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Science 31 January 1997:
Vol. 275. no. 5300, pp. 632 - 637
DOI: 10.1126/science.275.5300.632
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Articles

How Cells Get the Right Chromosomes

R. Bruce Nicklas

When cells divide, the chromosomes must be delivered flawlessly to the daughter cells. Missing or extra chromosomes can result in birth defects and cancer. Chance events are the starting point for chromosome delivery, which makes the process prone to error. Errors are avoided by diverse uses of mechanical tension from mitotic forces. Tension stabilizes the proper chromosome configuration, controls a cell cycle checkpoint, and changes chromosome chemistry.

The author is in the Departments of Zoology and Cell Biology, LSRC Building, Duke University, Box B91000, Durham, NC 27708-1000, USA. E-mail: bnicklas{at}acpub.duke.edu

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J. Cell Biol. 151, 131-142
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Probing Spindle Assembly Mechanisms with Monastrol, a Small Molecule Inhibitor of the Mitotic Kinesin, Eg5.
T. M. Kapoor, T. U. Mayer, M. L. Coughlin, and T. J. Mitchison (2000)
J. Cell Biol. 150, 975-988
   Abstract »    Full Text »    PDF »
Restriction of ectopic recombination by interhomolog interactions during Saccharomyces cerevisiae meiosis.
A. S. H. Goldman and M. Lichten (2000)
PNAS 97, 9537-9542
   Abstract »    Full Text »    PDF »
CENP-meta, an Essential Kinetochore Kinesin Required for the Maintenance of Metaphase Chromosome Alignment in Drosophila.
J. K. Yucel, J. D. Marszalek, J. R. McIntosh, L. S.B. Goldstein, D. W. Cleveland, and A. V. Philp (2000)
J. Cell Biol. 150, 1-12
   Abstract »    Full Text »    PDF »
Chromosomal Position Effects Reveal Different cis-Acting Requirements for rDNA Transcription and Sex Chromosome Pairing in Drosophila melanogaster.
A. Briscoe , Jr. and J. E. Tomkiel (2000)
Genetics 155, 1195-1211
   Abstract »    Full Text »


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