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Science 23 May 1997:
Vol. 276. no. 5316, pp. 1268 - 1272
DOI: 10.1126/science.276.5316.1268
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Reports

Gene Expression Profiles in Normal and Cancer Cells

Lin Zhang, * Wei Zhou, * Victor E. Velculescu, Scott E. Kern, Ralph H. Hruban, Stanley R. Hamilton, Bert Vogelstein, Kenneth W. Kinzler dagger

As a step toward understanding the complex differences between normal and cancer cells in humans, gene expression patterns were examined in gastrointestinal tumors. More than 300,000 transcripts derived from at least 45,000 different genes were analyzed. Although extensive similarity was noted between the expression profiles, more than 500 transcripts that were expressed at significantly different levels in normal and neoplastic cells were identified. These data provide insight into the extent of expression differences underlying malignancy and reveal genes that may prove useful as diagnostic or prognostic markers.

L. Zhang, W. Zhou, B. Vogelstein, Howard Hughes Medical Institute, The Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.
V. E. Velculescu, Oncology Center and Program in Human Genetics and Molecular Biology, The Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.
S. E. Kern, R. H. Hruban, S. R. Hamilton, Department of Pathology and Oncology Center, The Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.
K. W. Kinzler, Oncology Center, The Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.
*   These authors contributed equally to this work.

dagger    To whom correspondence should be addressed.

