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Science 4 April 1997:
Vol. 276. no. 5309, pp. 75 - 81
DOI: 10.1126/science.276.5309.75
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Articles

Wound Healing--Aiming for Perfect Skin Regeneration

Paul Martin

The healing of an adult skin wound is a complex process requiring the collaborative efforts of many different tissues and cell lineages. The behavior of each of the contributing cell types during the phases of proliferation, migration, matrix synthesis, and contraction, as well as the growth factor and matrix signals present at a wound site, are now roughly understood. Details of how these signals control wound cell activities are beginning to emerge, and studies of healing in embryos have begun to show how the normal adult repair process might be readjusted to make it less like patching up and more like regeneration.

The author is in the Department of Anatomy and Developmental Biology and Division of Plastic and Reconstructive Surgery, Department of Surgery, University College London, Gower Street, London WC1E 6BT, UK. E-mail: paul.martin{at}ucl.ac.uk

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Blood 107, 2720-2727
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COMP-angiopoietin-1 promotes wound healing through enhanced angiogenesis, lymphangiogenesis, and blood flow in a diabetic mouse model.
C.-H. Cho, H.-K. Sung, K.-T. Kim, H. G. Cheon, G. T. Oh, H. J. Hong, O.-J. Yoo, and G. Y. Koh (2006)
PNAS 103, 4946-4951
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A "traffic control" role for TGF{beta}3: orchestrating dermal and epidermal cell motility during wound healing.
B. Bandyopadhyay, J. Fan, S. Guan, Y. Li, M. Chen, D. T. Woodley, and W. Li (2006)
J. Cell Biol. 172, 1093-1105
   Abstract »    Full Text »    PDF »
Mechanism of Akt1 inhibition of breast cancer cell invasion reveals a protumorigenic role for TSC2..
H. Liu, D. C. Radisky, C. M. Nelson, H. Zhang, J. E. Fata, R. A. Roth, and M. J. Bissell (2006)
PNAS 103, 4134-4139
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What is the future of diabetic wound care?.
S. M. Sweitzer, S. A. Fann, T. K. Borg, J. W. Baynes, and M. J. Yost (2006)
The Diabetes Educator 32, 197-210
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The {beta}2-adrenergic receptor activates pro-migratory and pro-proliferative pathways in dermal fibroblasts via divergent mechanisms.
C. E. Pullar and R. R. Isseroff (2006)
J. Cell Sci. 119, 592-602
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Elimination of Epiplakin by Gene Targeting Results in Acceleration of Keratinocyte Migration in Mice.
M. Goto, H. Sumiyoshi, T. Sakai, R. Fassler, S. Ohashi, E. Adachi, H. Yoshioka, and S. Fujiwara (2006)
Mol. Cell. Biol. 26, 548-558
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{beta}2-Adrenergic receptor activation delays wound healing.
C. E. Pullar, J. C. Grahn, W. Liu, and R. R. Isseroff (2006)
FASEB J 20, 76-86
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Targeted ablation of plectin isoform 1 uncovers role of cytolinker proteins in leukocyte recruitment.
C. Abrahamsberg, P. Fuchs, S. Osmanagic-Myers, I. Fischer, F. Propst, A. Elbe-Burger, and G. Wiche (2005)
PNAS 102, 18449-18454
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The Ternary Complex Factor Net Regulates Cell Migration through Inhibition of PAI-1 Expression.
G. Buchwalter, C. Gross, and B. Wasylyk (2005)
Mol. Cell. Biol. 25, 10853-10862
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Tissue Regeneration Using Macrophage Migration Inhibitory Factor-Impregnated Gelatin Microbeads in Cutaneous Wounds.
Y. Zhao, T. Shimizu, J. Nishihira, Y. Koyama, T. Kushibiki, A. Honda, H. Watanabe, R. Abe, Y. Tabata, and H. Shimizu (2005)
Am. J. Pathol. 167, 1519-1529
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Biomimetic Delivery of Keratinocyte Growth Factor upon Cellular Demand for Accelerated Wound Healing in Vitro and in Vivo.
D. J. Geer, D. D. Swartz, and S. T. Andreadis (2005)
Am. J. Pathol. 167, 1575-1586
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