Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 14 February 1997:
Vol. 275. no. 5302, pp. 969 - 973
DOI: 10.1126/science.275.5302.969
Prev | Table of Contents | Next

Reports

Involvement of Pre- and Postsynaptic Mechanisms in Posttetanic Potentiation at Aplysia Synapses

Jian-Xin Bao, * Eric R. Kandel, Robert D. Hawkins dagger

Posttetanic potentiation (PTP) is a common form of short-term synaptic plasticity that is generally thought to be entirely presynaptic. Consistent with that idea, PTP of evoked excitatory postsynaptic potentials at Aplysia sensory-motor neuron synapses in cell culture was reduced by presynaptic injection of a slow calcium chelator and was accompanied by an increase in the frequency but not the amplitude of spontaneous excitatory postsynaptic potentials. However, PTP was also reduced by postsynaptic injection of a rapid calcium chelator or postsynaptic hyperpolarization. Thus, PTP at these synapses is likely to involve a postsynaptic induction mechanism in addition to the known presynaptic mechanisms.

J.-X. Bao, Center for Neurobiology and Behavior, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.
E. R. Kandel, Center for Neurobiology and Behavior, College of Physicians and Surgeons, Columbia University; New York State Psychiatric Institute; and Howard Hughes Medical Institute, New York, NY 10032, USA.
R. D. Hawkins, Center for Neurobiology and Behavior, College of Physicians and Surgeons, Columbia University, and New York State Psychiatric Institute, New York, NY 10032, USA.
*   Present address: Department of Opthalmology and Physiology, University of California San Francisco, School of Medicine, San Francisco, CA 94143, USA.

dagger    To whom correspondence should be addressed. E-mail: RHawkins{at}NYPImail.CPMC.Columbia.edu

