Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 28 February 1997:
Vol. 275. no. 5304, pp. 1318 - 1320
DOI: 10.1126/science.275.5304.1318
Prev | Table of Contents | Next

Reports

Role of Transforming Growth Factor-beta in Long-Term Synaptic Facilitation in Aplysia

Fan Zhang, Shogo Endo, Leonard J. Cleary, Arnold Eskin, John H. Byrne *

The role of transforming growth factor-beta (TGF-beta ) in long-term synaptic facilitation was examined in isolated Aplysia ganglia. Treatment with TGF-beta 1 induced long-term facilitation (24 and 48 hours), but not short-term (5 to 15 minutes) or intermediate-term (2 to 4 hours) facilitation. The long-term effects of TGF-beta 1 were not additive with those of serotonin. Moreover, serotonin-induced facilitation was blocked by an inhibitor of TGF-beta . Thus, activation of TGF-beta may be part of the cascade of events underlying long-term sensitization, consistent with the hypothesis that signaling molecules that participate in development also have roles in adult neuronal plasticity.

F. Zhang, L. J. Cleary, J. H. Byrne, Department of Neurobiology and Anatomy, University of Texas Medical School, Houston, TX 77030, USA.
S. Endo and A. Eskin, Department of Biochemical and Biophysical Sciences, University of Houston, Houston, TX 77204, USA.
*   To whom correspondence should be addressed. E-mail: jbyrne{at}nba19.med.uth.tmc.edu

