Science 21 March 1997: Vol. 275. no. 5307, pp. 1790 - 1792 DOI: 10.1126/science.275.5307.1790

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Overactive Beta-Catenin Signaling Causes Testicular Sertoli Cell Tumor Development in the Mouse.

H. Chang, F. Guillou, M. M. Taketo, and R. R. Behringer (2009)
Biol Reprod 81, 842-849
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Requirement of the Akt/{beta}-Catenin Pathway for Uterine Carcinosarcoma Genesis, Modulating E-Cadherin Expression Through the Transactivation of Slug.

M. Saegusa, M. Hashimura, T. Kuwata, and I. Okayasu (2009)
Am. J. Pathol. 174, 2107-2115
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Wnt/{beta}-Catenin Signaling Regulates Cytokine-Induced Human Inducible Nitric Oxide Synthase Expression by Inhibiting Nuclear Factor-{kappa}B Activation in Cancer Cells.

Q. Du, X. Zhang, J. Cardinal, Z. Cao, Z. Guo, L. Shao, and D. A. Geller (2009)
Cancer Res. 69, 3764-3771
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Noncanonical frizzled signaling regulates cell polarity of growth plate chondrocytes.

Y. Li and A. T. Dudley (2009)
Development 136, 1083-1092
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Stabilized {beta}-Catenin in Thymic Epithelial Cells Blocks Thymus Development and Function.

S. Zuklys, J. Gill, M. P. Keller, M. Hauri-Hohl, S. Zhanybekova, G. Balciunaite, K.-J. Na, L. T. Jeker, K. Hafen, N. Tsukamoto, et al. (2009)
J. Immunol. 182, 2997-3007
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Activated Wnt/ss-catenin signaling in melanoma is associated with decreased proliferation in patient tumors and a murine melanoma model.

A. J. Chien, E. C. Moore, A. S. Lonsdorf, R. M. Kulikauskas, B. G. Rothberg, A. J. Berger, M. B. Major, S. T. Hwang, D. L. Rimm, and R. T. Moon (2009)
PNAS 106, 1193-1198
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The {beta}-catenin/TCF4 pathway modifies alternative splicing through modulation of SRp20 expression.

V. Goncalves, P. Matos, and P. Jordan (2008)
RNA 14, 2538-2549
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Brn-2 Represses Microphthalmia-Associated Transcription Factor Expression and Marks a Distinct Subpopulation of Microphthalmia-Associated Transcription Factor-Negative Melanoma Cells.

J. Goodall, S. Carreira, L. Denat, D. Kobi, I. Davidson, P. Nuciforo, R. A. Sturm, L. Larue, and C. R. Goding (2008)
Cancer Res. 68, 7788-7794
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Widespread hyperplasia induced by transgenic TGF{alpha} in ApcMin mice is associated with only regional effects on tumorigenesis.

A. Bilger, R. Sullivan, A. J. Prunuske, L. Clipson, N. R. Drinkwater, and W. F. Dove (2008)
Carcinogenesis 29, 1825-1830
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Combinatorial patterns of somatic gene mutations in cancer.

C.-H. Yeang, F. McCormick, and A. Levine (2008)
FASEB J 22, 2605-2622
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Genetic Changes of Wnt Pathway Genes Are Common Events in Metaplastic Carcinomas of the Breast.

M. J. Hayes, D. Thomas, A. Emmons, T. J. Giordano, and C. G. Kleer (2008)
Clin. Cancer Res. 14, 4038-4044
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Human Colon Cancer Stem Cells: A New Paradigm in Gastrointestinal Oncology.

B. M. Boman and E. Huang (2008)
J. Clin. Oncol. 26, 2828-2838
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Signatures Associated with Rejection or Recurrence in HER-2/neu-Positive Mammary Tumors.

A. Worschech, M. Kmieciak, K. L. Knutson, H. D. Bear, A. A. Szalay, E. Wang, F. M. Marincola, and M. H. Manjili (2008)
Cancer Res. 68, 2436-2446
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Homozygous deletion of glycogen synthase kinase 3{beta} bypasses senescence allowing Ras transformation of primary murine fibroblasts.

