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Science 20 June 1997:
Vol. 276. no. 5320, pp. 1851 - 1854
DOI: 10.1126/science.276.5320.1851
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Reports

Kaposi's Sarcoma-Associated Herpesvirus Infection of Bone Marrow Dendritic Cells from Multiple Myeloma Patients

M. B. Rettig, * H. J. Ma, R. A. Vescio, M. Põld, G. Schiller, D. Belson, A. Savage, C. Nishikubo, C. Wu, J. Fraser, J. W. Said, J. R. Berenson

Kaposi's sarcoma-associated herpesvirus (KSHV) was found in the bone marrow dendritic cells of multiple myeloma patients but not in malignant plasma cells or bone marrow dendritic cells from normal individuals or patients with other malignancies. In addition the virus was detected in the bone marrow dendritic cells from two out of eight patients with monoclonal gammopathy of undetermined significance (MGUS), a precursor to myeloma. Viral interleukin-6, the human homolog of which is a growth factor for myeloma, was found to be transcribed in the myeloma bone marrow dendritic cells. KSHV may be required for transformation from MGUS to myeloma and perpetuate the growth of malignant plasma cells.

M. B. Rettig, R. A. Vescio, J. R. Berenson, Division of Hematology and Oncology, Veterans Affairs West Los Angeles Medical Center, 11301 Wilshire Boulevard, 111-H, Los Angeles, CA 90073, USA, and Jonsson Comprehensive Cancer Center and Division of Hematology and Oncology, University of California Los Angeles School of Medicine, 10833 LeConte Avenue, Los Angeles, CA 90095, USA.
H. J. Ma, M. Põld, D. Belson, C. Wu, Division of Hematology and Oncology, Veterans Affairs West Los Angeles Medical Center, 11301 Wilshire Boulevard, 111-H, Los Angeles, CA 90073, USA.
G. Schiller, A. Savage, C. Nishikubo, J. Fraser, Jonsson Comprehensive Cancer Center and Division of Hematology and Oncology, UCLA School of Medicine, 10833 LeConte Avenue, Los Angeles, CA 90095, USA.
J. W. Said, Jonsson Comprehensive Cancer Center and Department of Pathology, UCLA School of Medicine, 10833 LeConte Avenue, Los Angeles, CA 90095, USA.
*   To whom correspondence should be addressed at Division of Hematology and Oncology, Veterans Affairs West Los Angeles Medical Center, 11301 Wilshire Boulevard, 111-H, Los Angeles, CA 90073, USA. E-mail: RETTIG.MATTHEW@WEST-LA.VA.GOV

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Overview of the Epidemiology of Immunodeficiency-Associated Cancers.
V. Beral and R. Newton (1998)
J Natl Cancer Inst Monographs 1998, 1-6
   Abstract »    Full Text »
Kaposi's Sarcoma-Associated Herpesvirus-Encoded Oncogenes and Oncogenesis.
P. S. Moore and Y. Chang (1998)
J Natl Cancer Inst Monographs 1998, 65-71
   Abstract »    Full Text »
AIDS-Related Malignancies.
D. T. Scadden and W. W. Howard (1998)
Oncologist 3, 119-123
   Abstract »    Full Text »
Mechanisms of Growth Control of Kaposi's Sarcoma-Associated Herpes Virus-Associated Primary Effusion Lymphoma Cells.
H. Asou, J. W. Said, R. Yang, R. Munker, D. J. Park, N. Kamada, and H. P. Koeffler (1998)
Blood 91, 2475-2481
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Clinical-Grade Functional Dendritic Cells From Patients With Multiple Myeloma Are Not Infected With Kaposi's Sarcoma-Associated Herpesvirus.
K. Tarte, S. J. Olsen, Z. Yang Lu, E. Legouffe, J.-F. Rossi, Y. Chang, and B. Klein (1998)
Blood 91, 1852-1857
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Human Herpesvirus Type 8 Interleukin-6 Homologue Is Functionally Active on Human Myeloma Cells.
R. Burger, F. Neipel, B. Fleckenstein, R. Savino, G. Ciliberto, J. R. Kalden, and M. Gramatzki (1998)
Blood 91, 1858-1863
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The Influence of Human Immunodeficiency Virus-1 on Hematopoiesis.
A. Moses, J. Nelson, and G. C. Bagby Jr (1998)
Blood 91, 1479-1495
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Seroprevalence of Kaposi's Sarcoma-Associated Herpes Virus Antibody in Young Adult Hodgkin's Disease.
W. Cozen, R. Masood, T. Mack, P. S. Gill, and D. V. Ablashi (1998)
Blood 91, 724
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Multiple Myeloma: Increasing Evidence for a Multistep Transformation Process.
M. Hallek, P. Leif Bergsagel, and K. C. Anderson (1998)
Blood 91, 3-21
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Association of Kaposi's Sarcoma-Associated Herpesvirus-Positive Primary Effusion Lymphoma With Expression of the CD138/Syndecan-1 Antigen.
G. Gaidano, A. Gloghini, V. Gattei, M.F. Rossi, A.M. Cilia, C. Godeas, M. Degan, T. Perin, V. Canzonieri, D. Aldinucci, et al. (1997)
Blood 90, 4894-4900
   Abstract »    Full Text »    PDF »
Kaposi's Sarcoma-Associated Herpesvirus Infection and Multiple Myeloma.
C. Parravicini, E. Lauri, L. Baldini, A. Neri, F. Poli, G. Sirchia, M. Moroni, M. Galli, M. Corbellino;, R. Masood, et al. (1997)
Science 278, 1969-1973
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Localization of Kaposi's Sarcoma-Associated Herpesvirus in Bone Marrow Biopsy Samples From Patients With Multiple Myeloma.
J. W. Said, M. R. Rettig, K. Heppner, R. A. Vescio, G. Schiller, H. J. Ma, D. Belson, A. Savage, I. P. Shintaku, H. P. Koeffler, et al. (1997)
Blood 90, 4278-4282
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Generation of Virtually Pure and Potentially Proliferating Dendritic Cells From Non-CD34 Apheresis Cells From Patients With Multiple Myeloma.
K. Tarte, Z. Y. Lu, G. Fiol, E. Legouffe, J.-F. Rossi, and B. Klein (1997)
Blood 90, 3482-3495
   Abstract »    Full Text »    PDF »
SV40 replication in human mesothelial cells induces HGF/Met receptor activation: A model for viral-related carcinogenesis of human malignant mesothelioma.
P. Cacciotti, R. Libener, P. Betta, F. Martini, C. Porta, A. Procopio, L. Strizzi, L. Penengo, M. Tognon, L. Mutti, et al. (2001)
PNAS 98, 12032-12037
   Abstract »    Full Text »    PDF »


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