Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 14 February 1997:
Vol. 275. no. 5302, pp. 964 - 966
DOI: 10.1126/science.275.5302.964
Prev | Table of Contents | Next

Reports

Isolation of Putative Progenitor Endothelial Cells for Angiogenesis

Takayuki Asahara, Toyoaki Murohara, Alison Sullivan, Marcy Silver, Rien van der Zee, Tong Li, Bernhard Witzenbichler, Gina Schatteman, Jeffrey M. Isner *

Putative endothelial cell (EC) progenitors or angioblasts were isolated from human peripheral blood by magnetic bead selection on the basis of cell surface antigen expression. In vitro, these cells differentiated into ECs. In animal models of ischemia, heterologous, homologous, and autologous EC progenitors incorporated into sites of active angiogenesis. These findings suggest that EC progenitors may be useful for augmenting collateral vessel growth to ischemic tissues (therapeutic angiogenesis) and for delivering anti- or pro-angiogenic agents, respectively, to sites of pathologic or utilitarian angiogenesis.

Departments of Medicine (Cardiology) and Biomedical Research, St. Elizabeth's Medical Center, Tufts University School of Medicine, 736 Cambridge Street, Boston, MA 02135, USA.
*   To whom correspondence should be addressed.

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Hyperoxia disrupts vascular endothelial growth factor-nitric oxide signaling and decreases growth of endothelial colony-forming cells from preterm infants.
H. Fujinaga, C. D. Baker, S. L. Ryan, N. E. Markham, G. J. Seedorf, V. Balasubramaniam, and S. H. Abman (2009)
Am J Physiol Lung Cell Mol Physiol 297, L1160-L1169
   Abstract »    Full Text »    PDF »
Endothelial progenitor cells in chronic kidney disease.
F. H. Bahlmann, T. Speer, and D. Fliser (2009)
Nephrol. Dial. Transplant.
   Full Text »    PDF »
Diabetic retinopathy is associated with bone marrow neuropathy and a depressed peripheral clock.
J. V. Busik, M. Tikhonenko, A. Bhatwadekar, M. Opreanu, N. Yakubova, S. Caballero, D. Player, T. Nakagawa, A. Afzal, J. Kielczewski, et al. (2009)
J. Exp. Med.
   Abstract »    Full Text »    PDF »
GenousTM endothelial progenitor cell capturing stent vs. the Taxus Liberte stent in patients with de novo coronary lesions with a high-risk of coronary restenosis: a randomized, single-centre, pilot study.
M. A.M. Beijk, M. Klomp, N. J.W. Verouden, N. van Geloven, K. T. Koch, J. P.S. Henriques, J. Baan, M. M. Vis, E. Scheunhage, J. J. Piek, et al. (2009)
Eur. Heart J.
   Abstract »    Full Text »    PDF »
Gene Therapy With the Angiogenic Cytokine Secretoneurin Induces Therapeutic Angiogenesis by a Nitric Oxide-Dependent Mechanism.
W. Schgoer, M. Theurl, J. Jeschke, A. G.E. Beer, K. Albrecht, R. Gander, S. Rong, D. Vasiljevic, M. Egger, A. M. Wolf, et al. (2009)
Circ. Res. 105, 994-1002
   Abstract »    Full Text »    PDF »
Bone marrow stem and progenitor cell contribution to neovasculogenesis is dependent on model system with SDF-1 as a permissive trigger.
G. J. Madlambayan, J. M. Butler, K. Hosaka, M. Jorgensen, D. Fu, S. M. Guthrie, A. K. Shenoy, A. Brank, K. J. Russell, J. Otero, et al. (2009)
Blood 114, 4310-4319
   Abstract »    Full Text »    PDF »
.
K. Bogos, F. Renyi-Vamos, J. Dobos, J. Tovari, G. Ostoros, and B. Dome (2009)
Clin. Cancer Res. 15, 6740-6741
   Full Text »    PDF »
Sildenafil Increases Endothelial Progenitor Cell Function and Improves Ischemia-Induced Neovascularization in Hypercholesterolemic Apolipoprotein E-Deficient Mice.
