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Science 14 February 1997:
Vol. 275. no. 5302, pp. 969 - 973
DOI: 10.1126/science.275.5302.969
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Reports

Involvement of Pre- and Postsynaptic Mechanisms in Posttetanic Potentiation at Aplysia Synapses

Jian-Xin Bao, * Eric R. Kandel, Robert D. Hawkins dagger

Posttetanic potentiation (PTP) is a common form of short-term synaptic plasticity that is generally thought to be entirely presynaptic. Consistent with that idea, PTP of evoked excitatory postsynaptic potentials at Aplysia sensory-motor neuron synapses in cell culture was reduced by presynaptic injection of a slow calcium chelator and was accompanied by an increase in the frequency but not the amplitude of spontaneous excitatory postsynaptic potentials. However, PTP was also reduced by postsynaptic injection of a rapid calcium chelator or postsynaptic hyperpolarization. Thus, PTP at these synapses is likely to involve a postsynaptic induction mechanism in addition to the known presynaptic mechanisms.

J.-X. Bao, Center for Neurobiology and Behavior, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.
E. R. Kandel, Center for Neurobiology and Behavior, College of Physicians and Surgeons, Columbia University; New York State Psychiatric Institute; and Howard Hughes Medical Institute, New York, NY 10032, USA.
R. D. Hawkins, Center for Neurobiology and Behavior, College of Physicians and Surgeons, Columbia University, and New York State Psychiatric Institute, New York, NY 10032, USA.
*   Present address: Department of Opthalmology and Physiology, University of California San Francisco, School of Medicine, San Francisco, CA 94143, USA.

dagger    To whom correspondence should be addressed. E-mail: RHawkins{at}NYPImail.CPMC.Columbia.edu

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