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Science 4 April 1997: Vol. 276. no. 5309, pp. 71 - 74 DOI: 10.1126/science.276.5309.71
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Articles
Marrow Stromal Cells as Stem Cells for Nonhematopoietic Tissues
Darwin J. Prockop
Marrow stromal cells can be isolated from other cells in marrow by
their tendency to adhere to tissue culture plastic. The cells have many
of the characteristics of stem cells for tissues that can roughly be
defined as mesenchymal, because they can be differentiated in culture
into osteoblasts, chondrocytes, adipocytes, and even myoblasts.
Therefore, marrow stromal cells present an intriguing model for
examining the differentiation of stem cells. Also, they have several
characteristics that make them potentially useful for cell and gene
therapy.
The author is director of the Center for Gene Therapy, Allegheny
University of the Health Sciences, MCP-Hahnemann School of Medicine,
245 North 15 Street, Mail Stop 421, Philadelphia, PA 19102, USA.
E-mail: prockop{at}allegheny.edu
Read the Full Text
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- Intrapulmonary Delivery of Bone Marrow-Derived Mesenchymal Stem Cells Improves Survival and Attenuates Endotoxin-Induced Acute Lung Injury in Mice.
- N. Gupta, X. Su, B. Popov, J. W. Lee, V. Serikov, and M. A. Matthay (2007)
J. Immunol.
179, 1855-1863
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- Mesenchymal stromal cells, from indifferent spectators to principal actors. Are we going to witness a revolution in the scenario of allograft and immune-mediated disorders?.
- F. Locatelli, R. Maccario, and F. Frassoni (2007)
Haematologica
92, 872-877
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- Senescence-unrelated impediment of osteogenesis from Flk1+ bone marrow mesenchymal stem cells induced by total body irradiation and its contribution to long-term bone and hematopoietic injury.
- J. Ma, M. Shi, J. Li, B. Chen, H. Wang, B. Li, J. Hu, Y. Cao, B. Fang, and R. C. Zhao (2007)
Haematologica
92, 889-896
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- The In Vitro Migration Capacity of Human Bone Marrow Mesenchymal Stem Cells: Comparison of Chemokine and Growth Factor Chemotactic Activities.
- A. L. Ponte, E. Marais, N. Gallay, A. Langonne, B. Delorme, O. Herault, P. Charbord, and J. Domenech (2007)
Stem Cells
25, 1737-1745
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- A Novel Function of Interleukin-10 Promoting Self-Renewal of Hematopoietic Stem Cells.
- Y.-J. Kang, S.-J. Yang, G. Park, B. Cho, C.-K. Min, T.-Y. Kim, J.-S. Lee, and I.-H. Oh (2007)
Stem Cells
25, 1814-1822
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- Greater Bone Formation of Y2 Knockout Mice Is Associated with Increased Osteoprogenitor Numbers and Altered Y1 Receptor Expression.
- P. Lundberg, S. J. Allison, N. J. Lee, P. A. Baldock, N. Brouard, S. Rost, R. F. Enriquez, A. Sainsbury, M. Lamghari, P. Simmons, et al. (2007)
J. Biol. Chem.
282, 19082-19091
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- A high-throughput siRNA library screen identifies osteogenic suppressors in human mesenchymal stem cells.
- Y. Zhao and S. Ding (2007)
PNAS
104, 9673-9678
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- Evaluation of Sca-1 and c-Kit As Selective Markers for Muscle Remodelling by Nonhemopoietic Bone Marrow Cells.
- S. H.A. Wong, K. N. Lowes, I. Bertoncello, A. F. Quigley, P. J. Simmons, M. J. Cook, A. J. Kornberg, and R. M.I. Kapsa (2007)
Stem Cells
25, 1364-1374
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- Murine but Not Human Mesenchymal Stem Cells Generate Osteosarcoma-Like Lesions in the Lung.
- S. Aguilar, E. Nye, J. Chan, M. Loebinger, B. Spencer-Dene, N. Fisk, G. Stamp, D. Bonnet, and S. M. Janes (2007)
Stem Cells
25, 1586-1594
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- Bone allografts: WHAT THEY CAN OFFER AND WHAT THEY CANNOT.
- C. Delloye, O. Cornu, V. Druez, and O. Barbier (2007)
J Bone Joint Surg Br
89-B, 574-580
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- Bone Marrow-Derived Mesenchymal Stem Cells Promote Neuronal Networks with Functional Synaptic Transmission After Transplantation into Mice with Neurodegeneration.
