Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 14 March 1997:
Vol. 275. no. 5306, pp. 1652 - 1654
DOI: 10.1126/science.275.5306.1652
Prev | Table of Contents | Next

Reports

A Member of the Frizzled Protein Family Mediating Axis Induction by Wnt-5A

Xi He, *dagger Jean-Pierre Saint-Jeannet, Yanshu Wang, Jeremy Nathans, Igor Dawid, Harold Varmus

In Xenopus laevis embryos, the Wingless/Wnt-1 subclass of Wnt molecules induces axis duplication, whereas the Wnt-5A subclass does not. This difference could be explained by distinct signal transduction pathways or by a lack of one or more Wnt-5A receptors during axis formation. Wnt-5A induced axis duplication and an ectopic Spemann organizer in the presence of hFz5, a member of the Frizzled family of seven-transmembrane receptors. Wnt-5A/hFz5 signaling was antagonized by glycogen synthase kinase-3 and by the amino-terminal ectodomain of hFz5. These results identify hFz5 as a receptor for Wnt-5A.

X. He and H. Varmus, National Cancer Institute, Building 49, Room 4A56, National Institutes of Health, Bethesda, MD 20892, USA.
J.-P. Saint-Jeannet and I. Dawid, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.
Y. Wang and J. Nathans, Howard Hughes Medical Institute, Department of Molecular Biology and Genetics, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
X. He and H. Varmus, National Cancer Institute, Building 49, Room 4A56, National Institutes of Health, Bethesda, MD 20892, USA.
J.-P. Saint-Jeannet and I. Dawid, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.
Y. Wang and J. Nathans, Howard Hughes Medical Institute, Department of Molecular Biology and Genetics, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
*   Present address: Division of Neuroscience, Enders 379, Children's Hospital/Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA

dagger    To whom correspondence should be addressed. E-mail: xhe{at}nhgri.nih.gov

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Towards an integrated view of Wnt signaling in development.
R. van Amerongen and R. Nusse (2009)
Development 136, 3205-3214
   Abstract »    Full Text »    PDF »
Wnt5a Is Required for Endothelial Differentiation of Embryonic Stem Cells and Vascularization via Pathways Involving Both Wnt/{beta}-Catenin and Protein Kinase C{alpha}.
D.-H. Yang, J.-Y. Yoon, S.-H. Lee, V. Bryja, E. R. Andersson, E. Arenas, Y.-G. Kwon, and K.-Y. Choi (2009)
Circ. Res. 104, 372-379
   Abstract »    Full Text »    PDF »
The Extracellular Domain of Lrp5/6 Inhibits Noncanonical Wnt Signaling In Vivo.
V. Bryja, E. R. Andersson, A. Schambony, M. Esner, L. Bryjova, K. K. Biris, A. C. Hall, B. Kraft, L. Cajanek, T. P. Yamaguchi, et al. (2009)
Mol. Biol. Cell 20, 924-936
   Abstract »    Full Text »    PDF »
Alternative Wnt Signaling Is Initiated by Distinct Receptors.
R. van Amerongen, A. Mikels, and R. Nusse (2008)
Science Signaling 1, re9
   Abstract »    Full Text »    PDF »
From individual Wnt pathways towards a Wnt signalling network.
H. A Kestler and M. Kuhl (2008)
Phil Trans R Soc B 363, 1333-1347
   Abstract »    Full Text »    PDF »
Chick pulmonary Wnt5a directs airway and vascular tubulogenesis.
M. Loscertales, A. J. Mikels, J. K.-H. Hu, P. K. Donahoe, and D. J. Roberts (2008)
Development 135, 1365-1376
   Abstract »    Full Text »    PDF »
WNT5A Exhibits Tumor-Suppressive Activity through Antagonizing the Wnt/ -Catenin Signaling, and Is Frequently Methylated in Colorectal Cancer.
J. Ying, H. Li, J. Yu, K. M. Ng, F. F. Poon, S. C. C. Wong, A. T.C. Chan, J. J.Y. Sung, and Q. Tao (2008)
Clin. Cancer Res. 14, 55-61
   Abstract »    Full Text »    PDF »
Wnt5a inhibits canonical Wnt signaling in hematopoietic stem cells and enhances repopulation.
