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Science 30 May 1997:
Vol. 276. no. 5317, pp. 1404 - 1407
DOI: 10.1126/science.276.5317.1404
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Reports

Control of Mouse Cardiac Morphogenesis and Myogenesis by Transcription Factor MEF2C

Qing Lin, John Schwarz, Corazon Bucana, Eric N. Olson *

Members of the myocyte enhancer factor-2 (MEF2) family of MADS (MCM1, agamous, deficiens, serum response factor)-box transcription factors bind an A-T-rich DNA sequence associated with muscle-specific genes. The murine MEF2C gene is expressed in heart precursor cells before formation of the linear heart tube. In mice homozygous for a null mutation of MEF2C, the heart tube did not undergo looping morphogenesis, the future right ventricle did not form, and a subset of cardiac muscle genes was not expressed. The absence of the right ventricular region of the mutant heart correlated with down-regulation of the dHAND gene, which encodes a basic helix-loop-helix transcription factor required for cardiac morphogenesis. Thus, MEF2C is an essential regulator of cardiac myogenesis and right ventricular development.

Q. Lin and E. N. Olson, Department of Molecular Biology and Oncology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75235-9148, USA.
J. Schwarz, Division of Cardiology, Department of Internal Medicine, University of Texas Medical School, Houston, TX 77030, USA.
C. Bucana, Department of Cell Biology, University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA.
*   To whom correspondence should be addressed.

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E. N. Olson (2003)
Sci. Aging Knowl. Environ. 2003, pe33-33
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Cardia bifida, defective heart development and abnormal neural crest migration in embryos lacking hypoxia-inducible factor-1{alpha}.
V. Compernolle, K. Brusselmans, D. Franco, A. Moorman, M. Dewerchin, D. Collen, and P. Carmeliet (2003)
Cardiovasc Res 60, 569-579
   Abstract »    Full Text »    PDF »
The Death Domain Kinase RIP1 Is Essential for Tumor Necrosis Factor Alpha Signaling to p38 Mitogen-Activated Protein Kinase.
T. H. Lee, Q. Huang, S. Oikemus, J. Shank, J.-J. Ventura, N. Cusson, R. R. Vaillancourt, B. Su, R. J. Davis, and M. A. Kelliher (2003)
Mol. Cell. Biol. 23, 8377-8385
   Abstract »    Full Text »    PDF »
Developmental Changes in Ventricular Diastolic Function Correlate With Changes in Ventricular Myoarchitecture in Normal Mouse Embryos.
T. Ishiwata, M. Nakazawa, W. T. Pu, S. G. Tevosian, and S. Izumo (2003)
Circ. Res. 93, 857-865
   Abstract »    Full Text »    PDF »
JUMONJI, a Critical Factor for Cardiac Development, Functions as a Transcriptional Repressor.
T.-G. Kim, J. C. Kraus, J. Chen, and Y. Lee (2003)
J. Biol. Chem. 278, 42247-42255
   Abstract »    Full Text »    PDF »
Cardiac Chamber Formation: Development, Genes, and Evolution.
A. F. M. MOORMAN and V. M. CHRISTOFFELS (2003)
Physiol Rev 83, 1223-1267
   Abstract »    Full Text »    PDF »
Sizing up the heart: development redux in disease.
E. N. Olson and M. D. Schneider (2003)
Genes & Dev. 17, 1937-1956
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Phosphatidylinositol 3-Kinase Regulates Bone Morphogenetic Protein-2 (BMP-2)-induced Myocyte Enhancer Factor 2A-dependent Transcription of BMP-2 Gene in Cardiomyocyte Precursor Cells.
N. Ghosh-Choudhury, S. L. Abboud, L. Mahimainathan, B. Chandrasekar, and G. G. Choudhury (2003)
J. Biol. Chem. 278, 21998-22005
   Abstract »    Full Text »    PDF »
Roles of Cardiac Transcription Factors in Cardiac Hypertrophy.
H. Akazawa and I. Komuro (2003)
Circ. Res. 92, 1079-1088
   Abstract »    Full Text »    PDF »
E-Tmod capping of actin filaments at the slow-growing end is required to establish mouse embryonic circulation.
X. Chu, J. Chen, M. C. Reedy, C. Vera, K.-L. P. Sung, and L. A. Sung (2003)
Am J Physiol Heart Circ Physiol 284, H1827-H1838
   Abstract »    Full Text »    PDF »
Stem cells and cardiac disorders: an appraisal.
M. J. Goldenthal and J. Marin-Garcia (2003)
Cardiovasc Res 58, 369-377
   Abstract »    Full Text »    PDF »
Phosphorylation Motifs Regulating the Stability and Function of Myocyte Enhancer Factor 2A.
D. M. Cox, M. Du, M. Marback, E. C. C. Yang, J. Chan, K. W. M. Siu, and J. C. McDermott (2003)
J. Biol. Chem. 278, 15297-15303
   Abstract »    Full Text »    PDF »
Dishevelled 2 is essential for cardiac outflow tract development, somite segmentation and neural tube closure.
N. S. Hamblet, N. Lijam, P. Ruiz-Lozano, J. Wang, Y. Yang, Z. Luo, L. Mei, K. R. Chien, D. J. Sussman, and A. Wynshaw-Boris (2003)
Development 129, 5827-5838
   Abstract »    Full Text »    PDF »
Structural Adaptation of the Nuclear Pore Complex in Stem Cell-Derived Cardiomyocytes.
C. Perez-Terzic, A. Behfar, A. Mery, J. M.A. van Deursen, A. Terzic, and M. Puceat (2003)
Circ. Res. 92, 444-452
   Abstract »    Full Text »    PDF »
Pressure Overload Selectively Up-Regulates Ca2+/Calmodulin-Dependent Protein Kinase II in Vivo.
J. M. Colomer, L. Mao, H. A. Rockman, and A. R. Means (2003)
Mol. Endocrinol. 17, 183-192
   Abstract »    Full Text »    PDF »
Cardiac Endothelial-Myocardial Signaling: Its Role in Cardiac Growth, Contractile Performance, and Rhythmicity.
D. L. Brutsaert (2003)
Physiol Rev 83, 59-115
   Abstract »    Full Text »    PDF »


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