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Science 2 May 1997:
Vol. 276. no. 5313, pp. 718 - 725
DOI: 10.1126/science.276.5313.718
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Articles

Exploitation of Mammalian Host Cell Functions by Bacterial Pathogens

B. Brett Finlay, Pascale Cossart

Interest in bacterial pathogenesis has recently increased because of antibiotic resistance, the emergence of new pathogens and the resurgence of old ones, and the lack of effective therapeutics. The molecular and cellular mechanisms of microbial pathogenesis are currently being defined, with precise knowledge of both the common strategies used by multiple pathogenic bacteria and the unique tactics evolved by individual species to help establish infection. What is emerging is a new appreciation of how bacterial pathogens interact with host cells. Many host cell functions, including signal transduction pathways, cytoskeletal rearrangements, and vacuolar trafficking, are exploited, and these are the focus of this review. A bonus of this work is that bacterial virulence factors are providing new tools to study various aspects of mammalian cell functions, in addition to mechanisms of bacterial disease. Together these developments may lead to new therapeutic strategies.

B. B. Finlay, Biotechnology Laboratory, University of British Columbia, Vancouver, B.C., Canada, V6T-1Z3. E-mail: bfinlay{at}unixg.ubc.ca
P. Cossart, Unité des Interactions Bactéries-Cellules, Institut Pasteur, 75724 Paris Cedex 15, France. E-mail: pcossart{at}pasteur.fr

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Identification of new loci involved in adhesion of Listeria monocytogenes to eukaryotic cells.
E. Milohanic, B. Pron, P. Berche, and J.-L. Gaillard (2000)
Microbiology 146, 731-739
   Abstract »    Full Text »
Effect of Oral Genistein and Isoflavone-Free Diet on Cecal Flora and Bacterial Translocation in Antibiotic-Treated Mice.
C. L. Wells, R. P. Jechorek, and S. L. Erlandsen (2000)
JPEN J Parenter Enteral Nutr 24, 56-60
   Abstract »    PDF »
Syndecan-1 Shedding Is Enhanced by LasA, a Secreted Virulence Factor of Pseudomonas aeruginosa.
P. W. Park, G. B. Pier, M. J. Preston, O. Goldberger, M. L. Fitzgerald, and M. Bernfield (2000)
J. Biol. Chem. 275, 3057-3064
   Abstract »    Full Text »    PDF »
Membrane recruitment of Rac1 triggers phagocytosis.
F Castellano, P Montcourrier, and P Chavrier (2000)
J. Cell Sci. 113, 2955-2961
   Abstract »    PDF »
Use of green fluorescent protein (GFP) to study the invasion pathways of Edwardsiella tarda in in vivo and in vitro fish models.
S. H. M. Ling, X. H. Wang, L. Xie, T. M. Lim, and K. Y. Leung (2000)
Microbiology 146, 7-19
   Abstract »    Full Text »
Mycobacterial infection of macrophages results in membrane-permeable phagosomes.
R. Teitelbaum, M. Cammer, M. L. Maitland, N. E. Freitag, J. Condeelis, and B. R. Bloom (1999)
PNAS 96, 15190-15195
   Abstract »    Full Text »    PDF »
Invasion of Human Coronary Artery Cells by Periodontal Pathogens.
B. R. Dorn, W. A. Dunn Jr., and A. Progulske-Fox (1999)
Infect. Immun. 67, 5792-5798
   Abstract »    Full Text »    PDF »
Suppression of T and B Lymphocyte Activation by a Yersinia pseudotuberculosis Virulence Factor, Yoph.
T. Yao, J. Mecsas, J. I. Healy, S. Falkow, and Y.-h. Chien (1999)
J. Exp. Med. 190, 1343-1350
   Abstract »    Full Text »    PDF »
Tyrosine Phosphatase SHP-1 Is Involved in CD66-Mediated Phagocytosis of Opa52-Expressing Neisseria gonorrhoeae.
C. R. Hauck, E. Gulbins, F. Lang, and T. F. Meyer (1999)
Infect. Immun. 67, 5490-5494
   Abstract »    Full Text »    PDF »
Group A Streptococcus Induces Apoptosis in Human Epithelial Cells.
P.-J. Tsai, Y.-S. Lin, C.-F. Kuo, H.-Y. Lei, and J.-J. Wu (1999)
Infect. Immun. 67, 4334-4339
   Abstract »    Full Text »    PDF »
Invasive Ability of an Escherichia coli Strain Isolated from the Ileal Mucosa of a Patient with Crohn's Disease.
J. Boudeau, A.-L. Glasser, E. Masseret, B. Joly, and A. Darfeuille-Michaud (1999)
Infect. Immun. 67, 4499-4509
   Abstract »    Full Text »    PDF »
Fibronectin Binding Protein and Host Cell Tyrosine Kinase Are Required for Internalization of Staphylococcus aureus by Epithelial Cells.
K. Dziewanowska, J. M. Patti, C. F. Deobald, K. W. Bayles, W. R. Trumble, and G. A. Bohach (1999)
Infect. Immun. 67, 4673-4678
   Abstract »    Full Text »    PDF »
Structure of Adenovirus Complexed with Its Internalization Receptor, alpha vbeta 5 Integrin.
C. Y. Chiu, P. Mathias, G. R. Nemerow, and P. L. Stewart (1999)
J. Virol. 73, 6759-6768
   Abstract »    Full Text »
NF-{kappa}B Is a Central Regulator of the Intestinal Epithelial Cell Innate Immune Response Induced by Infection with Enteroinvasive Bacteria.
D. Elewaut, J. A. DiDonato, J. Mogg Kim, F. Truong, L. Eckmann, and M. F. Kagnoff (1999)
J. Immunol. 163, 1457-1466
   Abstract »    Full Text »    PDF »
Influence of Temperature and Growth Phase on Expression of a 104-Kilodalton Listeria Adhesion Protein in Listeria monocytogenes.
N. I. Santiago, A. Zipf, and A. K. Bhunia (1999)
Appl. Envir. Microbiol. 65, 2765-2769
   Abstract »    Full Text »
Strain Variation in Glycosaminoglycan Recognition Influences Cell-Type-Specific Binding by Lyme Disease Spirochetes.
N. Parveen, D. Robbins, and J. M. Leong (1999)
Infect. Immun. 67, 1743-1749
   Abstract »    Full Text »    PDF »


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