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Science 24 January 1997:
Vol. 275. no. 5299, pp. 536 - 540
DOI: 10.1126/science.275.5299.536
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Reports

DCP-1, a Drosophila Cell Death Protease Essential for Development

Zhiwei Song, Kimberly McCall, Hermann Steller *

Apoptosis, a form of cellular suicide, involves the activation of CED-3-related cysteine proteases (caspases). The regulation of caspases by apoptotic signals and the precise mechanism by which they kill the cell remain unknown. In Drosophila, different death-inducing stimuli induce the expression of the apoptotic activator reaper. Cell killing by reaper and two genetically linked apoptotic activators, hid and grim, requires caspase activity. A Drosophila caspase, named Drosophila caspase-1 (DCP-1), was identified and found to be structurally and biochemically similar to Caenorhabditis elegans CED-3. Loss of zygotic DCP-1 function in Drosophila caused larval lethality and melanotic tumors, showing that this gene is essential for normal development.

Howard Hughes Medical Institute, Department of Brain and Cognitive Sciences and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
*   To whom correspondence should be addressed.

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