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Science 4 April 1997:
Vol. 276. no. 5309, pp. 71 - 74
DOI: 10.1126/science.276.5309.71
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Articles

Marrow Stromal Cells as Stem Cells for Nonhematopoietic Tissues

Darwin J. Prockop

Marrow stromal cells can be isolated from other cells in marrow by their tendency to adhere to tissue culture plastic. The cells have many of the characteristics of stem cells for tissues that can roughly be defined as mesenchymal, because they can be differentiated in culture into osteoblasts, chondrocytes, adipocytes, and even myoblasts. Therefore, marrow stromal cells present an intriguing model for examining the differentiation of stem cells. Also, they have several characteristics that make them potentially useful for cell and gene therapy.

The author is director of the Center for Gene Therapy, Allegheny University of the Health Sciences, MCP-Hahnemann School of Medicine, 245 North 15 Street, Mail Stop 421, Philadelphia, PA 19102, USA. E-mail: prockop{at}allegheny.edu

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   Abstract »    Full Text »    PDF »
Recovery of Function Following Grafting of Human Bone Marrow-Derived Stromal Cells into the Injured Spinal Cord.
B. T. Himes, B. Neuhuber, C. Coleman, R. Kushner, S. A. Swanger, G. C. Kopen, J. Wagner, J. S. Shumsky, and I. Fischer (2006)
Neurorehabil Neural Repair 20, 278-296
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Ablation of proliferating marrow with 5-Fluorouracil allows partial purification of mesenchymal stem cells..
Z. Wang, J. Song, R. S. Taichman, and P. H. Krebsbach (2006)
Stem Cells 24, 1573-1582
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Mesenchymal stem cells reside in virtually all post-natal organs and tissues.
L. d. S. Meirelles, P. C. Chagastelles, and N. B. Nardi (2006)
J. Cell Sci. 119, 2204-2213
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Erythropoietin Delivery by Genetically Engineered Bone Marrow Stromal Cells for Correction of Anemia in Mice with Chronic Renal Failure.
N. Eliopoulos, R. F. Gagnon, M. Francois, and J. Galipeau (2006)
J. Am. Soc. Nephrol. 17, 1576-1584
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Interleukin-17A: A T-Cell-Derived Growth Factor for Murine and Human Mesenchymal Stem Cells.
W. Huang, V. La Russa, A. Alzoubi, and P. Schwarzenberger (2006)
Stem Cells 24, 1512-1518
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