S. Liu, X. Fang, H. Hall, S. Yu, D. Smith, Z. Lu, D. Fang, J. Liu, L. C. Stephens, J. R. Woodgett, et al. (2008)
PNAS 105, 5248-5253
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Beyond Good and Evil in the Oral Cavity: Insights into Host-Microbe Relationships Derived from Transcriptional Profiling of Gingival Cells.

M. Handfield, H.V. Baker, and R.J. Lamont (2008)
Journal of Dental Research 87, 203-223
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Agelastatin A: a novel inhibitor of osteopontin-mediated adhesion, invasion, and colony formation.

C. K. Mason, S. McFarlane, P. G. Johnston, P. Crowe, P. J. Erwin, M. M. Domostoj, F. C. Campbell, S. Manaviazar, K. J. Hale, and M. El-Tanani (2008)
Mol. Cancer Ther. 7, 548-558
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Conservation of Genetic Alterations in Recurrent Melanoma Supports the Melanoma Stem Cell Hypothesis.

M. Sabatino, Y. Zhao, S. Voiculescu, A. Monaco, P. Robbins, L. Karai, B. J. Nickoloff, M. Maio, S. Selleri, F. M. Marincola, et al. (2008)
Cancer Res. 68, 122-131
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REIC/Dkk-3 induces cell death in human malignant glioma.

Y. Mizobuchi, K. Matsuzaki, K. Kuwayama, K. Kitazato, H. Mure, T. Kageji, and S. Nagahiro (2008)
Neuro-oncol 10, 244-253
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beta-Catenin induces immortalization of melanocytes by suppressing p16INK4a expression and cooperates with N-Ras in melanoma development.

V. Delmas, F. Beermann, S. Martinozzi, S. Carreira, J. Ackermann, M. Kumasaka, L. Denat, J. Goodall, F. Luciani, A. Viros, et al. (2007)
Genes & Dev. 21, 2923-2935
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WNT10B Functional Dualism: beta-Catenin/Tcf-dependent Growth Promotion or Independent Suppression with Deregulated Expression in Cancer.

H. Yoshikawa, K. Matsubara, X. Zhou, S. Okamura, T. Kubo, Y. Murase, Y. Shikauchi, M. Esteller, J. G. Herman, X. Wei Wang, et al. (2007)
Mol. Biol. Cell 18, 4292-4303
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{beta}-catenin/TCF/Lef controls a differentiation-associated transcriptional program in renal epithelial progenitors.

K. M. Schmidt-Ott, T. N. H. Masckauchan, X. Chen, B. J. Hirsh, A. Sarkar, J. Yang, N. Paragas, V. A. Wallace, D. Dufort, P. Pavlidis, et al. (2007)
Development 134, 3177-3190
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A functional role of Cdx2 in {beta}-catenin signaling during transdifferentiation in endometrial carcinomas.

M. Saegusa, M. Hashimura, T. Kuwata, M. Hamano, Y. Wani, and I. Okayasu (2007)
Carcinogenesis 28, 1885-1892
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Haploinsufficiency of Kruppel-Like Factor 4 Promotes Adenomatous Polyposis Coli Dependent Intestinal Tumorigenesis.

A. M. Ghaleb, B. B. McConnell, M. O. Nandan, J. P. Katz, K. H. Kaestner, and V. W. Yang (2007)
Cancer Res. 67, 7147-7154
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Development of Gastric Tumors in ApcMin/+ Mice by the Activation of the {beta}-Catenin/Tcf Signaling Pathway.

H. Tomita, Y. Yamada, T. Oyama, K. Hata, Y. Hirose, A. Hara, T. Kunisada, Y. Sugiyama, Y. Adachi, H. Linhart, et al. (2007)
Cancer Res. 67, 4079-4087
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Tumor prone phenotype of mice deficient in a novel apoptosis-inducing gene, drs.

Y. Tambe, A. Yoshioka-Yamashita, K.-i. Mukaisho, S. Haraguchi, T. Chano, T. Isono, T. Kawai, Y. Suzuki, R. Kushima, T. Hattori, et al. (2007)
Carcinogenesis 28, 777-784
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Dual alterations in casein kinase I-{epsilon} and GSK-3beta modulate beta-catenin stability in hyperproliferating colonic epithelia.

