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Science 18 April 1997:
Vol. 276. no. 5311, pp. 425 - 428
DOI: 10.1126/science.276.5311.425
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Reports

Quantitative Trait Loci for Refractoriness of Anopheles gambiae to Plasmodium cynomolgi B

Liangbiao Zheng, Anton J. Cornel, Rui Wang, Holger Erfle, Hartmut Voss, Wilhelm Ansorge, Fotis C. Kafatos, Frank H. Collins *

The severity of the malaria pandemic in the tropics is aggravated by the ongoing spread of parasite resistance to antimalarial drugs and mosquito resistance to insecticides. A strain of Anopheles gambiae, normally a major vector for human malaria in Africa, can encapsulate and kill the malaria parasites within a melanin-rich capsule in the mosquito midgut. Genetic mapping revealed one major and two minor quantitative trait loci (QTLs) for this encapsulation reaction. Understanding such antiparasite mechanisms in mosquitoes may lead to new strategies for malaria control.

L. Zheng, R. Wang, H. Erfle, H. Voss, W. Ansorge, F. C. Kafatos, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany.
A. J. Cornel and F. H. Collins, Centers for Disease Control and Prevention, 4770 Buford Highway, Mail Stop F22, Chamblee, GA 30341, USA.
*   To whom correspondence should be addressed. E-mail: fhc1{at}cdc.gov

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