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Science 4 April 1997:
Vol. 276. no. 5309, pp. 71 - 74
DOI: 10.1126/science.276.5309.71
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Articles

Marrow Stromal Cells as Stem Cells for Nonhematopoietic Tissues

Darwin J. Prockop

Marrow stromal cells can be isolated from other cells in marrow by their tendency to adhere to tissue culture plastic. The cells have many of the characteristics of stem cells for tissues that can roughly be defined as mesenchymal, because they can be differentiated in culture into osteoblasts, chondrocytes, adipocytes, and even myoblasts. Therefore, marrow stromal cells present an intriguing model for examining the differentiation of stem cells. Also, they have several characteristics that make them potentially useful for cell and gene therapy.

The author is director of the Center for Gene Therapy, Allegheny University of the Health Sciences, MCP-Hahnemann School of Medicine, 245 North 15 Street, Mail Stop 421, Philadelphia, PA 19102, USA. E-mail: prockop{at}allegheny.edu

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Br. J. Sports Med. 40, 719-722
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Implantation of Mesenchymal Stem Cells Overexpressing Endothelial Nitric Oxide Synthase Improves Right Ventricular Impairments Caused by Pulmonary Hypertension.
S. Kanki-Horimoto, H. Horimoto, S. Mieno, K. Kishida, F. Watanabe, E. Furuya, and T. Katsumata (2006)
Circulation 114, I-181-I-185
   Abstract »    Full Text »    PDF »
Recovery of Function Following Grafting of Human Bone Marrow-Derived Stromal Cells into the Injured Spinal Cord.
B. T. Himes, B. Neuhuber, C. Coleman, R. Kushner, S. A. Swanger, G. C. Kopen, J. Wagner, J. S. Shumsky, and I. Fischer (2006)
Neurorehabil Neural Repair 20, 278-296
   Abstract »    PDF »
Mesenchymal stem cells reside in virtually all post-natal organs and tissues.
L. d. S. Meirelles, P. C. Chagastelles, and N. B. Nardi (2006)
J. Cell Sci. 119, 2204-2213
   Abstract »    Full Text »    PDF »
Erythropoietin Delivery by Genetically Engineered Bone Marrow Stromal Cells for Correction of Anemia in Mice with Chronic Renal Failure.
N. Eliopoulos, R. F. Gagnon, M. Francois, and J. Galipeau (2006)
J. Am. Soc. Nephrol. 17, 1576-1584
   Abstract »    Full Text »    PDF »
Human mesenchymal stem cells exert potent antitumorigenic effects in a model of Kaposi's sarcoma.
A. Y. Khakoo, S. Pati, S. A. Anderson, W. Reid, M. F. Elshal, I. I. Rovira, A. T. Nguyen, D. Malide, C. A. Combs, G. Hall, et al. (2006)
J. Exp. Med. 203, 1235-1247
   Abstract »    Full Text »    PDF »
High-level expression of porcine factor VIII from genetically modified bone marrow-derived stem cells.
B. Gangadharan, E. T. Parker, L. M. Ide, H. T. Spencer, and C. B. Doering (2006)
Blood 107, 3859-3864
   Abstract »    Full Text »    PDF »
Stem Cells as a Source of Regenerative Cardiomyocytes.
K. Fukuda and S. Yuasa (2006)
Circ. Res. 98, 1002-1013
   Abstract »    Full Text »    PDF »
Evidence supporting paracrine hypothesis for Akt-modified mesenchymal stem cell-mediated cardiac protection and functional improvement.
M. Gnecchi, H. He, N. Noiseux, O. D. Liang, L. Zhang, F. Morello, H. Mu, L. G. Melo, R. E. Pratt, J. S. Ingwall, et al. (2006)
FASEB J 20, 661-669
   Abstract »    Full Text »    PDF »
The Properties of Prospectively Isolated Mesenchymal Stem Cells from Man and Mouse.
P. J. Simmons, B. Short, and N. Brouard (2006)
Am. Assoc. Cancer Res. Educ. Book 2006, 334-338
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Xenobiotic Kidney Organogenesis from Human Mesenchymal Stem Cells Using a Growing Rodent Embryo.
T. Yokoo, A. Fukui, T. Ohashi, Y. Miyazaki, Y. Utsunomiya, T. Kawamura, T. Hosoya, M. Okabe, and E. Kobayashi (2006)
J. Am. Soc. Nephrol. 17, 1026-1034
   Abstract »    Full Text »    PDF »


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