S. Dussault, F. Maingrette, C. Menard, S.-E. Michaud, P. Haddad, J. Groleau, J. Turgeon, G. Perez, and A. Rivard (2009)
Hypertension 54, 1043-1049
   Abstract »    Full Text »    PDF »
Concurrent Vasculogenesis and Neurogenesis From Adult Neural Stem Cells.
M. Ii, H. Nishimura, H. Sekiguchi, N. Kamei, A. Yokoyama, M. Horii, and T. Asahara (2009)
Circ. Res. 105, 860-868
   Abstract »    Full Text »    PDF »
Suppression of Tumor Angiogenesis by G{alpha}13 Haploinsufficiency.
L. Chen, J. J. Zhang, S. Rafii, and X.-Y. Huang (2009)
J. Biol. Chem. 284, 27409-27415
   Abstract »    Full Text »    PDF »
Retinal Endothelial Cell Apoptosis Stimulates Recruitment of Endothelial Progenitor Cells.
A. D. Bhatwadekar, J. V. Glenn, T. M. Curtis, M. B. Grant, A. W. Stitt, and T. A. Gardiner (2009)
Invest. Ophthalmol. Vis. Sci. 50, 4967-4973
   Abstract »    Full Text »    PDF »
Development of microfluidics as endothelial progenitor cell capture technology for cardiovascular tissue engineering and diagnostic medicine.
B. D. Plouffe, T. Kniazeva, J. E. Mayer Jr., S. K. Murthy, and V. L. Sales (2009)
FASEB J 23, 3309-3314
   Abstract »    Full Text »    PDF »
Contribution of Granulocyte Colony-Stimulating Factor to the Acute Mobilization of Endothelial Precursor Cells by Vascular Disrupting Agents.
Y. Shaked, T. Tang, J. Woloszynek, L. G. Daenen, S. Man, P. Xu, S.-R. Cai, J. M. Arbeit, E. E. Voest, D. J. Chaplin, et al. (2009)
Cancer Res. 69, 7524-7528
   Abstract »    Full Text »    PDF »
Heme Oxygenase-1 Increases Endothelial Progenitor Cells.
B. J. Wu, R. G. Midwinter, C. Cassano, K. Beck, Y. Wang, D. Changsiri, J. R. Gamble, and R. Stocker (2009)
Arterioscler Thromb Vasc Biol 29, 1537-1542
   Abstract »    Full Text »    PDF »
Nox2-Containing NADPH Oxidase Deficiency Confers Protection From Hindlimb Ischemia in Conditions of Increased Oxidative Stress.
P. Haddad, S. Dussault, J. Groleau, J. Turgeon, S.-E. Michaud, C. Menard, G. Perez, F. Maingrette, and A. Rivard (2009)
Arterioscler Thromb Vasc Biol 29, 1522-1528
   Abstract »    Full Text »    PDF »
Circulating Endothelial Progenitor Cells and Age-Related White Matter Changes.
G. Jickling, A. Salam, A. Mohammad, M. S. Hussain, J. Scozzafava, A. M. Nasser, T. Jeerakathil, A. Shuaib, and R. Camicioli (2009)
Stroke 40, 3191-3196
   Abstract »    Full Text »    PDF »
Reduced number of endothelial progenitor cells is predictive of early relapse in anti-neutrophil cytoplasmic antibody-associated vasculitis.
J. Zavada, L. Kideryova, R. Pytlik, Z. Hruskova, and V. Tesar (2009)
Rheumatology 48, 1197-1201
   Abstract »    Full Text »    PDF »
Molecular Insights and Therapeutic Targets for Diabetic Endothelial Dysfunction.
J. Xu and M.-H. Zou (2009)
Circulation 120, 1266-1286
   Full Text »    PDF »
Association of Leukocyte Telomere Length With Echocardiographic Left Ventricular Mass: The Framingham Heart Study.
R. S. Vasan, S. Demissie, M. Kimura, L. A. Cupples, C. White, J. P. Gardner, X. Cao, D. Levy, E. J. Benjamin, and A. Aviv (2009)
Circulation 120, 1195-1202
   Abstract »    Full Text »    PDF »
Cardiomyocyte-Specific Overexpression of Human Stem Cell Factor Improves Cardiac Function and Survival After Myocardial Infarction in Mice.
