. B. Adams, M. B. Walsh, N. Shirasugi, T. M. Onami, T. C. Pearson, R. Ahmed, and C. P. Larsen (2003)
J. Immunol. 170, 2382-2389
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IL-15 enhances survival and function of HIV-specific CD8+ T cells.
Y. M. Mueller, P. M. Bojczuk, E. S. Halstead, A. H. J. Kim, J. Witek, J. D. Altman, and P. D. Katsikis (2003)
Blood 101, 1024-1029
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