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Science 30 May 1997:
Vol. 276. no. 5317, pp. 1425 - 1428
DOI: 10.1126/science.276.5317.1425
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Reports

Geometric Control of Cell Life and Death

Christopher S. Chen, Milan Mrksich, Sui Huang, George M. Whitesides, Donald E. Ingber *

Human and bovine capillary endothelial cells were switched from growth to apoptosis by using micropatterned substrates that contained extracellular matrix-coated adhesive islands of decreasing size to progressively restrict cell extension. Cell spreading also was varied while maintaining the total cell-matrix contact area constant by changing the spacing between multiple focal adhesion-sized islands. Cell shape was found to govern whether individual cells grow or die, regardless of the type of matrix protein or antibody to integrin used to mediate adhesion. Local geometric control of cell growth and viability may therefore represent a fundamental mechanism for developmental regulation within the tissue microenvironment.

C. S. Chen, S. Huang, D. E. Ingber, Departments of Surgery and Pathology, Children's Hospital-Harvard Medical School, Enders 1007, 300 Longwood Avenue, Boston, MA 02115, USA.
M. Mrksich and G. M. Whitesides, Department of Chemistry, Harvard University, Cambridge, MA 02138, USA.
*   To whom correspondence should be addressed. E-mail: ingber{at}a1.tch.harvard.edu

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C. G. Galbraith, K. M. Yamada, and M. P. Sheetz (2002)
J. Cell Biol. 159, 695-705
   Abstract »    Full Text »    PDF »
Concerted Action of Androgens and Mechanical Strain Shifts Bone Metabolism from High Turnover into an Osteoanabolic Mode.
U. M. Liegibel, U. Sommer, P. Tomakidi, U. Hilscher, L. van den Heuvel, R. Pirzer, J. Hillmeier, P. Nawroth, and C. Kasperk (2002)
J. Exp. Med. 196, 1387-1392
   Abstract »    Full Text »    PDF »
Mechanical Signaling and the Cellular Response to Extracellular Matrix in Angiogenesis and Cardiovascular Physiology.
D. E. Ingber (2002)
Circ. Res. 91, 877-887
   Abstract »    Full Text »    PDF »
A finite element model of cell deformation during magnetic bead twisting.
S. M. Mijailovich, M. Kojic, M. Zivkovic, B. Fabry, and J. J. Fredberg (2002)
J Appl Physiol 93, 1429-1436
   Abstract »    Full Text »    PDF »
Spatial and temporal traction response in human airway smooth muscle cells.
I. M. Tolic-Norrelykke, J. P. Butler, J. Chen, and N. Wang (2002)
Am J Physiol Cell Physiol 283, C1254-C1266
   Abstract »    Full Text »    PDF »
cAMP inhibits bile acid-induced apoptosis by blocking caspase activation and cytochrome c release.
C. R. L. Webster, P. Usechak, and M. S. Anwer (2002)
Am J Physiol Gastrointest Liver Physiol 283, G727-G738
   Abstract »    Full Text »    PDF »
Signal Transduction from N-cadherin Increases Bcl-2. REGULATION OF THE PHOSPHATIDYLINOSITOL 3-KINASE/Akt PATHWAY BY HOMOPHILIC ADHESION AND ACTIN CYTOSKELETAL ORGANIZATION.
N. L. Tran, D. G. Adams, R. R. Vaillancourt, and R. L. Heimark (2002)
J. Biol. Chem. 277, 32905-32914
   Abstract »    Full Text »    PDF »
Biomaterial adherent macrophage apoptosis is increased by hydrophilic and anionic substrates invivo.
W. G. Brodbeck, J. Patel, G. Voskerician, E. Christenson, M. S. Shive, Y. Nakayama, T. Matsuda, N. P. Ziats, and J. M. Anderson (2002)
PNAS 99, 10287-10292
   Abstract »    Full Text »    PDF »


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