F.-L. Xiang, X. Lu, L. Hammoud, P. Zhu, P. Chidiac, J. Robbins, and Q. Feng (2009)
Circulation 120, 1065-1074
   Abstract »    Full Text »    PDF »
Endothelial Progenitors in the Risk of Developing Bronchopulmonary Dysplasia: Can We Include Endothelial Progenitor Cells in BPD Risk Assessment?.
V. Balasubramaniam and D. A. Ingram (2009)
Am. J. Respir. Crit. Care Med. 180, 488-490
   Full Text »    PDF »
Circulating Endothelial Progenitor Cells in Preterm Infants with Bronchopulmonary Dysplasia.
A. Borghesi, M. Massa, R. Campanelli, L. Bollani, C. Tzialla, T. A. Figar, G. Ferrari, E. Bonetti, G. Chiesa, A. de Silvestri, et al. (2009)
Am. J. Respir. Crit. Care Med. 180, 540-546
   Abstract »    Full Text »    PDF »
Vascular effects of a low-carbohydrate high-protein diet.
S. Y. Foo, E. R. Heller, J. Wykrzykowska, C. J. Sullivan, J. J. Manning-Tobin, K. J. Moore, R. E. Gerszten, and A. Rosenzweig (2009)
PNAS 106, 15418-15423
   Abstract »    Full Text »    PDF »
Endogenous stem cells in patients undergoing coronary artery bypass graft surgery.
O. Dotsenko and M. Jahangiri (2009)
Eur. J. Cardiothorac. Surg. 36, 563-571
   Abstract »    Full Text »    PDF »
Endothelial Colony-forming Cells from Preterm Infants Are Increased and More Susceptible to Hyperoxia.
C. D. Baker, S. L. Ryan, D. A. Ingram, G. J. Seedorf, S. H. Abman, and V. Balasubramaniam (2009)
Am. J. Respir. Crit. Care Med. 180, 454-461
   Abstract »    Full Text »    PDF »
Mixed origin of neovascularization of human endometrial grafts in immunodeficient mouse models.
M.-L. Alvarez Gonzalez, F. Frankenne, C. Galant, E. Marbaix, J.-M. Foidart, M. Nisolle, and A. Beliard (2009)
Hum. Reprod. 24, 2217-2224
   Abstract »    Full Text »    PDF »
Prevascularization of cardiac patch on the omentum improves its therapeutic outcome.
T. Dvir, A. Kedem, E. Ruvinov, O. Levy, I. Freeman, N. Landa, R. Holbova, M. S. Feinberg, S. Dror, Y. Etzion, et al. (2009)
PNAS 106, 14990-14995
   Abstract »    Full Text »    PDF »
Vascular actions of insulin with implications for endothelial dysfunction.
M. A. Potenza, F. Addabbo, and M. Montagnani (2009)
Am J Physiol Endocrinol Metab 297, E568-E577
   Abstract »    Full Text »    PDF »
Effects of the Menstrual Cycle on Lung Function Variables in Women with Asthma.
S. Farha, K. Asosingh, D. Laskowski, J. Hammel, R. A. Dweik, H. P. Wiedemann, and S. C. Erzurum (2009)
Am. J. Respir. Crit. Care Med. 180, 304-310
   Abstract »    Full Text »    PDF »
Syngeneic bone marrow mononuclear cells improve pulmonary arterial hypertension through vascular endothelial growth factor upregulation..
H. Yoshida, T. Kitaichi, M. Urata, H. Kurobe, T. Kanbara, T. Motoki, and T. Kitagawa (2009)
Ann. Thorac. Surg. 88, 418-424
   Abstract »    Full Text »    PDF »
Matrix Metalloproteinase-9 Is Essential for Ischemia-Induced Neovascularization by Modulating Bone Marrow-Derived Endothelial Progenitor Cells.
P.-H. Huang, Y.-H. Chen, C.-H. Wang, J.-S. Chen, H.-Y. Tsai, F.-Y. Lin, W.-Y. Lo, T.-C. Wu, M. Sata, J.-W. Chen, et al. (2009)
Arterioscler Thromb Vasc Biol 29, 1179-1184
   Abstract »    Full Text »    PDF »
Non-ischaemic titrated cardiac injury caused by radiofrequency catheter ablation of atrial fibrillation mobilizes CD34-positive mononuclear cells by non-stromal cell-derived factor-1{alpha} mechanism.