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
PKC Differentially Translocates during Spaced and Massed Training in Aplysia.
C. A. Farah, D. Weatherill, T. W. Dunn, and W. S. Sossin (2009)
J. Neurosci. 29, 10281-10286
   Abstract »    Full Text »    PDF »
cAMP Response Element-Binding Protein 1 Feedback Loop Is Necessary for Consolidation of Long-Term Synaptic Facilitation in Aplysia.
R.-Y. Liu, D. Fioravante, S. Shah, and J. H. Byrne (2008)
J. Neurosci. 28, 1970-1976
   Abstract »    Full Text »    PDF »
BMP1 controls TGF{beta}1 activation via cleavage of latent TGF{beta}-binding protein.
G. Ge and D. S. Greenspan (2006)
J. Cell Biol. 175, 111-120
   Abstract »    Full Text »    PDF »
A tropomyosin-related kinase B ligand is required for ERK activation, long-term synaptic facilitation, and long-term memory in Aplysia.
S. K. Sharma, C. M. Sherff, S. Stough, V. Hsuan, and T. J. Carew (2006)
PNAS 103, 14206-14210
   Abstract »    Full Text »    PDF »
TGF-beta1-Induced Long-Term Changes in Neuronal Excitability in Aplysia Sensory Neurons Depend on MAPK.
J. Chin, R.-Y. Liu, L. J. Cleary, A. Eskin, and J. H. Byrne (2006)
J Neurophysiol 95, 3286-3290
   Abstract »    Full Text »    PDF »
cAMP-response Elements in Aplysia creb1, creb2, and Ap-uch Promoters: IMPLICATIONS FOR FEEDBACK LOOPS MODULATING LONG TERM MEMORY.
H. A. Mohamed, W. Yao, D. Fioravante, P. D. Smolen, and J. H. Byrne (2005)
J. Biol. Chem. 280, 27035-27043
   Abstract »    Full Text »    PDF »
Coregulation of Glutamate Uptake and Long-Term Sensitization in Aplysia.
O. Khabour, J. Levenson, L. C. Lyons, L. S. Kategaya, J. Chin, J. H. Byrne, and A. Eskin (2004)
J. Neurosci. 24, 8829-8837
   Abstract »    Full Text »    PDF »
Dissociation of Morphological and Physiological Changes Associated With Long-Term Memory in Aplysia.
M. L. Wainwright, J. H. Byrne, and L. J. Cleary (2004)
J Neurophysiol 92, 2628-2632
   Abstract »    Full Text »    PDF »
The Roles of MAPK Cascades in Synaptic Plasticity and Memory in Aplysia: Facilitatory Effects and Inhibitory Constraints.
S. K. Sharma and T. J. Carew (2004)
Learn. Mem. 11, 373-378
   Abstract »    Full Text »    PDF »
Intermediate-Term Memory for Site-Specific Sensitization in Aplysia Is Maintained by Persistent Activation of Protein Kinase C.
M. A. Sutton, M. W. Bagnall, S. K. Sharma, J. Shobe, and T. J. Carew (2004)
J. Neurosci. 24, 3600-3609
   Abstract »    Full Text »    PDF »
Retrograde Gbb signaling through the Bmp type 2 receptor Wishful Thinking regulates systemic FMRFa expression in Drosophila.
G. Marques, T. E. Haerry, M. L. Crotty, M. Xue, B. Zhang, and M. B. O'Connor (2003)
Development 130, 5457-5470
   Abstract »    Full Text »    PDF »
Neuromodulation in invertebrate sensory systems: from biophysics to behavior.
J. T. Birmingham and D. L. Tauck (2003)
J. Exp. Biol. 206, 3541-3546
   Abstract »    Full Text »    PDF »
Multiple Serotonergic Mechanisms Contributing to Sensitization in Aplysia: Evidence of Diverse Serotonin Receptor Subtypes.
D. Barbas, L. DesGroseillers, V. F. Castellucci, T. J. Carew, and S. Marinesco (2003)
Learn. Mem. 10, 373-386
   Abstract »    Full Text »    PDF »
Behavioral, Cellular, and Molecular Analysis of Memory in Aplysia I: Intermediate-Term Memory.
M. A. Sutton and T. J. Carew (2002)
Integr. Comp. Biol. 42, 725-735
   Abstract »    Full Text »    PDF »
Localized Neuronal Outgrowth Induced by Long-Term Sensitization Training in Aplysia.
M. L. Wainwright, H. Zhang, J. H. Byrne, and L. J. Cleary (2002)
J. Neurosci. 22, 4132-4141
   Abstract »    Full Text »    PDF »
Interaction between Amount and Pattern of Training in the Induction of Intermediate- and Long-Term Memory for Sensitization in Aplysia.
M. A. Sutton, J. Ide, S. E. Masters, and T. J. Carew (2002)
Learn. Mem. 9, 29-40
   Abstract »    Full Text »    PDF »
Modulation of Excitability in Aplysia Tail Sensory Neurons by Tyrosine Kinases.
A. L. Purcell and T. J. Carew (2001)
J Neurophysiol 85, 2398-2411
   Abstract »    Full Text »    PDF »
Episodic but not continuous hypoxia elicits long-term facilitation of phrenic motor output in rats.