- J.-S. Bae, H. S. Han, D.-H. Youn, J. E. Carter, M. Modo, E. H. Schuchman, and H. K. Jin (2007)
Stem Cells
25, 1307-1316
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- Functional Expression of N-Formyl Peptide Receptors in Human Bone Marrow-Derived Mesenchymal Stem Cells.
- A. Viswanathan, R. G. Painter, N. A. Lanson Jr., and G. Wang (2007)
Stem Cells
25, 1263-1269
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- Molecular profile of mouse stromal mesenchymal stem cells.
- S. Chateauvieux, J.-L. Ichante, B. Delorme, V. Frouin, G. Pietu, A. Langonne, N. Gallay, L. Sensebe, M. T. Martin, K. A. Moore, et al. (2007)
Physiol Genomics
29, 128-138
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- Transplantation of Mesenchymal Stem Cells Is an Optimal Approach for Plastic Surgery.
- D. Fang, B.-M. Seo, Y. Liu, W. Sonoyama, T. Yamaza, C. Zhang, S. Wang, and S. Shi (2007)
Stem Cells
25, 1021-1028
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- Report on the Workshop "New Technologies in Stem Cell Research," Society for Pediatric Research, San Francisco, California, April 29, 2006.
- J. C. Cheng, K. M. Sakamoto, E. M. Horwitz, S. L. Karsten, L. Shoemaker, H. I. Kornblumc, and P. Malik (2007)
Stem Cells
25, 1070-1088
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- Identification of resident and inflammatory bone marrow derived cells in the sclera by bone marrow and haematopoietic stem cell transplantation.
- T. Hisatomi, K.-h. Sonoda, F. Ishikawa, H. Qiao, T. Nakazawa, M. Fukata, T. Nakamura, K. Noda, S. Miyahara, M. Harada, et al. (2007)
Br. J. Ophthalmol.
91, 520-526
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- Synovial Stem Cells Are Regionally Specified According to Local Microenvironments After Implantation for Cartilage Regeneration.
- H. Koga, T. Muneta, Y.-J. Ju, T. Nagase, A. Nimura, T. Mochizuki, S. Ichinose, K. von der Mark, and I. Sekiya (2007)
Stem Cells
25, 689-696
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- Mesenchymal stem cells alone or ex vivo gene modified with endothelial nitric oxide synthase reverse age-associated erectile dysfunction.
- T. J. Bivalacqua, W. Deng, M. Kendirci, M. F. Usta, C. Robinson, B. K. Taylor, S. N. Murthy, H. C. Champion, W. J. G. Hellstrom, and P. J. Kadowitz (2007)
Am J Physiol Heart Circ Physiol
292, H1278-H1290
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- Brain protection using autologous bone marrow cell, metalloproteinase inhibitors, and metabolic treatment in cerebral ischemia.
- A. H. Baker, V. Sica, L. M. Work, S. Williams-Ignarro, F. de Nigris, L. O. Lerman, A. Casamassimi, A. Lanza, C. Schiano, M. Rienzo, et al. (2007)
PNAS
104, 3597-3602
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- SSEA-4 identifies mesenchymal stem cells from bone marrow.
- E. J. Gang, D. Bosnakovski, C. A. Figueiredo, J. W. Visser, and R. C. R. Perlingeiro (2007)
Blood
109, 1743-1751
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- Hematopoietic Stem-Cell Contribution to Ectopic Skeletogenesis.
- F. S. Kaplan, D. L. Glaser, E. M. Shore, R. J. Pignolo, M. Xu, Y. Zhang, D. Senitzer, S. J. Forman, and S. G. Emerson (2007)
J. Bone Joint Surg. Am.
89, 347-357
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- Phosphate Stimulates Matrix Gla Protein Expression in Chondrocytes through the Extracellular Signal Regulated Kinase Signaling Pathway.
- M. Julien, D. Magne, M. Masson, M. Rolli-Derkinderen, O. Chassande, C. Cario-Toumaniantz, Y. Cherel, P. Weiss, and J. Guicheux (2007)
Endocrinology
148, 530-537
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- Enhanced In Vivo Homing of Uncultured and Selectively Amplified Cord Blood CD34+ Cells by Cotransplantation with Cord Blood-Derived Unrestricted Somatic Stem Cells.
- S. L. Chan, M. Choi, S. Wnendt, M. Kraus, E. Teng, H. F. Leong, and S. Merchav (2007)
Stem Cells
25, 529-536
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