M. J. Nemeth, L. Topol, S. M. Anderson, Y. Yang, and D. M. Bodine (2007)
PNAS 104, 15436-15441
   Abstract »    Full Text »    PDF »
Dynamic recruitment of axin by Dishevelled protein assemblies.
T. Schwarz-Romond, C. Metcalfe, and M. Bienz (2007)
J. Cell Sci. 120, 2402-2412
   Abstract »    Full Text »    PDF »
WNT Signaling Pathway and Stem Cell Signaling Network.
M. Katoh and M. Katoh (2007)
Clin. Cancer Res. 13, 4042-4045
   Abstract »    Full Text »    PDF »
Profilin is an effector for Daam1 in non-canonical Wnt signaling and is required for vertebrate gastrulation.
A. Sato, D. K. Khadka, W. Liu, R. Bharti, L. W. Runnels, I. B. Dawid, and R. Habas (2006)
Development 133, 4219-4231
   Abstract »    Full Text »    PDF »
Wnt-5a/Ca2+-Induced NFAT Activity Is Counteracted by Wnt-5a/Yes-Cdc42-Casein Kinase 1{alpha} Signaling in Human Mammary Epithelial Cells..
J. Dejmek, A. Safholm, C. Kamp Nielsen, T. Andersson, and K. Leandersson (2006)
Mol. Cell. Biol. 26, 6024-6036
   Abstract »    Full Text »    PDF »
The Wingless homolog WNT5A and its receptor Frizzled-5 regulate inflammatory responses of human mononuclear cells induced by microbial stimulation.
A. Blumenthal, S. Ehlers, J. Lauber, J. Buer, C. Lange, T. Goldmann, H. Heine, E. Brandt, and N. Reiling (2006)
Blood 108, 965-973
   Abstract »    Full Text »    PDF »
Gene Expression Profile Signatures Indicate a Role for Wnt Signaling in Endothelial Commitment From Embryonic Stem Cells.
H. Wang, P. C. Charles, Y. Wu, R. Ren, X. Pi, M. Moser, M. Barshishat-Kupper, J. S. Rubin, C. Perou, V. Bautch, et al. (2006)
Circ. Res. 98, 1331-1339
   Abstract »    Full Text »    PDF »
Foxf1 and Foxf2 control murine gut development by limiting mesenchymal Wnt signaling and promoting extracellular matrix production.
M. Ormestad, J. Astorga, H. Landgren, T. Wang, B. R. Johansson, N. Miura, and P. Carlsson (2006)
Development 133, 833-843
   Abstract »    Full Text »    PDF »
Wnt signaling: complexity at the surface.
K. M. Cadigan and Y. I. Liu (2006)
J. Cell Sci. 119, 395-402
   Abstract »    Full Text »    PDF »
Wnt5a Expression Is Associated With the Tumor Proliferation and the Stromal Vascular Endothelial Growth Factor--An Expression in Non-Small-Cell Lung Cancer.
C.-l. Huang, D. Liu, J. Nakano, S. Ishikawa, K. Kontani, H. Yokomise, and M. Ueno (2005)
J. Clin. Oncol. 23, 8765-8773
   Abstract »    Full Text »    PDF »
The Mechanism of Endogenous Receptor Activation Functionally Distinguishes Prototype Canonical and Noncanonical Wnts.
G. Liu, A. Bafico, and S. A. Aaronson (2005)
Mol. Cell. Biol. 25, 3475-3482
   Abstract »    Full Text »    PDF »
Three's Company: Two or More Unrelated Receptors Pair with the Same Ligand.
I. Ben-Shlomo and A. J. W. Hsueh (2005)
Mol. Endocrinol. 19, 1097-1109
   Abstract »    Full Text »    PDF »
Canonical Wnt Signaling Is Critical to Estrogen-Mediated Uterine Growth.
X. Hou, Y. Tan, M. Li, S. K. Dey, and S. K. Das (2004)
Mol. Endocrinol. 18, 3035-3049
   Abstract »    Full Text »    PDF »
Zebrafish Dapper1 and Dapper2 play distinct roles in Wnt-mediated developmental processes.