T L Baker and G S Mitchell (2000)
J. Physiol. 529, 215-219
   Abstract »    Full Text »    PDF »
P23H Rhodopsin Transgenic Rat: Correlation of Retinal Function with Histopathology.
S. Machida, M. Kondo, J. A. Jamison, N. W. Khan, L. T. Kononen, T. Sugawara, R. A. Bush, and P. A. Sieving (2000)
Invest. Ophthalmol. Vis. Sci. 41, 3200-3209
   Abstract »    Full Text »
Limited Contributions of Serotonin to Long-Term Hyperexcitability of Aplysia Sensory Neurons.
X. Liao, C. G. Brou, and E. T. Walters (1999)
J Neurophysiol 82, 3223-3235
   Abstract »    Full Text »    PDF »
Levels of Serotonin in the Hemolymph of Aplysia Are Modulated by Light/Dark Cycles and Sensitization Training.
J. Levenson, J. H. Byrne, and A. Eskin (1999)
J. Neurosci. 19, 8094-8103
   Abstract »    Full Text »    PDF »
Serotonin 5-HT2A receptor induces TGF-beta 1 expression in mesangial cells via ERK: proliferative and fibrotic signals.
J. S. Grewal, Y. V. Mukhin, M. N. Garnovskaya, J. R. Raymond, and E. L. Greene (1999)
Am J Physiol Renal Physiol 276, F922-F930
   Abstract »    Full Text »    PDF »
Regulation of Synaptic Function by Neurotrophic Factors in Vertebrates and Invertebrates: Implications for Development and Learning.
S. E. McKay, A. L. Purcell, and T. J. Carew (1999)
Learn. Mem. 6, 193-215
   Abstract »    Full Text »
Growth Factor Modulation of Substrate-Specific Morphological Patterns in Aplysia Bag Cell Neurons.
L. M. Gruenbaum and T. J. Carew (1999)
Learn. Mem. 6, 292-306
   Abstract »    Full Text »
TGF-beta 1 in Aplysia: Role in Long-Term Changes in the Excitability of Sensory Neurons and Distribution of Tbeta R-II-Like Immunoreactivity.
J. Chin, A. Angers, L. J. Cleary, A. Eskin, and J. H. Byrne (1999)
Learn. Mem. 6, 317-330
   Abstract »    Full Text »
Inflammation Causes a Long-Term Hyperexcitability in the Nociceptive Sensory Neurons of Aplysia.
M. Farr, J. Mathews, D.-F. Zhu, and R. T. Ambron (1999)
Learn. Mem. 6, 331-340
   Abstract »    Full Text »
Cellular Correlates of Long-Term Sensitization in Aplysia.
L. J. Cleary, W. L. Lee, and J. H. Byrne (1998)
J. Neurosci. 18, 5988-5998
   Abstract »    Full Text »    PDF »
Differential Induction of Long-Term Synaptic Facilitation by Spaced and Massed Applications of Serotonin at Sensory Neuron Synapses of Aplysia californica.
J. Mauelshagen, C. M. Sherff, and T. J. Carew (1998)
Learn. Mem. 5, 246-256
   Abstract »    Full Text »
Localized Synaptic Actions of Neurotrophin-4.
X.-h. Wang, B. Berninger, and M.-m. Poo (1998)
J. Neurosci. 18, 4985-4992
   Abstract »    Full Text »    PDF »
Molecular Mechanisms of Transforming Growth Factor-{beta} Signaling.
P. P.-c. Hu, M. B. Datto, and X.-f. Wang (1998)
Endocr. Rev. 19, 349-363
   Abstract »    Full Text »
Long-Term Effects of Axotomy on Excitability and Growth of Isolated Aplysia Sensory Neurons in Cell Culture: Potential Role of cAMP.
S. S. Bedi, A. Salim, S. Chen, and D. L. Glanzman (1998)
J Neurophysiol 79, 1371-1383
   Abstract »    Full Text »    PDF »
Repeated pulses of serotonin required for long-term facilitation activate mitogen-activated protein kinase in sensory neurons of Aplysia.
D. Michael, K. C. Martin, R. Seger, M.-M. Ning, R. Baston, and E. R. Kandel (1998)
PNAS 95, 1864-1869
   Abstract »    Full Text »    PDF »
Identification of specific mRNAs affected by treatments producing long-term facilitation in Aplysia..
R E Zwartjes, H West, S Hattar, X Ren, F Noel, M Nunez-Regueiro, K MacPhee, R Homayouni, M T Crow, J H Byrne, et al. (1998)
Learn. Mem. 4, 478-495
   Abstract »    PDF »
Role of Calcium-Calmodulin-Dependent Protein Kinase II in Modulation of Sensorimotor Synapses in Aplysia.
K. Nakanishi, F. Zhang, D. A. Baxter, A. Eskin, and J. H. Byrne (1997)
J Neurophysiol 78, 409-416
   Abstract »    Full Text »    PDF »
Synapse Formation between Central Neurons Requires Postsynaptic Expression of the MEN1 Tumor Suppressor Gene.
R. E. van Kesteren, N. I. Syed, D. W. Munno, J. Bouwman, Z.-P. Feng, W. P. M. Geraerts, and A. B. Smit (2001)
J. Neurosci. 21, RC161
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)