S. Umar, Y. Wang, A. P. Morris, and J. H. Sellin (2007)
Am J Physiol Gastrointest Liver Physiol 292, G599-G607
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Accumulation of Nonphosphorylated {beta}-Catenin and c-myc in Primary and Uremic Secondary Hyperparathyroid Tumors.

P. Bjorklund, G. Akerstrom, and G. Westin (2007)
J. Clin. Endocrinol. Metab. 92, 338-344
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Mitf regulation of Dia1 controls melanoma proliferation and invasiveness.

S. Carreira, J. Goodall, L. Denat, M. Rodriguez, P. Nuciforo, K. S. Hoek, A. Testori, L. Larue, and C. R. Goding (2006)
Genes & Dev. 20, 3426-3439
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The Microphthalmia-Associated Transcription Factor Mitf Interacts with {beta}-Catenin To Determine Target Gene Expression.

A. Schepsky, K. Bruser, G. J. Gunnarsson, J. Goodall, J. H. Hallsson, C. R. Goding, E. Steingrimsson, and A. Hecht (2006)
Mol. Cell. Biol. 26, 8914-8927
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{beta}-Catenin stabilizes Cyclooxygenase-2 mRNA by interacting with AU-rich elements of 3'-UTR.

H. K. Lee and S. Jeong (2006)
Nucleic Acids Res. 34, 5705-5714
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Modulation of Oncogenic Transcription and Alternative Splicing by {beta}-Catenin and an RNA Aptamer in Colon Cancer Cells.

H. K. Lee, Y. S. Choi, Y. A. Park, and S. Jeong (2006)
Cancer Res. 66, 10560-10566
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Targeting the active {beta}-catenin pathway to treat cancer cells..

H. Dvory-Sobol, E. Sagiv, D. Kazanov, A. Ben-Ze'ev, and N. Arber (2006)
Mol. Cancer Ther. 5, 2861-2871
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Effective Treatment of Tumors with Strong {beta}-Catenin/T-Cell Factor Activity by Transcriptionally Targeted Oncolytic Herpes Simplex Virus Vector..

T. Kuroda, S. D. Rabkin, and R. L. Martuza (2006)
Cancer Res. 66, 10127-10135
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Malignant melanoma: genetics and therapeutics in the genomic era..

L. Chin, L. A. Garraway, and D. E. Fisher (2006)
Genes & Dev. 20, 2149-2182
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Melanoma..

A. J. Miller and M. C. Mihm Jr. (2006)
N. Engl. J. Med. 355, 51-65
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Physiological and Functional Interactions between Tcf4 and Daxx in Colon Cancer Cells.

S.-L. Tzeng, Y.-W. Cheng, C.-H. Li, Y.-S. Lin, H.-C. Hsu, and J.-J. Kang (2006)
J. Biol. Chem. 281, 15405-15411
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Protein-tyrosine Phosphatase PCP-2 Inhibits beta-Catenin Signaling and Increases E-cadherin-dependent Cell Adhesion.

H.-X. Yan, W. Yang, R. Zhang, L. Chen, L. Tang, B. Zhai, S.-Q. Liu, H.-F. Cao, X.-B. Man, H.-P. Wu, et al. (2006)
J. Biol. Chem. 281, 15423-15433
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Negative Regulation of LRP6 Function by Casein Kinase I {epsilon} Phosphorylation.

W. Swiatek, H. Kang, B. A. Garcia, J. Shabanowitz, G. S. Coombs, D. F. Hunt, and D. M. Virshup (2006)
J. Biol. Chem. 281, 12233-12241
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{beta}-Catenin/Wnt Signaling Regulates Expression of the Membrane Type 3 Matrix Metalloproteinase in Gastric Cancer..

A. M. Lowy, W. M. Clements, J. Bishop, L. Kong, T. Bonney, K. Sisco, B. Aronow, C. Fenoglio-Preiser, and J. Groden (2006)
Cancer Res. 66, 4734-4741
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Absence of {beta}-Catenin Alteration in Hepatic Tumors Induced by p-Nitroanisole in Crj:BDF1 Mice.