J. S. Waxman, A. M. Hocking, C. L. Stoick, and R. T. Moon (2004)
Development 131, 5909-5921
   Abstract »    Full Text »    PDF »
Wnt signals across the plasma membrane to activate the {beta}-catenin pathway by forming oligomers containing its receptors, Frizzled and LRP.
F. Cong, L. Schweizer, and H. Varmus (2004)
Development 131, 5103-5115
   Abstract »    Full Text »    PDF »
Expression and Estradiol Regulation of Wnt Genes in the Mouse Blastocyst Identify a Candidate Pathway for Embryo-Maternal Signaling at Implantation.
O. A. Mohamed, D. Dufort, and H. J. Clarke (2004)
Biol Reprod 71, 417-424
   Abstract »    Full Text »    PDF »
Multiple Mechanisms for Wnt11-mediated Repression of the Canonical Wnt Signaling Pathway.
P. Maye, J. Zheng, L. Li, and D. Wu (2004)
J. Biol. Chem. 279, 24659-24665
   Abstract »    Full Text »    PDF »
LDL receptor-related proteins 5 and 6 in Wnt/{beta}-catenin signaling: Arrows point the way.
X. He, M. Semenov, K. Tamai, and X. Zeng (2004)
Development 131, 1663-1677
   Abstract »    Full Text »    PDF »
Gene Profiling of Frizzled-1 and Frizzled-2 Signaling: Expression of G-Protein-Coupled Receptor Chimeras in Mouse F9 Teratocarcinoma Embryonal Cells.
H. Li, C. C. Malbon, and H.-Y. Wang (2004)
Mol. Pharmacol. 65, 45-55
   Abstract »    Full Text »    PDF »
Functional Characterization of WNT7A Signaling in PC12 Cells: INTERACTION WITH A FZD5{middle dot}LRP6 RECEPTOR COMPLEX AND MODULATION BY DICKKOPF PROTEINS.
A. Caricasole, T. Ferraro, L. Iacovelli, E. Barletta, A. Caruso, D. Melchiorri, G. C. Terstappen, and F. Nicoletti (2003)
J. Biol. Chem. 278, 37024-37031
   Abstract »    Full Text »    PDF »
Wnt-5/pipetail functions in vertebrate axis formation as a negative regulator of Wnt/{beta}-catenin activity.
T. A. Westfall, R. Brimeyer, J. Twedt, J. Gladon, A. Olberding, M. Furutani-Seiki, and D. C. Slusarski (2003)
J. Cell Biol. 162, 889-898
   Abstract »    Full Text »    PDF »
A Novel Mechanism for Wnt Activation of Canonical Signaling through the LRP6 Receptor.
G. Liu, A. Bafico, V. K. Harris, and S. A. Aaronson (2003)
Mol. Cell. Biol. 23, 5825-5835
   Abstract »    Full Text »    PDF »
Secreted antagonists of the Wnt signalling pathway.
Y. Kawano and R. Kypta (2003)
J. Cell Sci. 116, 2627-2634
   Abstract »    Full Text »    PDF »
Wnt regulation of chondrocyte differentiation.
V. Church, T. Nohno, C. Linker, C. Marcelle, and P. Francis-West (2003)
J. Cell Sci. 115, 4809-4818
   Abstract »    Full Text »    PDF »
Wnt5a and Wnt5b exhibit distinct activities in coordinating chondrocyte proliferation and differentiation.
Y. Yang, L. Topol, H. Lee, and J. Wu (2003)
Development 130, 1003-1015
   Abstract »    Full Text »    PDF »
The secreted Frizzled-related protein Sizzled functions as a negative feedback regulator of extreme ventral mesoderm.
L. Collavin and M. W. Kirschner (2003)
Development 130, 805-816
   Abstract »    Full Text »    PDF »
Coactivation of Rac and Rho by Wnt/Frizzled signaling is required for vertebrate gastrulation.
R. Habas, I. B. Dawid, and X. He (2003)
Genes & Dev. 17, 295-309
   Abstract »    Full Text »    PDF »
FrzA, a Secreted Frizzled Related Protein, Induced Angiogenic Response.
P. Dufourcq, T. Couffinhal, J. Ezan, L. Barandon, C. Moreau, D. Daret, and C. Duplaa (2002)
Circulation 106, 3097-3103
   Abstract »    Full Text »    PDF »
Ligand Receptor Interactions in the Wnt Signaling Pathway in Drosophila.