S. K. Kim, H.-N. Pak, J. H. Park, J. I. Choi, M.-H. Nam, Y. Jo, and Y.-H. Kim (2009)
Europace 11, 1024-1031
   Abstract »    Full Text »    PDF »
Angiogenesis in Platelet Endothelial Cell Adhesion Molecule-1-Null Mice.
G. Cao, M. L. Fehrenbach, J. T. Williams, J. M. Finklestein, J.-X. Zhu, and H. M. DeLisser (2009)
Am. J. Pathol. 175, 903-915
   Abstract »    Full Text »    PDF »
Dialysis modality is independently associated with circulating endothelial progenitor cells in end-stage renal diseases patients.
H. Ueno, H. Koyama, S. Fukumoto, S. Tanaka, T. Shoji, T. Shoji, M. Emoto, H. Tahara, Y. Tsujimoto, T. Tabata, et al. (2009)
Nephrol. Dial. Transplant.
   Abstract »    Full Text »    PDF »
Proteomic analysis reveals presence of platelet microparticles in endothelial progenitor cell cultures.
M. Prokopi, G. Pula, U. Mayr, C. Devue, J. Gallagher, Q. Xiao, C. M. Boulanger, N. Westwood, C. Urbich, J. Willeit, et al. (2009)
Blood 114, 723-732
   Abstract »    Full Text »    PDF »
Cardiac repair and regeneration: the Rubik's cube of cell therapy for heart disease.
K. D. Boudoulas and A. K. Hatzopoulos (2009)
Dis. Model. Mech. 2, 344-358
   Abstract »    Full Text »    PDF »
ACE inhibition promotes upregulation of endothelial progenitor cells and neoangiogenesis in cardiac pressure overload.
P. Muller, A. Kazakov, P. Jagoda, A. Semenov, M. Bohm, and U. Laufs (2009)
Cardiovasc Res 83, 106-114
   Abstract »    Full Text »    PDF »
Development and pathology of pulmonary hypertension..
R. M. Tuder, S. H. Abman, T. Braun, F. Capron, T. Stevens, P. A. Thistlethwaite, and S. G. Haworth (2009)
J. Am. Coll. Cardiol. 54, S3-S9
   Abstract »    Full Text »    PDF »
Humanized large-scale expanded endothelial colony-forming cells function in vitro and in vivo.
A. Reinisch, N. A. Hofmann, A. C. Obenauf, K. Kashofer, E. Rohde, K. Schallmoser, K. Flicker, G. Lanzer, W. Linkesch, M. R. Speicher, et al. (2009)
Blood 113, 6716-6725
   Abstract »    Full Text »    PDF »
Promoting Mechanisms of Vascular Health: Circulating Progenitor Cells, Angiogenesis, and Reverse Cholesterol Transport.
P. R. Moreno, J. Sanz, and V. Fuster (2009)
J. Am. Coll. Cardiol. 53, 2315-2323
   Abstract »    Full Text »    PDF »
Add Some Fat to Vascular Progenitor Cell Therapy.
J. Saif, C. Heeschen, and A. Aicher (2009)
Circ. Res. 104, 1330-1332
   Full Text »    PDF »
Robust Functional Vascular Network Formation In Vivo by Cooperation of Adipose Progenitor and Endothelial Cells.
D. O. Traktuev, D. N. Prater, S. Merfeld-Clauss, A. R. Sanjeevaiah, M. R. Saadatzadeh, M. Murphy, B. H. Johnstone, D. A. Ingram, and K. L. March (2009)
Circ. Res. 104, 1410-1420
   Abstract »    Full Text »    PDF »
Microparticles From Ischemic Muscle Promotes Postnatal Vasculogenesis.
