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Science 28 February 1997:
Vol. 275. no. 5304, pp. 1318 - 1320
DOI: 10.1126/science.275.5304.1318
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Reports

Role of Transforming Growth Factor-beta in Long-Term Synaptic Facilitation in Aplysia

Fan Zhang, Shogo Endo, Leonard J. Cleary, Arnold Eskin, John H. Byrne *

The role of transforming growth factor-beta (TGF-beta ) in long-term synaptic facilitation was examined in isolated Aplysia ganglia. Treatment with TGF-beta 1 induced long-term facilitation (24 and 48 hours), but not short-term (5 to 15 minutes) or intermediate-term (2 to 4 hours) facilitation. The long-term effects of TGF-beta 1 were not additive with those of serotonin. Moreover, serotonin-induced facilitation was blocked by an inhibitor of TGF-beta . Thus, activation of TGF-beta may be part of the cascade of events underlying long-term sensitization, consistent with the hypothesis that signaling molecules that participate in development also have roles in adult neuronal plasticity.

F. Zhang, L. J. Cleary, J. H. Byrne, Department of Neurobiology and Anatomy, University of Texas Medical School, Houston, TX 77030, USA.
S. Endo and A. Eskin, Department of Biochemical and Biophysical Sciences, University of Houston, Houston, TX 77204, USA.
*   To whom correspondence should be addressed. E-mail: jbyrne{at}nba19.med.uth.tmc.edu

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