C.-h. Wu and R. Nusse (2002)
J. Biol. Chem. 277, 41762-41769
   Abstract »    Full Text »    PDF »
Frizzled-3 Is Required for the Development of Major Fiber Tracts in the Rostral CNS.
Y. Wang, N. Thekdi, P. M. Smallwood, J. P. Macke, and J. Nathans (2002)
J. Neurosci. 22, 8563-8573
   Abstract »    Full Text »    PDF »
Endothelial Cells Stimulate T Cell NFAT Nuclear Translocation in the Presence of Cyclosporin A: Involvement of the wnt/Glycogen Synthase Kinase-3{beta} Pathway.
L. L. Salazar Murphy and C. C. W. Hughes (2002)
J. Immunol. 169, 3717-3725
   Abstract »    Full Text »    PDF »
Frizzled-9 Is Activated by Wnt-2 and Functions in Wnt/beta -Catenin Signaling.
T. Karasawa, H. Yokokura, J. Kitajewski, and P. J. Lombroso (2002)
J. Biol. Chem. 277, 37479-37486
   Abstract »    Full Text »    PDF »
A Novel Set of Wnt-Frizzled Fusion Proteins Identifies Receptor Components That Activate beta -Catenin-dependent Signaling.
S. L. Holmen, A. Salic, C. R. Zylstra, M. W. Kirschner, and B. O. Williams (2002)
J. Biol. Chem. 277, 34727-34735
   Abstract »    Full Text »    PDF »
Activation of the beta -Catenin/Lef-Tcf Pathway Is Obligate for Formation of Primitive Endoderm by Mouse F9 Totipotent Teratocarcinoma Cells in Response to Retinoic Acid.
T. Liu, Y.-N. Lee, C. C. Malbon, and H.-y. Wang (2002)
J. Biol. Chem. 277, 30887-30891
   Abstract »    Full Text »    PDF »
Expression of Wnt ligands and Frizzled receptors in colonic mucosa and in colon carcinoma.
R F Holcombe, J L Marsh, M L Waterman, F Lin, T Milovanovic, and T Truong (2002)
Mol. Pathol. 55, 220-226
   Abstract »    Full Text »    PDF »
The wnt-frizzled cascade in cardiovascular disease.
M. E. van Gijn, M. J.A.P. Daemen, J. F.M. Smits, and W.M. Blankesteijn (2002)
Cardiovasc Res 55, 16-24
   Full Text »    PDF »
Protection against Anoikis and Down-regulation of Cadherin Expression by a Regulatable beta -Catenin Protein.
Z. Weng, M. Xin, L. Pablo, D. Grueneberg, M. Hagel, G. Bain, T. Muller, and J. Papkoff (2002)
J. Biol. Chem. 277, 18677-18686
   Abstract »    Full Text »    PDF »
Wnt signaling promotes oncogenic transformation by inhibiting c-Myc-induced apoptosis.
Z. You, D. Saims, S. Chen, Z. Zhang, D. C. Guttridge, K.-l. Guan, O. A. MacDougald, A. M.C. Brown, G. Evan, J. Kitajewski, et al. (2002)
J. Cell Biol. 157, 429-440
   Abstract »    Full Text »    PDF »
Functional Diversity of Xenopus Lymphoid Enhancer Factor/T-cell Factor Transcription Factors Relies on Combinations of Activating and Repressing Elements.
D. Gradl, A. Konig, and D. Wedlich (2002)
J. Biol. Chem. 277, 14159-14171
   Abstract »    Full Text »    PDF »
A role for frizzled 3 in neural crest development.
M. A. Deardorff, C. Tan, J.-P. Saint-Jeannet, and P. S. Klein (2001)
Development 128, 3655-3663
   Abstract »    Full Text »    PDF »
G Protein Signaling from Activated Rat Frizzled-1 to the beta -Catenin-Lef-Tcf Pathway.
T. Liu, A. J. DeCostanzo, X. Liu, H.-y. Wang, S. Hallagan, R. T. Moon, and C. C. Malbon (2001)
Science 292, 1718-1722
   Abstract »    Full Text »    PDF »
Difference in XTcf-3 dependency accounts for change in response to {beta}-catenin-mediated Wnt signalling in Xenopus blastula.