A. S. Leroyer, T. G. Ebrahimian, C. Cochain, A. Recalde, O. Blanc-Brude, B. Mees, J. Vilar, A. Tedgui, B. I. Levy, G. Chimini, et al. (2009)
Circulation 119, 2808-2817
   Abstract »    Full Text »    PDF »
Late Outgrowth Endothelial Cells Derived From Wharton Jelly in Human Umbilical Cord Reduce Neointimal Formation After Vascular Injury: Involvement of Pigment Epithelium-Derived Factor.
S.-H. Wang, S.-J. Lin, Y.-H. Chen, F.-Y. Lin, J.-C. Shih, C.-C. Wu, H.-L. Wu, and Y.-L. Chen (2009)
Arterioscler Thromb Vasc Biol 29, 816-822
   Abstract »    Full Text »    PDF »
Long-Term Outcome of Therapeutic Neovascularization Using Peripheral Blood Mononuclear Cells for Limb Ischemia.
J. Moriya, T. Minamino, K. Tateno, N. Shimizu, Y. Kuwabara, Y. Sato, Y. Saito, and I. Komuro (2009)
Circ Cardiovasc Interv 2, 245-254
   Abstract »    Full Text »    PDF »
Neovascular capacity of endothelial progenitor cells in the adult pulmonary circulation.
S. Majka and D. F. Alvarez (2009)
Am J Physiol Lung Cell Mol Physiol 296, L868-L869
   Full Text »    PDF »
Endothelial progenitor cell dysfunction in patients with progressive chronic kidney disease.
G. Krenning, P. Y. W. Dankers, J. W. Drouven, F. Waanders, C. F. M. Franssen, M. J. A. van Luyn, M. C. Harmsen, and E. R. Popa (2009)
Am J Physiol Renal Physiol 296, F1314-F1322
   Abstract »    Full Text »    PDF »
The presence of JAK2V617F mutation in the liver endothelial cells of patients with Budd-Chiari syndrome.
S. Sozer, M. I. Fiel, T. Schiano, M. Xu, J. Mascarenhas, and R. Hoffman (2009)
Blood 113, 5246-5249
   Abstract »    Full Text »    PDF »
Revascularization of ischemic limbs after transplantation of human bone marrow cells with high aldehyde dehydrogenase activity.
B. J. Capoccia, D. L. Robson, K. D. Levac, D. J. Maxwell, S. A. Hohm, M. J. Neelamkavil, G. I. Bell, A. Xenocostas, D. C. Link, D. Piwnica-Worms, et al. (2009)
Blood 113, 5340-5351
   Abstract »    Full Text »    PDF »
Inhibition of endothelial progenitor cell differentiation by VEGI.
F. Tian, P. H. Liang, and L.-Y. Li (2009)
Blood 113, 5352-5360
   Abstract »    Full Text »    PDF »
Cell therapies for therapeutic angiogenesis: back to the bench.
D. P Sieveking and M. K. Ng (2009)
Vascular Medicine 14, 153-166
   Abstract »    PDF »
Signals Through Glycoprotein 130 Regulate the Endothelial Differentiation of Cardiac Stem Cells.
T. Mohri, Y. Fujio, M. Obana, T. Iwakura, K. Matsuda, M. Maeda, and J. Azuma (2009)
Arterioscler Thromb Vasc Biol 29, 754-760
   Abstract »    Full Text »    PDF »
Angiogenic Monocytes: Another Colorful Blow to Endothelial Progenitors.
A. J.G. Horrevoets (2009)
Am. J. Pathol. 174, 1594-1596
   Abstract »    Full Text »    PDF »
Release of proinflammatory mediators and expression of proinflammatory adhesion molecules by endothelial progenitor cells.
Y. Zhang, D. A. Ingram, M. P. Murphy, M. R. Saadatzadeh, L. E. Mead, D. N. Prater, and J. Rehman (2009)
Am J Physiol Heart Circ Physiol 296, H1675-H1682
   Abstract »    Full Text »    PDF »
Circulating Monocytes Expressing CD31: Implications for Acute and Chronic Angiogenesis.
S.-J. Kim, J.-S. Kim, J. Papadopoulos, S. Wook Kim, M. Maya, F. Zhang, J. He, D. Fan, R. Langley, and I. J. Fidler (2009)
Am. J. Pathol. 174, 1972-1980
   Abstract »    Full Text »    PDF »
Pivotal Role of Lnk Adaptor Protein in Endothelial Progenitor Cell Biology for Vascular Regeneration.