M. Kushida, S. Aiso, K. Morimura, M. Wei, H. Wanibuchi, K. Nagano, and S. Fukushima (2006)
Toxicol Pathol 34, 237-242
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Microphthalmic-Associated Transcription Factor Integrates Melanocyte Biology and Melanoma Progression.

C. Goding and F. L. Meyskens Jr. (2006)
Clin. Cancer Res. 12, 1069-1073
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7,12-Dimethylbenzanthracene-dependent transcriptional regulation of adenomatous polyposis coli (APC) gene expression in normal breast epithelial cells is mediated by GC-box binding protein Sp3.

A. S. Jaiswal, R. Balusu, and S. Narayan (2006)
Carcinogenesis 27, 252-261
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Importance of P-Cadherin, {beta}-Catenin, and Wnt5a/Frizzled for Progression of Melanocytic Tumors and Prognosis in Cutaneous Melanoma.

I. M. Bachmann, O. Straume, H. E. Puntervoll, M. B. Kalvenes, and L. A. Akslen (2005)
Clin. Cancer Res. 11, 8606-8614
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MUC1 Oncoprotein Blocks Glycogen Synthase Kinase 3{beta}-Mediated Phosphorylation and Degradation of {beta}-Catenin.

L. Huang, D. Chen, D. Liu, L. Yin, S. Kharbanda, and D. Kufe (2005)
Cancer Res. 65, 10413-10422
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Coordinate Regulation of the Oxygen-Dependent Degradation Domains of Hypoxia-Inducible Factor 1{alpha}.

D. A. Chan, P. D. Sutphin, S.-E. Yen, and A. J. Giaccia (2005)
Mol. Cell. Biol. 25, 6415-6426
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{beta}-Catenin Functions Mainly as an Adhesion Molecule in Patients with Squamous Cell Cancer of the Head and Neck.

Z. Yu, P. M. Weinberger, E. Provost, B. G. Haffty, C. Sasaki, J. Joe, R.L. Camp, D.L. Rimm, and A. Psyrri (2005)
Clin. Cancer Res. 11, 2471-2477
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Self-Renewal and Cancer of the Gut: Two Sides of a Coin.

F. Radtke and H. Clevers (2005)
Science 307, 1904-1909
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Histologic Type, Organ of Origin, and Wnt Pathway Status: Effect on Gene Expression in Ovarian and Uterine Carcinomas.

K. A. Shedden, M. P. Kshirsagar, D. R. Schwartz, R. Wu, H. Yu, D. E. Misek, S. Hanash, H. Katabuchi, L. H. Ellenson, E. R. Fearon, et al. (2005)
Clin. Cancer Res. 11, 2123-2131
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The links between axin and carcinogenesis.

S Salahshor and J R Woodgett (2005)
J. Clin. Pathol. 58, 225-236
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Glycogen Synthase Kinase 3{beta} Is a Negative Regulator of Growth Factor-induced Activation of the c-Jun N-terminal Kinase.

S. Liu, S. Yu, Y. Hasegawa, R. LaPushin, H.-J. Xu, J. R. Woodgett, G. B. Mills, and X. Fang (2004)
J. Biol. Chem. 279, 51075-51081
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Integrin-linked Kinase Regulates the Nuclear Entry of the c-Jun Coactivator {alpha}-NAC and Its Coactivation Potency.

I. Quelo, C. Gauthier, G. E. Hannigan, S. Dedhar, and R. St-Arnaud (2004)
J. Biol. Chem. 279, 43893-43899
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Cellular FLIP Inhibits {beta}-Catenin Ubiquitylation and Enhances Wnt Signaling.

M. Naito, R. Katayama, T. Ishioka, A. Suga, K. Takubo, M. Nanjo, C. Hashimoto, M. Taira, S. Takada, R. Takada, et al. (2004)
Mol. Cell. Biol. 24, 8418-8427
 |  Abstract »  |  Full Text »  |  PDF »

Cyclin D1 Genetic Heterozygosity Regulates Colonic Epithelial Cell Differentiation and Tumor Number in ApcMin Mice.

