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Science 24 January 1997:
Vol. 275. no. 5299, pp. 540 - 543
DOI: 10.1126/science.275.5299.540
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Reports

Requirement for the Transcription Factor LSIRF/IRF4 for Mature B and T Lymphocyte Function

Hans-Willi Mittrücker, Toshifumi Matsuyama, Alex Grossman, Thomas M. Kündig, Julia Potter, Arda Shahinian, Andrew Wakeham, Bruce Patterson, Pamela S. Ohashi, Tak W. Mak *

Lymphocyte-specific interferon regulatory factor (LSIRF) (now called IRF4) is a transcription factor expressed only in lymphocytes. Mice deficient in IRF4 showed normal distribution of B and T lymphocyes at 4 to 5 weeks of age but developed progressive generalized lymphadenopathy. IRF4-deficient mice exhibited a profound reduction in serum immunoglobulin concentrations and did not mount detectable antibody responses. T lymphocyte function was also impaired in vivo; these mice could not generate cytotoxic or antitumor responses. Thus, IRF4 is essential for the function and homeostasis of both mature B and mature T lymphocytes.

H.-W. Mittrücker, A. Grossman, T. M. Kündig, J. Potter, A. Shahinian, A. Wakeham, P. S. Ohashi, T. W. Mak, Departments of Immunology and Medical Biophysics, University of Toronto, and the Amgen Institute, 610 University Avenue, Toronto, Ontario, M5G 2C1, Canada.
T. Matsuyama, Department of Oncology, Faculty of Medicine, Nagasaki University, Nagaskai, Japan.
B. Patterson, Department of Oncologic Pathology, Ontario Cancer Institute , 610 University Avenue, Toronto, Ontario, M5G 2C1, Canada.
*   To whom correspondence should be addressed.

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Interferon (IFN) Consensus Sequence-binding Protein, a Transcription Factor of the IFN Regulatory Factor Family, Regulates Immune Responses In Vivo through Control of Interleukin 12 Expression.
N. A. Giese, L. Gabriele, T. M. Doherty, D. M. Klinman, L. Tadesse-Heath, C. Contursi, S. L. Epstein, and H. C. Morse III (1997)
J. Exp. Med. 186, 1535-1546
   Abstract »    Full Text »    PDF »
Monocyte Differentiation to Macrophage Requires Interferon Regulatory Factor 7.
R. Lu and P. M. Pitha (2001)
J. Biol. Chem. 276, 45491-45496
   Abstract »    Full Text »    PDF »
AKT Induces Transcriptional Activity of PU.1 through Phosphorylation-mediated Modifications within Its Transactivation Domain.
P. Rieske and J. M. R. Pongubala (2001)
J. Biol. Chem. 276, 8460-8468
   Abstract »    Full Text »    PDF »
Regulation of Receptor Activator of NF-kappa B Ligand-induced Tartrate-resistant Acid Phosphatase Gene Expression by PU.1-interacting Protein/Interferon Regulatory Factor-4. SYNERGISM WITH MICROPHTHALMIA TRANSCRIPTION FACTOR.
M. Matsumoto, K. Hisatake, Y. Nogi, and M. Tsujimoto (2001)
J. Biol. Chem. 276, 33086-33092
   Abstract »    Full Text »    PDF »
Interferon Regulatory Factor 4 (IRF4) Interacts with NFATc2 to Modulate Interleukin 4 Gene Expression.
J. Rengarajan, K. A. Mowen, K. D. McBride, E. D. Smith, H. Singh, and L. H. Glimcher (2002)
J. Exp. Med. 195, 1003-1012
   Abstract »    Full Text »    PDF »


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