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Activity-dependent calpain activation plays a critical role in synaptic facilitation and post-tetanic potentiation.
A. Khoutorsky and M. E. Spira (2009)
Learn. Mem. 16, 129-141
   Abstract »    Full Text »    PDF »
Molecular Mechanisms of Memory Storage in Aplysia.
R. D. Hawkins, E. R. Kandel, and C. H. Bailey (2006)
Biol. Bull. 210, 174-191
   Abstract »    Full Text »    PDF »
Presynaptic and postsynaptic Ca2+ and CamKII contribute to long-term potentiation at synapses between individual CA3 neurons..
F.-M. Lu and R. D. Hawkins (2006)
PNAS 103, 4264-4269
   Abstract »    Full Text »    PDF »
Analysis of 5-HT-Induced Short-Term Facilitation at Aplysia Sensorimotor Synapse During Bursts: Increased Synaptic Gain That Does Not Require ERK Activation.
G. A. Phares and J. H. Byrne (2005)
J Neurophysiol 94, 871-877
   Abstract »    Full Text »    PDF »
Calcium-activated proteases are critical for refilling depleted vesicle stores in cultured sensory-motor synapses of Aplysia.
A. Khoutorsky and M. E. Spira (2005)
Learn. Mem. 12, 414-422
   Abstract »    Full Text »    PDF »
Synaptic Facilitation and Behavioral Dishabituation in Aplysia: Dependence on Release of Ca2+ from Postsynaptic Intracellular Stores, Postsynaptic Exocytosis, and Modulation of Postsynaptic AMPA Receptor Efficacy.
Q. Li, A. C. Roberts, and D. L. Glanzman (2005)
J. Neurosci. 25, 5623-5637
   Abstract »    Full Text »    PDF »
Post-tetanic potentiation in the rat calyx of Held synapse.
R. L. P Habets and J. G. G Borst (2005)
J. Physiol. 564, 173-187
   Abstract »    Full Text »    PDF »
Feeding status and serotonin rapidly and reversibly modulate a Caenorhabditis elegans chemosensory circuit.
M. Y. Chao, H. Komatsu, H. S. Fukuto, H. M. Dionne, and A. C. Hart (2004)
PNAS 101, 15512-15517
   Abstract »    Full Text »    PDF »
Changes in the Readily Releasable Pool of Transmitter and in Efficacy of Release Induced by High-Frequency Firing at Aplysia Sensorimotor Synapses in Culture.
Y. Zhao and M. Klein (2004)
J Neurophysiol 91, 1500-1509
   Abstract »    Full Text »    PDF »
Burst-Induced Synaptic Depression and Its Modulation Contribute to Information Transfer at Aplysia Sensorimotor Synapses: Empirical and Computational Analyses.
G. A. Phares, E. G. Antzoulatos, D. A. Baxter, and J. H. Byrne (2003)
J. Neurosci. 23, 8392-8401
   Abstract »    Full Text »    PDF »
Presynaptic and Postsynaptic Mechanisms of a Novel Form of Homosynaptic Potentiation at Aplysia Sensory-Motor Neuron Synapses.
I. Jin and R. D. Hawkins (2003)
J. Neurosci. 23, 7288-7297
   Abstract »    Full Text »    PDF »
Mutation and Activation of Galpha s Similarly Alters Pre- and Postsynaptic Mechanisms Modulating Neurotransmission.
R. B. Renden and K. Broadie (2003)
J Neurophysiol 89, 2620-2638
   Abstract »    Full Text »    PDF »
Mechanisms Involved in Persistent Facilitation of Neuromuscular Synapses in Aplysia.
L. E. Fox and P. E. Lloyd (2002)
J Neurophysiol 87, 2018-2030
   Abstract »    Full Text »    PDF »
Evidence That Post-Tetanic Potentiation Is Mediated by Neuropeptide Release in Aplysia.
L. E. Fox and P. E. Lloyd (2001)
J Neurophysiol 86, 2845-2855
   Abstract »    Full Text »    PDF »
The Contribution of Activity-Dependent Synaptic Plasticity to Classical Conditioning in Aplysia.
I. Antonov, I. Antonova, E. R. Kandel, and R. D. Hawkins (2001)
J. Neurosci. 21, 6413-6422
   Abstract »    Full Text »    PDF »
Synapsin Controls Both Reserve and Releasable Synaptic Vesicle Pools during Neuronal Activity and Short-Term Plasticity in Aplysia.
Y. Humeau, F. Doussau, F. Vitiello, P. Greengard, F. Benfenati, and B. Poulain (2001)
J. Neurosci. 21, 4195-4206
   Abstract »    Full Text »    PDF »
Modulation of Excitability in Aplysia Tail Sensory Neurons by Tyrosine Kinases.
A. L. Purcell and T. J. Carew (2001)
J Neurophysiol 85, 2398-2411
   Abstract »    Full Text »    PDF »
