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Science 16 May 1997:
Vol. 276. no. 5315, pp. 1128 - 1131
DOI: 10.1126/science.276.5315.1128
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Reports

Localization of Xenopus Vg1 mRNA by Vera Protein and the Endoplasmic Reticulum

James O. Deshler, * Martin I. Highett, * Bruce J. Schnapp dagger

In many organisms, pattern formation in the embryo develops from the polarized distributions of messenger RNAs (mRNAs) in the egg. In Xenopus, the mRNA encoding Vg1, a growth factor involved in mesoderm induction, is localized to the vegetal cortex of oocytes. A protein named Vera was shown to be involved in Vg1 mRNA localization. Vera cofractionates with endoplasmic reticulum (ER) membranes, and endogenous Vg1 mRNA is associated with a subcompartment of the ER. Vera may promote mRNA localization in Xenopus oocytes by mediating an interaction between the Vg1 3' untranslated region and the ER subcompartment.

Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA.
*   These authors contributed equally to this work.

dagger    To whom correspondence should be addressed.

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