F. S. Hamilton, G. N. Wheeler, and S. Hoppler (2001)
Development 128, 2063-2073
   Abstract »    Full Text »    PDF »
Regulation of eye development by frizzled signaling in Xenopus.
J. T. Rasmussen, M. A. Deardorff, C. Tan, M. S. Rao, P. S. Klein, and M. L. Vetter (2001)
PNAS 98, 3861-3866
   Abstract »    Full Text »    PDF »
Identification of a Mouse Homolog of the Human BTEB2 Transcription Factor as a {beta}-Catenin-Independent Wnt-1-Responsive Gene.
L. T. Ziemer, D. Pennica, and A. J. Levine (2001)
Mol. Cell. Biol. 21, 562-574
   Abstract »    Full Text »
Mouse Wnt receptor gene Fzd5 is essential for yolk sac and placental angiogenesis.
T Ishikawa, Y Tamai, A. Zorn, H Yoshida, M. Seldin, S Nishikawa, and M. Taketo (2001)
Development 128, 25-33
   Abstract »    PDF »
Wnt signaling and cancer.
P. Polakis (2000)
Genes & Dev. 14, 1837-1851
   Full Text »
WNT/Frizzled-2 Signaling Induces Aggregation and Adhesion among Cardiac Myocytes by Increased Cadherin-{beta}-Catenin Complex.
T. Toyofuku, Z. Hong, T. Kuzuya, M. Tada, and M. Hori (2000)
J. Cell Biol. 150, 225-242
   Abstract »    Full Text »    PDF »
Ca2+/Calmodulin-dependent Protein Kinase II Is Stimulated by Wnt and Frizzled Homologs and Promotes Ventral Cell Fates in Xenopus.
M. Kuhl, L. C. Sheldahl, C. C. Malbon, and R. T. Moon (2000)
J. Biol. Chem. 275, 12701-12711
   Abstract »    Full Text »    PDF »
Plakoglobin Suppresses Epithelial Proliferation and Hair Growth in Vivo.
E. Charpentier, R. M. Lavker, E. Acquista, and P. Cowin (2000)
J. Cell Biol. 149, 503-520
   Abstract »    Full Text »    PDF »
Interaction among Gsk-3, Gbp, Axin, and APC in Xenopus Axis Specification.
G. H. Farr III, D. M. Ferkey, C. Yost, S. B. Pierce, C. Weaver, and D. Kimelman (2000)
J. Cell Biol. 148, 691-702
   Abstract »    Full Text »    PDF »
Secreted Frizzled-related Protein-1 Binds Directly to Wingless and Is a Biphasic Modulator of Wnt Signaling.
A. Uren, F. Reichsman, V. Anest, W. G. Taylor, K. Muraiso, D. P. Bottaro, S. Cumberledge, and J. S. Rubin (2000)
J. Biol. Chem. 275, 4374-4382
   Abstract »    Full Text »    PDF »
Dual roles of Wnt signaling during chondrogenesis in the chicken limb.
C Hartmann and C. Tabin (2000)
Development 127, 3141-3159
   Abstract »    PDF »
The putative wnt receptor Xenopus frizzled-7 functions upstream of beta-catenin in vertebrate dorsoventral mesoderm patterning.
S Sumanas, P Strege, J Heasman, and S. Ekker (2000)
Development 127, 1981-1990
   Abstract »    PDF »
Differential Expression of Rat Frizzled-Related frzb-1 and Frizzled Receptor fz1 and fz2 Genes in the Rat Aorta After Balloon Injury.
C. Mao, O. T.-B. Malek, M. E. Pueyo, P. G. Steg, and F. Soubrier (2000)
Arterioscler Thromb Vasc Biol 20, 43-51
   Abstract »    Full Text »    PDF »
SHH-N upregulates Sfrp2 to mediate its competitive interaction with WNT1 and WNT4 in the somitic mesoderm.
C. Lee, L. Buttitta, N. May, A Kispert, and C. Fan (2000)
Development 127, 109-118
   Abstract »    PDF »
Activation of a Frizzled-2/beta -adrenergic receptor chimera promotes Wnt signaling and differentiation of mouse F9 teratocarcinoma cells via Galpha o and Galpha t.
