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Science 2 May 1997:
Vol. 276. no. 5313, pp. 817 - 821
DOI: 10.1126/science.276.5313.817
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Reports

Basal Cell Carcinomas in Mice Overexpressing Sonic Hedgehog

Anthony E. Oro, Kay M. Higgins, Zhilan Hu, Jeannette M. Bonifas, Ervin H. Epstein Jr., * Matthew P. Scott *

Mutations in the tumor suppressor gene PATCHED (PTC) are found in human patients with the basal cell nevus syndrome, a disease causing developmental defects and tumors, including basal cell carcinomas. Gene regulatory relationships defined in the fruit fly Drosophila suggest that overproduction of Sonic hedgehog (SHH), the ligand for PTC, will mimic loss of ptc function. It is shown here that transgenic mice overexpressing SHH in the skin develop many features of basal cell nevus syndrome, demonstrating that SHH is sufficient to induce basal cell carcinomas in mice. These data suggest that SHH may have a role in human tumorigenesis.

A. E. Oro, Howard Hughes Medical Institute, Departments of Dermatology, Developmental Biology, and Genetics, Stanford University School of Medicine, Stanford, CA 94305-5427, USA.
K. M. Higgins and M. P. Scott, Howard Hughes Medical Institute, Departments of Developmental Biology and Genetics, Stanford University School of Medicine, Stanford, CA 94305-5427, USA.
Z. Hu, J. M. Bonifas, E. H. Epstein Jr., Department of Dermatology, San Francisco General Hospital, University of California, San Francisco, CA 94110, USA.
*   To whom correspondence should be addressed. E-mail addresses: scott{at}cmgm.stanford.edu, ehepstein{at}orca.ucsf.edu

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