J. Hulit, C. Wang, Z. Li, C. Albanese, M. Rao, D. Di Vizio, S. Shah, S. W. Byers, R. Mahmood, L. H. Augenlicht, et al. (2004)
Mol. Cell. Biol. 24, 7598-7611
 |  Abstract »  |  Full Text »  |  PDF »

FrzA/sFRP-1, a secreted antagonist of the Wnt-Frizzled pathway, controls vascular cell proliferation in vitro and in vivo.

J. Ezan, L. Leroux, L. Barandon, P. Dufourcq, B. Jaspard, C. Moreau, C. Allieres, D. Daret, T. Couffinhal, and C. Duplaa (2004)
Cardiovasc Res 63, 731-738
 |  Abstract »  |  Full Text »  |  PDF »

Granulocyte-Macrophage Progenitors as Candidate Leukemic Stem Cells in Blast-Crisis CML.

C. H.M. Jamieson, L. E. Ailles, S. J. Dylla, M. Muijtjens, C. Jones, J. L. Zehnder, J. Gotlib, K. Li, M. G. Manz, A. Keating, et al. (2004)
N. Engl. J. Med. 351, 657-667
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T Cells Associated with Tumor Regression Recognize Frameshifted Products of the CDKN2A Tumor Suppressor Gene Locus and a Mutated HLA Class I Gene Product.

J. Huang, M. El-Gamil, M. E. Dudley, Y. F. Li, S. A. Rosenberg, and P. F. Robbins (2004)
J. Immunol. 172, 6057-6064
 |  Abstract »  |  Full Text »  |  PDF »

Ets Gene PEA3 Cooperates with {beta}-Catenin-Lef-1 and c-Jun in Regulation of Osteopontin Transcription.

M. El-Tanani, A. Platt-Higgins, P. S. Rudland, and F. C. Campbell (2004)
J. Biol. Chem. 279, 20794-20806
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Modulation of {beta}-Catenin Phosphorylation/Degradation by Cyclin-dependent Kinase 2.

C. S. Park, S. I. Kim, M. S. Lee, C.-y. Youn, D. J. Kim, E.-h. Jho, and W. K. Song (2004)
J. Biol. Chem. 279, 19592-19599
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{beta}-Catenin Simultaneously Induces Activation of the p53-p21WAF1 Pathway and Overexpression of Cyclin D1 during Squamous Differentiation of Endometrial Carcinoma Cells.

M. Saegusa, M. Hashimura, T. Kuwata, M. Hamano, and I. Okayasu (2004)
Am. J. Pathol. 164, 1739-1749
 |  Abstract »  |  Full Text »  |  PDF »

Brn-2 Expression Controls Melanoma Proliferation and Is Directly Regulated by {beta}-Catenin.

J. Goodall, S. Martinozzi, T. J. Dexter, D. Champeval, S. Carreira, L. Larue, and C. R. Goding (2004)
Mol. Cell. Biol. 24, 2915-2922
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Regulation of Casein Kinase I{epsilon} Activity by Wnt Signaling.

W. Swiatek, I-C. Tsai, L. Klimowski, A. Pepler, J. Barnette, H. J. Yost, and D. M. Virshup (2004)
J. Biol. Chem. 279, 13011-13017
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Sequential Analysis of Development of Invasive Thyroid Follicular Cell Carcinomas in Inflamed Capsular Regions of Rats Treated with Sulfadimethoxine after N-bis(2-hydroxypropyl)nitrosamine-initiation.

T. Imai, J.-I. Onose, M. Hasumura, M. Ueda, T. Takizawa, and M. Hirose (2004)
Toxicol Pathol 32, 229-236
 |  Abstract »  |  PDF »

Hepatocarcinogenesis in Mice with {beta}-Catenin and Ha-Ras Gene Mutations.

N. Harada, H. Oshima, M. Katoh, Y. Tamai, M. Oshima, and M. M. Taketo (2004)
Cancer Res. 64, 48-54
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Glucocorticoids Control {beta}-Catenin Protein Expression and Localization through Distinct Pathways that Can Be Uncoupled by Disruption of Signaling Events Required for Tight Junction Formation in Rat Mammary Epithelial Tumor Cells.