X. Liu, T. Liu, D. C. Slusarski, J. Yang-Snyder, C. C. Malbon, R. T. Moon, and H.-y. Wang (1999)
PNAS 96, 14383-14388
   Abstract »    Full Text »    PDF »
Wnt signaling in Xenopus embryos inhibits Bmp4 expression and activates neural development.
J. C. Baker, R. S.P. Beddington, and R. M. Harland (1999)
Genes & Dev. 13, 3149-3159
   Abstract »    Full Text »
Activation of Rat Frizzled-1 Promotes Wnt Signaling and Differentiation of Mouse F9 Teratocarcinoma Cells via Pathways That Require Galpha q and Galpha o Function.
T. Liu, X. Liu, H.-y. Wang, R. T. Moon, and C. C. Malbon (1999)
J. Biol. Chem. 274, 33539-33544
   Abstract »    Full Text »    PDF »
Isolation and Biochemical Characterization of the Human Dkk-1 Homologue, a Novel Inhibitor of Mammalian Wnt Signaling.
P. Fedi, A. Bafico, A. N. Soria, W. H. Burgess, T. Miki, D. P. Bottaro, M. H. Kraus, and S. A. Aaronson (1999)
J. Biol. Chem. 274, 19465-19472
   Abstract »    Full Text »    PDF »
Interaction of Frizzled Related Protein (FRP) with Wnt Ligands and the Frizzled Receptor Suggests Alternative Mechanisms for FRP Inhibition of Wnt Signaling.
A. Bafico, A. Gazit, T. Pramila, P. W. Finch, A. Yaniv, and S. A. Aaronson (1999)
J. Biol. Chem. 274, 16180-16187
   Abstract »    Full Text »    PDF »
Heptahelical Receptor Signaling: Beyond the G Protein Paradigm.
R. A. Hall, R. T. Premont, and R. J. Lefkowitz (1999)
J. Cell Biol. 145, 927-932
   Full Text »    PDF »
The Polycystic Kidney Disease 1 Gene Product Modulates Wnt Signaling.
E. Kim, T. Arnould, L. K. Sellin, T. Benzing, M. J. Fan, W. Gruning, S. Y. Sokol, I. Drummond, and G. Walz (1999)
J. Biol. Chem. 274, 4947-4953
   Abstract »    Full Text »    PDF »
Frizzled and Dfrizzled-2 function as redundant receptors for Wingless during Drosophila embryonic development.
P Bhanot, M Fish, J. Jemison, R Nusse, J Nathans, and K. Cadigan (1999)
Development 126, 4175-4186
   Abstract »    PDF »
Dishevelled Proteins Lead to Two Signaling Pathways. REGULATION OF LEF-1 AND c-Jun N-TERMINAL KINASE IN MAMMALIAN CELLS.
L. Li, H. Yuan, W. Xie, J. Mao, A. M. Caruso, A. McMahon, D. J. Sussman, and D. Wu (1999)
J. Biol. Chem. 274, 129-134
   Abstract »    Full Text »    PDF »
Role of Members of the Wnt Gene Family in Human Hematopoiesis.
D. J. Van Den Berg, A. K. Sharma, E. Bruno, and R. Hoffman (1998)
Blood 92, 3189-3202
   Abstract »    Full Text »    PDF »
A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta -catenin signals.
S. Tanaka, T. Akiyoshi, M. Mori, J. R. Wands, and K. Sugimachi (1998)
PNAS 95, 10164-10169
   Abstract »    Full Text »    PDF »
Differential recruitment of Dishevelled provides signaling specificity in the planar cell polarity and Wingless signaling pathways.
J. D. Axelrod, J. R. Miller, J. M. Shulman, R. T. Moon, and N. Perrimon (1998)
Genes & Dev. 12, 2610-2622
   Abstract »    Full Text »
Functional and biochemical interactions of Wnts with FrzA, a secreted Wnt antagonist.
Q Xu, P. D'Amore, and S. Sokol (1998)
Development 125, 4767-4776
   Abstract »    PDF »
In vivo evidence that Patched and Smoothened constitute distinct binding and transducing components of a Hedgehog receptor complex.
