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Science 4 April 1997:
Vol. 276. no. 5309, pp. 71 - 74
DOI: 10.1126/science.276.5309.71
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Articles

Marrow Stromal Cells as Stem Cells for Nonhematopoietic Tissues

Darwin J. Prockop

Marrow stromal cells can be isolated from other cells in marrow by their tendency to adhere to tissue culture plastic. The cells have many of the characteristics of stem cells for tissues that can roughly be defined as mesenchymal, because they can be differentiated in culture into osteoblasts, chondrocytes, adipocytes, and even myoblasts. Therefore, marrow stromal cells present an intriguing model for examining the differentiation of stem cells. Also, they have several characteristics that make them potentially useful for cell and gene therapy.

The author is director of the Center for Gene Therapy, Allegheny University of the Health Sciences, MCP-Hahnemann School of Medicine, 245 North 15 Street, Mail Stop 421, Philadelphia, PA 19102, USA. E-mail: prockop{at}allegheny.edu

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   Abstract »    Full Text »    PDF »
Greater Bone Formation of Y2 Knockout Mice Is Associated with Increased Osteoprogenitor Numbers and Altered Y1 Receptor Expression.
P. Lundberg, S. J. Allison, N. J. Lee, P. A. Baldock, N. Brouard, S. Rost, R. F. Enriquez, A. Sainsbury, M. Lamghari, P. Simmons, et al. (2007)
J. Biol. Chem. 282, 19082-19091
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A high-throughput siRNA library screen identifies osteogenic suppressors in human mesenchymal stem cells.
Y. Zhao and S. Ding (2007)
PNAS 104, 9673-9678
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Evaluation of Sca-1 and c-Kit As Selective Markers for Muscle Remodelling by Nonhemopoietic Bone Marrow Cells.
S. H.A. Wong, K. N. Lowes, I. Bertoncello, A. F. Quigley, P. J. Simmons, M. J. Cook, A. J. Kornberg, and R. M.I. Kapsa (2007)
Stem Cells 25, 1364-1374
   Abstract »    Full Text »    PDF »
Murine but Not Human Mesenchymal Stem Cells Generate Osteosarcoma-Like Lesions in the Lung.
S. Aguilar, E. Nye, J. Chan, M. Loebinger, B. Spencer-Dene, N. Fisk, G. Stamp, D. Bonnet, and S. M. Janes (2007)
Stem Cells 25, 1586-1594
   Abstract »    Full Text »    PDF »
Bone allografts: WHAT THEY CAN OFFER AND WHAT THEY CANNOT.
C. Delloye, O. Cornu, V. Druez, and O. Barbier (2007)
J Bone Joint Surg Br 89-B, 574-580
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Bone Marrow-Derived Mesenchymal Stem Cells Promote Neuronal Networks with Functional Synaptic Transmission After Transplantation into Mice with Neurodegeneration.
J.-S. Bae, H. S. Han, D.-H. Youn, J. E. Carter, M. Modo, E. H. Schuchman, and H. K. Jin (2007)
Stem Cells 25, 1307-1316
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Functional Expression of N-Formyl Peptide Receptors in Human Bone Marrow-Derived Mesenchymal Stem Cells.
A. Viswanathan, R. G. Painter, N. A. Lanson Jr., and G. Wang (2007)
Stem Cells 25, 1263-1269
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Molecular profile of mouse stromal mesenchymal stem cells.
S. Chateauvieux, J.-L. Ichante, B. Delorme, V. Frouin, G. Pietu, A. Langonne, N. Gallay, L. Sensebe, M. T. Martin, K. A. Moore, et al. (2007)
Physiol Genomics 29, 128-138
   Abstract »    Full Text »    PDF »
Transplantation of Mesenchymal Stem Cells Is an Optimal Approach for Plastic Surgery.
D. Fang, B.-M. Seo, Y. Liu, W. Sonoyama, T. Yamaza, C. Zhang, S. Wang, and S. Shi (2007)
Stem Cells 25, 1021-1028
   Abstract »    Full Text »    PDF »
Report on the Workshop "New Technologies in Stem Cell Research," Society for Pediatric Research, San Francisco, California, April 29, 2006.
J. C. Cheng, K. M. Sakamoto, E. M. Horwitz, S. L. Karsten, L. Shoemaker, H. I. Kornblumc, and P. Malik (2007)
Stem Cells 25, 1070-1088
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Identification of resident and inflammatory bone marrow derived cells in the sclera by bone marrow and haematopoietic stem cell transplantation.
T. Hisatomi, K.-h. Sonoda, F. Ishikawa, H. Qiao, T. Nakazawa, M. Fukata, T. Nakamura, K. Noda, S. Miyahara, M. Harada, et al. (2007)
Br. J. Ophthalmol. 91, 520-526
   Abstract »    Full Text »    PDF »
Synovial Stem Cells Are Regionally Specified According to Local Microenvironments After Implantation for Cartilage Regeneration.
H. Koga, T. Muneta, Y.-J. Ju, T. Nagase, A. Nimura, T. Mochizuki, S. Ichinose, K. von der Mark, and I. Sekiya (2007)
Stem Cells 25, 689-696
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Mesenchymal stem cells alone or ex vivo gene modified with endothelial nitric oxide synthase reverse age-associated erectile dysfunction.
T. J. Bivalacqua, W. Deng, M. Kendirci, M. F. Usta, C. Robinson, B. K. Taylor, S. N. Murthy, H. C. Champion, W. J. G. Hellstrom, and P. J. Kadowitz (2007)
Am J Physiol Heart Circ Physiol 292, H1278-H1290
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Brain protection using autologous bone marrow cell, metalloproteinase inhibitors, and metabolic treatment in cerebral ischemia.
A. H. Baker, V. Sica, L. M. Work, S. Williams-Ignarro, F. de Nigris, L. O. Lerman, A. Casamassimi, A. Lanza, C. Schiano, M. Rienzo, et al. (2007)
PNAS 104, 3597-3602
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SSEA-4 identifies mesenchymal stem cells from bone marrow.
E. J. Gang, D. Bosnakovski, C. A. Figueiredo, J. W. Visser, and R. C. R. Perlingeiro (2007)
Blood 109, 1743-1751
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Hematopoietic Stem-Cell Contribution to Ectopic Skeletogenesis.
F. S. Kaplan, D. L. Glaser, E. M. Shore, R. J. Pignolo, M. Xu, Y. Zhang, D. Senitzer, S. J. Forman, and S. G. Emerson (2007)
J. Bone Joint Surg. Am. 89, 347-357
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Phosphate Stimulates Matrix Gla Protein Expression in Chondrocytes through the Extracellular Signal Regulated Kinase Signaling Pathway.
M. Julien, D. Magne, M. Masson, M. Rolli-Derkinderen, O. Chassande, C. Cario-Toumaniantz, Y. Cherel, P. Weiss, and J. Guicheux (2007)
Endocrinology 148, 530-537
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Enhanced In Vivo Homing of Uncultured and Selectively Amplified Cord Blood CD34+ Cells by Cotransplantation with Cord Blood-Derived Unrestricted Somatic Stem Cells.
S. L. Chan, M. Choi, S. Wnendt, M. Kraus, E. Teng, H. F. Leong, and S. Merchav (2007)
Stem Cells 25, 529-536
   Abstract »    Full Text »    PDF »


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