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Science 14 March 1997:
Vol. 275. no. 5306, pp. 1640 - 1643
DOI: 10.1126/science.275.5306.1640
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Reports

Tyrosine Phosphorylation of Transmembrane Ligands for Eph Receptors

Katja Brückner, Elena B. Pasquale, Rüdiger Klein *

Axonal pathfinding in the nervous system is mediated in part by cell-to-cell signaling events involving members of the Eph receptor tyrosine kinase (RTK) family and their membrane-bound ligands. Genetic evidence suggests that transmembrane ligands may transduce signals in the developing embryo. The cytoplasmic domain of the transmembrane ligand Lerk2 became phosphorylated on tyrosine residues after contact with the Nuk/Cek5 receptor ectodomain, which suggests that Lerk2 has receptorlike intrinsic signaling potential. Moreover, Lerk2 is an in vivo substrate for the platelet-derived growth factor receptor, which suggests crosstalk between Lerk2 signaling and signaling cascades activated by tyrosine kinases. It is proposed that transmembrane ligands of Eph receptors act not only as conventional RTK ligands but also as receptorlike signaling molecules.

K. Brückner and R. Klein, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany.
E. B. Pasquale, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA.
*   To whom correspondence should be addressed. E-mail: Klein{at}EMBL-Heidelberg.de

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