S.-M. Kwon, T. Suzuki, A. Kawamoto, M. Ii, M. Eguchi, H. Akimaru, M. Wada, T. Matsumoto, H. Masuda, Y. Nakagawa, et al. (2009)
Circ. Res. 104, 969-977
   Abstract »    Full Text »    PDF »
Endogenous S-nitrosothiols protect against myocardial injury.
B. Lima, G. K. W. Lam, L. Xie, D. L. Diesen, N. Villamizar, J. Nienaber, E. Messina, D. Bowles, C. D. Kontos, J. M. Hare, et al. (2009)
PNAS 106, 6297-6302
   Abstract »    Full Text »    PDF »
From bone marrow to the arterial wall: the ongoing tale of endothelial progenitor cells.
A. M. Leone, M. Valgimigli, M. B. Giannico, V. Zaccone, M. Perfetti, D. D'Amario, A. G. Rebuzzi, and F. Crea (2009)
Eur. Heart J. 30, 890-899
   Abstract »    Full Text »    PDF »
Caspase-8, a Double-Edged Sword for EPC Functioning.
Q. Xiao and Q. Xu (2009)
Arterioscler Thromb Vasc Biol 29, 444-446
   Full Text »    PDF »
Cerebral Malaria Is Associated with Low Levels of Circulating Endothelial Progenitor Cells in African Children.
B. Gyan, B. Q. Goka, G. O. Adjei, J. K. A. Tetteh, K. A. Kusi, A. Aikins, D. Dodoo, M. L. Lesser, C. P. Sison, S. Das, et al. (2009)
Am J Trop Med Hyg 80, 541-546
   Abstract »    Full Text »    PDF »
Circulating Hematopoietic Stem Cells in Patients with Idiopathic Choroidal Neovascularization.
M. Sasahara, A. Otani, Y. Yodoi, and N. Yoshimura (2009)
Invest. Ophthalmol. Vis. Sci. 50, 1575-1579
   Abstract »    Full Text »    PDF »
Caspase-8 Is Involved in Neovascularization-Promoting Progenitor Cell Functions.
D. Scharner, L. Rossig, G. Carmona, E. Chavakis, C. Urbich, A. Fischer, T.-B. Kang, D. Wallach, Y. J. Chiang, Y. L. Deribe, et al. (2009)
Arterioscler Thromb Vasc Biol 29, 571-578
   Abstract »    Full Text »    PDF »
Local vessel injury following percutaneous coronary intervention does not promote early mobilisation of endothelial progenitor cells in the absence of myocardial necrosis.
H E Thomas, P J Avery, J M Ahmed, R Edwards, I Purcell, A G Zaman, H M Arthur, and B D Keavney (2009)
Heart 95, 555-558
   Abstract »    Full Text »    PDF »
Defining the potential for cell therapy for vascular disease using animal models.
R. Gulati and R. D. Simari (2009)
Dis. Model. Mech. 2, 130-137
   Abstract »    Full Text »    PDF »
Tissue engineering using autologous microcirculatory beds as vascularized bioscaffolds.
E. I. Chang, R. G. Bonillas, S. El-ftesi, E. I. Chang, D. J. Ceradini, I. N. Vial, D. A. Chan, J. Michaels V, and G. C. Gurtner (2009)
FASEB J 23, 906-915
   Abstract »    Full Text »    PDF »
Angiogenesis and antiangiogenic therapy in non-Hodgkin's lymphoma.
J. Ruan, K. Hajjar, S. Rafii, and J. P. Leonard (2009)
Ann. Onc. 20, 413-424
   Abstract »    Full Text »    PDF »
Sphingosine kinase regulates the rate of endothelial progenitor cell differentiation.
C. S. Bonder, W. Y. Sun, T. Matthews, C. Cassano, X. Li, H. S. Ramshaw, S. M. Pitson, A. F. Lopez, P. T. Coates, R. L. Proia, et al. (2009)
Blood 113, 2108-2117
   Abstract »    Full Text »    PDF »
Potential use of endothelial progenitor cells for regeneration of the vasculature.
