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Science 20 June 1997:
Vol. 276. no. 5320, pp. 1874 - 1878
DOI: 10.1126/science.276.5320.1874
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Reports

Identification of a Chemokine Receptor Encoded by Human Cytomegalovirus as a Cofactor for HIV-1 Entry

Olivier Pleskoff, Carole Tréboute, Anne Brelot, Nikolaus Heveker, Michel Seman, Marc Alizon *

The human cytomegalovirus encodes a beta -chemokine receptor (US28) that is distantly related to the human chemokine receptors CCR5 and CXCR4, which also serve as cofactors for the entry into cells of human immunodeficiency virus-type 1 (HIV-1). Like CCR5, US28 allowed infection of CD4-positive human cell lines by primary isolates of HIV-1 and HIV-2, as well as fusion of these cell lines with cells expressing the viral envelope proteins. In addition, US28 mediated infection by cell line-adapted HIV-1 for which CXCR4 was an entry cofactor.

O. Pleskoff, C. Tréboute, A. Brelot, N. Heveker, M. Alizon, Inserm U.332, Institut Cochin de Génétique Moléculaire, 22 rue Méchain, 75014 Paris, France.
M. Seman, Laboratoire d'Immunodifférenciation, Université Paris 7, 75005 Paris, France.
*   To whom correspondence should be addressed. E-mail: alizon{at}cochin.inserm.fr

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B. Labrosse, A. Brelot, N. Heveker, N. Sol, D. Schols, E. De Clercq, and M. Alizon (1998)
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Y. Isegawa, Z. Ping, K. Nakano, N. Sugimoto, and K. Yamanishi (1998)
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H. Choe, M. Farzan, M. Konkel, K. Martin, Y. Sun, L. Marcon, M. Cayabyab, M. Berman, M. E. Dorf, N. Gerard, et al. (1998)
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J. Virol. 72, 772-777
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