Y. Guan, N. M. Rubenstein, K. L. Failor, P. L. Woo, and G. L. Firestone (2004)
Mol. Endocrinol. 18, 214-227
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{beta}-Catenin regulates Cripto- and Wnt3-dependent gene expression programs in mouse axis and mesoderm formation.

M. Morkel, J. Huelsken, M. Wakamiya, J. Ding, M. van de Wetering, H. Clevers, M. M. Taketo, R. R. Behringer, M. M. Shen, and W. Birchmeier (2003)
Development 130, 6283-6294
 |  Abstract »  |  Full Text »  |  PDF »

SKI Activates Wnt/{beta}-Catenin Signaling in Human Melanoma.

D. Chen, W. Xu, E. Bales, C. Colmenares, M. Conacci-Sorrell, S. Ishii, E. Stavnezer, J. Campisi, D. E. Fisher, A. Ben-Ze'ev, et al. (2003)
Cancer Res. 63, 6626-6634
 |  Abstract »  |  Full Text »  |  PDF »

Wnt ligand expression in malignant melanoma: pilot study indicating correlation with histopathological features.

K Pham, T Milovanovic, R J Barr, T Truong, and R F Holcombe (2003)
Mol. Pathol. 56, 280-285
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Reduced {beta}-Catenin Expression in the Cytoplasm of Advanced-Stage Superficial Spreading Malignant Melanoma.

G. M. Maelandsmo, R. Holm, J. M. Nesland, O. Fodstad, and V. A. Florenes (2003)
Clin. Cancer Res. 9, 3383-3388
 |  Abstract »  |  Full Text »  |  PDF »

Novel Candidate Targets of {beta}-Catenin/T-cell Factor Signaling Identified by Gene Expression Profiling of Ovarian Endometrioid Adenocarcinomas.

D. R. Schwartz, R. Wu, S. L. R. Kardia, A. M. Levin, C.-C. Huang, K. A. Shedden, R. Kuick, D. E. Misek, S. M. Hanash, J. M. G. Taylor, et al. (2003)
Cancer Res. 63, 2913-2922
 |  Abstract »  |  Full Text »  |  PDF »

Reduction of {beta}-Catenin/T-Cell Transcription Factor Signaling by Aspirin and Indomethacin Is Caused by an Increased Stabilization of Phosphorylated {beta}-Catenin.

S. Dihlmann, S. Klein, and M. v. K. Doeberitz (2003)
Mol. Cancer Ther. 2, 509-516
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The Cohesin SMC3 Is a Target the for {beta}-Catenin/TCF4 Transactivation Pathway.

G. Ghiselli, N. Coffee, C. E. Munnery, R. Koratkar, and L. D. Siracusa (2003)
J. Biol. Chem. 278, 20259-20267
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Loss of Expression of the WNT/{beta}-Catenin-Signaling Pathway Transcription Factors Lymphoid Enhancer Factor-1 (LEF-1) and T Cell Factor-1 (TCF-1) in a Subset of Peripheral T Cell Lymphomas.

D. M. Dorfman, H. A. Greisman, and A. Shahsafaei (2003)
Am. J. Pathol. 162, 1539-1544
 |  Abstract »  |  Full Text »  |  PDF »

Lymphoid Enhancer Factor-1 and beta -Catenin Inhibit Runx2-dependent Transcriptional Activation of the Osteocalcin Promoter.

R. A. Kahler and J. J. Westendorf (2003)
J. Biol. Chem. 278, 11937-11944
 |  Abstract »  |  Full Text »  |  PDF »

Dictyostelium Differentiation-inducing Factor-3 Activates Glycogen Synthase Kinase-3beta and Degrades Cyclin D1 in Mammalian Cells.

F. Takahashi-Yanaga, Y. Taba, Y. Miwa, Y. Kubohara, Y. Watanabe, M. Hirata, S. Morimoto, and T. Sasaguri (2003)
J. Biol. Chem. 278, 9663-9670
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Human DNA methyltransferase gene DNMT1 is regulated by the APC pathway.

P. M. Campbell and M. Szyf (2003)
Carcinogenesis 24, 17-24
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Characterization of a Novel Mammalian Groucho Isoform and Its Role in Transcriptional Regulation.