Long-Lasting Reconfiguration of Two Interacting Networks by a Cooperation of Presynaptic and Postsynaptic Plasticity.
R. Nargeot (2001)
J. Neurosci. 21, 3282-3294
   Abstract »    Full Text »    PDF »
Contirbution of Postsynaptic Ca2+ to the Induction of Posttetanic Potentiation in the Neural Circuit for Siphon Withdrawal in Aplysia.
J. H. Schaffhausen, T. M. Fischer, and T. J. Carew (2001)
J. Neurosci. 21, 1739-1749
   Abstract »    Full Text »    PDF »
A novel function for serotonin-mediated short-term facilitation in Aplysia: Conversion of a transient, cell-wide homosynaptic Hebbian plasticity into a persistent, protein synthesis-independent synapse-specific enhancement.
C. H. Bailey, M. Giustetto, H. Zhu, M. Chen, and E. R. Kandel (2000)
PNAS 97, 11581-11586
   Abstract »    Full Text »    PDF »
Switching Off and On of Synaptic Sites at Aplysia Sensorimotor Synapses.
S. Royer, R. L. Coulson, and M. Klein (2000)
J. Neurosci. 20, 626-638
   Abstract »    Full Text »    PDF »
Active Motor Neurons Potentiate Their Own Sensory Inputs via Glutamate-Induced Long-Term Potentiation.
D. Le Ray and D. Cattaert (1999)
J. Neurosci. 19, 1473-1483
   Abstract »    Full Text »    PDF »
Use-Dependent Decline of Paired-Pulse Facilitation at Aplysia Sensory Neuron Synapses Suggests a Distinct Vesicle Pool or Release Mechanism.
X.-Y. Jiang and T. W. Abrams (1998)
J. Neurosci. 18, 10310-10319
   Abstract »    Full Text »    PDF »
Transmitter release modulation in nerve terminals of rat neocortical pyramidal cells by intracellular calcium buffers.
O. Ohana and B. Sakmann (1998)
J. Physiol. 513, 135-148
   Abstract »    Full Text »    PDF »
Presynaptic Induction and Expression of Homosynaptic Depression at Aplysia Sensorimotor Neuron Synapses.
B. A. Armitage and S. A. Siegelbaum (1998)
J. Neurosci. 18, 8770-8779
   Abstract »    Full Text »    PDF »
Target cell-specific modulation of transmitter release at terminals from a single axon.
M. Scanziani, B. H. Gahwiler, and S. Charpak (1998)
PNAS 95, 12004-12009
   Abstract »    Full Text »    PDF »
Differential roles of Ca2+/calmodulin-dependent kinases in posttetanic potentiation at input selective glutamatergic pathways.
D. Wang and L. Maler (1998)
PNAS 95, 7133-7138
   Abstract »    Full Text »    PDF »
Trophic and Contact Conditions Modulate Synapse Formation Between Identified Neurons.
N. S. Magoski and A. G. M. Bulloch (1998)
J Neurophysiol 79, 3279-3283
   Abstract »    Full Text »    PDF »
Binding of Serotonin to Receptors at Multiple Sites Is Required for Structural Plasticity Accompanying Long-Term Facilitation of Aplysia Sensorimotor Synapses.
Z.-Y. Sun and S. Schacher (1998)
J. Neurosci. 18, 3991-4000
   Abstract »    Full Text »    PDF »
Calcium-Dependent Regulation of Rab3 in Short-Term Plasticity.
F. Doussau, A. Clabecq, J.-P. Henry, F. Darchen, and B. Poulain (1998)
J. Neurosci. 18, 3147-3157
   Abstract »    Full Text »    PDF »
Comparison of Plasticity In Vivo and In Vitro in the Developing Visual Cortex of Normal and Protein Kinase A RIbeta -Deficient Mice.
T. K. Hensch, J. A. Gordon, E. P. Brandon, G. S. McKnight, R. L. Idzerda, and M. P. Stryker (1998)
J. Neurosci. 18, 2108-2117
   Abstract »    Full Text »    PDF »
Involvement of Presynaptic and Postsynaptic Mechanisms in a Cellular Analog of Classical Conditioning at Aplysia Sensory-Motor Neuron Synapses in Isolated Cell Culture.
J.-X. Bao, E. R. Kandel, and R. D. Hawkins (1998)
J. Neurosci. 18, 458-466
   Abstract »    Full Text »    PDF »
Activity-Dependent Potentiation of Synaptic Transmission From L30 Inhibitory Interneurons of Aplysia Depends on Residual Presynaptic Ca2+ But Not on Postsynaptic Ca2+.
T. M. Fischer, R. S. Zucker, and T. J. Carew (1997)
J Neurophysiol 78, 2061-2071
   Abstract »    Full Text »    PDF »
Multiple forms of facilitation produced by aversive tentacular stimuli in cerebral ganglion sensory neurons of Aplysia..
K K Fitzgerald and T J Carew (1997)
Learn. Mem. 3, 376-388
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)