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SAGE Analysis of Transcriptome Responses in Arabidopsis Roots Exposed to 2,4,6-Trinitrotoluene.
D. R. Ekman, W. W. Lorenz, A. E. Przybyla, N. L. Wolfe, and J. F.D. Dean (2003)
Plant Physiology 133, 1397-1406
   Abstract »    Full Text »    PDF »
Molecular Pharmacology of Cancer Therapy in Human Colorectal Cancer by Gene Expression Profiling.
P. A. Clarke, M. L. George, S. Easdale, D. Cunningham, R. I. Swift, M. E. Hill, D. M. Tait, and P. Workman (2003)
Cancer Res. 63, 6855-6863
   Abstract »    Full Text »    PDF »
Identification of Epithelial Cell Adhesion Molecule Autoantibody in Patients with Ovarian Cancer.
J.-H. Kim, D. Herlyn, K.-k. Wong, D.-C. Park, J. O. Schorge, K. H. Lu, S. J. Skates, D. W. Cramer, R. S. Berkowitz, and S. C. Mok (2003)
Clin. Cancer Res. 9, 4782-4791
   Abstract »    Full Text »    PDF »
Serial analysis of gene expression in the skeletal muscle of endurance athletes compared to sedentary men.
M. YOSHIOKA, H. TANAKA, N. SHONO, E. E. SNYDER, M. SHINDO, and J. ST-AMAND (2003)
FASEB J 17, 1812-1819
   Abstract »    Full Text »    PDF »
DNA Sequence-Based "Bar Codes" for Tracking the Origins of Expressed Sequence Tags from a Maize cDNA Library Constructed Using Multiple mRNA Sources.
F. Qiu, L. Guo, T.-J. Wen, F. Liu, D. A. Ashlock, and P. S. Schnable (2003)
Plant Physiology 133, 475-481
   Abstract »    Full Text »    PDF »
Simultaneous gene expression analysis of steady-state and actively translated mRNA populations from osteosarcoma MG-63 cells in response to IL-1{alpha} via an open expression analysis platform.
J. Ju, C. Huang, S. A. Minskoff, J. E. Mayotte, B. E. Taillon, and J. F. Simons (2003)
Nucleic Acids Res. 31, 5157-5166
   Abstract »    Full Text »    PDF »
Clusterin as a biomarker in murine and human intestinal neoplasia.
X. Chen, R. B. Halberg, W. M. Ehrhardt, J. Torrealba, and W. F. Dove (2003)
PNAS 100, 9530-9535
   Abstract »    Full Text »    PDF »
Conjugated Linoleic Acid Downregulates Insulin-Like Growth Factor-I Receptor Levels in HT-29 Human Colon Cancer Cells.
E. J. Kim, I.-J. Kang, H. J. Cho, W. K. Kim, Y.-L. Ha, and J. H. Y. Park (2003)
J. Nutr. 133, 2675-2681
   Abstract »    Full Text »    PDF »
Identifying Tumor Origin Using a Gene Expression-based Classification Map.
P. Buckhaults, Z. Zhang, Y.-C. Chen, T.-L. Wang, B. St. Croix, S. Saha, A. Bardelli, P. J. Morin, K. Polyak, R. H. Hruban, et al. (2003)
Cancer Res. 63, 4144-4149
   Abstract »    Full Text »    PDF »
A Novel Orthotopic Tumor Model to Study Growth Factors and Oncogenes in Hepatocarcinogenesis.
X. Yao, J.-F. Hu, M. Daniels, H. Yien, H. Lu, H. Sharan, X. Zhou, Z. Zeng, T. Li, Y. Yang, et al. (2003)
Clin. Cancer Res. 9, 2719-2726
   Abstract »    Full Text »    PDF »
Molecular Profiling of Pancreatic Adenocarcinoma and Chronic Pancreatitis Identifies Multiple Genes Differentially Regulated in Pancreatic Cancer.
C. D. Logsdon, D. M. Simeone, C. Binkley, T. Arumugam, J. K. Greenson, T. J. Giordano, D. E. Misek, and S. Hanash (2003)
Cancer Res. 63, 2649-2657
   Abstract »    Full Text »    PDF »
CD40-dependent Activation of Phosphatidylinositol 3-Kinase/Akt Pathway Mediates Endothelial Cell Survival and in Vitro Angiogenesis.
M. C. Deregibus, S. Buttiglieri, S. Russo, B. Bussolati, and G. Camussi (2003)
J. Biol. Chem. 278, 18008-18014
   Abstract »    Full Text »    PDF »
Identification of Down's syndrome critical locus gene SIM2-s as a drug therapy target for solid tumors.
M. P. DeYoung, M. Tress, and R. Narayanan (2003)
PNAS 100, 4760-4765
   Abstract »    Full Text »    PDF »
Gene Expression Profiling in a Renal Cell Carcinoma Cell Line: Dissecting VHL and Hypoxia-Dependent Pathways.
Y. Jiang, W. Zhang, K. Kondo, J. M. Klco, T. B. St. Martin, M. R. Dufault, S. L. Madden, W. G. Kaelin Jr, and M. Nacht (2003)
Mol. Cancer Res. 1, 453-462
   Abstract »    Full Text »    PDF »
Exploration of Global Gene Expression Patterns in Pancreatic Adenocarcinoma Using cDNA Microarrays.
C. A. Iacobuzio-Donahue, A. Maitra, M. Olsen, A. W. Lowe, N. T. Van Heek, C. Rosty, K. Walter, N. Sato, A. Parker, R. Ashfaq, et al. (2003)
Am. J. Pathol. 162, 1151-1162
   Abstract »    Full Text »    PDF »
Structural-proliferative units and organ growth: effects of insulin-like growth factor 2 on the growth of colon and skin.
W. R. Bennett, T. E. Crew, J. M. W. Slack, and A. Ward (2003)
Development 130, 1079-1088
   Abstract »    Full Text »    PDF »
Transcript profiling of human platelets using microarray and serial analysis of gene expression.
D. V. Gnatenko, J. J. Dunn, S. R. McCorkle, D. Weissmann, P. L. Perrotta, and W. F. Bahou (2003)
Blood 101, 2285-2293
   Abstract »    Full Text »    PDF »
Identification and Validation of Genes Involved in the Pathogenesis of Colorectal Cancer Using cDNA Microarrays and RNA Interference.
N. S. Williams, R. B. Gaynor, S. Scoggin, U. Verma, T. Gokaslan, C. Simmang, J. Fleming, D. Tavana, E. Frenkel, and C. Becerra (2003)
Clin. Cancer Res. 9, 931-946
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