M. Lepourcelet and R. A. Shivdasani (2002)
J. Biol. Chem. 277, 47732-47740
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RAG2 Is Down-regulated by Cytoplasmic Sequestration and Ubiquitin-dependent Degradation.

R. Mizuta, M. Mizuta, S. Araki, and D. Kitamura (2002)
J. Biol. Chem. 277, 41423-41427
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A yeast model system for functional analysis of {beta}-catenin signaling.

M. S. Lee, K. A. D'Amour, and J. Papkoff (2002)
J. Cell Biol. 158, 1067-1078
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{beta}-Catenin-induced melanoma growth requires the downstream target Microphthalmia-associated transcription factor.

H. R. Widlund, M. A. Horstmann, E. R. Price, J. Cui, S. L. Lessnick, M. Wu, X. He, and D. E. Fisher (2002)
J. Cell Biol. 158, 1079-1087
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Mutation and Expression of the {beta}-Catenin-interacting Protein ICAT in Human Colorectal Tumors.

T. Koyama, K.-i. Tago, T. Nakamura, S. Ohwada, Y. Morishita, J. Yokota, and T. Akiyama (2002)
Jpn. J. Clin. Oncol. 32, 358-362
 |  Abstract »  |  Full Text »  |  PDF »

Nr-CAM is a target gene of the beta -catenin/LEF-1 pathway in melanoma and colon cancer and its expression enhances motility and confers tumorigenesis.

M. E. Conacci-Sorrell, T. Ben-Yedidia, M. Shtutman, E. Feinstein, P. Einat, and A. Ben-Ze'ev (2002)
Genes & Dev. 16, 2058-2072
 |  Abstract »  |  Full Text »  |  PDF »

Expression and Characterization of GSK-3 Mutants and Their Effect on beta -Catenin Phosphorylation in Intact Cells.

T. Hagen, E. Di Daniel, A. A. Culbert, and A. D. Reith (2002)
J. Biol. Chem. 277, 23330-23335
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Targeted inactivation of CTNNB1 reveals unexpected effects of beta -catenin mutation.

T. A. Chan, Z. Wang, L. H. Dang, B. Vogelstein, and K. W. Kinzler (2002)
PNAS 99, 8265-8270
 |  Abstract »  |  Full Text »  |  PDF »

Turnover of Hepatitis B Virus X Protein Is Regulated by Damaged DNA-Binding Complex.

F. Bergametti, D. Sitterlin, and C. Transy (2002)
J. Virol. 76, 6495-6501
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Overexpression of Icat Induces G2 Arrest and Cell Death in Tumor Cell Mutants for Adenomatous Polyposis Coli, {beta}-catenin, or Axin.

T. Sekiya, T. Nakamura, Y. Kazuki, M. Oshimura, K. Kohu, K.-i. Tago, S. Ohwada, and T. Akiyama (2002)
Cancer Res. 62, 3322-3326
 |  Abstract »  |  Full Text »  |  PDF »

{beta}-Catenin Mutation Is a Frequent Cause of Wnt Pathway Activation in Gastric Cancer.

W. M. Clements, J. Wang, A. Sarnaik, O. J. Kim, J. MacDonald, C. Fenoglio-Preiser, J. Groden, and A. M. Lowy (2002)
Cancer Res. 62, 3503-3506
 |  Abstract »  |  Full Text »  |  PDF »

Protection against Anoikis and Down-regulation of Cadherin Expression by a Regulatable beta -Catenin Protein.

Z. Weng, M. Xin, L. Pablo, D. Grueneberg, M. Hagel, G. Bain, T. Muller, and J. Papkoff (2002)
J. Biol. Chem. 277, 18677-18686
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Protein Kinase C delta Regulates Function of the DF3/MUC1 Carcinoma Antigen in beta -Catenin Signaling.

J. Ren, Y. Li, and D. Kufe (2002)
J. Biol. Chem. 277, 17616-17622
 |  Abstract »  |  Full Text »  |  PDF »

Axin-mediated CKI phosphorylation of beta -catenin at Ser 45: a molecular switch for the Wnt pathway.