Y Chen and G Struhl (1998)
Development 125, 4943-4948
   Abstract »    PDF »
Evidence for a frizzled-mediated wnt pathway required for zebrafish dorsal mesoderm formation.
A Nasevicius, T Hyatt, H Kim, J Guttman, E Walsh, S Sumanas, Y Wang, and S. Ekker (1998)
Development 125, 4283-4292
   Abstract »    PDF »
Interactions between Wingless and DFz2 during Drosophila wing development.
J Zhang and R. Carthew (1998)
Development 125, 3075-3085
   Abstract »    PDF »
Frizzled-8 is expressed in the Spemann organizer and plays a role in early morphogenesis.
M. Deardorff, C Tan, L. Conrad, and P. Klein (1998)
Development 125, 2687-2700
   Abstract »    PDF »
Wnt signaling: a common theme in animal development.
K. M. Cadigan and R. Nusse (1997)
Genes & Dev. 11, 3286-3305
   Full Text »    PDF »
Autonomous and nonautonomous regulation of axis formation by antagonistic signaling via 7-span cAMP receptors and GSK3 in Dictyostelium.
G. T. Ginsburg and A. R. Kimmel (1997)
Genes & Dev. 11, 2112-2123
   Abstract »    Full Text »    PDF »
Specification of the Zebrafish Nervous System by Nonaxial Signals.
K. Woo and S. E. Fraser (1997)
Science 277, 254-257
   Abstract »    Full Text »
Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action.
P. W. Finch, X. He, M. J. Kelley, A. Uren, R. P. Schaudies, N. C. Popescu, S. Rudikoff, S. A. Aaronson, H. E. Varmus, and J. S. Rubin (1997)
PNAS 94, 6770-6775
   Abstract »    Full Text »    PDF »
Patterning the Xenopus blastula.
J Heasman (1997)
Development 124, 4179-4191
   Abstract »    PDF »
Patterning by Genes Expressed in Spemann's Organizer.
E.M. De Robertis, S. Kim, L. Leyns, S. Piccolo, D. Bachiller, E. Agius, J.A. Belo, A. Yamamoto, A. Hainski-Brousseau, B. Brizuela, et al. (1997)
Cold Spring Harb Symp Quant Biol 62, 169-175
   Abstract »    PDF »
Cell Culture and Whole Animal Approaches to Understanding Signaling by Wnt Proteins in Drosophila.
R. Nusse, C. Harryman Samos, M. Brink, K. Willert, K.M. Cadigan, A. Wodarz, M. Fish, and E. Rulifson (1997)
Cold Spring Harb Symp Quant Biol 62, 185-190
   Abstract »    PDF »
Expression of Wnt and Frizzled Genes during Chick Limb Bud Development.
M. Kengaku, V. Twombly, and C. Tabin (1997)
Cold Spring Harb Symp Quant Biol 62, 421-429
   Abstract »    PDF »
A Positive Role for the PP2A Catalytic Subunit in Wnt Signal Transduction.
M. J. Ratcliffe, K. Itoh, and S. Y. Sokol (2000)
J. Biol. Chem. 275, 35680-35683
   Abstract »    Full Text »    PDF »
Differential Molecular Assemblies Underlie the Dual Function of Axin in Modulating the Wnt and JNK Pathways.
Y. Zhang, W.-J. Qiu, D.-X. Liu, S. Y. Neo, X. He, and S.-C. Lin (2001)
J. Biol. Chem. 276, 32152-32159
   Abstract »    Full Text »    PDF »
Expression and function of wingless and frizzled homologs in rheumatoid arthritis.
M. Sen, K. Lauterbach, H. El-Gabalawy, G. S. Firestein, M. Corr, and D. A. Carson (2000)
PNAS 97, 2791-2796
   Abstract »    Full Text »    PDF »
Wnt signaling promotes oncogenic transformation by inhibiting c-Myc-induced apoptosis.
Z. You, D. Saims, S. Chen, Z. Zhang, D. C. Guttridge, K.-l. Guan, O. A. MacDougald, A. M.C. Brown, G. Evan, J. Kitajewski, et al. (2002)
J. Cell Biol. 157, 429-440
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)