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This article has been retracted

Science 14 February 1997:
Vol. 275. no. 5302, pp. 990 - 993
DOI: 10.1126/science.275.5302.990
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Reports

Defective Transcription-Coupled Repair of Oxidative Base Damage in Cockayne Syndrome Patients from XP Group G

Priscilla K. Cooper, * Thierry Nouspikel, Stuart G. Clarkson, Steven A. Leadon

In normal human cells, damage due to ultraviolet light is preferentially removed from active genes by nucleotide excision repair (NER) in a transcription-coupled repair (TCR) process that requires the gene products defective in Cockayne syndrome (CS). Oxidative damage, including thymine glycols, is shown to be removed by TCR in cells from normal individuals and from xeroderma pigmentosum (XP)-A, XP-F, and XP-G patients who have NER defects but not from XP-G patients who have severe CS. Thus, TCR of oxidative damage requires an XPG function distinct from its NER endonuclease activity. These results raise the possibility that defective TCR of oxidative damage contributes to the developmental defects associated with CS.

P. K. Cooper, Life Sciences Division, Building 934, Lawrence Berkeley National Laboratory, University of California, 1 Cyclotron Road, Berkeley, CA 94720, USA.
T. Nouspikel and S. G. Clarkson, Department of Genetics and Microbiology, University Medical Center (CMU), 1211 Geneva 4, Switzerland.
S. A. Leadon, Department of Radiation Oncology, University of North Carolina School of Medicine, Chapel Hill, NC 27599-7512, USA.
*   To whom correspondence should be addressed.

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