S. Amit, A. Hatzubai, Y. Birman, J. S. Andersen, E. Ben-Shushan, M. Mann, Y. Ben-Neriah, and I. Alkalay (2002)
Genes & Dev. 16, 1066-1076
 |  Abstract »  |  Full Text »  |  PDF »

Wnt signaling promotes oncogenic transformation by inhibiting c-Myc-induced apoptosis.

Z. You, D. Saims, S. Chen, Z. Zhang, D. C. Guttridge, K.-l. Guan, O. A. MacDougald, A. M.C. Brown, G. Evan, J. Kitajewski, et al. (2002)
J. Cell Biol. 157, 429-440
 |  Abstract »  |  Full Text »  |  PDF »

Synergistic Induction of Tumor Antigens by Wnt-1 Signaling and Retinoic Acid Revealed by Gene Expression Profiling.

D. A. Tice, W. Szeto, I. Soloviev, B. Rubinfeld, S. E. Fong, D. L. Dugger, J. Winer, P. M. Williams, D. Wieand, V. Smith, et al. (2002)
J. Biol. Chem. 277, 14329-14335
 |  Abstract »  |  Full Text »  |  PDF »

Secreted Frizzled Related Protein 1 Is Overexpressed in Uterine Leiomyomas, Associated with a High Estrogenic Environment and Unrelated to Proliferative Activity.

K. Fukuhara, M. Kariya, M. Kita, H. Shime, T. Kanamori, C. Kosaka, A. Orii, J. Fujita, and S. Fujii (2002)
J. Clin. Endocrinol. Metab. 87, 1729-1736
 |  Abstract »  |  Full Text »  |  PDF »

Lack of Tumorigenesis in the Mouse Liver after Adenovirus-mediated Expression of a Dominant Stable Mutant of {beta}-Catenin.

N. Harada, H. Miyoshi, N. Murai, H. Oshima, Y. Tamai, M. Oshima, and M. M. Taketo (2002)
Cancer Res. 62, 1971-1977
 |  Abstract »  |  Full Text »  |  PDF »

The Ubiquitin-Proteasome Proteolytic Pathway: Destruction for the Sake of Construction.

M. H. Glickman and A. Ciechanover (2002)
Physiol Rev 82, 373-428
 |  Abstract »  |  Full Text »  |  PDF »

Role of {beta}-Catenin/T-Cell Factor-Regulated Genes in Ovarian Endometrioid Adenocarcinomas.

Y. Zhai, R. Wu, D. R. Schwartz, D. Darrah, H. Reed, F. T. Kolligs, M. T. Nieman, E. R. Fearon, and K. R. Cho (2002)
Am. J. Pathol. 160, 1229-1238
 |  Abstract »  |  Full Text »  |  PDF »

Beckwith-Wiedemann Syndrome, Pancreatoblastoma, and the Wnt Signaling Pathway.

M. J. Sullivan, S. C. Abraham, R. H. Hruban, B. Bachtiary, G. Breitenecker, E. Selzer, G. Oberhuber, and J. T. Beranek (2002)
Am. J. Pathol. 160, 1541-1542
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Expression status of E-cadherin and {alpha}-, {beta}-, and {gamma}-catenins in thymoma.

I. Yoshino, S. Kase, T. Yano, K. Sugio, and K. Sugimachi (2002)
Ann. Thorac. Surg. 73, 933-937
 |  Abstract »  |  Full Text »  |  PDF »

Expression and Prognostic Roles of {beta}-Catenin in Hepatocellular Carcinoma: Correlation with Tumor Progression and Postoperative Survival.

S. Inagawa, M. Itabashi, S. Adachi, T. Kawamoto, M. Hori, J. Shimazaki, F. Yoshimi, and K. Fukao (2002)
Clin. Cancer Res. 8, 450-456
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of beta -Catenin Function by the Ikappa B Kinases.

C. Lamberti, K.-M. Lin, Y. Yamamoto, U. Verma, I. M. Verma, S. Byers, and R. B. Gaynor (2001)
J. Biol. Chem. 276, 42276-42286
 |  Abstract »  |  Full Text »  |  PDF »

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