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Science 14 February 1997:
Vol. 275. no. 5302, pp. 986 - 990
DOI: 10.1126/science.275.5302.986
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Reports

A Protein-Counting Mechanism for Telomere Length Regulation in Yeast

Stéphane Marcand, * Eric Gilson, David Shore dagger

In the yeast Saccharomyces cerevisiae, telomere elongation is negatively regulated by the telomere repeat-binding protein Rap1p, such that a narrow length distribution of telomere repeat tracts is observed. This length regulation was shown to function independently of the orientation of the telomere repeats. The number of repeats at an individual telomere was reduced when hybrid proteins containing the Rap1p carboxyl terminus were targeted there by a heterologous DNA-binding domain. The extent of this telomere tract shortening was proportional to the number of targeted molecules, consistent with a feedback mechanism of telomere length regulation that can discriminate the precise number of Rap1p molecules bound to the chromosome end.

S. Marcand, Department of Microbiology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA, and Laboratoire de Biologie Moléculaire et Cellulaire, Ecole Normale Supérieure de Lyon, 69364 Lyon Cédex 07, France.
E. Gilson, Laboratoire de Biologie Moléculaire et Cellulaire, Ecole Normale Supérieure de Lyon, UMR49 CNRS/ENSL, 69364 Lyon Cédex 07, France.
D. Shore, Department of Microbiology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA, and Department of Molecular Biology, University of Geneva, CH-1211 Geneva 4, Switzerland.
*   Present address: Ecole Normale Supérieure de Lyon, 69364 Lyon Cédex 07, France.

dagger    To whom correspondence should be addressed (at University of Geneva). E-mail: David.Shore{at}molbio.unige.ch

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