K. Yamahara and H. Itoh (2009)
Therapeutic Advances in Cardiovascular Disease 3, 17-27
   Abstract »    PDF »
Estradiol-induced, endothelial progenitor cell-mediated neovascularization in male mice with hind-limb ischemia.
W.-P. T Ruifrok, R. A de Boer, A. Iwakura, M. Silver, K. Kusano, R. A Tio, and D. W Losordo (2009)
Vascular Medicine 14, 29-36
   Abstract »    PDF »
Hyperbaric oxygen stimulates vasculogenic stem cell growth and differentiation in vivo.
T. N. Milovanova, V. M. Bhopale, E. M. Sorokina, J. S. Moore, T. K. Hunt, M. Hauer-Jensen, O. C. Velazquez, and S. R. Thom (2009)
J Appl Physiol 106, 711-728
   Abstract »    Full Text »    PDF »
Increased Levels of Circulating Endothelial Progenitor Cells in Patients With Moyamoya Disease.
N. Rafat, G. Ch. Beck, P. G. Pena-Tapia, P. Schmiedek, and P. Vajkoczy (2009)
Stroke 40, 432-438
   Abstract »    Full Text »    PDF »
EULAR Scleroderma Trials and Research group statement and recommendations on endothelial precursor cells.
J H W Distler, Y Allanore, J Avouac, R Giacomelli, S Guiducci, F Moritz, A Akhmetshina, U A Walker, A Gabrielli, U Muller-Ladner, et al. (2009)
Ann Rheum Dis 68, 163-168
   Abstract »    Full Text »    PDF »
Proteomics Identifies Thymidine Phosphorylase As a Key Regulator of the Angiogenic Potential of Colony-Forming Units and Endothelial Progenitor Cell Cultures.
G. Pula, U. Mayr, C. Evans, M. Prokopi, D. S. Vara, X. Yin, Z. Astroulakis, Q. Xiao, J. Hill, Q. Xu, et al. (2009)
Circ. Res. 104, 32-40
   Abstract »    Full Text »    PDF »
Adventitial transplantation of blood outgrowth endothelial cells in porcine haemodialysis grafts alleviates hypoxia and decreases neointimal proliferation through a matrix metalloproteinase-9-mediated pathway--a pilot study.
D. Hughes, A. A. Fu, A. Puggioni, J. F. Glockner, B. Anwer, A. M. McGuire, D. Mukhopadhyay, and S. Misra (2009)
Nephrol. Dial. Transplant. 24, 85-96
   Abstract »    Full Text »    PDF »
Microarray-Based Characterization of a Colony Assay Used to Investigate Endothelial Progenitor Cells and Relevance to Endothelial Function in Humans.
A. Desai, A. Glaser, D. Liu, N. Raghavachari, A. Blum, G. Zalos, M. Lippincott, J. P. McCoy, P. J. Munson, M. A. Solomon, et al. (2009)
Arterioscler Thromb Vasc Biol 29, 121-127
   Abstract »    Full Text »    PDF »
Cardiovascular Actions of Neurotrophins.
A. Caporali and C. Emanueli (2009)
Physiol Rev 89, 279-308
   Abstract »    Full Text »    PDF »
Correlation of Different Circulating Endothelial Progenitor Cells to Stages of Diabetic Retinopathy: First In Vivo Data.
S. Brunner, G.-H. Schernthaner, M. Satler, M. Elhenicky, F. Hoellerl, K. E. Schmid-Kubista, F. Zeiler, S. Binder, and G. Schernthaner (2009)
Invest. Ophthalmol. Vis. Sci. 50, 392-398
   Abstract »    Full Text »    PDF »
Fluid shear stress induces arterial differentiation of endothelial progenitor cells.
S. Obi, K. Yamamoto, N. Shimizu, S. Kumagaya, T. Masumura, T. Sokabe, T. Asahara, and J. Ando (2009)
J Appl Physiol 106, 203-211
   Abstract »    Full Text »    PDF »
Cell Therapy in Peripheral Arterial Disease.
I. Al Mheid and A. A. Quyyumi (2009)
Angiology 59, 705-716
   Abstract »    PDF »
Implantation of Adipose-Derived Regenerative Cells Enhances Ischemia-Induced Angiogenesis.
