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Science 28 March 1997: Vol. 275. no. 5308, pp. 1943 - 1947 DOI: 10.1126/science.275.5308.1943
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Reports
PTEN, a Putative Protein Tyrosine Phosphatase Gene Mutated in Human Brain, Breast, and Prostate Cancer
Jing Li,
*
Clifford Yen,
*
Danny Liaw,
*
Katrina Podsypanina,
*
Shikha Bose,
Steven I. Wang,
Janusz Puc,
Christa Miliaresis,
Linda Rodgers,
Richard McCombie,
Sandra H. Bigner,
Beppino C. Giovanella,
Michael Ittmann,
Ben Tycko,
Hanina Hibshoosh,
Michael H. Wigler,
Ramon Parsons
Mapping of homozygous deletions on human chromosome 10q23 has led
to the isolation of a candidate tumor suppressor gene, PTEN, that appears to be mutated at considerable frequency in human cancers.
In preliminary screens, mutations of PTEN were detected in
31% (13/42) of glioblastoma cell lines and xenografts, 100% (4/4) of
prostate cancer cell lines, 6% (4/65) of breast cancer cell lines and
xenografts, and 17% (3/18) of primary glioblastomas. The predicted
PTEN product has a protein tyrosine phosphatase domain and
extensive homology to tensin, a protein that interacts with actin
filaments at focal adhesions. These homologies suggest that
PTEN may suppress tumor cell growth by antagonizing protein tyrosine kinases and may regulate tumor cell invasion and metastasis through interactions at focal adhesions.
J. Li, D. Liaw, K. Podsypanina, S. I. Wang, J. Puc, C. Miliaresis,
R. Parsons, Department of Pathology and Department of Medicine, College
of Physicians & Surgeons, Columbia University, 630 West 168 Street, New
York, NY 10032, USA.
C. Yen, L. Rodgers, R. McCombie, M. Wigler, Cold Spring Harbor
Laboratory, Cold Spring Harbor, NY 11724, USA.
S. H. Bigner, Department of Pathology, Duke University Medical Center,
Durham, NC 27710, USA.
B. Giovanella, Stehlin Foundation for Cancer Research, St. Joseph
Hospital, Houston, TX 77003, USA.
M. Ittmann, New York VA Medical Center and Department of Pathology, New
York University, 423 East 23 Street, New York, NY 10010, USA.
S. Bose, B. Tycko, H. Hibshoosh, Department of Pathology, College of
Physicians & Surgeons, Columbia University, New York, NY 10032, USA.
*
These authors contributed equally to this work.
To whom correspondence should be addressed.
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Carcinogenesis
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Bioinformatics
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Genetics
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