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Science 25 April 1997:
Vol. 276. no. 5312, pp. 596 - 599
DOI: 10.1126/science.276.5312.596
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Reports

Repression of c-myc Transcription by Blimp-1, an Inducer of Terminal B Cell Differentiation

Yi Lin, Kwok-kin Wong, Kathryn Calame *

Transcription of c-myc in plasma cells, which are terminally differentiated B cells, is repressed by plasmacytoma repressor factor. This factor was identified as Blimp-1, known for its ability to induce B cell differentiation. Blimp-1 repressed c-myc promoter activity in a binding site-dependent manner. Treatment of BCL1 lymphoma cells with interleukin-2 (IL-2) plus IL-5 induced Blimp-1 and caused a subsequent decline in c-Myc protein. Ectopic expression of Blimp-1 in Abelson-transformed precursor B cells repressed endogenous c-Myc and caused apoptosis; Blimp-1-induced death was partially overcome by ectopic expression of c-Myc. Thus, repression of c-myc is a component of the Blimp-1 program of terminal B cell differentiation.

Y. Lin, Department of Microbiology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA.
K. Wong, Integrated Program in Cellular, Molecular, and Biophysical Studies, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA.
K. Calame, Department of Microbiology and the Integrated Program in Cellular, Molecular, and Biophysical Studies, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA.
*   To whom correspondence should be addressed.

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