K. Kondo, S. Shintani, R. Shibata, H. Murakami, R. Murakami, M. Imaizumi, Y. Kitagawa, and T. Murohara (2009)
Arterioscler Thromb Vasc Biol 29, 61-66
   Abstract »    Full Text »    PDF »
Formation of STAT5/PPAR{gamma} Transcriptional Complex Modulates Angiogenic Cell Bioavailability in Diabetes.
P. Dentelli, A. Trombetta, G. Togliatto, A. Zeoli, A. Rosso, B. Uberti, F. Orso, D. Taverna, L. Pegoraro, and M. F. Brizzi (2009)
Arterioscler Thromb Vasc Biol 29, 114-120
   Abstract »    Full Text »    PDF »
Statin ameliorates hypoxia-induced pulmonary hypertension associated with down-regulated stromal cell-derived factor-1.
K. Satoh, Y. Fukumoto, M. Nakano, K. Sugimura, J. Nawata, J. Demachi, A. Karibe, Y. Kagaya, N. Ishii, K. Sugamura, et al. (2009)
Cardiovasc Res 81, 226-234
   Abstract »    Full Text »    PDF »
Endothelial progenitor cell homing: prominent role of the IGF2-IGF2R-PLC{beta}2 axis.
Y.-S. Maeng, H.-J. Choi, J.-Y. Kwon, Y.-W. Park, K.-S. Choi, J.-K. Min, Y.-H. Kim, P.-G. Suh, K.-S. Kang, M.-H. Won, et al. (2009)
Blood 113, 233-243
   Abstract »    Full Text »    PDF »
Hepatocyte Growth Factor, but not Vascular Endothelial Growth Factor, Attenuates Angiotensin II-Induced Endothelial Progenitor Cell Senescence.
F. Sanada, Y. Taniyama, J. Azuma, K. Iekushi, N. Dosaka, T. Yokoi, N. Koibuchi, H. Kusunoki, Y. Aizawa, and R. Morishita (2009)
Hypertension 53, 77-82
   Abstract »    Full Text »    PDF »
Different mechanisms of saturated versus polyunsaturated FFA-induced apoptosis in human endothelial cells.
M. Artwohl, A. Lindenmair, V. Sexl, C. Maier, G. Rainer, A. Freudenthaler, N. Huttary, M. Wolzt, P. Nowotny, A. Luger, et al. (2008)
J. Lipid Res. 49, 2627-2640
   Abstract »    Full Text »    PDF »
Insights into mechanisms behind arteriogenesis: what does the future hold?.
M. C. van Oostrom, O. van Oostrom, P. H. A. Quax, M. C. Verhaar, and I. E. Hoefer (2008)
J. Leukoc. Biol. 84, 1379-1391
   Abstract »    Full Text »    PDF »
Contribution of Bone Marrow-Derived Cells Associated With Brain Angiogenesis Is Primarily Through CD69+.
Q. Hao, J. Liu, R. Pappu, H. Su, R. Rola, R. A. Gabriel, C. Z. Lee, W. L. Young, and G.-Y. Yang (2008)
Arterioscler Thromb Vasc Biol 28, 2151-2157
   Abstract »    Full Text »    PDF »
Showing up Isn't Enough for Vascularization: Persistence Is Essential.
M. A. Sussman (2008)
Circ. Res. 103, 1200-1201
   Full Text »    PDF »
Sustained Persistence of Transplanted Proangiogenic Cells Contributes to Neovascularization and Cardiac Function After Ischemia.
T. Ziebart, C.-H. Yoon, T. Trepels, A. Wietelmann, T. Braun, F. Kiessling, S. Stein, M. Grez, C. Ihling, M. Muhly-Reinholz, et al. (2008)
Circ. Res. 103, 1327-1334
   Abstract »    Full Text »    PDF »
Transcriptional Regulation of Bim by FOXO3a and Akt Mediates Scleroderma Serum-Induced Apoptosis in Endothelial Progenitor Cells.
S. Zhu, S. Evans, B. Yan, T. J. Povsic, V. Tapson, P. J. Goldschmidt-Clermont, and C. Dong (2008)
Circulation 118, 2156-2165
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)