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Science 18 April 1997:
Vol. 276. no. 5311, pp. 412 - 415
DOI: 10.1126/science.276.5311.412
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Reports

The Roles of gamma 1 Heavy Chain Membrane Expression and Cytoplasmic Tail in IgG1 Responses

Tsuneyasu Kaisho, *dagger Frieder Schwenk, Klaus Rajewsky

In antibody responses, B cells switch from the expression of immunoglobulin (Ig) µ and delta  heavy (H) chains to that of other Ig classes (alpha , gamma , or epsilon ), each with a distinct effector function. Membrane-bound forms of alpha , gamma , and epsilon , but not µ and delta , have highly conserved cytoplasmic tails. Mutant mice unable to express membrane gamma 1 H chains or producing tailless gamma 1 H chains failed to generate efficient IgG1 responses and IgG1 memory. H chain membrane expression after class switching is thus required for these functions, and class switching equips the B cell antigen receptor with a regulatory cytoplasmic tail that naïve B cells lack.

Institute for Genetics, University of Cologne, Weyertal 121, D-50931 Cologne, Germany.
*   To whom correspondence should be addressed.

dagger    Present address: Department of Biochemistry, Hyogo College of Medicine, Hyogo 663, Japan. E-mail: tkaisho{at}home.hyo-med.ac.jp

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